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- Product number
- 16643-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16643-1-AP, RRID:AB_10596794
- Product name
- PPAR Gamma antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PPAR Gamma antibody (Cat. #16643-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
TL1A serves as a positive regulator to promote adipocyte differentiation.
GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization.
Acetylshikonin mitigates diet-induced MASLD by targeting PPARγ-mediated metabolic dysfunction.
Mertk promotes early microglial-mediated synaptic engulfment in Alzheimer's disease.
An antibody-mediated versatile SERS sandwich biosensor for ultrasensitive detection of functional proteins in cells and tissues.
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen.
β-Sitosterol Suppresses Osteoclastogenesis and Alleviates Bone Loss by Targeting Tmed10 to Inhibit RANKL-Induced Hedgehog/MAPK Signaling and ROS.
Schisandrin B enhances autophagy and random flaps survival through the PPARG-mediated PI3K/AKT/mTOR signaling pathway.
Chaihu-Shugan San ameliorates perimenopausal obesity with depression by coordinately targeting hepatic PGC-1α/CYP8B1/PPARγ signaling and gut barrier integrity.
Fibroblast growth factor 21 with molybdenum nanodots in a self-contracting thermosensitive hydrogel promotes diabetic wound repair by reprogramming lipid metabolism.
Salvia miltiorrhiza Bge. processed with porcine cardiac blood alleviates cerebral ischemia reperfusion injury through activating PPARγ/NF-κB pathway via suppressing arachidonic acid metabolism.
USP2 promotes metabolic dysfunction-associated steatotic liver disease progression via stabilization of PPARγ.
Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.
M2 macrophage-derived exosome nanoplatform for targeted H(2)S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling.
CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels.
Integrating Mendelian randomization and multi-omics analysis unravels gut microbiota-driven metabolic mechanisms in sepsis and identifies diagnostic biomarkers through experimental validation.
Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway.
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Adipogenic transdifferentiation reprograms EMT-high PDAC cells into a post-mitotic adipocyte-like state and limits metastasis.
Biglycan knockdown improves Graves' orbitopathy (GO)-like features via inhibiting NF-kB and ERK signaling.
Maternal β-hydroxybutyrate during the dry period is associated with altered epithelial cell regulation and rumen morphology of offspring as calves.
Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification.
The Porcine Colitis Model Recapitulates the Visceral Adipose Metabolic Reprogramming of Human Ulcerative Colitis.
Integrating metabolomics and molecular dynamics simulation to elucidate the anti-atherosclerotic mechanisms of Gynostemma pentaphyllum.
Growth hormone enhances mitochondria biogenesis and endows mitochondrial thermogenesis in murine adipocytes.
Polystyrene nanoplastics promote adipogenesis by stimulating nuclear translocation of PPARγ.
Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the PPAR and CYP7A1 pathways in broilers.
Identification of blood-absorbed components of Qingkui Yuyang decoction and its mechanistic roles in ulcerative colitis based on UPLC-Q-Exactive Orbitrap-MS/MS and network pharmacology.
Babaodan alleviates MAFLD through hepatic glycerophospholipid metabolism and PPARγ/RXRA/GPAT3 based on spatial metabolomics and proteomics analysis.
HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.
Scutebarbatine A inhibits M2 macrophage polarization via blocking PI3K/AKT signaling to impair cell stemness, metastasis, and angiogenesis in non-small cell lung cancer.
Deficiency of Med1 in keratinocytes augments dermal fibrosis and inflammation in scleroderma.
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
The role of FOXO1/PPARγ in atrazine-induced hepatic lipid metabolism disorders.
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Network-guided discovery of Zeqi Decoction as a PPARγ-targeted therapy for pulmonary fibrosis.
Ginsenoside Rd promotes cardiac regeneration through PPARG/HMGCS2-driven ketone body metabolic reprogramming in myocardial ischemia-reperfusion injury.
Steap4 Promotes Senile Osteoporosis via Fe(2+)-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs.
TCM compatibility-driven mechanism of Shenshuaining (SSN) capsules against renal fibrosis: Integrated metabolomic and network analyses.
Chrysanthemum morifolium Ramat. water extract prevents and treats metabolic-associated fatty liver disease via pan-PPAR activity.
PPARγ agonism ameliorates acute kidney injury by inhibiting neutrophil extracellular trap formation-mediated renal tubular epithelial cell PANoptosis.
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Interorganelle competition for linoleic acid underlies steatotic liver pathology.
Streptococcus thermophilus alleviates fatty liver disease by regulating gut microbiota, lipid metabolism, and inflammation.
Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.
Engineered peripheral CD4 T cells delivery across the BBB promote intracerebral Treg conversion unleashes microglial phagocytotic activity for Alzheimer's disease treatment.
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.
A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis via PPARγ regulation.
Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation.
Naringenin Alleviates 5-Fluorouracil-Induced Intestinal Mucositis via Modulating the Gut Microbiota, Bile Acid Metabolism, and PPAR Signaling Pathway.
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.
FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.
FABP4 is highly expressed in preeclamptic placentas and regulates trophoblast lipid metabolism, mitochondrial function, and oxidative stress in vitro.
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling.
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway.
Computational-experimental integration reveals PPARγ/Nrf2-GPX4 dual-targeting by combined selenomethionine-magnolol as a novel therapy for sarcopenic obesity.
GPD1-mediated neuronal lipotoxicity drives aconitine-induced mitochondrial collapse and lethality.
Buyang Huanwu Decoction suppresses atherosclerosis by targeting IFITM1‑mediated lipid metabolism in vascular smooth muscle cells.
Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice.
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis.
Cardiomyopeptide-Regulated PPARγ Expression Plays a Critical Role in Maintaining Mitochondrial Integrity and Preventing Cardiac Ischemia/Reperfusion Injury.
Potentilla discolor Bunge Ameliorates Streptozotocin-Induced Diabetic Nephropathy in Mice by Modulating GAS5 and miR-21 Expression.
Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro.
PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions.
Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway.
Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy.
Sheng-Jiang Powder Alleviates Th17/Treg Immune Imbalance of Experimental Autoimmune Encephalomyelitis by Regulating the Fatty Acids Metabolism.
Shen-Hong-Tong-Luo formula ameliorates atherosclerosis by enhancing macrophage efferocytosis through activating the PPARγ/mfge8 pathway.
Study on the effect and mechanism of Ershiyiwei Lvronghao concentrated Pills in the treatment of nonalcoholic fatty liver disease.
A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities.
Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis.
Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.
miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.
Stromal vascular fraction inhibits renal fibrosis by regulating metabolism and inflammation in obstructive nephropathy.
Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation.
Effects of all-trans retinoic acid and oxygen concentration on the proliferation and differentiation of subcutaneous adipocytes in yak.
CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.
NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis.
PPARγ mediated lysosomal membrane permeabilization and lipophagy blockage were involved in microplastics and di (2-ethylhexyl) phthalate co-exposure induced immature testis injury.
Cigarette smoke-induced PPAR signaling dysregulation accelerates Alzheimer's disease pathogenesis and cognitive decline in 5xFAD mice.
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis.
Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.
Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation.
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells.
Penthorum chinense Pursh extract ameliorates lupus nephritis disease in MRL/lpr mice via the PPARγ/NFκB signaling axis.
Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia.
Environmental aminomethylphosphonic acid (AMPA) exposure increased the risk of spontaneous abortion through lactate-induced JunB lactylation in trophoblast.
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.
Translating m6A-Glycolysis Discovery into Therapy: GOQD-Based Multifunctional Bioactive Scaffolds Rejuvenates Bone Repair in Senescence.
TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis.
Chamazulene Induces Metabolic Reprogramming and Mitigates Inflammation in Photoaged Skin: PPARα/γ as Potential Regulators.
LLTH induces white adipose tissue browning via NF κB inhibition in ATM.
CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation.
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury.
One day of environment-induced heat stress causes injury to the murine kidney.
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ-ATF3-Gpx4 Signaling Pathway in Non-Small Cell Lung Cancer.
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
PLIN5 Promotes Lipid Reconstitution in Goat Intramuscular Fat via the PPARγ Signaling Pathway.
USP2-mediated PPARγ stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid.
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease.
HDM and mannose as novel tolerogenic inducers for dendritic cells: mTOR/PPARγ-mediated attenuation of allergic asthma.
Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2/MasR/PPARγ/NR1D1/Gas1 axis.
Establishment of spontaneously immortalized Japanese eel muscle-derived preadipocyte cell lines for cultured seafood production.
Adiponectin Signaling Ameliorates Cognitive Dysfunction in Type 2 Diabetic Mice by Activating the Hippocampal AdipoR2-PPARα/CREB Pathway.
CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis.
Methylparaben and propylparaben promote bladder cancer invasion via MMP2 and PPARG modulation.
TMEM132C and LIPE protein molecules drive synovial hyperplasia via the PPARγ signaling axis: Mechanistic insights into core pathogenic proteins in rheumatoid arthritis.
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity.
Huoxue Tongluo tablet enhances atherosclerosis efferocytosis by promoting the differentiation of Trem2(+) macrophages via PPARγ signaling pathway.
JiGuCao capsule formula alleviates metabolic fatty liver disease by regulating the gut-liver axis and lipid metabolism.
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.
Hepatic AKAP1 deficiency exacerbates diet-induced MASLD by enhancing GPAT1-mediated lysophosphatidic acid synthesis.
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson's Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway.
Carboxylesterase 1 regulates peroxisome proliferator-activated receptor gamma to inhibit the growth and metastasis of breast cancer cells.
Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice.
The mechanism underlying of Zuoguiyin on liver and kidney in D-gal-induced subacute aging female rats: A perspective on SIRT1-PPARγ pathway regulation of oxidative stress, inflammation and apoptosis.
Deubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing PPAR-γ.
Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells.
The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells.
Qishen Granules Modulate Metabolism Flexibility Against Myocardial Infarction via HIF-1 α-Dependent Mechanisms in Rats.
Targeting NAMPT-OPA1 for treatment of senile osteoporosis.
Anti-b diminishes hyperlipidaemia and hepatic steatosis in hamsters and mice by suppressing the mTOR/PPARγ and mTOR/SREBP1 signalling pathways.
Photothermal-Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy.
Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Adhesion strength of tumor cells predicts metastatic disease in vivo.
Plasma Lipidomics, Gut Microbiota Profile, and Phenotype of Adipose Tissue in an ApoE(-/-) Mouse Model of Plaque Instability.
Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway.
Regulation of PPARγ in the development of early sheep embryos in vitro.
Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.
A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARγ through promoting ubiquitination-mediated HDAC1 degradation.
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment.
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer.
Effect of isolated keratin 3 knockdown on gene expression of primary limbal epithelial cells without and with inflammatory stimuli.
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway.
Linghe granules reduces hepatic lipid accumulation in Non-alcoholic fatty liver disease through regulating lipid metabolism and redox balance.
Combined metabolomics and network pharmacology to elucidate the mechanisms of Huiyang Shengji decoction in treating diabetic skin ulcer mice.
18β-glycyrrhetinic acid improves pulmonary hypertension by regulating the vascular non-inflammatory molecule-1/L-arginine/nitric oxide signaling pathway.
Enzymatic Synthesis and Evaluation of Eight Methylated Quercetin Products: In Vitro Chemical Properties and Adipogenesis Regulation.
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Junctions by Modulating the PPAR-γ/NF-κB Signaling Pathway in Intestinal Cells and Organoids.
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Daqinjiao Decoction Ameliorates CSVD via RXR-γ/PPAR-γ/VEGF-α Pathway: Insights From Transcriptome Sequencing and Network Pharmacology.
Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression.
Lysophosphatidylcholine-induced aberrant adipogenesis in mesenchymal stem cells and impaired antibacterial function in adipocytes of creeping fat.
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Wenxia Changfu formula inhibits Lewis lung cancer metastasis by reprogramming tumor-associated macrophages through the PPAR-γ/CD36 pathway.
Ursolic acid suppresses triple-negative breast cancer progression through mediating FABP4/PPARG pathway.
Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury.
S100a4(+) alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.
Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
LRP1 mitigates intervertebral disc degeneration by inhibiting endoplasmic reticulum stress through stabilizing the PPARγ.
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.
Effects of duration of high-fat diet on adipocyte hyperplasia in rat epididymis.
Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis.
A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA.
Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats.
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation.
Seipin Deficiency Impairs Motor Coordination in Mice by Compromising Spinal Cord Myelination.
Docosahexaenoic acid mitigates experimental autoimmune prostatitis by inhibiting Th17 cell differentiation via the PPARγ/NF-κB/IL-17A pathway.
PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress.
Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia.
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation.
Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.
Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-κB pathway.
Alterations in the transcriptome and microRNAs of adipose-derived mesenchymal stem cells from different sites in rats during aging.
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.
Rosiglitazone Promotes Oligodendrocyte Development and Myelin Formation of Repeated Neonatal Sevoflurane Exposure via PPARγ Signaling.
Uncovering the mechanisms of diosmin in treating obesity-related kidney injury based on network pharmacology, molecular docking, and in vitro validation.
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
Olaparib promotes FABP4 expression and reduces antitumor effect in ovarian cancer cells with a BRCA1 mutation.
Inhibition of the Wnt/β‑catenin signaling pathway and SOX9 by XAV939 did not alleviate inflammation in a dextran sulfate sodium‑induced ulcerative colitis model.
DHA Improves neurodevelopmental abnormalities in offspring of gestational diabetes mellitus patients via the PPAR-γ/FATP4 pathway.
Mass spectrometry imaging reveals spatial metabolic variation and the crucial role of uridine metabolism in liver injury caused by Schistosoma japonicum.
Natural molecule isoliquiritigenin mitigates MASH and liver fibrosis in mice by promoting autophagy through the PI3K/Akt signaling pathway.
Acetoacetate Ameliorates Hepatic Fibrosis by Targeting Peroxisome Proliferator-Activated Receptor Gamma to Restore Lipid Droplets in Activated Hepatic Stellate Cells.
TRIM37 exacerbates cerebral ischemic injury by regulating the PPARγ/NF-κB pathway.
Network pharmacology study on the mechanism of berberine in Alzheimer's disease model.
Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ.
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Magnolol preserves the integrity of the intestinal epithelial barrier and mitigates intestinal injury through activation of PPAR γ in COPD rat.
Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period.
Baicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway.
Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy.
Phillyrin prevents calcium oxalate kidney stones through the PPARγ signaling pathway.
Impact of overexpression of wild-type CFTR and elexacaftor-tezacaftor-ivacaftor on oxylipin production by the CFBE41o- bronchial epithelial cell line.
Oncofetal dual‑specificity phosphatase 9 drives stem-like properties through ERK1/2-PPARG-SCD axis-mediated lipid metabolism in hepatocellular carcinoma.
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Hydroxytyrosol improved insulin resistance in male offspring born to high-fat diet dams by remodeling gut microbiota.
CEACAM1 regulates autophagy in oral squamous cell carcinoma through the PPAR signaling pathway.
Gpr109a alleviates mammary fibrosis via PPARγ-mediated reduction of ROS and mitochondrial damage.
Pathogenesis of impaired glucose tolerance in rats based on transcriptome analysis.
Residual tumor cells after insufficient radiofrequency ablation promote lung metastasis by educating CD177(hi)PAD4(hi) neutrophils.
Single-cell transcriptomic analysis of the heterogeneity of mesenchymal and stromal cells and their regulon alteration during airway remodeling in asthma.
Interleukin-27 is a multitarget regulator of fibroblast remodeling in thyroid-associated ophthalmopathy.
FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1.
Early life exposure to environmental levels of PCB138 induces lipid metabolism disorders through activating aryl hydrocarbon receptor in female mice.
Citri grandis Exocarpium Extract Alleviates Atherosclerosis in ApoE(-/-) Mice by Modulating the Expression of TGF-β1, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1.
The SCD5 Gene Modulates Adipogenic Differentiation via the WNT5B Signaling Pathway in Xinjiang Brown Cattle.
Prepregnancy GLP-1RA use improves maternal lipid metabolism via liver-secreted FGF21 during pregnancy in HFD-fed dams.
Genetic algorithm-back propagation artificial neural network model- and response surface methodology-based optimization of crude Lophatherum gracile Brongn. polysaccharides extraction and their anti-NAFLD effects via regulating liver-adipose tissue crosstalk.
Alcohol, Anti-HIV Drugs, and/or Hippuric Acid Deteriorate Cellular Stresses in Senescent Hepatocytes and Aging Murine Liver.
Ecliptasaponin II alleviates the radiation enteritis by activating PPARγ to inhibit the apoptosis of endothelial cells.
Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway.
Multi-omics reveals miR-181a-5p regulates PPAR-driven lipid metabolism in Oral squamous cell carcinoma: Insights from CRISPR/Cas9 knockout models.
CGKRK-targeted lipid nanoparticles enhance in vivo rosiglitazone delivery to the placenta to ameliorate murine preeclampsia.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Genetic and functional validation of CTSS in regulating intramuscular fat content of Duroc-Landrace-Yorkshire pigs.
A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration.
The influence of IMPDH activity on ciliogenesis and adipogenesis of 3T3-L1 cells while undergoing differentiation.
Proteomic analysis reveals that Acalypha australis L. mitigates chronic colitis by modulating the FABP4/PPARγ/NF-κB signaling pathway.
Docosahexaenoic Acid Supplementation in Postnatal Growth Restricted Rats Does Not Normalize Lung Function or PPARγ Activity.
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction.
Cold-Induced DHRS4 Promotes Thermogenesis via Enhanced Fatty Acid β-Oxidation in Porcine Subcutaneous Adipocytes.
Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation.
