MB0080

antibody from Bioworld Technology, Inc

Targeting: PPARG NR1C3, PPARG1, PPARG2, PPARgamma

No application information provided.

Antibody Data

Product number

MB0080

Provider

Bioworld Technology, Inc

Product name

PPAR ÎÛ (C terminus) monoclonal antibody

Antibody type

Monoclonal

Antigen

Synthetic peptide, corresponding to amino acids C-terminus of Human PPAR-ÎÛ.

Description

PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.

Reactivity

Human

Host

Mouse

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.