BS4865
antibody from Bioworld Technology, Inc
Targeting: PLCG1
NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS4865 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PLC ÎÛ1 (phospho Y1253) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human PLC ÎÛ1 around the phosphorylation site of Tyrosine 1253.
- Description
- Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC Ñ´1, PLC Ñ´2 and PLC ÷. PLC ÎÛ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC ÎÛ1 in the brush border of intestinal epithelial cells. Villin regulates PLC ÎÛ1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC ÎÛ1 binds Ï«1ÉÇ1 Integrin and modulates Ï«1ÉÇ1 Integrin-specific adhesion. PLC ÎÛ1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of p-PLC ¦Ã1 (Y1253) pAb at 1:500 dilutionLane1:MCF-7 cell lysate treated with EGF(0.1ng/ML,30mins)Lane2:Mouse liver tissue lysateLane3:H9C2 cell lysate treated with EGF(0.1ng/ML,30mins)