Aging and autophagic phenotypic changes in bone marrow mesenchymal stem cells in glucocorticoid-induced osteonecrosis.
A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A-PPAR Axis in Pancreatic Ductal Adenocarcinoma.
Cited2 inhibited hypoxia-induced proliferation and migration of PASMCs via the TGF-β1/Cited2/PPARγ pathway.
Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation.
Chemically Modified PPARγ mRNA Unleashes Adipogenic Potential in 3T3-L1-Predipocytes: An Approach for Accelerated Wound Healing.
Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway.
SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.
Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice.
Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation.
The autophagic regulation of rosiglitazone-promoted adipocyte browning.
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells.
Roburic acid inhibits lung cancer metastasis and triggers autophagy as verified by network pharmacology, molecular docking techniques and experiments.
Comprehensive analysis of peroxisome proliferator-activated receptors to predict the drug resistance, immune microenvironment, and prognosis in stomach adenocarcinomas.
Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Farrerol alleviates insulin resistance and hepatic steatosis of metabolic associated fatty liver disease by targeting PTPN1.
Day and Night Reversed Feeding Aggravates High-Fat Diet-Induced Abnormalities in Intestinal Flora and Lipid Metabolism in Adipose Tissue of Mice.
Rice bran active peptide (RBAP) inhibited macrophage differentiation to foam cell and atherosclerosis in mice via regulating cholesterol efflux.
Inhibiting Soluble Epoxide Hydrolase Suppresses NF-κB p65 Signaling and Reduces CXCL10 Expression as a Potential Therapeutic Target in Hashimoto's Thyroiditis.
PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.
Maternal Gestational Diabetes Mellitus and High-Fat Diet Influenced Hepatic Polyunsaturated Fatty Acids Profile in the Offspring of C57BL/6J Mice.
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator-activated receptor gamma.
The impact of NUMB on chicken abdominal adipogenesis: A comprehensive analysis.
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease.
Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system.
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells.
Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.
Ozone therapy mitigates parthanatos after ischemic stroke.
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.
Cystathionine-γ-lyase contributes to tamoxifen resistance, and the compound I194496 alleviates this effect by inhibiting the PPARγ/ACSL1/STAT3 signalling pathway in oestrogen receptor-positive breast cancer.
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Luteolin Protects against Vascular Calcification by Modulating SIRT1/CXCR4 Signaling Pathway and Promoting Autophagy.
Dynamically cultured, differentiated bovine adipose-derived stem cell spheroids as building blocks for biofabricating cultured fat.
A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.
FPR1 signaling aberrantly regulates S100A8/A9 production by CD14(+)FCN1(hi) macrophages and aggravates pulmonary pathology in severe COVID-19.
Preliminary study of the role of histone deacetylase (HDAC) in steroid-induced avascular necrosis of the femoral head induced by BMSC adipogenic differentiation.
m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1-mediated uncoupling lipid catabolism during in vitro maturation.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization.
Anti-Obesity Effects of Pleurotus ferulae Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice.
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration.
circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis.
l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy.
Total ginsenosides decrease Aβ production through activating PPARγ.
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells.
Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.
Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer.
Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells.
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ.
The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages.
Network pharmacology and pharmacological evaluation of Wenzheng Jiedu Powder Modified Formula for neuropathic pain relief.
B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling.
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway.
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.
Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through CCDC18.
Asprosin aggravates nonalcoholic fatty liver disease via inflammation and lipid metabolic disturbance mediated by reactive oxygen species.
Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via activation of PPARγ signaling.
Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria.
Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action.
Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis.
Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation.
AN698/40746067 suppresses bone marrow adiposity to ameliorate hyperlipidemia-induced osteoporosis through targeted inhibition of ENTR1.
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
Myriocin enhances the clearance of M. tuberculosis by macrophages through the activation of PLIN2.
Chrysanthemum morifolium attenuates metabolic and alcohol-associated liver disease via gut microbiota and PPARα/γ activation.
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Exploring the Mechanism of Asiatic Acid against Atherosclerosis Based on Molecular Docking, Molecular Dynamics, and Experimental Verification.
KLF2/PPARγ axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction.
ATR induces hepatic lipid metabolism disorder in rats by activating IRE1α/XBP1 signaling pathway.
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Yi-shen-hua-shi granules modulate immune and inflammatory damage via the ALG3/PPARγ/NF-κB pathway in the treatment of immunoglobulin a nephropathy.
Period circadian regulator 2-mediated steroid hormone synthesis by regulating transcription of steroidogenic acute regulatory protein in porcine granulosa cells.
Diallyl trisulfide inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer via modulating gut microbiota and the PPARγ/NF-κB pathway.
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF-κB signaling pathway.
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Exposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke.
Protective effects of electroacupuncture on senile osteoporosis in rats.
Yanghe Decoction promotes ferroptosis through PPARγ-dependent autophagy to inhibit the malignant progression of triple-negative breast cancer.
Key role of PPAR-γ-mediated suppression of the NFκB signaling pathway in rutin's antidepressant effect.
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
IFIT2 mediates iron retention and cholesterol efflux in atherosclerosis.
DT-13 Mediates Ligand-Dependent Activation of PPARγ Response Elements In Vitro.
Circ_0000284 Is Involved in Arsenite-Induced Hepatic Insulin Resistance Through Blocking the Plasma Membrane Translocation of GLUT4 in Hepatocytes via IGF2BP2/PPAR-γ.
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages.
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure.
High-iron diet damages brown adipose tissue mitochondria and exacerbates metabolic hazards of a high-fat diet.
Ginsenoside Rb1 affects mitochondrial Ca(2+) transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1.
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells.
Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1.
Anti-Inflammatory and Anticancer Effects of Kaurenoic Acid in Overcoming Radioresistance in Breast Cancer Radiotherapy.
A Novel PPARγ Modulator Falcarindiol Mediates ER Stress-Mediated Apoptosis by Regulating NOX4 and Overcomes Radioresistance in Breast Cancer.
ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation.
Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish.
Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway.
Permethrin exposure impacts zebrafish lipid metabolism via the KRAS-PPAR-GLUT signaling pathway, which is mediated by oxidative stress.
White adipose tissue, a novel antirheumatic target: Clues from its secretory capability and adipectomy-based therapy.
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Air-ventilated normothermic mechanical perfusion improves susceptibility to donation after circulatory death and cold preservation-induced cholestatic liver injury through PPAR-γ/UGT1A1 axis.
Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma.
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy.
Elucidating the Role of circTIAM1 in Guangling Large-Tailed Sheep Adipocyte Proliferation and Differentiation via the miR-485-3p/PLCB1 Pathway.
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake.
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
The role of miR-369-3p in proliferation and differentiation of preadipocytes in Aohan fine-wool sheep.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Abdominal Massage Ameliorates Inguinal Fat Accumulation via Augmentation of PPARγ Signaling in High-Fat Diet-Induced Obese Mice.
Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway.
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress.
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway.
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.
Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Protective effects and mechanisms of Yi Qi Huo Xue Fang in cerebral ischemic stroke based on network pharmacology and experimental verification.
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Korean red ginseng formula attenuates non-alcoholic fatty liver disease in oleic acid-induced HepG2 cells and high-fat diet-induced rats.
PPARγ regulates lipid metabolism and viability of sheep trophoblast cells.
Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling.
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene.
Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization.
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation.
Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Xiao-Yao-San in the Treatment of Inflammatory Response in CUMS Mice.
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Impaired PPARγ activation by cadmium exacerbates infection-induced lung injury.
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Fructooligosaccharides attenuate non-alcoholic fatty liver disease by remodeling gut microbiota and association with lipid metabolism.
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.
An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.
Shared Genes of PPARG and NOS2 in Alzheimer's Disease and Ulcerative Colitis Drive Macrophages and Microglia Polarization: Evidence from Bioinformatics Analysis and Following Validation.
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
The role of PPARγ in intermittent hypoxia-related human umbilical vein endothelial cell injury.
5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ.
PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.
PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.
Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway.
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition.
Millet Bran Protein Hydrolysate Displays the Anti-non-alcoholic Fatty Liver Disease Effect via Activating Peroxisome Proliferator-Activated Receptor γ to Restrain Fatty Acid Uptake.
Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-γ.
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.
circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep.
Effects of the CDC10 (Septin 7) Gene on the Proliferation and Differentiation of Bovine Intramuscular Preadipocyte and 3T3-L1 Cells.
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
[A convenient and time-saving method for primary culture of mature white adipocytes from mice].
Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia.
Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling.
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients.
Diethylaminoethyl-dextran and monocyte cell membrane coated 1,8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis.
Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithelial Homeostasis and Ameliorates Colitis.
Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D.
An optimized protocol for chromatin immunoprecipitation from murine inguinal white adipose tissue.
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-γ/TXNIP pathways.
MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets.
PPARγ agonist inhibits c-Myc-mediated colorectal cancer tumor immune escape.
C1q(+) tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion.
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway.
RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect.
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.
PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis.
Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis.
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway.
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
Upregulated estrogen receptors impairs myogenesis and elevates adipogenesis related factor levels in the paravertebral muscles of patients with idiopathic scoliosis.
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet.
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Smilax china Polyphenols Stimulate Browning via [Formula: see text]3-Adrenergic Receptor/AMP-Activated Protein Kinase [Formula: see text] Signaling Pathway in 3T3-L1 Adipocytes.
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21.
Protective Effect of Shengmaiyin in Myocardial Hypertrophy-Induced Rats: A Genomic Analysis by 16S rDNA.
Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's mouse model.
Effects of PPARD gene variants on the therapeutic responses to exenatide in chinese patients with type 2 diabetes mellitus.
Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats.
Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation.
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Role and mechanism of the zinc finger protein ZNF580 in foam-cell formation.
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo.
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.
PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo.
The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Rectal administration of butyrate ameliorates pulmonary fibrosis in mice through induction of hepatocyte growth factor in the colon via the HDAC-PPARγ pathway.
Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats.
Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis.
Serpina3c regulates adipose differentiation via the Wnt/β-catenin-PPARγ pathway.
Acid-treated high-amylose corn starch suppresses high-fat diet-induced steatosis.
PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.
Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
CRISPR/Cas9-Mediated Knockout of miR-130b Affects Mono- and Polyunsaturated Fatty Acid Content via PPARG-PGC1α Axis in Goat Mammary Epithelial Cells.
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
MicroRNA 573 Rescues Endothelial Dysfunction during Dengue Virus Infection under PPARγ Regulation.
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression.
Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco.
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation.
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway.
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth.
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells.
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease.
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice.
Myoblast-derived exosomes promote the repair and regeneration of injured skeletal muscle in mice.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Angiogenesis-Browning Interplay Mediated by Asprosin-Knockout Contributes to Weight Loss in Mice with Obesity.
Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation.
PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT.
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice.
Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.
Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice.
Inhibition of DNA methylation de-represses peroxisome proliferator-activated receptor-γ and attenuates pulmonary fibrosis.
The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα.
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome.
Gold nanoclusters eliminate obesity induced by antipsychotics.
PPARγ/SOD2 Protects Against Mitochondrial ROS-Dependent Apoptosis via Inhibiting ATG4D-Mediated Mitophagy to Promote Pancreatic Cancer Proliferation.
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α.
Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons.
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Identification of miRNA in Sheep Intramuscular Fat and the Role of miR-193a-5p in Proliferation and Differentiation of 3T3-L1.
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
mTOR regulates PRMT1 expression and mitochondrial mass through STAT1 phosphorylation in hepatic cell.
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.
A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models.
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model.
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-κB and in a PPARγ-dependent manner.
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Effects of energy supplements on the differentiation of skeletal muscle satellite cells.
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.
Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring.
Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway.
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis.
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.
Bergenin alleviates H(2) O(2) -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway.
Decreased expression of PPARγ is associated with aortic endothelial cell apoptosis in intermittently hypoxic rats.
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet.
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway.
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.
A small nucleolar RNA, SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway.
Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.
Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.
Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia.
ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression.
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.
Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPARγ and LPL Gene in a High-Fat Diet C57BL/6 Mice Model.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway.
Alveolar Epithelial Cells Promote IGF-1 Production by Alveolar Macrophages Through TGF-β to Suppress Endogenous Inflammatory Signals.
Sevoflurane Protects against Intestinal Ischemia-Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-κB Pathway in Rats.
Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma.
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Tissue Inhibitor of Metalloprotease-1 (TIMP-1) Regulates Adipogenesis of Adipose-derived Stem Cells (ASCs) via the Wnt Signaling Pathway in an MMP-independent Manner.
The total flavonoids from Selaginella tamariscina (beauv.) Spring improve glucose and lipid metabolism in db/db mice.
3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells.
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Citri Reticulatae Pericarpium protects against isoproterenol-induced chronic heart failure via activation of PPARγ.
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Unconservative_15_2570409 suppresses progesterone receptor expression in the granulosa cells of Hu sheep.
TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ(12,14) -PGJ(2) and Nogo.
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
The opposite functions of miR-24 in the osteogenesis and adipogenesis of adipose-derived mesenchymal stem cells are mediated by the HOXB7/β-catenin complex.
m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Tributyltin reduces bone mineral density by reprograming bone marrow mesenchymal stem cells in rat.
Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma.
PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis.
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway.
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.
Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway.
CB11, a novel purine-based PPARɣ ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells.
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ(1).
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
IL-29 promoted obesity-induced inflammation and insulin resistance.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Effect of MicroRNA-20a on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells.
UHRF1 Promotes Proliferation of Human Adipose-Derived Stem Cells and Suppresses Adipogenesis via Inhibiting Peroxisome Proliferator-Activated Receptor γ.
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
A Network Pharmacology Approach for Uncovering the Osteogenic Mechanisms of Psoralea corylifolia Linn.
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis.
Cathelicidin-WA Facilitated Intestinal Fatty Acid Absorption Through Enhancing PPAR-γ Dependent Barrier Function.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Hydroxytyrosol prevents PM(2.5)-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model.
PPAR Gamma-Regulated MicroRNA 199a-5p Underlies Bone Marrow Adiposity in Aplastic Anemia.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression.
MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice.
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Rosiglitazone attenuates paraquat-induced lung fibrosis in rats in a PPAR gamma-dependent manner.
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.
Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells.
EETs/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy.
Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.
Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice.
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Phenethyl isothiocyanate induces IPEC-J2 cells cytotoxicity and apoptosis via S-G(2)/M phase arrest and mitochondria-mediated Bax/Bcl-2 pathway.
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Evaluation of MEDAG gene expression in papillary thyroid microcarcinoma: associations with histological features, regional lymph node metastasis and prognosis.
Dan-Lou Prescription Inhibits Foam Cell Formation Induced by ox-LDL via the TLR4/NF-κB and PPARγ Signaling Pathways.
Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice.
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway.
PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection.
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ.
Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
Sini Decoction Intervention on Atherosclerosis via PPARγ-LXRα-ABCA1 Pathway in Rabbits.
Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
Corilagin Counteracts IL-13Rα1 Signaling Pathway in Macrophages to Mitigate Schistosome Egg-Induced Hepatic Fibrosis.
Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway.
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression.
Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
miR-148a-3p regulates adipocyte and osteoblast differentiation by targeting lysine-specific demethylase 6b.
5-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway.
The novel ZIP4 regulation and its role in ovarian cancer.
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1.
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.
Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.
Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.
Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction.
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM.
Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.
Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells.
Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop.
miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling.
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.
miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling.
miR-20a regulates adipocyte differentiation by targeting lysine-specific demethylase 6b and transforming growth factor-β signaling.
Systemic adaptation of lipid metabolism in response to low- and high-fat diet in Nile tilapia (Oreochromis niloticus).
Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients.
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Potent effects of dioscin against liver fibrosis.
Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways.
miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6.
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
TL1A serves as a positive regulator to promote adipocyte differentiation.
Chang Z, Wang Q, Zhai Y, Li K, Zheng X, Wang Y, Zhao D
PloS one 2026;21(2):e0343036
PloS one 2026;21(2):e0343036
GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization.
Hu M, Zhang N, Wang YQ, Wang XM, Shi Y, Yao M, Hou LG, Jiang LL
Frontiers in immunology 2026;17:1765930
Frontiers in immunology 2026;17:1765930
Acetylshikonin mitigates diet-induced MASLD by targeting PPARγ-mediated metabolic dysfunction.
Ou L, Du Q, Liu J, Tai H, Chai Y, Tan X, Li B, Tan L, Cao Y, Zhu T
Frontiers in pharmacology 2026;17:1735481
Frontiers in pharmacology 2026;17:1735481
Mertk promotes early microglial-mediated synaptic engulfment in Alzheimer's disease.
Wu Y, Fan Y, Bao S, Song Y, Wang R, Wu J, Liu X, Jin J, Kong L, Hou B, Liang P, Chen T, Liu W, Peng B, He F, Zhou Y, Xu J, Chen Y, Han S, Yin J, He X
Theranostics 2026;16(3):1238-1261
Theranostics 2026;16(3):1238-1261
An antibody-mediated versatile SERS sandwich biosensor for ultrasensitive detection of functional proteins in cells and tissues.
Ou Y, Yuan Y, Shu P, Chen W, Li J, Zhao Y, Xing Y, Peng N, Li Q, Wang J
Talanta 2026 Sep 1;307:129787
Talanta 2026 Sep 1;307:129787
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen.
Sui X, Guo Y, Wu F, Wang H, Yang C, Zhang H, Jiang S, Dai Z
Life sciences in space research 2026 May;50:113-123
Life sciences in space research 2026 May;50:113-123
β-Sitosterol Suppresses Osteoclastogenesis and Alleviates Bone Loss by Targeting Tmed10 to Inhibit RANKL-Induced Hedgehog/MAPK Signaling and ROS.
