CABT-L1822

antibody from Creative Diagnostics

Targeting: PLCB1 KIAA0581, PLC-I, PLC154

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1822

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human PLCB1 polyclonal antibody

Antibody type

Polyclonal

Description

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC Ñ´1, PLC Ñ´2 and PLC š÷) with molecular weights ranging from 85 to 150 kDa. PLC ÉÇ1, one of the PLC ÉÇ isozymes, exists as two immunologically distinguishable proteins of 150 (PLC-ÉÇ1a) and 140 kDa (PLC ÉÇ1b) . The two isoforms encode in two distinct transcripts and generated by alternative splicing of a single gene. PLC ÉÇ1a is preferentially expressed in the cytosol, whereas PLC ÉÇ1b is predominantly localized in the nuclei. PLC ÉÇ1 is a G-protein-dependent phosphodiesterase that hydrolyses phosphatidylinositol 4,5 biphosphate into inositol 1,4,5-triphosphate and diacylglycerol after the stimulation of a variety of neurotransmitter receptors at the cell surface.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.