SUMO1

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Description

Small ubiquitin like modifier 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane, Nucleoli, Nuclear bodies

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (202206182 - 202238599)

Ensembl ID

ENSG00000116030  (ver. 103.38)

Orthologs

Mouse Sumo1: ENSMUSG00000026021

UniProt

P63165

neXtProt

NX_P63165

Human splice variants
Mouse splice variants

Protein structure