Huang W, Liu T, Liao J, Lian D, Zeng X, Yao Z, He M, Zhang X, Cai Z
Phytotherapy research : PTR 2026 May;40(5):2491-2513
Phytotherapy research : PTR 2026 May;40(5):2491-2513
Schisandrin B enhances autophagy and random flaps survival through the PPARG-mediated PI3K/AKT/mTOR signaling pathway.
Li Y, Zhang J, Yang J, Gao J, Jin Y, Zhang Y, Chen H, Cai L
Free radical biology & medicine 2026 May;248:92-108
Free radical biology & medicine 2026 May;248:92-108
Chaihu-Shugan San ameliorates perimenopausal obesity with depression by coordinately targeting hepatic PGC-1α/CYP8B1/PPARγ signaling and gut barrier integrity.
Chen Q, Liu J, Wang J, Yin T, Wu Y, Zhang T, Yu F
Journal of ethnopharmacology 2026 May 23;363:121407
Journal of ethnopharmacology 2026 May 23;363:121407
Fibroblast growth factor 21 with molybdenum nanodots in a self-contracting thermosensitive hydrogel promotes diabetic wound repair by reprogramming lipid metabolism.
Zhang D, Jin C, Xue K, Jin M, Zhang Y, Li J, Wu Y, Huang J, Dong X, Du S, Chen Z, Wang J, Shi K, Lu Y, Jiang X, Xia W, Li Z, Li X, Xiao J
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114802
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114802
Salvia miltiorrhiza Bge. processed with porcine cardiac blood alleviates cerebral ischemia reperfusion injury through activating PPARγ/NF-κB pathway via suppressing arachidonic acid metabolism.
Zhou S, Jiang W, Sun Z, Zhang J, Zhang T, Ma B, Liu C, Zhang Y, Zhang L, Yan X
Journal of ethnopharmacology 2026 May 10;362:121385
Journal of ethnopharmacology 2026 May 10;362:121385
USP2 promotes metabolic dysfunction-associated steatotic liver disease progression via stabilization of PPARγ.
Luo H, Zhu C, Wang Y, Dai Y, Hao P, Cai H, Bai W, Zhang Z, Wan J, Zhang Y, Sun Y, Zhang Z, Wu Y, Zhai Y, Wu W, Lei H, Xu H, He M, Wu Y
Cell death and differentiation 2026 Mar;33(3):525-538
Cell death and differentiation 2026 Mar;33(3):525-538
Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.
Wei M, Tian Z, Song L, Xue R, Li H, Ji H, Sun J
The Journal of biological chemistry 2026 Mar;302(3):111195
The Journal of biological chemistry 2026 Mar;302(3):111195
M2 macrophage-derived exosome nanoplatform for targeted H(2)S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Zuo T, Shi C, Li J, Li D, Luo X, Xu M, Su M, Lu H, Zhang Y, Hu X, Zhou Q, Shubhra QTH, He X, Cai X
Acta biomaterialia 2026 Mar;212:593-612
Acta biomaterialia 2026 Mar;212:593-612
Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling.
Huang W, Zhou C, Wu R, Zhao K, Wu J, Song D
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168139
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168139
CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels.
Lu Q, Zheng Q, Zhou Z, Chen Y, Chen Y, Chen W, Wang J, Guo R, Wu R, Chen L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e22295
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e22295
Integrating Mendelian randomization and multi-omics analysis unravels gut microbiota-driven metabolic mechanisms in sepsis and identifies diagnostic biomarkers through experimental validation.
Wang G, Liu Y, Tan J, Li L, Yan J, Liang J, Hong X, Xie S
APL bioengineering 2026 Mar;10(1):016102
APL bioengineering 2026 Mar;10(1):016102
Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway.
Liang Y, Su S, Jin T, Mou J, Wu H, Yan N, Li X, Yao S, Wen Y, Liu F, Li P
Chinese medicine 2026 Mar 4;21(1)
Chinese medicine 2026 Mar 4;21(1)
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Qian C, Pei Z, Yang Z, Sun M, Zhang Y, Liu H, Sun Y
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Adipogenic transdifferentiation reprograms EMT-high PDAC cells into a post-mitotic adipocyte-like state and limits metastasis.
Qian Y, Yan Z, Wang J, An Q, Luo J, Mutailifu M, Tulamaiti A, Zhang XL, Zhang ZG, Li DX
Cell death & disease 2026 Mar 20;17(1)
Cell death & disease 2026 Mar 20;17(1)
Biglycan knockdown improves Graves' orbitopathy (GO)-like features via inhibiting NF-kB and ERK signaling.
Chenzhao C, Zhu M, Zhang F, Xie B, Cao J, Xiong W, Tan Y
Journal of endocrinological investigation 2026 Mar 2;
Journal of endocrinological investigation 2026 Mar 2;
Maternal β-hydroxybutyrate during the dry period is associated with altered epithelial cell regulation and rumen morphology of offspring as calves.
Zheng J, Zhang Y, Zhao X, Gai Y, Luo F, Gu Z, Mao S, Ma G, Ghaffari MH, Chen Y
Journal of dairy science 2026 Mar 16;
Journal of dairy science 2026 Mar 16;
Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification.
Koirala P, Chen Z, Hanumantharao SN, Siegel AE, Liu C, Williams Z, Sekhon H, Maridas D, Mishina Y, Rosen V, Agarwal S
bioRxiv : the preprint server for biology 2026 Mar 16;
bioRxiv : the preprint server for biology 2026 Mar 16;
The Porcine Colitis Model Recapitulates the Visceral Adipose Metabolic Reprogramming of Human Ulcerative Colitis.
Peng Y, Lv Q, Han X, Zhao C, Luo H, Tang J, Jiang Y, Wu T, Yang S, Wang Y, Tao C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71612
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71612
Integrating metabolomics and molecular dynamics simulation to elucidate the anti-atherosclerotic mechanisms of Gynostemma pentaphyllum.
Bu W, Xia Y, Qiu J, Zong W, Zhu S, Du Y, Liu Y, Yu Q, Huang X, Geng Z, Liu F
Archives of biochemistry and biophysics 2026 Jun;780:110793
Archives of biochemistry and biophysics 2026 Jun;780:110793
Growth hormone enhances mitochondria biogenesis and endows mitochondrial thermogenesis in murine adipocytes.
Sadiq E, Liu Y, Li N, Zong C, Li X, Yu T, Pu Z, Alameri L, Li Z, Li S, Wang X, Zhao R
Molecular and cellular endocrinology 2026 Jun;616:112758
Molecular and cellular endocrinology 2026 Jun;616:112758
Polystyrene nanoplastics promote adipogenesis by stimulating nuclear translocation of PPARγ.
Zheng Y, Liu Z, Zhao Z, Sheng C, Li W, Tang D, Ning Y, Zhou R, Li A, Zhou Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jun;212:116030
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jun;212:116030
Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the PPAR and CYP7A1 pathways in broilers.
Long F, Lou Z, Qi J, Li W, Liang Y, Yu D, Zhuang S, Han Y, Chen Q, Zhong X
Journal of the science of food and agriculture 2026 Jun;106(8):4600-4612
Journal of the science of food and agriculture 2026 Jun;106(8):4600-4612
Identification of blood-absorbed components of Qingkui Yuyang decoction and its mechanistic roles in ulcerative colitis based on UPLC-Q-Exactive Orbitrap-MS/MS and network pharmacology.
Chen Y, Liu L, Wei Y, Zhang Q, Wang Y
Journal of pharmaceutical and biomedical analysis 2026 Jun 15;273:117408
Journal of pharmaceutical and biomedical analysis 2026 Jun 15;273:117408
Babaodan alleviates MAFLD through hepatic glycerophospholipid metabolism and PPARγ/RXRA/GPAT3 based on spatial metabolomics and proteomics analysis.
Qiu S, Lai Z, Wang Z, Zeng J, Guo S, Yang L, Xie D, Cai Y, Wang Y, Che L, Zhang A
Journal of ethnopharmacology 2026 Jun 12;364:121475
Journal of ethnopharmacology 2026 Jun 12;364:121475
HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.
Zhang T, Zhao Y, He W, Chen Y, Liu Q, Tang Y, Geng S, Xu L, Tao L, Yu Z, Zhang X, Yang Y, Zhao J, Zhang L
International immunopharmacology 2026 Jun 1;178:116522
International immunopharmacology 2026 Jun 1;178:116522
Scutebarbatine A inhibits M2 macrophage polarization via blocking PI3K/AKT signaling to impair cell stemness, metastasis, and angiogenesis in non-small cell lung cancer.
Zhang Y, He C, Yang X, Gu M
Gene 2026 Jul 5;997:150118
Gene 2026 Jul 5;997:150118
Deficiency of Med1 in keratinocytes augments dermal fibrosis and inflammation in scleroderma.
Luo J, Kang Y, Zhang Z, Zhang E, Huang J, Zhu Q, Guo Q, Song S, Wang B, Li M, Yuan Q, Li H, Zhao D, Chen H, Wang S, Li Y, Zhang B, He J, Hu L
International immunopharmacology 2026 Jul 15;181:116667
International immunopharmacology 2026 Jul 15;181:116667
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Hsieh CP, Hsu YW, Pan TM, Lee CL
Molecular nutrition & food research 2026 Jan;70(1):e70342
Molecular nutrition & food research 2026 Jan;70(1):e70342
The role of FOXO1/PPARγ in atrazine-induced hepatic lipid metabolism disorders.
Yingchao H, Haoyan M, Zengchen W, Haotang Z, Tong L, Ying Q, Xiaotong W, Yuezhu Z
Toxicology letters 2026 Jan;415:111797
Toxicology letters 2026 Jan;415:111797
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
Wang J, Fang S, Wang J, Liu W, Meng F, Zhou X, Gao L
Experimental eye research 2026 Jan;262:110741
Experimental eye research 2026 Jan;262:110741
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Shi M, Ye Y, Hu L, Yan Y, Jiang S, Wang P, Li F, Ai M, Huang J, Yang L, Huang K, Liang M
EMBO molecular medicine 2026 Jan;18(1):55-90
EMBO molecular medicine 2026 Jan;18(1):55-90
Network-guided discovery of Zeqi Decoction as a PPARγ-targeted therapy for pulmonary fibrosis.
Qiu Y, Xin G, Wei Z, Wang T, Zhang S, Zhou Q, Li K, Sun D, Xu X, Wen A, Huang W, Chen S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157717
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157717
Ginsenoside Rd promotes cardiac regeneration through PPARG/HMGCS2-driven ketone body metabolic reprogramming in myocardial ischemia-reperfusion injury.
Zhang H, Lin A, Zhai C, Lai T, Gong X, Wang M, Wu H, Ye T, Wang L, Tawulie D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157694
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157694
Steap4 Promotes Senile Osteoporosis via Fe(2+)-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs.
Wang L, Yin G, Li W, Li M, Lu F, Xu C, Zhao G, Geng D, Bai J, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09926
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09926
TCM compatibility-driven mechanism of Shenshuaining (SSN) capsules against renal fibrosis: Integrated metabolomic and network analyses.
Tsai Y, Yang H, Yao Z, Tu Y, Cai M, Song X
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120712
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120712
Chrysanthemum morifolium Ramat. water extract prevents and treats metabolic-associated fatty liver disease via pan-PPAR activity.
Zhu W, Chang W, Chen T, Li M, Han Z, Sun N, Fang W, Wang D
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120571
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120571
PPARγ agonism ameliorates acute kidney injury by inhibiting neutrophil extracellular trap formation-mediated renal tubular epithelial cell PANoptosis.
Du C, Wang Z, Zhang P, Cao C, Wang M, Zhang W, Cheng J, Meng W, Zhang Y, Liu Z, Cai N, Zhang Z, Huang C, Li J, Ma T
Cell communication and signaling : CCS 2026 Jan 24;24(1):122
Cell communication and signaling : CCS 2026 Jan 24;24(1):122
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Chen C, Ma L, Dawuti A, Feng X, Chen S, An X, Bai Y, Zhang T, Aydin M, Kashmiri K, Ma Z, Zhang W, Yaermaimaiti S, Abulizi A
NPJ science of food 2026 Jan 23;10(1):73
NPJ science of food 2026 Jan 23;10(1):73
Interorganelle competition for linoleic acid underlies steatotic liver pathology.
Zhang C, Yang D, Suzuki H, Dias do Vale G, Chen J, Vaidya A, Melikov K, Swisher A, Wang J, Ye M, Zhou J, Zeng Q, Bai M, Lin MJ, Lee J, Zhu H, Siegwart DJ, Hoshida Y, McDonald JG, Zeng X
bioRxiv : the preprint server for biology 2026 Jan 11;
bioRxiv : the preprint server for biology 2026 Jan 11;
Streptococcus thermophilus alleviates fatty liver disease by regulating gut microbiota, lipid metabolism, and inflammation.
Xia J, Cheng Y, Sang L, Wei Q, Li Q, Chang B
International immunopharmacology 2026 Jan 1;168(Pt 2):115905
International immunopharmacology 2026 Jan 1;168(Pt 2):115905
Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.
Chen C, Tao M, Wang L, Yan W, Lin R, Fu Y
International immunopharmacology 2026 Jan 1;168(Pt 2):115882
International immunopharmacology 2026 Jan 1;168(Pt 2):115882
Engineered peripheral CD4 T cells delivery across the BBB promote intracerebral Treg conversion unleashes microglial phagocytotic activity for Alzheimer's disease treatment.
Zuo Z, Xiao Z, Zhang L, Deng S, He X, Mu Y, Wang P, Feng Y, Wang Z, Li S, Yang X, Xu J, Guo K, Guo W, Shuai X, Hu X, Zheng H
Biomaterials 2026 Feb;325:123574
Biomaterials 2026 Feb;325:123574
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.
Zhang B, Yang AT, Wang LN, Yu Q, Tan CC, Chao WH, Geng HY, Pei TX, Zhang L, Cao SJ, Qiu F, Kang N
Journal of ethnopharmacology 2026 Feb 28;357:120954
Journal of ethnopharmacology 2026 Feb 28;357:120954
A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis via PPARγ regulation.
Xu SY, Liu QX, Luo Y, Wu WH, Li Q, Liao SG, Ao JL, Xu GB
RSC medicinal chemistry 2026 Feb 26;17(3):1493-512
RSC medicinal chemistry 2026 Feb 26;17(3):1493-512
Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation.
He Q, Li S, Chen Y, Liu Y, Li Y, Min S, Yi S, Li F, Zhou X
BMC pharmacology & toxicology 2026 Feb 25;27(1)
BMC pharmacology & toxicology 2026 Feb 25;27(1)
Naringenin Alleviates 5-Fluorouracil-Induced Intestinal Mucositis via Modulating the Gut Microbiota, Bile Acid Metabolism, and PPAR Signaling Pathway.
Zhang Z, Adiham A, Yan Y, Huang F, Li J, Liu W, Fei Y, Guo Y, Gong P
Journal of agricultural and food chemistry 2026 Feb 18;74(6):5172-5187
Journal of agricultural and food chemistry 2026 Feb 18;74(6):5172-5187
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Wang Z, Wei J, Huang Z, Liu X, Li S, Fang Z, Hu L, Li R, Tao L, Li C, Chen H
Nutrients 2026 Feb 17;18(4)
Nutrients 2026 Feb 17;18(4)
The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.
Shen Y, Zhang M, Yang T, Wu Y, Qiu Y, Zhang L, Li F, Chen M, Chen Q, Wei W, Li H, Shen Y
Cellular & molecular biology letters 2026 Feb 11;31(1):22
Cellular & molecular biology letters 2026 Feb 11;31(1):22
FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.
Chen Z, Wu Q, Ma J, Shi Y, Zhang Q, Wu H, Zhang Y, Li Z, Ruan X, Xiong L, Cong P, Tian L
Journal of neuroinflammation 2026 Feb 11;23(1)
Journal of neuroinflammation 2026 Feb 11;23(1)
FABP4 is highly expressed in preeclamptic placentas and regulates trophoblast lipid metabolism, mitochondrial function, and oxidative stress in vitro.
Sun H, Wang Q, Wu L, Jing R, Xuan S, Zhuang W
BMC pregnancy and childbirth 2026 Feb 10;26(1)
BMC pregnancy and childbirth 2026 Feb 10;26(1)
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling.
Lin J, Zeng X, Su Z, Li X, Yu Y, Qian S, Hou Q, Duan W, Wang Z, Liu C, Zhang J, Huang C, Liao L
Journal of advanced research 2026 Apr;82:881-900
Journal of advanced research 2026 Apr;82:881-900
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway.
Shang H, Yang S, Sun M, Zhao Y, Guo R, Wang W, Qian B, Li Y, Hu M, Bian X, Cao Q, Li C, Fan B, Li B
PLoS pathogens 2026 Apr;22(4):e1014170
PLoS pathogens 2026 Apr;22(4):e1014170
Computational-experimental integration reveals PPARγ/Nrf2-GPX4 dual-targeting by combined selenomethionine-magnolol as a novel therapy for sarcopenic obesity.
Li Z, Liu B, Zhou L, Chen N, Wang Y, Yang S, Fan X, Wang Y, Chen X
Free radical biology & medicine 2026 Apr 7;251:243-255
Free radical biology & medicine 2026 Apr 7;251:243-255
GPD1-mediated neuronal lipotoxicity drives aconitine-induced mitochondrial collapse and lethality.
Jiang C, Hu W, Deng S, Huang Y, Wang L, Yang Z, Li Y, Li P, Wu H
Chemico-biological interactions 2026 Apr 29;434:112104
Chemico-biological interactions 2026 Apr 29;434:112104
Buyang Huanwu Decoction suppresses atherosclerosis by targeting IFITM1‑mediated lipid metabolism in vascular smooth muscle cells.
