AGTO-G028G

antibody from Creative Biolabs

Targeting: FGFR3 ACH, CD333, CEK2, JTK4

No application information provided.

Antibody Data

Product number

AGTO-G028G

Provider

Creative Biolabs

Product name

Anti-FGFR3 immunotoxin (scFv)-Gel

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-FGFR3 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating bladder carcinoma .

Reactivity

Human

Host

Mouse