CABT-B9287
antibody from Creative Diagnostics
Targeting: PLCG1
NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- CABT-B9287 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Cow Phospholipase CÎÛ1 monoclonal antibody, clone 20
- Antibody type
- Monoclonal
- Description
- The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLCÎÛ is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLCÎÛ1, which is ubiquitously expressed, and 2) PLCÎÛ2, found primarily in the lymphoid system. PLCÎÛ is essential for growth factor-induced cell motility and mitogenesis. PLCÎÛ1 null mice exhibit retarded embryonic growth and lethality in midgestation. Overexpression of PLCÎÛ is evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of PLCÎÛ activity by growth factors is involved in cell growth and transformation.
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 20
- Vial size
- 50ug, 150ug
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
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