Huang Q, Tang X, Huang Q, Zhi S, Zheng X, Deng Q, Zhu J, Huang M, Pan Z, Hou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 20;156:158224
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 20;156:158224
Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice.
Jiang H, Ni S, Li Z, Chen S, Li X, Zhang H, Shen WL, Jiang X, Luo P, Shu Y, Yuan F, Tong K, Xiao F, Guo F
Nature communications 2026 Apr 10;
Nature communications 2026 Apr 10;
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis.
Chien Y, Xia R, Zhou D, Ai Y, Wu L, Zeng X, Chen S
Hepatology communications 2026 Apr 1;10(4)
Hepatology communications 2026 Apr 1;10(4)
Cardiomyopeptide-Regulated PPARγ Expression Plays a Critical Role in Maintaining Mitochondrial Integrity and Preventing Cardiac Ischemia/Reperfusion Injury.
Guo Z, Qian G, Pan X, Zou Y, Chen S, Zhu Q, Chen Z
International journal of medical sciences 2025;22(1):44-52
International journal of medical sciences 2025;22(1):44-52
Potentilla discolor Bunge Ameliorates Streptozotocin-Induced Diabetic Nephropathy in Mice by Modulating GAS5 and miR-21 Expression.
Yang Y, Qiu W, Xiao J, Hu X, Han J, Jiang L
International journal of endocrinology 2025;2025:1394709
International journal of endocrinology 2025;2025:1394709
Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro.
Li S, Stachon T, Liu S, Li Z, Hsu SL, Kundu S, Fries FN, Seitz B, Amini M, Suiwal S, Szentmáry N
PloS one 2025;20(6):e0326967
PloS one 2025;20(6):e0326967
PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions.
Chen KY, Li XH, Chen D, Qian SD, Mei RH, Li Q, Yu XF, He XJ
PloS one 2025;20(6):e0325190
PloS one 2025;20(6):e0325190
Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway.
You Y, Shen Y, Yang Y, Wei X, Zhou Y, Tan F, Deng L, Du H, Wang S, Wang C, Huang Y
PloS one 2025;20(10):e0335225
PloS one 2025;20(10):e0335225
Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy.
Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N
International journal of nanomedicine 2025;20:5017-5037
International journal of nanomedicine 2025;20:5017-5037
Sheng-Jiang Powder Alleviates Th17/Treg Immune Imbalance of Experimental Autoimmune Encephalomyelitis by Regulating the Fatty Acids Metabolism.
Wu L, Xu H, Xia H, Peng L, Qin L, Gong Q, Zhao M, Wu Z, Zhao Y, Zheng Z
Drug design, development and therapy 2025;19:4755-4776
Drug design, development and therapy 2025;19:4755-4776
Shen-Hong-Tong-Luo formula ameliorates atherosclerosis by enhancing macrophage efferocytosis through activating the PPARγ/mfge8 pathway.
Shi Y, Zhang Z, Liu J, Xu X, Xiao X, Zhang T, Zhang Y, Cui H, Li X, Chen Y
Frontiers in immunology 2025;16:1727378
Frontiers in immunology 2025;16:1727378
Study on the effect and mechanism of Ershiyiwei Lvronghao concentrated Pills in the treatment of nonalcoholic fatty liver disease.
Wu Y, Chen B, Long J, Pai M, Xiao Z, Huang Q, Li K, Ye B
Frontiers in pharmacology 2025;16:1725610
Frontiers in pharmacology 2025;16:1725610
A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities.
Gao W, Lin Z, Bao Y, Liu M, Ma G, Chen X, Yu S, Zeng Y
Frontiers in immunology 2025;16:1711388
Frontiers in immunology 2025;16:1711388
Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis.
Deng H, Li M, Fang X, Tang K, Xu S, Ding R, Li Z
Frontiers in pharmacology 2025;16:1646545
Frontiers in pharmacology 2025;16:1646545
Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.
Ni J, Yu L, Wang B, Chen S, Shang W, Fang P, Du B, Min W
Frontiers in pharmacology 2025;16:1604096
Frontiers in pharmacology 2025;16:1604096
miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.
Zhang J, Wang L, Shen Y, Qian X, Wang Z, Wang C
Frontiers in immunology 2025;16:1598781
Frontiers in immunology 2025;16:1598781
Stromal vascular fraction inhibits renal fibrosis by regulating metabolism and inflammation in obstructive nephropathy.
Yue G, Yang Y, Jia H, Wu Y, Ma L, Yi X, Tao Y, Zhou H
Frontiers in pharmacology 2025;16:1559446
Frontiers in pharmacology 2025;16:1559446
Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation.
Zhang W, Fu C, Lai J, Xin J, Zhang W
Frontiers in pharmacology 2025;16:1530635
Frontiers in pharmacology 2025;16:1530635
Effects of all-trans retinoic acid and oxygen concentration on the proliferation and differentiation of subcutaneous adipocytes in yak.
Yasenjian S, Shan S, Zhe Y, Zhang Y, Chai Z
Frontiers in veterinary science 2025;12:1643818
Frontiers in veterinary science 2025;12:1643818
CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.
Xia D, Xu X, Zhang Y, Zhang C, Wang H
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):3086-3102
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):3086-3102
NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis.
Wan X, Wang L, Khan MA, Peng L, Sun X, Yi X, Wang Z, Chen K
Cell death and differentiation 2025 Sep;32(9):1613-1629
Cell death and differentiation 2025 Sep;32(9):1613-1629
PPARγ mediated lysosomal membrane permeabilization and lipophagy blockage were involved in microplastics and di (2-ethylhexyl) phthalate co-exposure induced immature testis injury.
Zhou X, Yan H, Hong Y, Ding Y, Chen J, Tang H, Wei Y, Long C, Shen L, Wei G, Wu S
Free radical biology & medicine 2025 Sep;237:615-630
Free radical biology & medicine 2025 Sep;237:615-630
Cigarette smoke-induced PPAR signaling dysregulation accelerates Alzheimer's disease pathogenesis and cognitive decline in 5xFAD mice.
Xie Y, Wang H, Zhang Y, Lin B, Chen Y, Li K, Tang H, Sun Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115596
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115596
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Zhou X, Guo Q, Qiao Q, Fang X, Jiang Y, Wang X, Hu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157059
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157059
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis.
Wr H, Yq L, Xg L, Yf Z, Y W, P Z, Js L, Q Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156986
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156986
Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.
Liu M, Li H, Zhang J, Zhong Y, Huang C, Zhu L, Hu Z, Xu Y, Zhao S, Pan W
Food science & nutrition 2025 Sep;13(9):e70892
Food science & nutrition 2025 Sep;13(9):e70892
Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation.
Jiang Y, Yu H, Pan Y, Zhang B, Jing Y, Lei J, Li N, Yang J
Pharmaceuticals (Basel, Switzerland) 2025 Sep 8;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 8;18(9)
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells.
Wang S, Lv Y, Wang X, Zhang Z, Li J, Pan TI, Yung MAC, Zhang F, Zhang H, Meng J, Lian H, Wen S, Hao X, Wang P, Zhang Q, He T, Zhang Y, Wang X, Song J, Cui Y
Journal of nanobiotechnology 2025 Sep 29;23(1):618
Journal of nanobiotechnology 2025 Sep 29;23(1):618
Penthorum chinense Pursh extract ameliorates lupus nephritis disease in MRL/lpr mice via the PPARγ/NFκB signaling axis.
Li Y, Hua Y, Xin X, He W, Xu L, Ding B, Huang Q, Fan Y, Tian F, Ji J
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120379
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120379
Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia.
Huang Y, Zhang X, Yu C, Liu Y, Kang H, Liu Y, Ni Y, Xia Y, Jiang Z, Chen J, Zhao K, Han L, Zou X, Wang J, Lei T, Gan C, Zhang H
Cell host & microbe 2025 Sep 10;33(9):1484-1501.e12
Cell host & microbe 2025 Sep 10;33(9):1484-1501.e12
Environmental aminomethylphosphonic acid (AMPA) exposure increased the risk of spontaneous abortion through lactate-induced JunB lactylation in trophoblast.
Kong C, Li R, Wang X, Li L, Kang N, Zhen X, Dong Y, Yan G
Ecotoxicology and environmental safety 2025 Sep 1;302:118743
Ecotoxicology and environmental safety 2025 Sep 1;302:118743
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.
Peng Z, Gao J, Xu L, Huang S, Wang R, Du J, Zhang Z, Zhang L, Feng L, Wang X, Guo X
International journal of obesity (2005) 2025 Oct;49(10):2081-2093
International journal of obesity (2005) 2025 Oct;49(10):2081-2093
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
Jie L, Liu J, Zhu Z, Huang Z, Liu Y, Liu G, Shen X, Li Y, Shi X
Journal of cellular and molecular medicine 2025 Oct;29(19):e70880
Journal of cellular and molecular medicine 2025 Oct;29(19):e70880
Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.
Xu J, Zhu L, Li J, Xu J, Cui T, Jia S, Zhu T, Shi S, Gao F, Jin C, Tian H, Wang J, Ou Q, Xu JY, Bi YL, Xu GT, Zhang X, Lu L
Pharmacological research 2025 Oct;220:107937
Pharmacological research 2025 Oct;220:107937
Translating m6A-Glycolysis Discovery into Therapy: GOQD-Based Multifunctional Bioactive Scaffolds Rejuvenates Bone Repair in Senescence.
Wang Z, Deng T, Chang H, Li Y, Zhang Y, Jiao X, Gan Y
Small (Weinheim an der Bergstrasse, Germany) 2025 Oct;21(43):e07315
Small (Weinheim an der Bergstrasse, Germany) 2025 Oct;21(43):e07315
TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.
Chen Y, Han X, Liu T, Ni Y, Deng X, Wei W, Jiang M
Cellular signalling 2025 Oct;134:111954
Cellular signalling 2025 Oct;134:111954
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis.
Xie B, Xiong W, Zhang F, Cao J, Chenzhao C, Chen X
Journal of biomedical materials research. Part A 2025 Oct;113(10):e38000
Journal of biomedical materials research. Part A 2025 Oct;113(10):e38000
Chamazulene Induces Metabolic Reprogramming and Mitigates Inflammation in Photoaged Skin: PPARα/γ as Potential Regulators.
Zhou Y, Wang W, He L, Zhang N, Zhou B, Chen Z, Ma L, Yao L
Antioxidants (Basel, Switzerland) 2025 Oct 31;14(11)
Antioxidants (Basel, Switzerland) 2025 Oct 31;14(11)
LLTH induces white adipose tissue browning via NF κB inhibition in ATM.
Lu Y, Feng J, Yan Y, Qiu J, Feng L
Scientific reports 2025 Oct 28;15(1):37716
Scientific reports 2025 Oct 28;15(1):37716
CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation.
Wu J, Zhu S, Zang G, Wang H, Yang N, Qiao Y, Wei Q, Wang L, Ren Z, Liu YJ, Chen J
Journal for immunotherapy of cancer 2025 Oct 23;13(10)
Journal for immunotherapy of cancer 2025 Oct 23;13(10)
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury.
Xie M, Zheng J, Yu Y, Yang Q, Zhou Z, Xue J, Wang B, Qiu Y, Zhu Z, Sun Q, Shi X, Shangguan W, Li L, Zou Z, Zhao J, Wu P
Cell reports. Medicine 2025 Oct 21;6(10):102373
Cell reports. Medicine 2025 Oct 21;6(10):102373
One day of environment-induced heat stress causes injury to the murine kidney.
Roths M, Michael A, Schlader ZJ, Selsby JT
Experimental physiology 2025 Oct 2;
Experimental physiology 2025 Oct 2;
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Luo W, Bu W, Zhang G, Dong Y, Wang Y, Wang J, Liu C, Hu X, Jia Y, Ren H
Behavioural brain research 2025 Oct 18;495:115805
Behavioural brain research 2025 Oct 18;495:115805
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
Shu M, Ma Y, Zhao D, Meng C, Chen L, Wang L, Liu J, Yang D
Journal of translational medicine 2025 Oct 1;23(1):1041
Journal of translational medicine 2025 Oct 1;23(1):1041
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.
Qi X, Zhang J, Li Y, Shi Y, Yao J, Tong B
Archives of biochemistry and biophysics 2025 Nov;773:110588
Archives of biochemistry and biophysics 2025 Nov;773:110588
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ-ATF3-Gpx4 Signaling Pathway in Non-Small Cell Lung Cancer.
Kim TW, Ko SG
Phytotherapy research : PTR 2025 Nov;39(11):5345-5364
Phytotherapy research : PTR 2025 Nov;39(11):5345-5364
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Huang C, Chen X, Wu D, Chen J, Wang J, Li S, Hu J, Yan Z, Zhu Y, Zhang Y
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
Xie B, Zhang F, Yin J, Ouyang S, Cao J, Tan Y, Xiong W
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Yong W, Li Z, Xu W, Gao D, Sha B, Jin Y, Shen Y, Zhang Y, Pan Y, Liu J, Zhang F, Yu J, Jin L, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
PLIN5 Promotes Lipid Reconstitution in Goat Intramuscular Fat via the PPARγ Signaling Pathway.
Dai Y, Yang Y, Li H, Wang Y, Wang Y, Lin Y, Huang L, Du Z, Xiang H, Zhang C, Zhu J
Biology 2025 Nov 4;14(11)
Biology 2025 Nov 4;14(11)
USP2-mediated PPARγ stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid.
Cao J, Chen K, Hu K, Mi X, Pan Y, Xiao D, Liu S, Xiao L, Zhou L, Tao Y, Tang J
Journal for immunotherapy of cancer 2025 Nov 4;13(11)
Journal for immunotherapy of cancer 2025 Nov 4;13(11)
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease.
Du J, Du Q, Zhang Y, Gao J, Wang C, Kou B, Jiang Y, Zhao D, Lin J
Cell & bioscience 2025 Nov 28;15(1):164
Cell & bioscience 2025 Nov 28;15(1):164
HDM and mannose as novel tolerogenic inducers for dendritic cells: mTOR/PPARγ-mediated attenuation of allergic asthma.
Wang F, Min Z, Gao J, Qian Y, Jiang Z, Gao X, Chen Z
European journal of medical research 2025 Nov 25;30(1):1281
European journal of medical research 2025 Nov 25;30(1):1281
Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2/MasR/PPARγ/NR1D1/Gas1 axis.
Chen Q, Liu J, Madonna R, Li F, Chen S, Li L, Wu X, Maimati Y, Ding F, Wang X, Shen Y, Zhang R, Shen W, Dai Y, Lu L, De Caterina R
Cardiovascular research 2025 Nov 22;121(14):2260-2277
Cardiovascular research 2025 Nov 22;121(14):2260-2277
Establishment of spontaneously immortalized Japanese eel muscle-derived preadipocyte cell lines for cultured seafood production.
Kishino E, Saegusa S, Ikeda D
NPJ science of food 2025 Nov 20;9(1):240
NPJ science of food 2025 Nov 20;9(1):240
Adiponectin Signaling Ameliorates Cognitive Dysfunction in Type 2 Diabetic Mice by Activating the Hippocampal AdipoR2-PPARα/CREB Pathway.
Gong H, Liu Y, Xia L, Niu B, Kong J, Wang B, Lin X, Lin L, Bi Y
Molecular neurobiology 2025 Nov 19;63(1):68
Molecular neurobiology 2025 Nov 19;63(1):68
CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis.
Li Y, Li H, Chen X, Li X, Su J, Yang S, Xiao W, Deng Z
Cellular & molecular biology letters 2025 Nov 13;30(1):135
Cellular & molecular biology letters 2025 Nov 13;30(1):135
Methylparaben and propylparaben promote bladder cancer invasion via MMP2 and PPARG modulation.
Zhu T, Luo W, Zhang Y, Liang Z, Wu S, Yang C, Zhou R, Tan W, Liu C
Ecotoxicology and environmental safety 2025 Nov 1;306:119383
Ecotoxicology and environmental safety 2025 Nov 1;306:119383
TMEM132C and LIPE protein molecules drive synovial hyperplasia via the PPARγ signaling axis: Mechanistic insights into core pathogenic proteins in rheumatoid arthritis.
Cheng F, Dai Z, Zhang J
International journal of biological macromolecules 2025 May;309(Pt 3):143027
International journal of biological macromolecules 2025 May;309(Pt 3):143027
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity.
Chang YC, Hsieh ML, Lee HL, Hee SW, Chang CF, Yen HY, Chen YA, Chen YR, Chou YW, Li FA, Ke YY, Chen SY, Hung MS, Hung AF, Huang JY, Chiu CH, Lin SY, Shih SF, Hsu CN, Hwang JJ, Yeh TK, Cheng TR, Liao KC, Laio D, Lin SW, Chen TY, Hu CM, Vogel U, Saar D, Kragelund BB, Tsou LK, Tseng YH, Chuang LM
EMBO molecular medicine 2025 May;17(5):938-966
EMBO molecular medicine 2025 May;17(5):938-966
Huoxue Tongluo tablet enhances atherosclerosis efferocytosis by promoting the differentiation of Trem2(+) macrophages via PPARγ signaling pathway.
He X, Li Z, Li S, Zhang X, Liu D, Han X, He H, Chen J, Dong X, Long W, Lu H, Ye T, Meng F, Liao H, Yang Z, Lu L, Ni S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156579
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156579
JiGuCao capsule formula alleviates metabolic fatty liver disease by regulating the gut-liver axis and lipid metabolism.
Qi W, Cao X, Chen Y, Chen H, Zhang N, Liu R, Wang W, Liu Q, Zheng S, Li S, Li X, Zao X, Ye Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156559
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156559
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.
