Antibody data

Product number
BS64003 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PLC ÎÛ2 (phospho Y759) polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human PLC ÎÛ2 around the phosphorylation site of Tyrosine 759.
Description
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptormediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol fromphosphatidylinositol 4,5-bisphosphate.There are manymammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC Ñ´1, PLC Ñ´2 and PLC š÷. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC ÎÛ2 associateswith several tyrosine-phosphorylated proteins(Syk, SLP-76,Lyn, linker for activation of T cells(LAT) and the FcR ÎÛ chain),which bind to its C-terminal SH2 domain. PLC ÎÛ1 associateswith Syk in B cells, but PLC ÎÛ2 does not associatewith Sykin platelets. The C-terminal SH2 domain isinvolved in the regulation of PLC ÎÛ2. In addition, Btkcan induce PLC ÎÛ2 tyrosine phosphorylation and initiate calcium moblization in CD72- stimulated B lymphocytes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PLCG2 protein structure - BS64003 shown in red.