66607-1-Ig

antibody from Proteintech Group

Targeting: XRCC6 D22S671, D22S731, G22P1, KU70, ML8

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66607-1-Ig

Provider

Proteintech Group

Product name

KU70,XRCC6 antibody

Antibody type

Monoclonal

Description

KU70,XRCC6 antibody (Cat. #66607-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3C12D9

Vial size

20ul, 150ul

References

Submitted references

Crocetin suppresses colorectal cancer progression by targeting TGM2 and inhibiting the JAK2/STAT3 pathway.

Chen S, Su W, Wang K, Xu M, Su B
Investigational new drugs 2026 Mar 14;

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ATG9 inhibits Rickettsia binding to the host cell surface by blocking the rOmpB-XRCC6/KU70 interaction.

Chen C, Liu G, Xu K, Chen A, Cheng Z, Yan X, Zhang T, Sun Y, Yu T, Wang J, Luo S, Zhou W, Deng S, Liu Y, Yang Y
Autophagy 2025 Oct;21(10):2213-2229

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USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency.

Ma LZ, Wang A, Lai YH, Zhang J, Zhang XF, Chen SL, Zhou XY
Journal of translational medicine 2024 Sep 11;22(1):834

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Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.

Lu Q, Ren N, Chen H, Zhang S, Yan R, Li M, Zheng L, Tan W, Lin D
Frontiers of medicine 2024 Oct;18(5):921-937

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Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma.

Huang Q, Tian N, Zhang J, Song S, Cheng H, Liu X, Zhang W, Ye Y, Du Y, Dai X, Liang R, Li D, Dai SM, Wang C, Chen Z, Zhou Q, Li B
The Journal of clinical investigation 2024 Oct 24;134(23)

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MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.

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Interactome of intact chromatosome variants with site-specifically ubiquitylated and acetylated linker histone H1.2.

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MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC.

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Cell & bioscience 2023 Sep 27;13(1):178

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NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.

Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
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ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

Zhou C, Li S, Bin K, Qin G, Pan P, Ren D, Zhao Y, Xia W, Chen J, Liu J, Wu H, Zhou Y
Cancer letters 2022 Oct 28;547:215855

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circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.

Li Q, Yao H, Wang Y, Wu Y, Thorne RF, Zhu Y, Wu M, Liu L
Cell reports 2022 Nov 22;41(8):111707

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WASH interacts with Ku to regulate DNA double-stranded break repair.

Wang T, Du XH, Hong Y, Hong X, Fan L, Zhou JW, Sun H, Ge J, Billadeau DD, Deng ZH
iScience 2022 Jan 21;25(1):103676

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Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles.

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Cytoplasmic DNA sensing by KU complex in aged CD4(+) T cell potentiates T cell activation and aging-related autoimmune inflammation.

Wang Y, Fu Z, Li X, Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M, Xiao Y
Immunity 2021 Apr 13;54(4):632-647.e9