Wang J, Du J, Song Y, Tan X, Wu J, Wang T, Shi Y, Xu X, Yu Z, Song B
Cell death & disease 2025 May 9;16(1):371
Cell death & disease 2025 May 9;16(1):371
Hepatic AKAP1 deficiency exacerbates diet-induced MASLD by enhancing GPAT1-mediated lysophosphatidic acid synthesis.
He L, She X, Guo L, Gao M, Wang S, Lu Z, Guo H, Li R, Nie Y, Xing J, Ji L
Nature communications 2025 May 8;16(1):4286
Nature communications 2025 May 8;16(1):4286
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson's Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway.
Ni Y, Hayat MA, Si Y, Guo T, Zhang J, Hong Y, Cao Y, He S, Weng Z, Li F, Chen B, Zuo H, Sun X, Hu J
Neurochemical research 2025 May 30;50(3):177
Neurochemical research 2025 May 30;50(3):177
Carboxylesterase 1 regulates peroxisome proliferator-activated receptor gamma to inhibit the growth and metastasis of breast cancer cells.
Wen J, Geng L, Wang R, Zhang X, Sui Y, Liu X, Han X
Journal of molecular histology 2025 May 26;56(3):167
Journal of molecular histology 2025 May 26;56(3):167
Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice.
Zhang C, Yang D, Suzuki H, Chen J, Wang J, Ye M, Zhou J, Zeng Q, Bai M, Lin MJ, Lee J, Zhu H, Hoshida Y, Zeng X
bioRxiv : the preprint server for biology 2025 May 25;
bioRxiv : the preprint server for biology 2025 May 25;
The mechanism underlying of Zuoguiyin on liver and kidney in D-gal-induced subacute aging female rats: A perspective on SIRT1-PPARγ pathway regulation of oxidative stress, inflammation and apoptosis.
Xie J, Li B, He C, Yang S, Yang S, Sun P, Zhu G, Wang J
Journal of ethnopharmacology 2025 May 12;347:119811
Journal of ethnopharmacology 2025 May 12;347:119811
Deubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing PPAR-γ.
Yang S, Xiong L, Liao T, Li L, Li Y, Kang L, Yang G, Liang Z
Diabetes 2025 May 1;74(5):773-786
Diabetes 2025 May 1;74(5):773-786
Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells.
Li Y, Wang W, Liu Z, Liu G, Li X
Cell biochemistry and biophysics 2025 Mar;83(1):1105-1111
Cell biochemistry and biophysics 2025 Mar;83(1):1105-1111
The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells.
Bozdag D, Entezari B, Gurer-Orhan H
Toxicology letters 2025 Mar;405:67-75
Toxicology letters 2025 Mar;405:67-75
Qishen Granules Modulate Metabolism Flexibility Against Myocardial Infarction via HIF-1 α-Dependent Mechanisms in Rats.
Sun XQ, Li X, Li YQ, Lu XY, Liu XN, Cui LW, Wang G, Zhang M, Li C, Wang W
Chinese journal of integrative medicine 2025 Mar;31(3):215-227
Chinese journal of integrative medicine 2025 Mar;31(3):215-227
Targeting NAMPT-OPA1 for treatment of senile osteoporosis.
Bai CW, Tian B, Zhang MC, Qin Q, Shi X, Yang X, Gao X, Zhou XZ, Shan HJ, Bai JY
Aging cell 2025 Mar;24(3):e14400
Aging cell 2025 Mar;24(3):e14400
Anti-b diminishes hyperlipidaemia and hepatic steatosis in hamsters and mice by suppressing the mTOR/PPARγ and mTOR/SREBP1 signalling pathways.
Bian Y, Wu H, Jiang W, Kong X, Xiong Y, Zeng L, Zhang F, Song J, Wang C, Yang Y, Zhang X, Zhang Y, Pang P, Duo T, Wang Z, Pan T, Yang B
British journal of pharmacology 2025 Mar;182(5):1254-1272
British journal of pharmacology 2025 Mar;182(5):1254-1272
Photothermal-Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy.
Yu F, Zhao X, Wang Q, Niu Y, Xiao P, Zhang J, Fei K, Huang Y, Liu L, Fang PH, Du X, Li W, He D, Zhang T, Li S, Yuan J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2413962
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2413962
Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Ouyang P, Qi J, Tong B, Li Y, Cao J, Wang L, Niu T, Qi X
Investigative ophthalmology & visual science 2025 Mar 3;66(3):5
Investigative ophthalmology & visual science 2025 Mar 3;66(3):5
Adhesion strength of tumor cells predicts metastatic disease in vivo.
Kane MA, Birmingham KG, Yeoman B, Patel N, Sperinde H, Molley TG, Beri P, Tuler J, Kumar A, Klein S, Zare S, Wallace A, Katira P, Engler AJ
Cell reports 2025 Mar 25;44(3):115359
Cell reports 2025 Mar 25;44(3):115359
Plasma Lipidomics, Gut Microbiota Profile, and Phenotype of Adipose Tissue in an ApoE(-/-) Mouse Model of Plaque Instability.
Yang G, Tan X, Zhai Q, Wang Y, Zhang X, Zhao P, Liang F, Lu J, Bao L
Frontiers in bioscience (Landmark edition) 2025 Mar 21;30(3):27236
Frontiers in bioscience (Landmark edition) 2025 Mar 21;30(3):27236
Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway.
Huang R, Zhou C, Wang T, Chen Y, Xie Z, Wei L, Duan Y, Liao C, Ma C, Yang X
Life sciences 2025 Mar 15;365:123452
Life sciences 2025 Mar 15;365:123452
Regulation of PPARγ in the development of early sheep embryos in vitro.
Yu H, Liu C, Zhang Y, Li Z, Pi W, Hu G
Theriogenology 2025 Mar 1;234:143-150
Theriogenology 2025 Mar 1;234:143-150
Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.
Ni D, Qi Z, Ma S, Wang Y, Liang D, Zhang X, Man Y, Chen J, Dou K, Li G
Molecular metabolism 2025 Jun;96:102137
Molecular metabolism 2025 Jun;96:102137
A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARγ through promoting ubiquitination-mediated HDAC1 degradation.
Zhang F, Song J, Wu H, Lin K, Wang C, Zeng L, Kong X, Zou K, Diao H, Wang Z, Si W, Jiang W, Yang Y, Yao F, Zhang X, Xiong Y, Zhao Q, Duo T, Ju J, Pan T, Yang B, Bian Y
Science China. Life sciences 2025 Jun;68(6):1740-1754
Science China. Life sciences 2025 Jun;68(6):1740-1754
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.
Wang L, Wang Y, Ding K, Li Z, Zhang Z, Li X, Song Y, Xie L, Chen Z
The EMBO journal 2025 Jun;44(12):3360-3380
The EMBO journal 2025 Jun;44(12):3360-3380
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment.
Li T, Zhao J, Yuan J, Ding R, Yang G, Cao J, Zhao X, Liu J, Liu Y, Xu P, Deng J, Miao X, Cheng X
Materials today. Bio 2025 Jun;32:101648
Materials today. Bio 2025 Jun;32:101648
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Xie E, Wang Q, Yi H, Wang J, Liu X, Ye R, Lu L, Tian T, Chen A, Zheng G, Zhang G, Wang H
International journal of biological macromolecules 2025 Jun;312:144097
International journal of biological macromolecules 2025 Jun;312:144097
Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer.
Qian LH, Wen KL, Guo Y, Liao YN, Li MY, Li ZQ, Li SX, Nie HZ
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1391-1409
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1391-1409
Effect of isolated keratin 3 knockdown on gene expression of primary limbal epithelial cells without and with inflammatory stimuli.
Kundu S, Amini M, Stachon T, Fries F, Seitz B, Li Z, Li S, Liu S, Shu SL, Suiwal S, Szentmáry N
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2025 Jun;260:152670
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2025 Jun;260:152670
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
Li L, Yuan H, Li H, Cheng R, Zhou Z, Hu F, Xu L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
Lu S, Xiong W, Yi J, Liu S, Zhang F
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119937
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119937
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway.
Li H, Guan Y, Chen X, Tian W, Xie J, Yang B
Journal of reproductive immunology 2025 Jun;169:104526
Journal of reproductive immunology 2025 Jun;169:104526
Linghe granules reduces hepatic lipid accumulation in Non-alcoholic fatty liver disease through regulating lipid metabolism and redox balance.
Hu Y, Li N, Zhang R, Wang J, Fang D, Zhou Q, Zhang H, Cai H, Lu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156654
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156654
Combined metabolomics and network pharmacology to elucidate the mechanisms of Huiyang Shengji decoction in treating diabetic skin ulcer mice.
Chen J, Qu B, Yang D, Wang Y, Zhu H, Wang Z, Zhang X, Ma H, Zhao N, Zhao L, Zhou L, He X, Li P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156569
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156569
18β-glycyrrhetinic acid improves pulmonary hypertension by regulating the vascular non-inflammatory molecule-1/L-arginine/nitric oxide signaling pathway.
Shanahati D, Yang T, Fang L, Nijiati Y, Aihemaitituoheti A, Abudukeremu A, Aikemu A
European journal of pharmacology 2025 Jun 5;996:177382
European journal of pharmacology 2025 Jun 5;996:177382
Enzymatic Synthesis and Evaluation of Eight Methylated Quercetin Products: In Vitro Chemical Properties and Adipogenesis Regulation.
Ang B, Yang T, Jiang H, Cheng Y, Chen Y, Qie X, Yin L, Wang T, Chen Q, Wang Z, Zeng M, Adhikari B, He Z, Chen J
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13973-13984
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13973-13984
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Ying W, Weng W, Wang P, Pan C, Qiu J, Huang Q, Zhan G, Chen X
Journal of neuroinflammation 2025 Jun 27;22(1):167
Journal of neuroinflammation 2025 Jun 27;22(1):167
Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Junctions by Modulating the PPAR-γ/NF-κB Signaling Pathway in Intestinal Cells and Organoids.
Zheng X, Cao Z, Wang M, Yuan R, Han Y, Li A, Wang X
Nutrients 2025 Jun 20;17(13)
Nutrients 2025 Jun 20;17(13)
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Ding Y, Zhang L, Zhao W, Wang T, Shi Y, Zhuang C, Qu Z
Molecular nutrition & food research 2025 Jul;69(13):e70103
Molecular nutrition & food research 2025 Jul;69(13):e70103
Daqinjiao Decoction Ameliorates CSVD via RXR-γ/PPAR-γ/VEGF-α Pathway: Insights From Transcriptome Sequencing and Network Pharmacology.
Lv M, Yang X, Shi X, Cao S, Li W, Zhou M, Gou X, Huang Y
Journal of cellular and molecular medicine 2025 Jul;29(14):e70712
Journal of cellular and molecular medicine 2025 Jul;29(14):e70712
Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression.
Feng K, Wang W, Gao X, Yan H, Xu M, Fan B, Jia Q, Wang C, Yu J, Li Y, Xu Q, An Y, Jiao P, Wang M, Sun H, Kong F, Gong Y, Zhao S
Nature communications 2025 Jul 4;16(1):6151
Nature communications 2025 Jul 4;16(1):6151
Lysophosphatidylcholine-induced aberrant adipogenesis in mesenchymal stem cells and impaired antibacterial function in adipocytes of creeping fat.
Wu F, Xie W, Yu A, Lin X, Ouyang T, Fei J, Liu X, Yang H, Zhang D, Shi J, Wang W, Huang M, Chen G, Xie F, Wu F, Bai L
Journal of Crohn's & colitis 2025 Jul 3;19(7)
Journal of Crohn's & colitis 2025 Jul 3;19(7)
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Casati S, Dei Cas M, d'Adduzio L, Cruz-Chamorro I, Santos-Sánchez G, Bollati C, Fanzaga M, Pedroche J, Millán-Linares MDC, Roda G, Carrillo-Vico A, Lammi C
NPJ science of food 2025 Jul 28;9(1):154
NPJ science of food 2025 Jul 28;9(1):154
Wenxia Changfu formula inhibits Lewis lung cancer metastasis by reprogramming tumor-associated macrophages through the PPAR-γ/CD36 pathway.
Yin X, Sun X, Li A, Ruan J, Niu H, Zhou Y, Chen G, Guo J, He Q, Ji X
Journal of ethnopharmacology 2025 Jul 24;351:120103
Journal of ethnopharmacology 2025 Jul 24;351:120103
Ursolic acid suppresses triple-negative breast cancer progression through mediating FABP4/PPARG pathway.
Deng Y, Wu J, Pan D, Su W, Wang S
European journal of medical research 2025 Jul 2;30(1):550
European journal of medical research 2025 Jul 2;30(1):550
Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury.
Zheng M, Chen H, Liu Z, Wang Z, Jiang T, He Y
Stem cell research & therapy 2025 Jul 18;16(1):388
Stem cell research & therapy 2025 Jul 18;16(1):388
S100a4(+) alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.
Huang H, Yang Y, Zhang Q, Yang Y, Xiong Z, Mao S, Song T, Wang Y, Liu Z, Bu H, Zhang L, Zhang L
eLife 2025 Jul 14;13
eLife 2025 Jul 14;13
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.
Mao MZ, Zheng MH, Guo B, Ling YL, Lin X, Li FX, Shan SK, Dai DX, Qiu L, Cai XY, Ding Y, Gu YY, Deng QR, Zhou ZA, Lei LM, Tao C, Cui RR, Wu F, Zhang F, Wu B, Liao LL, Tan CM, Liao XB, Yuan LQ, Xu F
Journal of nanobiotechnology 2025 Jul 12;23(1):504
Journal of nanobiotechnology 2025 Jul 12;23(1):504
Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.
Liang F, Huang N, Tian Y, Fang Y, Huang C, Qiu B, Lu T, Zheng L, Cheng J, Zhu B, Zhao J
Stem cell research & therapy 2025 Jul 1;16(1):341
Stem cell research & therapy 2025 Jul 1;16(1):341
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
Wang X, Ning C, Cheng X, Wu Z, Wu D, Ding X, Ju C, Zhou Z, Wan L, Zhao W, Shi P
Animal models and experimental medicine 2025 Jan;8(1):114-125
Animal models and experimental medicine 2025 Jan;8(1):114-125
LRP1 mitigates intervertebral disc degeneration by inhibiting endoplasmic reticulum stress through stabilizing the PPARγ.
Yao D, Li M, Zeng W, Wang K, Liao Z, Chen E, Xing T, Liang Y, Tang J, Wen G, Ning Q, Li Y, Huang L
Journal of orthopaedic translation 2025 Jan;50:196-210
Journal of orthopaedic translation 2025 Jan;50:196-210
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.
Zhang H, Hu J, Zhao X, Zheng B, Han Y, Luo G, Dou D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156271
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156271
Effects of duration of high-fat diet on adipocyte hyperplasia in rat epididymis.
Wang Z, Liu X, Sheng L, Xie Y, Feng W, Yu L
Obesity research & clinical practice 2025 Jan-Feb;19(1):54-62
Obesity research & clinical practice 2025 Jan-Feb;19(1):54-62
Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis.
Wang G, Dong Y, Qiao X, Jia C, Wang J, Chen G, Zheng K, Jiang C, Li X
Kidney diseases (Basel, Switzerland) 2025 Jan-Dec;11(1):450-468
Kidney diseases (Basel, Switzerland) 2025 Jan-Dec;11(1):450-468
A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA.
Li D, Chen Y, Zhu X, Yang Y, Li H, Zhao RC
Journal of biomedical science 2025 Jan 8;32(1):6
Journal of biomedical science 2025 Jan 8;32(1):6
Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats.
Ding Y, Jie K, Xin L, Shao B
Behavioural brain research 2025 Jan 5;476:115267
Behavioural brain research 2025 Jan 5;476:115267
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation.
Luo S, Wang X, Ma B, Liu D, Li L, Wang L, Ding N, Zou L, Wang J, Pan J, Sang D, Zhou H, Qu H, Lu Y, Yang L
Biomolecules & biomedicine 2025 Jan 30;25(3):632-647
Biomolecules & biomedicine 2025 Jan 30;25(3):632-647
Seipin Deficiency Impairs Motor Coordination in Mice by Compromising Spinal Cord Myelination.
Chen H, Wang W, Cui W, Tu C, Han Y, Zhang C, Yang L, Huang X, Zhang Q, Lu L
Neuromolecular medicine 2025 Jan 27;27(1):12
Neuromolecular medicine 2025 Jan 27;27(1):12
Docosahexaenoic acid mitigates experimental autoimmune prostatitis by inhibiting Th17 cell differentiation via the PPARγ/NF-κB/IL-17A pathway.
Wu W, Yue S, Wang X, Li W, Xu L, Guan Y, Liang CZ
Clinical and experimental immunology 2025 Jan 21;219(1)
Clinical and experimental immunology 2025 Jan 21;219(1)
PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress.
Li M, Zhuo X, Liu Y, You J, Lin J
BMC gastroenterology 2025 Jan 20;25(1):22
BMC gastroenterology 2025 Jan 20;25(1):22
Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia.
Li Z, Xiang YJ, Zou ZC, Feng YM, Wang H, Chen WQ, Ge X, Ma JZ, Jing J, Yao B
Zoological research 2025 Jan 18;46(1):177-192
Zoological research 2025 Jan 18;46(1):177-192
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Wang H, Zhang H, Miao L, Wang C, Teng H, Li X, Zhang X, Yang G, Wang S, Zeng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation.
Zhou C, Zhong R, Zhang L, Yang R, Luo Y, Lei H, Li L, Cao J, Yuan Z, Tan X, Xie M, Qu H, He Z
Discover oncology 2025 Jan 15;16(1):47
Discover oncology 2025 Jan 15;16(1):47
Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.
