ABIN196907

antibody from antibodies-online

Targeting: PLCG2

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

ABIN196907

Provider

antibodies-online

Product name

anti-Phospholipase C gamma 2 (PLCG2) (pTyr753) antibody

Antibody type

Polyclonal

Description

Affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pTyr753

Vial size

50 μL

Storage

Store the antibody (in aliquots) at -20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.

Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
The Journal of biological chemistry 2004 Sep 3;279(36):37651-61

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Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.

Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG
Molecular and cellular biology 2004 Nov;24(22):9986-99

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Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.

Suzuki-Inoue K, Wilde JI, Andrews RK, Auger JM, Siraganian RP, Sekiya F, Rhee SG, Watson SP
The Biochemical journal 2004 Mar 15;378(Pt 3):1023-9

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Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.

Rodriguez R, Matsuda M, Storey A, Katan M
The Biochemical journal 2003 Aug 15;374(Pt 1):269-80