Tissue expression
Cell line expression
Protein structure
BAD
BCL2 associated agonist of cell deathBBC2, BCL2L8
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]
Top validated antibodies |
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Boster Biological Technology | ![]() |
12 references | Monoclonal |
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Proteintech Group | ![]() |
92 references | Polyclonal |
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LSBio | ![]() |
Polyclonal |
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Cell Signaling Technology, Inc | ![]() |
6 references | Polyclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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