Yang S, Duan H, Zeng J, Yan Z, Niu T, Ma X, Zhang Y, Hu J, Zhang L, Zhao X
Journal of ethnopharmacology 2025 Jan 13;339:119157
Journal of ethnopharmacology 2025 Jan 13;339:119157
Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-κB pathway.
Xiong F, Wang B, Zhang H, Zhang G, Liu Y, Liu Y, Wang C
International immunopharmacology 2025 Jan 10;144:113706
International immunopharmacology 2025 Jan 10;144:113706
Alterations in the transcriptome and microRNAs of adipose-derived mesenchymal stem cells from different sites in rats during aging.
Su Z, Xu T, Sun JY, Sun W, Kong X
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C78-C94
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C78-C94
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
Yang Z, Chen Q, Wang J, Qiu Y, Thepsuwan P, Yi Z, Heng HH, Sun Q, Chen X, Li L, He P, Zhang R, Zhang K
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Zhao J, Xu Y, Yu H, Li X, Wang W, Mao D
Theriogenology 2025 Jan 1;231:62-72
Theriogenology 2025 Jan 1;231:62-72
Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.
Qin W, Ding Y, Zhang W, Sun L, Weng J, Zheng X, Luo S
Journal of lipid research 2025 Feb;66(2):100740
Journal of lipid research 2025 Feb;66(2):100740
Rosiglitazone Promotes Oligodendrocyte Development and Myelin Formation of Repeated Neonatal Sevoflurane Exposure via PPARγ Signaling.
Cao T, Jiang S, Wang X, Huang P, Zhou L, Di L, Han S, Huang L
Molecular neurobiology 2025 Feb;62(2):2348-2361
Molecular neurobiology 2025 Feb;62(2):2348-2361
Uncovering the mechanisms of diosmin in treating obesity-related kidney injury based on network pharmacology, molecular docking, and in vitro validation.
Zhu JX, Chu F, Zhao WM, Shi R, Wang ZJ, Li XL, Zhu YY, Wang DG
Naunyn-Schmiedeberg's archives of pharmacology 2025 Feb;398(2):1973-1989
Naunyn-Schmiedeberg's archives of pharmacology 2025 Feb;398(2):1973-1989
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Kuang G, Zhao Y, Wang L, Wen T, Liu P, Ma B, Peng Q, Xu F, Ye L, Fan J
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
Wu T, Li W, Hu Y, Zhang D, Tian L, Xu H, Zhang F, Xiao B, Shi Y, Chen Y, Liao X, Ma K, Chen L
Forensic science international 2025 Feb;367:112371
Forensic science international 2025 Feb;367:112371
Olaparib promotes FABP4 expression and reduces antitumor effect in ovarian cancer cells with a BRCA1 mutation.
Huang W, Meng H, Xu Y, Huang L, Lou G
Oncology letters 2025 Feb;29(2):67
Oncology letters 2025 Feb;29(2):67
Inhibition of the Wnt/β‑catenin signaling pathway and SOX9 by XAV939 did not alleviate inflammation in a dextran sulfate sodium‑induced ulcerative colitis model.
Liang SJ, Wang K, Mao DB, Xie LW, Zhu DJ
Experimental and therapeutic medicine 2025 Feb;29(2):24
Experimental and therapeutic medicine 2025 Feb;29(2):24
DHA Improves neurodevelopmental abnormalities in offspring of gestational diabetes mellitus patients via the PPAR-γ/FATP4 pathway.
Jiang Y, Zhou X, He Z, Wei L, Zhu S, Zhang H, Zhang J, Chen Y, Du Y, Ding W, Wang S, Wang Z, Feng L
Biochemical pharmacology 2025 Feb;232:116726
Biochemical pharmacology 2025 Feb;232:116726
Mass spectrometry imaging reveals spatial metabolic variation and the crucial role of uridine metabolism in liver injury caused by Schistosoma japonicum.
Xue Q, Zhou X, Wang Y, Liu Y, Li X, Xiong C, Liu X, Huang Y
PLoS neglected tropical diseases 2025 Feb;19(2):e0012854
PLoS neglected tropical diseases 2025 Feb;19(2):e0012854
Natural molecule isoliquiritigenin mitigates MASH and liver fibrosis in mice by promoting autophagy through the PI3K/Akt signaling pathway.
Liu R, Zhang Y, Liu M, Shang Z, Song S, Zhang Y, Zhou Y, Tu C
The Journal of nutritional biochemistry 2025 Feb;136:109808
The Journal of nutritional biochemistry 2025 Feb;136:109808
Acetoacetate Ameliorates Hepatic Fibrosis by Targeting Peroxisome Proliferator-Activated Receptor Gamma to Restore Lipid Droplets in Activated Hepatic Stellate Cells.
Zhou Y, Wang F, Hu M, Xia S, Li Y, Zheng S, Zhang F
Pharmaceuticals (Basel, Switzerland) 2025 Feb 6;18(2)
Pharmaceuticals (Basel, Switzerland) 2025 Feb 6;18(2)
TRIM37 exacerbates cerebral ischemic injury by regulating the PPARγ/NF-κB pathway.
Shi G, Fu L, Xiao H, Cao F
Neuroreport 2025 Feb 5;36(2):105-115
Neuroreport 2025 Feb 5;36(2):105-115
Network pharmacology study on the mechanism of berberine in Alzheimer's disease model.
Zhang Y, Lv S, Huang P, Xiao L, Lin N, Huang E
NPJ science of food 2025 Feb 4;9(1):16
NPJ science of food 2025 Feb 4;9(1):16
Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ.
Qian B, Yin B, Yu H, Wang C, Lu S, Ke S, Li Z, Li X, Hua Y, Li Z, Zhou Y, Meng Z, Fu Y, Tang W, Ma Y
Nature communications 2025 Feb 19;16(1):1776
Nature communications 2025 Feb 19;16(1):1776
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Zhao L, Li M, Zhu Q, Fang X, Yang H, Zhao Y
International journal of molecular sciences 2025 Feb 14;26(4)
International journal of molecular sciences 2025 Feb 14;26(4)
Magnolol preserves the integrity of the intestinal epithelial barrier and mitigates intestinal injury through activation of PPAR γ in COPD rat.
Tao L, Zhang Q, Liu L, Wang K, Liu X, Li J, Zhao P
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119068
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119068
Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period.
Cao G, Liao X, Zhao S, Li M, Xie Z, Yang J, Li Y, Zhu Z, Jin X, Huang R, Guo Z, Niu X, Ji X
International journal of molecular sciences 2025 Feb 10;26(4)
International journal of molecular sciences 2025 Feb 10;26(4)
Baicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway.
Bao N, Gu MJ, Huang QY, Sun HJ, Zhu XX, Gu X, Wang J, Yu X, Lu QB, Yu YF
Renal failure 2025 Dec;47(1):2508908
Renal failure 2025 Dec;47(1):2508908
Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy.
Tan YY, Wang YK, Luo XM, Chen CY, Liu XQ, Liu XR, Wu YG
Renal failure 2025 Dec;47(1):2508297
Renal failure 2025 Dec;47(1):2508297
Phillyrin prevents calcium oxalate kidney stones through the PPARγ signaling pathway.
Chu X, Chang X, Liu S, Zhang S, Xie E, Zhou B
Renal failure 2025 Dec;47(1):2486559
Renal failure 2025 Dec;47(1):2486559
Impact of overexpression of wild-type CFTR and elexacaftor-tezacaftor-ivacaftor on oxylipin production by the CFBE41o- bronchial epithelial cell line.
Brown DG, Manke J, Armstrong M, Yadav S, Marentette JO, Roede JR, Vladar EK, Reisdorph N, Phelan VV
Prostaglandins & other lipid mediators 2025 Dec;181:107043
Prostaglandins & other lipid mediators 2025 Dec;181:107043
Oncofetal dual‑specificity phosphatase 9 drives stem-like properties through ERK1/2-PPARG-SCD axis-mediated lipid metabolism in hepatocellular carcinoma.
Peng W, Huang H, Zhao Y, Zhou Q, Cao M, Liu L, Liang J, Cui H, Chen S, Chen W, Xiong S, Cheng B, Bai S
Clinical and translational medicine 2025 Dec;15(12):e70550
Clinical and translational medicine 2025 Dec;15(12):e70550
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Fu L, Tai S, Liao J, Du Y, Zhang G, Guo D, Chen X, Zheng T, Hu X, Yao W, Tao L, Wang X, Xu Y, Shen X
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Hydroxytyrosol improved insulin resistance in male offspring born to high-fat diet dams by remodeling gut microbiota.
Yi D, Li T, Xiao Y, Li X, Shao B, Wu Z, Hao Q, Zhang F, Zhang X, Yang G, Zhang C, Deng H, Sun X, Wang N
The Journal of nutritional biochemistry 2025 Dec;146:110041
The Journal of nutritional biochemistry 2025 Dec;146:110041
CEACAM1 regulates autophagy in oral squamous cell carcinoma through the PPAR signaling pathway.
Ma S, Wang Z, Li C, Liu Z, Zhang X
Journal of stomatology, oral and maxillofacial surgery 2025 Dec 5;127(3):102676
Journal of stomatology, oral and maxillofacial surgery 2025 Dec 5;127(3):102676
Gpr109a alleviates mammary fibrosis via PPARγ-mediated reduction of ROS and mitochondrial damage.
Bi J, He D, Li F, Xu P, Huang Y, Guo W, Fu S, Kan X, Li Y
International immunopharmacology 2025 Dec 3;166:115603
International immunopharmacology 2025 Dec 3;166:115603
Pathogenesis of impaired glucose tolerance in rats based on transcriptome analysis.
Yi R, Xie Y, Fan Y, Liu X, Yang Z, Liu S
Scientific reports 2025 Dec 29;15(1):44908
Scientific reports 2025 Dec 29;15(1):44908
Residual tumor cells after insufficient radiofrequency ablation promote lung metastasis by educating CD177(hi)PAD4(hi) neutrophils.
Huang N, Fang Y, Zheng S, Wu J, Huang G, Deng X, Guan Y, Liang B, Zeng D, Xu B, Huang Y, Rong X, Wang C, Bin J, Liao Y, Wu Z, Shi M, Liao W
Nature communications 2025 Dec 2;17(1):208
Nature communications 2025 Dec 2;17(1):208
Single-cell transcriptomic analysis of the heterogeneity of mesenchymal and stromal cells and their regulon alteration during airway remodeling in asthma.
Chen X, Zhang H, Sun Z, Sun M, Wang J, Qiao G, Kang J, Liu K
Scientific reports 2025 Dec 2;15(1):42972
Scientific reports 2025 Dec 2;15(1):42972
Interleukin-27 is a multitarget regulator of fibroblast remodeling in thyroid-associated ophthalmopathy.
Zhang P, Wang X, Lu N, Nie Y, Zhang X, Liu L
iScience 2025 Dec 19;28(12):113982
iScience 2025 Dec 19;28(12):113982
FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1.
Wang Z, Wen S, Li H, Wang X, Guo S, Yang S
Stem cell research & therapy 2025 Dec 17;17(1):39
Stem cell research & therapy 2025 Dec 17;17(1):39
Early life exposure to environmental levels of PCB138 induces lipid metabolism disorders through activating aryl hydrocarbon receptor in female mice.
Zhu S, He R, Ruan J, Chen P, Zhang Y, Yang C, Wang W, He C, Zuo Z
Environmental research 2025 Dec 15;287:123038
Environmental research 2025 Dec 15;287:123038
Citri grandis Exocarpium Extract Alleviates Atherosclerosis in ApoE(-/-) Mice by Modulating the Expression of TGF-β1, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1.
Xu J, Wen WZ, Zhao JH, Guo JR, Zhang ZY, Xiong P
Foods (Basel, Switzerland) 2025 Dec 11;14(24)
Foods (Basel, Switzerland) 2025 Dec 11;14(24)
The SCD5 Gene Modulates Adipogenic Differentiation via the WNT5B Signaling Pathway in Xinjiang Brown Cattle.
Wang Y, Ren W, Shao W, Zhou Y, Liu Y, Cao J, Wang F, Bi J, Yang L
Animals : an open access journal from MDPI 2025 Dec 10;15(24)
Animals : an open access journal from MDPI 2025 Dec 10;15(24)
Prepregnancy GLP-1RA use improves maternal lipid metabolism via liver-secreted FGF21 during pregnancy in HFD-fed dams.
Guo H, Jing Y, Zhang Y, Song L, Wu W, Wang J, Wang M, Niu X, Wang M, Pan X, Wang T, Cui W, Sun B, Wang N
Obesity (Silver Spring, Md.) 2025 Aug;33(8):1504-1517
Obesity (Silver Spring, Md.) 2025 Aug;33(8):1504-1517
Genetic algorithm-back propagation artificial neural network model- and response surface methodology-based optimization of crude Lophatherum gracile Brongn. polysaccharides extraction and their anti-NAFLD effects via regulating liver-adipose tissue crosstalk.
Wu C, Chen QC, Ni Q, Cai WF, Jiang CP, Yi YK, Liu L, Shen CY
International journal of biological macromolecules 2025 Aug;320(Pt 1):145806
International journal of biological macromolecules 2025 Aug;320(Pt 1):145806
Alcohol, Anti-HIV Drugs, and/or Hippuric Acid Deteriorate Cellular Stresses in Senescent Hepatocytes and Aging Murine Liver.
Chen L, Kaypaghian M, Duran E, Ji C
Journal of addiction & prevention 2025 Aug;13(1)
Journal of addiction & prevention 2025 Aug;13(1)
Ecliptasaponin II alleviates the radiation enteritis by activating PPARγ to inhibit the apoptosis of endothelial cells.
Zeng X, Zhang L, He J, Zhang Y, Lu H, Liu Z, Wang Z, Wei Z
International immunopharmacology 2025 Aug 28;161:115080
International immunopharmacology 2025 Aug 28;161:115080
Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway.
Zhu Q, Zeng C, Peng W, Chen H, Huang H, Zhou Y, Huang C, Zhao C
International immunopharmacology 2025 Aug 28;161:115068
International immunopharmacology 2025 Aug 28;161:115068
Multi-omics reveals miR-181a-5p regulates PPAR-driven lipid metabolism in Oral squamous cell carcinoma: Insights from CRISPR/Cas9 knockout models.
Wang T, Liu Y, Wu X, Wang X, Shi S, Song X, Ma Y, Zhang Z, Gao J, Sun R, Song G
Journal of proteomics 2025 Aug 15;319:105480
Journal of proteomics 2025 Aug 15;319:105480
CGKRK-targeted lipid nanoparticles enhance in vivo rosiglitazone delivery to the placenta to ameliorate murine preeclampsia.
Li K, Jia X, Guo D, Wang H, Shui H, Qi H, Zhang H
iScience 2025 Aug 15;28(8):112744
iScience 2025 Aug 15;28(8):112744
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Genetic and functional validation of CTSS in regulating intramuscular fat content of Duroc-Landrace-Yorkshire pigs.
Tian Y, Zhao Y, Yao Y, Li M, Zhang L, Wei W, Chen J
Animal genetics 2025 Apr;56(2):e70010
Animal genetics 2025 Apr;56(2):e70010
A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration.
Chocarro-Wrona C, Pleguezuelos-Beltrán P, López de Andrés J, Antich C, de Vicente J, Jiménez G, Arias-Santiago S, Gálvez-Martín P, López-Ruiz E, Marchal JA
Materials today. Bio 2025 Apr;31:101592
Materials today. Bio 2025 Apr;31:101592
The influence of IMPDH activity on ciliogenesis and adipogenesis of 3T3-L1 cells while undergoing differentiation.
Shahdadnejad K, Yazdanparast R
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Apr;1870(3):159603
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Apr;1870(3):159603
Proteomic analysis reveals that Acalypha australis L. mitigates chronic colitis by modulating the FABP4/PPARγ/NF-κB signaling pathway.
Quan X, Miao Z, Han R, Deng R, Cao Y, Tian J, Lu Y, Wang G, Yu X, Wu Y, Dai C
Journal of ethnopharmacology 2025 Apr 9;345:119585
Journal of ethnopharmacology 2025 Apr 9;345:119585
Docosahexaenoic Acid Supplementation in Postnatal Growth Restricted Rats Does Not Normalize Lung Function or PPARγ Activity.
Cohen AJ, Chidester WR, Wray DT, Jessen N, Jones A, Bitsui C, Zhao J, Maschek JA, Cox JE, Martin CR, Joss-Moore LA
Biomolecules 2025 Apr 9;15(4)
Biomolecules 2025 Apr 9;15(4)
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction.
Li N, Fang X, Li H, Liu J, Chen N, Zhao X, Yang Q, Chen X
Metabolic brain disease 2025 Apr 3;40(4):168
Metabolic brain disease 2025 Apr 3;40(4):168
Cold-Induced DHRS4 Promotes Thermogenesis via Enhanced Fatty Acid β-Oxidation in Porcine Subcutaneous Adipocytes.
Ma X, Ye Z, Li M, Wei W, Chen J, Zhang L
Animals : an open access journal from MDPI 2025 Apr 22;15(9)
Animals : an open access journal from MDPI 2025 Apr 22;15(9)
Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation.
Ma Z, Li J, Zhu J, Yang Z, Li X, Wang H, Tang Q, Zhou Y, Manzoor R, Chen X, Ma H, Ye X
International immunopharmacology 2025 Apr 16;152:114405
International immunopharmacology 2025 Apr 16;152:114405
Aging and autophagic phenotypic changes in bone marrow mesenchymal stem cells in glucocorticoid-induced osteonecrosis.
