Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS61288 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PLC ÎÛ2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human PLC ÎÛ2.
- Description
- Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC ÉÇ1, PLC ÉÇ2, PLC ÉÇ3, PLC ÉÇ4, PLC ÎÛ1, PLC ÎÛ2, PLC Ñ´1, PLC Ñ´2 and PLC ÷. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC ÎÛ2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR ÎÛ chain), which bind to its C-terminal SH2 domain. PLC ÎÛ1 associates with Syk in B cells, but PLC ÎÛ2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC ÎÛ2. In addition, Btk can induce PLC ÎÛ2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of PLC ¦Ã2 pAb at 1:500 Line1:HEK293T whole cell lysateLine2:H9C2 whole cell lysateLine3:Raw264.7 whole cell lysate