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- Antigen structure
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- Product number
- 10435-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10435-1-AP, RRID:AB_2061994
- Product name
- BAD antibody
- Antibody type
- Polyclonal
- Description
- BAD antibody (Cat. #10435-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Melatonin Exerts an Anti-Panoptoic Role in Spinal Cord Ischemia-Reperfusion Injured Rats.
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Stromal-derived MAOB promotes prostate cancer growth and progression.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Bacillus subtilis alleviates excessive apoptosis of intestinal epithelial cells in intrauterine growth restriction suckling piglets via the members of Bcl-2 and caspase families.
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
A Terphenyllin Derivative CHNQD-00824 from the Marine Compound Library Induced DNA Damage as a Potential Anticancer Agent.
Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma.
Celastrol attenuates streptozotocin-induced diabetic cardiomyopathy in mice by inhibiting the ACE / Ang II / AGTR1 signaling pathway.
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Methylcrotonyl-CoA carboxylase subunit 1 (MCCA) regulates multidrug resistance in multiple myeloma.
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Tongmai Yangxin Pills in Ameliorating Doxorubicin-Induced Cardiotoxicity.
Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Nrf2 Overexpression Decreases Vincristine Chemotherapy Sensitivity Through the PI3K-AKT Pathway in Adult B-Cell Acute Lymphoblastic Leukemia.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587.
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Resveratrol inhibits proliferation and induces apoptosis via the Hippo/YAP pathway in human colon cancer cells.
miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
SPAG6-silencing enhances decitabine-induced apoptosis and demethylation of PTEN in SKM-1 cells and in a xenograft mouse model.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Effects of targeted Notch1 silencing on the biological processes of the T24 and 5637 cells in vitro.
Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway.
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis.
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway.
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1.
Downregulation of 5-hydroxytryptamine receptor 3A expression exerts an anticancer activity against cell growth in colorectal carcinoma cells in vitro.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells.
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Recombinant hirudin suppresses the viability, adhesion, migration and invasion of Hep-2 human laryngeal cancer cells.
Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
Li J, Mo JR, Hu SY, Dong X, Li JW, Yang LY, Wu YJ
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Melatonin Exerts an Anti-Panoptoic Role in Spinal Cord Ischemia-Reperfusion Injured Rats.
Xie L, Wu H, Shi W, Zhang J, Huang X, Yu T
Advanced biology 2024 Jan;8(1):e2300424
Advanced biology 2024 Jan;8(1):e2300424
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Xie L, Wu H, He Q, Shi W, Zhang J, Xiao X, Yu T
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Stromal-derived MAOB promotes prostate cancer growth and progression.
Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, Yin L, Li J, Lin TP, Melamed J, Corey E, Gao AC, Wu BJ
Science advances 2024 Feb 9;10(6):eadi4935
Science advances 2024 Feb 9;10(6):eadi4935
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Bacillus subtilis alleviates excessive apoptosis of intestinal epithelial cells in intrauterine growth restriction suckling piglets via the members of Bcl-2 and caspase families.
Xie Z, Yun Y, Yu G, Zhang X, Zhang H, Wang T, Zhang L
Journal of the science of food and agriculture 2024 Aug 30;104(11):6924-6932
Journal of the science of food and agriculture 2024 Aug 30;104(11):6924-6932
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
Duan SF, Zhang MM, Dong Q, Yang B, Liu W, Zhang X, Yu HL, Zhang SH, Khan NH, Wu DD, Zhang XJ, Cen J
Journal of oncology 2023;2023:8456852
Journal of oncology 2023;2023:8456852
A Terphenyllin Derivative CHNQD-00824 from the Marine Compound Library Induced DNA Damage as a Potential Anticancer Agent.
Cao XZ, Zhang BQ, Wang CF, Yin JN, Haider W, Said G, Wei MY, Lu L
Marine drugs 2023 Sep 27;21(10)
Marine drugs 2023 Sep 27;21(10)
Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma.
