Antibody data
- Antibody Data
- Antigen structure
- References [29]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10723-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10723-1-AP, RRID:AB_2218756
- Product name
- KU70 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KU70 antibody (Cat. #10723-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance.
CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites.
CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
C9orf72 functions in the nucleus to regulate DNA damage repair.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.
Screening and characterization of myositis-related autoantibodies in COVID-19 patients.
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process.
WASH interacts with Ku to regulate DNA double-stranded break repair.
Proteomic Analysis of Vero Cells Infected with Pseudorabies Virus.
Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer.
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.
Increasing CRISPR/Cas9-mediated homology-directed DNA repair by histone deacetylase inhibitors.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the β-Catenin/Wnt Signaling Pathway and Is Associated with Poor Prognosis.
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549.
Wang H, Zhang Y, Tian Y, Yang W, Wang Y, Hou H, Pan H, Pei S, Zhu H, Gu Z, Zhang Y, Dai D, Chen W, Zheng M, Luo Q, Xiao Y, Huang J
Cancer research 2024 Mar 4;84(5):688-702
Cancer research 2024 Mar 4;84(5):688-702
CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.
Lyu F, Huang S, Yan Z, He Q, Liu C, Cheng L, Cong Y, Chen K, Song Y, Xing Y
Cellular signalling 2024 Jul;119:111164
Cellular signalling 2024 Jul;119:111164
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites.
Wang T, Zheng AX, Li P, Tang T, Zhang LP, Hong Y, Hong X, Deng ZH
DNA repair 2024 Jan;133:103603
DNA repair 2024 Jan;133:103603
CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.
Lin L, Hu P, Luo M, Chen X, Xiao M, Zhong Z, Peng S, Chen G, Yang G, Zhang F, Zhang Y
International journal of biological macromolecules 2024 Apr;264(Pt 2):130541
International journal of biological macromolecules 2024 Apr;264(Pt 2):130541
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Bao K, Ma Y, Li Y, Shen X, Zhao J, Tian S, Zhang C, Liang C, Zhao Z, Yang Y, Zhang K, Yang N, Meng FL, Hao J, Yang J, Liu T, Yao Z, Ai D, Shi L
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
C9orf72 functions in the nucleus to regulate DNA damage repair.
He L, Liang J, Chen C, Chen J, Shen Y, Sun S, Li L
Cell death and differentiation 2023 Mar;30(3):716-730
Cell death and differentiation 2023 Mar;30(3):716-730
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122
Journal of ovarian research 2023 Jun 27;16(1):122
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645
The FEBS journal 2023 Jul;290(14):3629-3645
Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.
Chen M, Zhao E, Li M, Xu M, Hao S, Gao Y, Wu X, Li X, Yu Y, Yu Z, Yin Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154876
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154876
Screening and characterization of myositis-related autoantibodies in COVID-19 patients.
Teo KF, Chen DY, Hsu JT, Lai YH, Chang CK, Hsueh PR, Lan JL, Hsu JL
Clinical and translational science 2023 Jan;16(1):140-150
Clinical and translational science 2023 Jan;16(1):140-150
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068
Frontiers in oncology 2022;12:887068
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Li Q, Yao H, Wang Y, Wu Y, Thorne RF, Zhu Y, Wu M, Liu L
Cell reports 2022 Nov 22;41(8):111707
Cell reports 2022 Nov 22;41(8):111707
NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process.
Shen W, Luo P, Sun Y, Zhang W, Zhou N, Zhan H, Zhang Q, Shen J, Lin A, Cheng Q, Wang Q, Zhang J, Wang HH, Wei T
iScience 2022 Jun 17;25(6):104471
iScience 2022 Jun 17;25(6):104471
WASH interacts with Ku to regulate DNA double-stranded break repair.
Wang T, Du XH, Hong Y, Hong X, Fan L, Zhou JW, Sun H, Ge J, Billadeau DD, Deng ZH
iScience 2022 Jan 21;25(1):103676
iScience 2022 Jan 21;25(1):103676
Proteomic Analysis of Vero Cells Infected with Pseudorabies Virus.
Yang X, Xu S, Chen D, Jiang R, Kang H, Ge X, Zhou L, Han J, Zhang Y, Guo X, Yang H
Viruses 2022 Apr 4;14(4)
Viruses 2022 Apr 4;14(4)
Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.
Cao C, Han P, Liu L, Tang Y, Tian S, Zhang K, Shi L, Liu Z, Zhuo D, Ge W, Gong W
The Journal of biological chemistry 2021 Sep;297(3):101036
The Journal of biological chemistry 2021 Sep;297(3):101036
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837
Cell death & disease 2021 Sep 6;12(9):837
Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer.
Li S, Sun W, Luo Y, Gao Y, Jiang X, Yuan C, Han L, Cao K, Gong Y, Xie C
Journal of materials chemistry. B 2021 Jun 16;9(23):4643-4653
Journal of materials chemistry. B 2021 Jun 16;9(23):4643-4653
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
Cui Y, Xie R, Zhang X, Liu Y, Hu Y, Li Y, Liu X, Yu X, Wu C
Cell death & disease 2021 Jun 16;12(7):622
Cell death & disease 2021 Jun 16;12(7):622
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.
Guo Z, Wang YH, Xu H, Yuan CS, Zhou HH, Huang WH, Wang H, Zhang W
Cell death & disease 2021 Jan 4;12(1):69
Cell death & disease 2021 Jan 4;12(1):69
Increasing CRISPR/Cas9-mediated homology-directed DNA repair by histone deacetylase inhibitors.
Li G, Zhang X, Wang H, Liu D, Li Z, Wu Z, Yang H
The international journal of biochemistry & cell biology 2020 Aug;125:105790
The international journal of biochemistry & cell biology 2020 Aug;125:105790
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
The Journal of physiology 2019 May;597(9):2391-2401
The Journal of physiology 2019 May;597(9):2391-2401
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7758-7766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7758-7766
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
Wang A, Ning Z, Lu C, Gao W, Liang J, Yan Q, Tan G, Liu J
Frontiers in pharmacology 2017;8:274
Frontiers in pharmacology 2017;8:274
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO, Weng C
Oncogene 2017 Feb 23;36(8):1145-1156
Oncogene 2017 Feb 23;36(8):1145-1156
High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the β-Catenin/Wnt Signaling Pathway and Is Associated with Poor Prognosis.
Zhu B, Cheng D, Li S, Zhou S, Yang Q
International journal of molecular sciences 2016 Jul 22;17(7)
International journal of molecular sciences 2016 Jul 22;17(7)
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549.
Zhou H, Mu X, Chen J, Liu H, Shi W, Xing E, Yang K, Wu G
International journal of radiation biology 2013 Sep;89(9):708-15
International journal of radiation biology 2013 Sep;89(9):708-15
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10723-1-AP(KU70,XRCC6 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using XRCC6 antibody 10723-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10723-1-AP(KU70,XRCC6 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded rat testis using 10723-1-AP(KU70,XRCC6 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue