BS1709

antibody from Bioworld Technology, Inc
Targeting: PLCG1 NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Provider product page for BS1709
Western blot
Immunohistochemistry

Antibody data

Product number
BS1709 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1709, RRID:AB_1662923
Product name
PLC ÎÛ1 (G765) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 730-780 of Human PLC ÎÛ1.
Description
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC Ñ´1, PLC Ñ´2 and PLC š÷. PLC ÎÛ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC ÎÛ1 in the brush border of intestinal epithelial cells. Villin regulates PLC ÎÛ1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC ÎÛ1 binds Ï«1ÉÇ1 Integrin and modulates Ï«1ÉÇ1 Integrin-specific adhesion. PLC ÎÛ1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PLCG1 protein structure - BS1709 shown in red.