Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS1418 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1418, RRID:AB_1663343
- Product name
- PLC ÎÛ2 (R747) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 720-770 of Human PLC ÎÛ2.
- Description
- Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLCÎÛ1, PLCÎÛ2, PLC Ñ´1, PLC Ñ´2 and PLCe. PLCÑ´ exists as four different isoforms. PLC Ñ´1, a calcium signal amplifier, is activated by an atypical GTP-binding protein. In addition, PLC Ñ´1 is an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and Ï«1B-adrenoreceptor signaling. Mouse PLC Ñ´1 is highly expressed in brain, heart, lung and testis.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of PLC ¦Ã2 (R747) pAb at 1:500 dilutionLane1:A549 cell lysateLane2:NIH-3T3 cell lysateLane3:Mouse brain tissue lysateLane4:Rat brain tissue lysate