Dong Y, Tan H, Wang L, Liu Z
Cancer cell international 2023 Sep 2;23(1):191
Cancer cell international 2023 Sep 2;23(1):191
Celastrol attenuates streptozotocin-induced diabetic cardiomyopathy in mice by inhibiting the ACE / Ang II / AGTR1 signaling pathway.
Zhao X, Huang B, Zhang J, Xiang W, Zhu N
Diabetology & metabolic syndrome 2023 Sep 12;15(1):186
Diabetology & metabolic syndrome 2023 Sep 12;15(1):186
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Zhang M, Zhu LZ, Yang CJ, Yan JX, Wang ZP, Bai YP, Peng LZ, Luo HB, Zhang ZJ, Li L, Xu CR, Liu YQ
Bioorganic chemistry 2023 Oct;139:106652
Bioorganic chemistry 2023 Oct;139:106652
Methylcrotonyl-CoA carboxylase subunit 1 (MCCA) regulates multidrug resistance in multiple myeloma.
Feng Y, Huang J, Wang F, Lin Z, Luo H, Li Q, Wang X, Liu X, Zhai X, Gao Q, Li L, Zhang Y, Wen J, Zhang L, Niu T, Zheng Y
Life sciences 2023 Nov 15;333:122157
Life sciences 2023 Nov 15;333:122157
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
Wang DY, Zhang J, Li HX, Zhang YX, Jing MR, Cai CB, Wang D, Qi HW, Wang YZ, Chen HJ, Li T, Zhai YK, Ji XY, Wu DD
Molecular carcinogenesis 2023 May;62(5):652-664
Molecular carcinogenesis 2023 May;62(5):652-664
Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Tongmai Yangxin Pills in Ameliorating Doxorubicin-Induced Cardiotoxicity.
Shu L, Wang Y, Huang W, Fan S, Pan J, Lv Q, Wang L, Wang Y, Xu J, Yan H, Bai Y, Wang Y, Li Y
ACS omega 2023 May 23;8(20):18128-18139
ACS omega 2023 May 23;8(20):18128-18139
Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.
Lin CL, Yu CI, Lee TH, Chuang JM, Han KF, Lin CS, Huang WP, Chen JY, Chen CY, Lin MY, Lee CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154655
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Duan S, Xia Y, Tian X, Cui J, Zhang X, Yang Q, Zhao T, Lin Y, Zhang F, Zhang X, Cen J
Carbohydrate polymers 2023 Jun 15;310:120695
Carbohydrate polymers 2023 Jun 15;310:120695
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Wang Y, Liu Q, Chu C, Li L, Wang Z, Liu Q, Wu G, Wei X, An L, Ma J
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Toxicology and applied pharmacology 2023 Feb 15;461:116385
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
Kuang C, Xia M, An G, Liu C, Hu C, Zhang J, Liu Z, Meng B, Su P, Xia J, Guo J, Zhu Y, Liu X, Wu X, Shen Y, Feng X, He Y, Li J, Qiu L, Zhou J, Zhou W
Nature communications 2023 Apr 13;14(1):2093
Nature communications 2023 Apr 13;14(1):2093
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Zhang T, Wang WL, Liu TJ, Lu S, Bian YC, Xiao R, Zhang CL
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.
Jiang QY, Li JM, Jing MR, Zhang YX, Zhang QQ, Cai CB, Wang D, Qi HW, Li T, Li YZ, Ji XY, Wu DD
Oxidative medicine and cellular longevity 2022;2022:8678363
Oxidative medicine and cellular longevity 2022;2022:8678363
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Chen YG, Liu HX, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY, Wu DD, Ji XY
International journal of biological sciences 2022;18(9):3605-3620
International journal of biological sciences 2022;18(9):3605-3620
Nrf2 Overexpression Decreases Vincristine Chemotherapy Sensitivity Through the PI3K-AKT Pathway in Adult B-Cell Acute Lymphoblastic Leukemia.
