Explore
Validate
Learn
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MAB710 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse FGFR3 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse FGF R3 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with the (IIIb) and (IIIc) isoforms of recombinant human FGF R3 is observed. Neutralizes the bioactivity of mouse FGF R3. Functions equally as well in the neutralization of recombinant mouse (rm) FGF R3 alpha (IIIb) and rmFGF R3 alpha (IIIc).
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
NP_001156689- Isotype
- IgG
- Antibody clone number
- 136812
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes.
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis.
Zhang Y, Xu S, Liang KY, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC
The Journal of biological chemistry 2017 Jan 6;292(1):100-111
The Journal of biological chemistry 2017 Jan 6;292(1):100-111
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis.
Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK
Molecular biology of the cell 2006 Feb;17(2):576-84
Molecular biology of the cell 2006 Feb;17(2):576-84
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- FGF R3 Inhibition of FGF acidic-dependent Cell Proliferation and Neutral-ization by Mouse FGF R3 Antibody. Recombinant Mouse FGF R3 (IIIc) Fc Chimera (Catalog # 710-MF) inhibits Recom-binant Human FGF acidic (Catalog # 232-FA) induced proliferation in the NR6R-3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of Recom-binant Human FGF acidic (0.3 ng/mL) activity elicited by Recom-binant Mouse FGF R3 (IIIc) Fc Chimera (12 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse FGF R3 Mono-clonal Antibody (Catalog # MAB710). The ND50 is typically 3-12 µg/mL in the presence of heparin (10 µg/mL).