Cao R, Li H, Liu G, Yan P, Zhang J, Chen Y, Duan X, Zhao Y, Lei Y, Liu C, Guan H, Xing F, Li Y, Wang K, Kong N, Tian R, Yang P
International immunopharmacology 2025 Apr 16;152:114389
International immunopharmacology 2025 Apr 16;152:114389
A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A-PPAR Axis in Pancreatic Ductal Adenocarcinoma.
Pan H, Sun Y, Qian LH, Liao YN, Gai YZ, Huo YM, Li ZQ, Nie HZ
Research (Washington, D.C.) 2024;7:0300
Research (Washington, D.C.) 2024;7:0300
Cited2 inhibited hypoxia-induced proliferation and migration of PASMCs via the TGF-β1/Cited2/PPARγ pathway.
Wang HJ, Ma L, Yu Q
Iranian journal of basic medical sciences 2024;27(4):509-517
Iranian journal of basic medical sciences 2024;27(4):509-517
Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation.
Chen L, Yin Y, Liu C, Liu J, Zheng M, Tang Y, Yang Q, Liu J, Chen F, Liu L, Liu G
Iranian journal of basic medical sciences 2024;27(3):343-351
Iranian journal of basic medical sciences 2024;27(3):343-351
Chemically Modified PPARγ mRNA Unleashes Adipogenic Potential in 3T3-L1-Predipocytes: An Approach for Accelerated Wound Healing.
Luo Z, Lu Y, Zheng S, Liu K, Fu W, Pan Y
International journal of medical sciences 2024;21(13):2480-2493
International journal of medical sciences 2024;21(13):2480-2493
Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway.
Zhang X, Zheng Y, Wang G, Liu Y, Wang Y, Jiang X, Liang Y, Zhao X, Li P, Zhang Y
Stem cells international 2024;2024:6693292
Stem cells international 2024;2024:6693292
SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.
Liu LX, Zheng XH, Hai JH, Zhang CM, Ti Y, Chen TS, Bu PL
PloS one 2024;19(4):e0301990
PloS one 2024;19(4):e0301990
Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.
Luan J, Yu M, Gu Q, Zhou X, Shao Y, Chen T, Zhang J, Zhu Z, Song N, Yang J
Frontiers in immunology 2024;15:1532021
Frontiers in immunology 2024;15:1532021
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice.
Li Y, Ye Z, Zhao Y, Xu B, Xue W, Wang Z, An R, Wang F, Wu R
Frontiers in physiology 2024;15:1427722
Frontiers in physiology 2024;15:1427722
Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation.
Yijie D, Siqi Z, Ruiyin H, YuJing S, Hong M, Yinmao D, Tao Y, Changyong L
Frontiers in pharmacology 2024;15:1414856
Frontiers in pharmacology 2024;15:1414856
The autophagic regulation of rosiglitazone-promoted adipocyte browning.
Li Y, Zheng W, Li X, Lue Z, Liu Y, Wu J, Zhang X
Frontiers in pharmacology 2024;15:1412520
Frontiers in pharmacology 2024;15:1412520
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells.
Ye Z, Zhao Y, Cui Y, Xu B, Wang F, Zhao D, Dong G, Wang Z, Wu R
Frontiers in pharmacology 2024;15:1386794
Frontiers in pharmacology 2024;15:1386794
Roburic acid inhibits lung cancer metastasis and triggers autophagy as verified by network pharmacology, molecular docking techniques and experiments.
Wang L, Chen H, Deng L, Hu M, Wang Z, Zhang K, Lian C, Wang X, Zhang J
Frontiers in oncology 2024;14:1449143
Frontiers in oncology 2024;14:1449143
Comprehensive analysis of peroxisome proliferator-activated receptors to predict the drug resistance, immune microenvironment, and prognosis in stomach adenocarcinomas.
Jia Q, Li B, Wang X, Ma Y, Li G
PeerJ 2024;12:e17082
PeerJ 2024;12:e17082
Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.
Liu X, Yu Q, Mao HB, Hu JB, Liu WH
Frontiers in bioengineering and biotechnology 2024;12:1506909
Frontiers in bioengineering and biotechnology 2024;12:1506909
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Farrerol alleviates insulin resistance and hepatic steatosis of metabolic associated fatty liver disease by targeting PTPN1.
Gao J, Cang X, Liu L, Lin J, Zhu S, Liu L, Liu X, Zhu J, Xu C
Journal of cellular and molecular medicine 2024 Sep;28(18):e70096
Journal of cellular and molecular medicine 2024 Sep;28(18):e70096
Day and Night Reversed Feeding Aggravates High-Fat Diet-Induced Abnormalities in Intestinal Flora and Lipid Metabolism in Adipose Tissue of Mice.
Qiu Y, Wu L, Zhou W, Wang F, Li N, Wang H, He R, Tian Y, Liu Z
The Journal of nutrition 2024 Sep;154(9):2772-2783
The Journal of nutrition 2024 Sep;154(9):2772-2783
Rice bran active peptide (RBAP) inhibited macrophage differentiation to foam cell and atherosclerosis in mice via regulating cholesterol efflux.
Mu J, Lin Q, Chen Y, Wang J, Yu X, Huang F, Liu X, Fang Y, Li Y, Zhu B, Liang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155864
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155864
Inhibiting Soluble Epoxide Hydrolase Suppresses NF-κB p65 Signaling and Reduces CXCL10 Expression as a Potential Therapeutic Target in Hashimoto's Thyroiditis.
Feng J, Xu X, Cai W, Yang X, Niu R, Han Z, Tian L
The Journal of clinical endocrinology and metabolism 2024 Sep 16;109(10):2579-2588
The Journal of clinical endocrinology and metabolism 2024 Sep 16;109(10):2579-2588
PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.
Cohen ED, Roethlin K, Yee M, Woeller CF, Brookes PS, Porter GA Jr, O'Reilly MA
Redox biology 2024 Oct;76:103351
Redox biology 2024 Oct;76:103351
Maternal Gestational Diabetes Mellitus and High-Fat Diet Influenced Hepatic Polyunsaturated Fatty Acids Profile in the Offspring of C57BL/6J Mice.
Gong J, Xu W, Chen Y, Chen S, Wu Y, Chen Y, Li Y, He Y, Yu H, Xie L
Molecular nutrition & food research 2024 Oct;68(19):e2400386
Molecular nutrition & food research 2024 Oct;68(19):e2400386
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator-activated receptor gamma.
Qin J, Zhao Y, Li S, Liu Q, Huang S, Yu X
The FEBS journal 2024 Oct;291(20):4581-4601
The FEBS journal 2024 Oct;291(20):4581-4601
The impact of NUMB on chicken abdominal adipogenesis: A comprehensive analysis.
Wang Z, Zhao M, Su Y, Zhao Q, Ma Z, Yue Q, Zhu Z, Zhang L, Hou Z, Li H
International journal of biological macromolecules 2024 Oct;278(Pt 3):134904
International journal of biological macromolecules 2024 Oct;278(Pt 3):134904
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease.
Chen N, Luo J, Zhou T, Shou Y, Du C, Song G, Xu L, Zhao K, Jin Y, Li C, Yu D
Biochemical pharmacology 2024 Oct;228:115936
Biochemical pharmacology 2024 Oct;228:115936
Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system.
Hu R, Geng Y, Huang Y, Liu Z, Li F, Song K, Ma W, Dong H, Zhang M, Lei T, Song Y, Zhang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155931
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155931
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells.
Yu C, Liu J, Sakurai R, Wang Y, Afrose L, Gour A, Sharma A, Chandan G, Rehan VK
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108673
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108673
Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.
Zhao J, Alimu A, Li Y, Lin Z, Li J, Wang X, Wang Y, Lv G, Lin H, Lin Z
Pharmaceuticals (Basel, Switzerland) 2024 Oct 9;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 9;17(10)
Ozone therapy mitigates parthanatos after ischemic stroke.
Li J, Liu X, Wang Z, Xie P, Zhu M, Zhong H, Luo S, Tang J, Mo G
Biological research 2024 Oct 5;57(1):71
Biological research 2024 Oct 5;57(1):71
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.
Yang S, Cao SJ, Li CY, Zhang Q, Zhang BL, Qiu F, Kang N
Journal of ethnopharmacology 2024 Oct 5;332:118354
Journal of ethnopharmacology 2024 Oct 5;332:118354
Cystathionine-γ-lyase contributes to tamoxifen resistance, and the compound I194496 alleviates this effect by inhibiting the PPARγ/ACSL1/STAT3 signalling pathway in oestrogen receptor-positive breast cancer.
Fu H, Han X, Guo W, Zhao X, Yu C, Zhao W, Feng S, Wang J, Zhang Z, Lei K, Li M, Wang T
Scientific reports 2024 Oct 3;14(1):22988
Scientific reports 2024 Oct 3;14(1):22988
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Xuan W, Wu X, Zheng L, Jia H, Zhang X, Zhang X, Cao B
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Luteolin Protects against Vascular Calcification by Modulating SIRT1/CXCR4 Signaling Pathway and Promoting Autophagy.
Yu X, Xu L, Su C, Wang C, Wang Z, Wang Y, Lu X, Sun H
The AAPS journal 2024 Oct 22;26(6):111
The AAPS journal 2024 Oct 22;26(6):111
Dynamically cultured, differentiated bovine adipose-derived stem cell spheroids as building blocks for biofabricating cultured fat.
Klatt A, Wollschlaeger JO, Albrecht FB, Rühle S, Holzwarth LB, Hrenn H, Melzer T, Heine S, Kluger PJ
Nature communications 2024 Oct 22;15(1):9107
Nature communications 2024 Oct 22;15(1):9107
A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.
Wu J, Jin X, Li W, Liu E
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280
FPR1 signaling aberrantly regulates S100A8/A9 production by CD14(+)FCN1(hi) macrophages and aggravates pulmonary pathology in severe COVID-19.
Wang Z, Wang Y, Yan Q, Cai C, Feng Y, Huang Q, Li T, Yuan S, Huang J, Luo ZH, Zhou J
Communications biology 2024 Oct 14;7(1):1321
Communications biology 2024 Oct 14;7(1):1321
Preliminary study of the role of histone deacetylase (HDAC) in steroid-induced avascular necrosis of the femoral head induced by BMSC adipogenic differentiation.
Yu YL, Duan P, Zheng L, Xu JM, Pan ZY
Journal of orthopaedic surgery and research 2024 Oct 12;19(1):645
Journal of orthopaedic surgery and research 2024 Oct 12;19(1):645
m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9
Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1-mediated uncoupling lipid catabolism during in vitro maturation.
Luo Y, Li J, Zheng L, Reyimjan Y, Ma Y, Huang S, Liu H, Zhou G, Bai J, Zhu Y, Sun Y, Zou X, Hou Y, Fu X
Cell proliferation 2024 Nov;57(11):e13687
Cell proliferation 2024 Nov;57(11):e13687
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization.
Li B, Xia C, He W, Liu J, Duan R, Ji Z, Pan X, Zhou Y, Yu G, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2401931
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2401931
Anti-Obesity Effects of Pleurotus ferulae Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice.
Hong S, Park S, Lee J, Park S, Park J, Lee Y
Nutrients 2024 Nov 29;16(23)
Nutrients 2024 Nov 29;16(23)
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Yang S, Fang Z, Duan H, Dong W, Xiao L
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Huang W, Jiang M, Wang X, Pan D, Chen W, Fan L
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration.
Guo X, Zhou J, La Yan, Liu X, Yuan Y, Ye J, Zhang Z, Chen H, Ma Y, Zhong Z, Luo G, Chen H
Developmental cell 2024 Nov 18;59(22):3008-3024.e8
Developmental cell 2024 Nov 18;59(22):3008-3024.e8
circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis.
Shen Y, Liang Y, Yuan Z, Qiao L, Liu J, Pan Y, Yang K, Liu W
International journal of molecular sciences 2024 Nov 18;25(22)
International journal of molecular sciences 2024 Nov 18;25(22)
l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy.
Shen Y, Wang H, Xie H, Zhang J, Ma Q, Wang S, Yuan P, Xue H, Hong H, Fan S, Xu W, Xie Z
Journal of orthopaedic translation 2024 May;46:53-64
Journal of orthopaedic translation 2024 May;46:53-64
Total ginsenosides decrease Aβ production through activating PPARγ.
He S, Shi J, Ma L, Pei H, Zhang P, Shi D, Li H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116577
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116577
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells.
Zhang J, Jiang J, Liu H, Wang S, Ke K, Liu S, Jiang Y, Liu L, Gao X, He B, Su Y
Genes & diseases 2024 May;11(3):101075
Genes & diseases 2024 May;11(3):101075
Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.
Shi M, Yang S, Zhao X, Sun D, Li Y, Yang J, Li M, Cai C, Guo X, Li B, Lu C, Cao G
BMC genomics 2024 May 30;25(1):530
BMC genomics 2024 May 30;25(1):530
Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer.
Yang X, Li F, Shi Y, Wu Y, Yang R, Liu X, Zhang Y, Zhang G, Ma M, Luo Z, Han X, Xie Y, Liu S
Acta biochimica et biophysica Sinica 2024 May 25;56(5):763-775
Acta biochimica et biophysica Sinica 2024 May 25;56(5):763-775
Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells.
Xia B, Dai X, Shi H, Yin J, Xu T, Liu T, Yue G, Guo H, Liang R, Liu Y, Gao J, Wang X, Chen X, Tang J, Wang L, Zhu R, Zhang D
Nutrients 2024 May 10;16(10)
Nutrients 2024 May 10;16(10)
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ.
Yi T, Zhang W, Hua Y, Xin X, Wu Z, Li Y, Wen C, Fan Y, Ji J, Xu L
Chemico-biological interactions 2024 May 1;394:110972
Chemico-biological interactions 2024 May 1;394:110972
The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.
Yu W, Yao Y, Ye N, Zhao Y, Ye Z, Wei W, Zhang L, Chen J
American journal of physiology. Cell physiology 2024 May 1;326(5):C1320-C1333
American journal of physiology. Cell physiology 2024 May 1;326(5):C1320-C1333
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages.
Fu Q, Shen N, Fang T, Zhang H, Di Y, Liu X, Du C, Guo J
Genes & genomics 2024 Mar;46(3):323-332
Genes & genomics 2024 Mar;46(3):323-332
Network pharmacology and pharmacological evaluation of Wenzheng Jiedu Powder Modified Formula for neuropathic pain relief.
Li Y, Yang F, Lang W, An Q, Pan Z, Shi W, Shi X
General physiology and biophysics 2024 Mar;43(2):139-152
General physiology and biophysics 2024 Mar;43(2):139-152
B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling.
Zeng C, Chen H, Cao T, Wang L, Jiao S, Lin C, Zhang B, Cai H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114490
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114490
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Yu S, Lee HM, Lee J, Hwang JT, Choi HK, Lee YG
International journal of molecular sciences 2024 Mar 4;25(5)
International journal of molecular sciences 2024 Mar 4;25(5)
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway.
Wang H, Tian Q, Zhang R, Du Q, Hu J, Gao T, Gao S, Fan K, Cheng X, Yan S, Zheng G, Dong H
Lipids in health and disease 2024 Mar 11;23(1):76
Lipids in health and disease 2024 Mar 11;23(1):76
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.
Wan X, Wang L, Khan MA, Peng L, Zhang K, Sun X, Yi X, Wang Z, Chen K
Cell death discovery 2024 Mar 11;10(1):129
Cell death discovery 2024 Mar 11;10(1):129
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.
Liu T, Yang L, Li Z, Sun M, Lv N
Chemico-biological interactions 2024 Mar 1;391:110891
Chemico-biological interactions 2024 Mar 1;391:110891
Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through CCDC18.
Liu L, Wang W, Liu W, Li X, Yi G, Adetula AA, Huang H, Tang Z
International journal of molecular sciences 2024 Mar 1;25(5)
International journal of molecular sciences 2024 Mar 1;25(5)
Asprosin aggravates nonalcoholic fatty liver disease via inflammation and lipid metabolic disturbance mediated by reactive oxygen species.
Wang C, Zeng W, Wang L, Xiong X, Chen S, Huang Q, Zeng G, Huang Q
Drug development research 2024 Jun;85(4):e22213
Drug development research 2024 Jun;85(4):e22213
Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via activation of PPARγ signaling.
Ye J, Yan L, Yuan Y, Fu F, Yuan L, Fan X, Zhou J, Zhu Y, Liu X, Ren G, Chen H
Life medicine 2024 Jun;3(3):lnae025
Life medicine 2024 Jun;3(3):lnae025
Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria.
Al Rawi S, Simpson L, Agnarsdóttir G, McDonald NQ, Chernuha V, Elpeleg O, Zeviani M, Barker RA, Spiegel R, Laman H
The FEBS journal 2024 Jun;291(12):2565-2589
The FEBS journal 2024 Jun;291(12):2565-2589
Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action.
Tan B, Lan X, Zhang Y, Liu P, Jin Q, Wang Z, Liang Z, Song W, Xuan Y, Sun Y, Li Y
Experimental and therapeutic medicine 2024 Jun;27(6):239
Experimental and therapeutic medicine 2024 Jun;27(6):239
Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.
Jing R, Fu M, Huang Y, Zhang K, Ye J, Gong F, Jihea Ali Naji Nasser AB, Xu X, Xiao J, Yu G, Lin S, Zhao W, Xu N, Li X, Li Z, Gao S
British journal of pharmacology 2024 Jun;181(11):1596-1613
British journal of pharmacology 2024 Jun;181(11):1596-1613
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis.