Wang L, Liu X, Kang Q, Pan C, Zhang T, Feng C, Chen L, Wei S, Wang J
Frontiers in oncology 2022;12:876556
Frontiers in oncology 2022;12:876556
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
Duan SF, Zhang MM, Zhang X, Liu W, Zhang SH, Yang B, Dong Q, Han JG, Yu HL, Li T, Ji XY, Wu DD, Zhang XJ
Experimental cell research 2022 Nov 1;420(1):113341
Experimental cell research 2022 Nov 1;420(1):113341
TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Cai J, Gao L, Wang Y, Li Y, Ye Z, Tong S, Yan T, Sun Q, Xu Y, Jiang H, Zhang S, Zhao L, Yang J, Chen Q
Translational oncology 2022 May;19:101391
Translational oncology 2022 May;19:101391
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
Khan NH, Wang D, Wang W, Shahid M, Khattak S, Ngowi EE, Sarfraz M, Ji XY, Zhang CY, Wu DD
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
Lin Z, Yang S, Zhou Y, Hou Z, Li L, Meng M, Ge C, Zeng B, Lai J, Gao H, Zhao Y, Xie Y, He S, Tang W, Li R, Tan J, Wang W
Translational oncology 2022 Feb;16:101331
Translational oncology 2022 Feb;16:101331
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587.
Lin K, Shen SH, Lu F, Zheng P, Wu S, Liao J, Jiang X, Zeng G, Wei D
Journal of translational medicine 2022 Feb 19;20(1):96
Journal of translational medicine 2022 Feb 19;20(1):96
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Zhang Q, Gao Y, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X, Li Y, Wu D
Oncogene 2022 Dec;41(49):5238-5252
Oncogene 2022 Dec;41(49):5238-5252
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Zhou X, Song L, Cong R, Luan J, Zhou X, Wang Y, Yao L, Zhang X, Ren X, Zhang T, Yu M, Song N
Chemosphere 2022 Dec;308(Pt 3):136486
Chemosphere 2022 Dec;308(Pt 3):136486
Resveratrol inhibits proliferation and induces apoptosis via the Hippo/YAP pathway in human colon cancer cells.
Qin X, Luo H, Deng Y, Yao X, Zhang J, He B
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):197-204
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):197-204
miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis.
Zhao J, Ma X, Xu H
Oncology letters 2022 Aug;24(2):289
Oncology letters 2022 Aug;24(2):289
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
SPAG6-silencing enhances decitabine-induced apoptosis and demethylation of PTEN in SKM-1 cells and in a xenograft mouse model.
Luo J, Mu J, Zhang M, Zhao B, Liu L
Leukemia & lymphoma 2021 Sep;62(9):2242-2252
Leukemia & lymphoma 2021 Sep;62(9):2242-2252
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Jhou AJ, Chang HC, Hung CC, Lin HC, Lee YC, Liu WT, Han KF, Lai YW, Lin MY, Lee CH
Biochemical pharmacology 2021 Feb;184:114403
Biochemical pharmacology 2021 Feb;184:114403
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Chang L, Zhou R, He Y, Meng M, Hu J, Liu Y, Pan Y, Tang Z, Yue Z
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Zhou X, Zhang T, Song L, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhang W, Song N, Wang S
Ecotoxicology and environmental safety 2021 Aug;219:112323
Ecotoxicology and environmental safety 2021 Aug;219:112323
Effects of targeted Notch1 silencing on the biological processes of the T24 and 5637 cells in vitro.
Zheng K, Han X, Su Y, Wang Q, Ma Q, Zheng K
Oncology letters 2021 Apr;21(4):305
Oncology letters 2021 Apr;21(4):305
Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways.
Wu X, Liu Y, Zhang E, Chen J, Huang X, Yan H, Cao W, Qu J, Gu H, Xu R, He J, Cai Z
Oxidative medicine and cellular longevity 2020;2020:6096391
Oxidative medicine and cellular longevity 2020;2020:6096391
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway.
