PPARG

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Peroxisome proliferator activated receptor gamma

Tissue specificity

Tissue enhanced (adipose tissue)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

3:p25.2 (12287368 - 12434356)

Ensembl ID

ENSG00000132170  (ver. 103.38)

Orthologs

Mouse Pparg: ENSMUSG00000000440

UniProt

P37231

neXtProt

NX_P37231

Human splice variants
Mouse splice variants