Zhao J, Xu H, Duan Z, Chen X, Ao Z, Chen Y, Ruan Y, Ni M
Cancer management and research 2020;12:6679-6694
Cancer management and research 2020;12:6679-6694
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Yin Z, Wang X, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X, Zhang S
Frontiers in aging neuroscience 2020;12:582455
Frontiers in aging neuroscience 2020;12:582455
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
Su W, Zhao J, Fan TJ
Frontiers in pharmacology 2020;11:202
Frontiers in pharmacology 2020;11:202
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
Wu S, Zhang X, Dong M, Yang Z, Zhang M, Chen Q
Oncology reports 2020 Oct;44(4):1467-1478
Oncology reports 2020 Oct;44(4):1467-1478
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Li Q, Ma Y, Liu XL, Mu L, He BC, Wu K, Sun WJ
Oncology reports 2020 Nov;44(5):2093-2107
Oncology reports 2020 Nov;44(5):2093-2107
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
Wu P, Shi X, Luo M, Inam-U-Llah, Li K, Zhang M, Ma J, Li Y, Liu Y, Zhang C, Liu X, Li S, Li Q, Chen X, Che X, Piao F
Amino acids 2020 Jan;52(1):87-102
Amino acids 2020 Jan;52(1):87-102
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Liu Y, Fan D
Nutrients 2020 Jan 18;12(1)
Nutrients 2020 Jan 18;12(1)
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
Ding XY, Hu HY, Huang KN, Wei RQ, Min J, Qi C, Tang H, Qin X
Cancer science 2020 Feb;111(2):489-501
Cancer science 2020 Feb;111(2):489-501
Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis.
Li L, He Y, He XJ, Bi MR, Qi YH, Zhu WW
Experimental and molecular pathology 2020 Dec;117:104562
Experimental and molecular pathology 2020 Dec;117:104562
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Han J, Kan J, Wang X, Yuan Q, Song X, Huang M, Wu H
Translational cancer research 2020 Aug;9(8):4715-4725
Translational cancer research 2020 Aug;9(8):4715-4725
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Su Q, Wang J, Liu F, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771
International journal of nanomedicine 2019;14:3753-3771
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Xu B, Sui YL, Fan TJ
International journal of ophthalmology 2019;12(10):1524-1530
International journal of ophthalmology 2019;12(10):1524-1530
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, Liu Z, Zheng M, Wang H, Wang J, Teng T, Zhang L, Ji X, Xie Z, Ji A, Li Y
Journal of Cancer 2019;10(7):1693-1706
Journal of Cancer 2019;10(7):1693-1706
Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.
Li M, Hao S, Li C, Xiao H, Sun L, Yu Z, Zhang N, Xiong Y, Zhao D, Yin Y
Biomolecules 2019 Sep 19;9(9)
Biomolecules 2019 Sep 19;9(9)
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y
European journal of medicinal chemistry 2019 Sep 15;178:177-194
European journal of medicinal chemistry 2019 Sep 15;178:177-194
Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway.
Li K, Shi X, Luo M, Inam-U-Llah, Wu P, Zhang M, Zhang C, Li Q, Wang Y, Piao F
Experimental cell research 2019 Oct 15;383(2):111557
Experimental cell research 2019 Oct 15;383(2):111557
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Dong Q, Yang B, Han JG, Zhang MM, Liu W, Zhang X, Yu HL, Liu ZG, Zhang SH, Li T, Wu DD, Ji XY, Duan SF
Cancer letters 2019 Jul 28;455:60-72
Cancer letters 2019 Jul 28;455:60-72
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Zhao G, Li K, Chen J, Li L
Translational neuroscience 2018;9:183-189
Translational neuroscience 2018;9:183-189
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Zhang GY, Lu D, Duan SF, Gao YR, Liu SY, Hong Y, Dong PZ, Chen YG, Li T, Wang DY, Cheng XS, He F, Wei JS, Li GY, Zhang QY, Wu DD, Ji XY
Oxidative medicine and cellular longevity 2018;2018:9647809
Oxidative medicine and cellular longevity 2018;2018:9647809
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Yu G, Liao J, Wu J, Ding J, Zhang L
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1.
Peng X, Yan B, Shen Y
Breast cancer (Tokyo, Japan) 2018 Nov;25(6):742-752
Breast cancer (Tokyo, Japan) 2018 Nov;25(6):742-752
Downregulation of 5-hydroxytryptamine receptor 3A expression exerts an anticancer activity against cell growth in colorectal carcinoma cells in vitro.
Tang J, Wang Z, Liu J, Zhou C, Chen J
Oncology letters 2018 Nov;16(5):6100-6108
Oncology letters 2018 Nov;16(5):6100-6108
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Wu DD, Gao YR, Li T, Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS, Ji XY
BMC cancer 2018 May 2;18(1):499
BMC cancer 2018 May 2;18(1):499
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)
Marine drugs 2018 Mar 26;16(4)
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
Han B, Jiang P, Liu W, Xu H, Li Y, Li Z, Ma H, Yu Y, Li X, Ye X
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, Xiong Y, Wang Y, Ye Q
Molecular medicine reports 2018 Jul;18(1):815-826
Molecular medicine reports 2018 Jul;18(1):815-826
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Mehmood T, Maryam A, Tian X, Khan M, Ma T
Journal of Cancer 2017;8(18):3707-3717
Journal of Cancer 2017;8(18):3707-3717
Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.
Chen M, Lv JM, Ye JQ, Cui XG, Qu FJ, Chen L, Liu X, Pan XW, Li L, Huang H, Yang QW, Chen J, Wang LH, Gao Y, Xu DF
International journal of oncology 2017 Jul;51(1):39-48
International journal of oncology 2017 Jul;51(1):39-48
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, Polin L, Dyson G, Taub JW, Mohammad RM, Azmi AS, Zhao L, Ge Y
Oncotarget 2017 Jul 4;8(27):44295-44311
Oncotarget 2017 Jul 4;8(27):44295-44311
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y, Bi B
SpringerPlus 2016;5:235
SpringerPlus 2016;5:235
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, Wang Y
BMC microbiology 2016 Sep 23;16(1):222
BMC microbiology 2016 Sep 23;16(1):222
Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells.
Chai R, Yu X, Tu S, Zheng B
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13225-13235
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13225-13235
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Radiation research 2016 Jan;185(1):77-86
Radiation research 2016 Jan;185(1):77-86
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
Xie HX, Xu ZY, Tang JN, DU YA, Huang L, Yu PF, Cheng XD
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Dai B, Wang W, Liu R, Wang H, Zhang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33
Recombinant hirudin suppresses the viability, adhesion, migration and invasion of Hep-2 human laryngeal cancer cells.
Lu Q, Lv M, Xu E, Shao F, Feng Y, Yang J, Shi L
Oncology reports 2015 Mar;33(3):1358-64
Oncology reports 2015 Mar;33(3):1358-64
Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.
Wang J, Lao L, Zhao H, Huang Y
International journal of clinical and experimental medicine 2014;7(2):348-55
International journal of clinical and experimental medicine 2014;7(2):348-55
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Zhao L, Teng B, Wen L, Feng Q, Wang H, Li N, Wang Y, Liang Z
International journal of clinical and experimental medicine 2014;7(2):337-47
International journal of clinical and experimental medicine 2014;7(2):337-47
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
Yu G, Jiang L, Xu Y, Guo H, Liu H, Zhang Y, Yang H, Yuan C, Ma J
PloS one 2012;7(11):e48146
PloS one 2012;7(11):e48146
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Tunicamycin treated HeLa cells were subjected to SDS PAGE followed by western blot with 10435-1-AP( BAD Antibody) at dilution of 1:300
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BAD antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BAD. This antibody recognizes human,mouse,rat antigen. The BAD antibody has been validated for the following applications: ELISA, WB analysis.