Gautheron J, Elsayed S, Pistorio V, Lockhart S, Zammouri J, Auclair M, Koulman A, Meadows SR, Lhomme M, Ponnaiah M, Si-Bouazza R, Fabrega S, Belkadi A, Qatar Genome Project, Delaunay JL, Aït-Slimane T, Fève B, Vigouroux C, Abdel Ghaffar TY, O'Rahilly S, Jéru I
Proceedings of the National Academy of Sciences of the United States of America 2024 Jun 11;121(24):e2319301121
Proceedings of the National Academy of Sciences of the United States of America 2024 Jun 11;121(24):e2319301121
Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation.
Zheng Z, Sun J, Wang J, He S, Liu Z, Xie J, Yu CY, Wei H
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:570-587
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:570-587
AN698/40746067 suppresses bone marrow adiposity to ameliorate hyperlipidemia-induced osteoporosis through targeted inhibition of ENTR1.
Ren H, Mao K, Yuan X, Mu Y, Zhao S, Fan X, Zhu L, Ye Z, Lan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116843
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116843
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
Bian H, Liang X, Lu D, Lin J, Lu X, Jin J, Zhang L, Wu Y, Chen H, Zhang W, Luan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2308435
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2308435
Myriocin enhances the clearance of M. tuberculosis by macrophages through the activation of PLIN2.
Zhang X, Ding G, Yang X, Lu H, Xu Y, Hu Y, Liu S, Zhang H, Huang K, Deng G, Ye T, Yu Q, Cai Y, Xie S, Wang W, Chen X
mSphere 2024 Jul 30;9(7):e0025724
mSphere 2024 Jul 30;9(7):e0025724
Chrysanthemum morifolium attenuates metabolic and alcohol-associated liver disease via gut microbiota and PPARα/γ activation.
Liu D, Zhan J, Wang S, Chen L, Zhu Q, Nie R, Zhou X, Zheng W, Luo X, Wang B, Nie J, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155774
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155774
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Zhu Q, Han Y, He Y, Meng P, Fu Y, Yang H, He G, Long M, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Exploring the Mechanism of Asiatic Acid against Atherosclerosis Based on Molecular Docking, Molecular Dynamics, and Experimental Verification.
Wu Z, Yang L, Wang R, Yang J, Liang P, Ren W, Yu H
Pharmaceuticals (Basel, Switzerland) 2024 Jul 22;17(7)
Pharmaceuticals (Basel, Switzerland) 2024 Jul 22;17(7)
KLF2/PPARγ axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Liu W, Tu B, Ruan H, Li J, Fan C
Cell proliferation 2024 Jan;57(1):e13521
Cell proliferation 2024 Jan;57(1):e13521
ATR induces hepatic lipid metabolism disorder in rats by activating IRE1α/XBP1 signaling pathway.
Qian H, Zhao Y, Wang Y, Zhao H, Cui J, Wang Z, Ye H, Fang X, Ge Z, Zhang Y, Ye L
Toxicology 2024 Jan;501:153696
Toxicology 2024 Jan;501:153696
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Peng L, Yang R, Wang Z, Jian H, Tan X, Li J, He Z, Huang R, Zeng P, Gao W
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
Yi-shen-hua-shi granules modulate immune and inflammatory damage via the ALG3/PPARγ/NF-κB pathway in the treatment of immunoglobulin a nephropathy.
Xu R, Zhang J, Hu X, Xu P, Huang S, Cui S, Guo Y, Yang H, Chen X, Jiang C
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117204
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117204
Period circadian regulator 2-mediated steroid hormone synthesis by regulating transcription of steroidogenic acute regulatory protein in porcine granulosa cells.
Zhang Z, Cheng J, Yang L, Li X, Li Q
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
Diallyl trisulfide inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer via modulating gut microbiota and the PPARγ/NF-κB pathway.
Qu Z, Tian J, Sun J, Shi Y, Yu J, Zhang W, Zhuang C
Food & function 2024 Jan 2;15(1):158-171
Food & function 2024 Jan 2;15(1):158-171
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Liu H, Chang Z, Liu S, Zhu R, Ma J, Lu X, Li L, Zhang Z
Heliyon 2024 Jan 15;10(1):e24241
Heliyon 2024 Jan 15;10(1):e24241
Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
Zhao MF, Zhang XG, Tang YP, Zhu YX, Nie HY, Bu DD, Fang L, Li CJ
The Journal of biological chemistry 2024 Feb;300(2):105617
The Journal of biological chemistry 2024 Feb;300(2):105617
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF-κB signaling pathway.
Zhao T, Jia J
CNS neuroscience & therapeutics 2024 Feb;30(2):e14581
CNS neuroscience & therapeutics 2024 Feb;30(2):e14581
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Meng M, Wang J, Wang C, Zhao J, Wang H, Zhang Y, Sun H, Liu M
Calcified tissue international 2024 Feb;114(2):182-199
Calcified tissue international 2024 Feb;114(2):182-199
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Wu D, Shen Z, Gou Y, Yu T, Hong J, Wang Y, Ni F, Qiqige N, Lu H, Xue E
Chemico-biological interactions 2024 Feb 25;390:110877
Chemico-biological interactions 2024 Feb 25;390:110877
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D
Cell death discovery 2024 Feb 22;10(1):95
Cell death discovery 2024 Feb 22;10(1):95
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Sun DY, Wu WB, Wu JJ, Shi Y, Xu JJ, Ouyang SX, Chi C, Shi Y, Ji QX, Miao JH, Fu JT, Tong J, Zhang PP, Zhang JB, Li ZY, Qu LF, Shen FM, Li DJ, Wang P
Nature communications 2024 Feb 16;15(1):1429
Nature communications 2024 Feb 16;15(1):1429
Exposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome.
Wang S, Xu K, Du W, Gao X, Ma P, Yang X, Chen M
Toxicology 2024 Dec;509:153952
Toxicology 2024 Dec;509:153952
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke.
Wang S, Li C, Kang X, Su X, Liu Y, Wang Y, Liu S, Deng X, Huang H, Li T, Lu D, Cai W, Lu Z, Wei L, Lu T
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Dec;44(12):1487-1500
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Dec;44(12):1487-1500
Protective effects of electroacupuncture on senile osteoporosis in rats.
Zhou J, Wang J, Qu M, Wang Q, Wang L, Liu S, Liu J, Sun G, Zhong P, Huang X, Liu D, Yin L, He C
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2024 Dec;42(6):334-341
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2024 Dec;42(6):334-341
Yanghe Decoction promotes ferroptosis through PPARγ-dependent autophagy to inhibit the malignant progression of triple-negative breast cancer.
Cheng Y, Yu G, Du C, Chen Z, Liu X
Prostaglandins & other lipid mediators 2024 Dec;175:106909
Prostaglandins & other lipid mediators 2024 Dec;175:106909
Key role of PPAR-γ-mediated suppression of the NFκB signaling pathway in rutin's antidepressant effect.
Yin SY, Shao XX, Shen SY, Zhang JR, Shen ZQ, Liang LF, Chen C, Yue N, Fu XJ, Yu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156178
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156178
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
Wang J, Zhen C, Zhang G, Yang Z, Shang P
International journal of molecular sciences 2024 Dec 6;25(23)
International journal of molecular sciences 2024 Dec 6;25(23)
IFIT2 mediates iron retention and cholesterol efflux in atherosclerosis.
Chen H, Wu H, Wang Q, Zhang H
International immunopharmacology 2024 Dec 5;142(Pt A):113131
International immunopharmacology 2024 Dec 5;142(Pt A):113131
DT-13 Mediates Ligand-Dependent Activation of PPARγ Response Elements In Vitro.
Raina S, Samuel E, Fuchs H
Biology 2024 Dec 4;13(12)
Biology 2024 Dec 4;13(12)
Circ_0000284 Is Involved in Arsenite-Induced Hepatic Insulin Resistance Through Blocking the Plasma Membrane Translocation of GLUT4 in Hepatocytes via IGF2BP2/PPAR-γ.
Xu S, Hu Z, Wang Y, Zhang Q, Wang Z, Ma T, Wang S, Wang X, Wang L
Toxics 2024 Dec 4;12(12)
Toxics 2024 Dec 4;12(12)
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages.
Aerbajinai W, Zhu J, Chin K, Rodgers GP
Journal of leukocyte biology 2024 Dec 31;117(1)
Journal of leukocyte biology 2024 Dec 31;117(1)
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
Su P, Liu L, Gong Y, Peng S, Yan X, Bai M, Xu E, Li Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure.
Wu H, Wu L, Luo L, Wu YT, Zhang QX, Li HY, Zhang BF
International immunopharmacology 2024 Dec 25;143(Pt 2):113444
International immunopharmacology 2024 Dec 25;143(Pt 2):113444
High-iron diet damages brown adipose tissue mitochondria and exacerbates metabolic hazards of a high-fat diet.
Zhang Y, Bai Z, Song K, Liu Y, Zhang W
Biochemical and biophysical research communications 2024 Dec 20;739:151008
Biochemical and biophysical research communications 2024 Dec 20;739:151008
Ginsenoside Rb1 affects mitochondrial Ca(2+) transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1.
Yin Y, Hu H, Yang Y, Wu S
Molecular medicine (Cambridge, Mass.) 2024 Dec 2;30(1):240
Molecular medicine (Cambridge, Mass.) 2024 Dec 2;30(1):240
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells.
Xie W, Deng L, Zhang X, Huang X, Ding J, Liu W, Tang SY
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27737-27749
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27737-27749
Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1.
Feng H, Li Z, Zheng R
Respiratory research 2024 Dec 18;25(1):431
Respiratory research 2024 Dec 18;25(1):431
Anti-Inflammatory and Anticancer Effects of Kaurenoic Acid in Overcoming Radioresistance in Breast Cancer Radiotherapy.
Kim TW, Ko SG
Nutrients 2024 Dec 14;16(24)
Nutrients 2024 Dec 14;16(24)
A Novel PPARγ Modulator Falcarindiol Mediates ER Stress-Mediated Apoptosis by Regulating NOX4 and Overcomes Radioresistance in Breast Cancer.
Kim TW, Ko SG
Antioxidants (Basel, Switzerland) 2024 Dec 14;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 14;13(12)
ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation.
Feng Y, Luo S, Fang C, Ma S, Fan D, Chen Y, Chen Z, Zheng X, Tang Y, Duan X, Liu X, Ruan X, Guo X
Journal of lipid research 2024 Aug;65(8):100595
Journal of lipid research 2024 Aug;65(8):100595
Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish.
Zhang L, Zhao J, Peng Z, Zhang Z, Huang S, Dong X, Gao J, Guo X
Acta diabetologica 2024 Aug;61(8):975-985
Acta diabetologica 2024 Aug;61(8):975-985
Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway.
Liu C, Pan X, Hao Z, Wang X, Wang C, Song G
Experimental and therapeutic medicine 2024 Aug;28(2):326
Experimental and therapeutic medicine 2024 Aug;28(2):326
Permethrin exposure impacts zebrafish lipid metabolism via the KRAS-PPAR-GLUT signaling pathway, which is mediated by oxidative stress.
Khan A, Khan B, Hussain S, Wang Y, Mai W, Hou Y
Aquatic toxicology (Amsterdam, Netherlands) 2024 Aug;273:107021
Aquatic toxicology (Amsterdam, Netherlands) 2024 Aug;273:107021
White adipose tissue, a novel antirheumatic target: Clues from its secretory capability and adipectomy-based therapy.
Ye P, Wang QH, Kong WY, Liu CS, Wang DD, Olatunji OJ, Li Y, Zuo J
British journal of pharmacology 2024 Aug;181(16):2774-2793
British journal of pharmacology 2024 Aug;181(16):2774-2793
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Zheng Y, Wang Y, Xiong X, Zhang L, Zhu J, Huang B, Liu X, Liu J, Zhu Z, Yang G, Qu H, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Cheng X, Hu Y, Kuang J, Guo X, Cao H, Wu H, Hu G, Zhuang Y
Poultry science 2024 Aug;103(8):103968
Poultry science 2024 Aug;103(8):103968
Air-ventilated normothermic mechanical perfusion improves susceptibility to donation after circulatory death and cold preservation-induced cholestatic liver injury through PPAR-γ/UGT1A1 axis.
Wang Y, Tao RL, Yu DS, Wu KW, Bai Y, Yang DJ, Gu Y, Guo WZ, Zhang SJ, Jin Y, Shi JH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e70014
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e70014
Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma.
Liu X, Li Z, Wang HC, Yuan M, Chen J, Huang J, Yu N, Zhou Z, Long X
Cellular & molecular biology letters 2024 Aug 30;29(1):115
Cellular & molecular biology letters 2024 Aug 30;29(1):115
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.
Fang L, Liu C, Jiang ZZ, Wang M, Geng K, Xu Y, Zhu Y, Fu Y, Xue J, Shan W, Zhang Q, Chen J, Chen J, Zhao M, Guo Y, Siu KWM, Chen YE, Xu Y, Liu D, Zheng L
Signal transduction and targeted therapy 2024 Aug 23;9(1):218
Signal transduction and targeted therapy 2024 Aug 23;9(1):218
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Zhang Y, Zeng X, Wu F, Yang X, Che T, Zheng Y, Li J, Zhang Y, Zhang X, Wu Z
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117
EMBO reports 2024 Apr;25(4):2097-2117
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy.
Su Q, Huang W, Huang Y, Dai R, Chang C, Li QY, Liu H, Li Z, Zhao Y, Wu Q, Pan DG
Cardiovascular diabetology 2024 Apr 25;23(1):139
Cardiovascular diabetology 2024 Apr 25;23(1):139
Elucidating the Role of circTIAM1 in Guangling Large-Tailed Sheep Adipocyte Proliferation and Differentiation via the miR-485-3p/PLCB1 Pathway.
Liang Y, Zhao B, Shen Y, Peng M, Qiao L, Liu J, Pan Y, Yang K, Liu W
International journal of molecular sciences 2024 Apr 23;25(9)
International journal of molecular sciences 2024 Apr 23;25(9)
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake.
Cheng Y, Zhu Y, Liu Y, Liu X, Ding Y, Li D, Zhang X, Liu Y
International journal of oral science 2024 Apr 16;16(1):31
International journal of oral science 2024 Apr 16;16(1):31
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.
Chu Y, Gui S, Zheng Y, Zhao J, Zhao Y, Li Y, Chen X
European journal of pharmacology 2024 Apr 15;969:176438
European journal of pharmacology 2024 Apr 15;969:176438
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Ang B, Yang T, Wang Z, Cheng Y, Chen Q, Wang Z, Zeng M, Chen J, He Z
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
The role of miR-369-3p in proliferation and differentiation of preadipocytes in Aohan fine-wool sheep.
Xue S, Liu K, Zhao L, Zhou L, Gao X, Liu L, Liu N, He J
Archives animal breeding 2023;66(1):93-102
Archives animal breeding 2023;66(1):93-102
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Wu YJ, Zhang SS, Yin Q, Lei M, Wang QH, Chen WG, Luo TT, Zhou P, Ji CL
Drug design, development and therapy 2023;17:563-577
Drug design, development and therapy 2023;17:563-577
Abdominal Massage Ameliorates Inguinal Fat Accumulation via Augmentation of PPARγ Signaling in High-Fat Diet-Induced Obese Mice.
Zhang J, Wang T, Shi Y, Liu Y, Lu T
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:2409-2418
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:2409-2418
Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway.
Chen NN, Ma XD, Miao Z, Zhang XM, Han BY, Almaamari AA, Huang JM, Chen XY, Liu YJ, Su SW
Frontiers in pharmacology 2023;14:1150861
Frontiers in pharmacology 2023;14:1150861
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Tan Y, Kang J, Li H, Zhong A, Liu Y, Zhang Z, Huang R, Cheng X, Peng W
Frontiers in immunology 2023;14:1149810
Frontiers in immunology 2023;14:1149810
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Wang L, Yang K, Jing R, Zhao W, Guo K, Hu Z, Liu G, Xu N, Zhao J, Lin L, Gao S
Frontiers in pharmacology 2023;14:1089537
Frontiers in pharmacology 2023;14:1089537
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Zhang C, Wu X, Shi P, Ma H, Fang F, Feng Q, Zhao S, Zhang R, Huang J, Xu X, Xiao W, Cao G, Ji X
Frontiers in pharmacology 2023;14:1066758
Frontiers in pharmacology 2023;14:1066758
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.
Xu H, Gao K, Liu C, Li T, Ding Y, Ma J
PeerJ 2023;11:e15280
PeerJ 2023;11:e15280
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
Chen X, Shi W, Zhu L, Zhou X, Wang Y
Cellular signalling 2023 Sep;109:110752
Cellular signalling 2023 Sep;109:110752
Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Zeng Q, Zhou TT, Huang WJ, Huang XT, Huang L, Zhang XH, Sang XX, Luo YY, Tian YM, Wu B, Liu L, Luo ZQ, He B, Liu W, Tang SY
Scientific reports 2023 Sep 7;13(1):14706
Scientific reports 2023 Sep 7;13(1):14706
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693
Chemico-biological interactions 2023 Sep 25;383:110693
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress.
Mao Z, Ma X, Jing Y, Shen M, Ma X, Zhu J, Liu H, Zhang G, Chen F
Cell death & disease 2023 Sep 2;14(9):584
Cell death & disease 2023 Sep 2;14(9):584
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway.
Yan SW, Zhang R, Guo X, Wang BN, Long SR, Liu RD, Wang ZQ, Cui J
Veterinary research 2023 Sep 13;54(1):77
Veterinary research 2023 Sep 13;54(1):77
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.
Hong S, Park SK, Lee J, Park SH, Kim YS, Park JH, Yu S, Lee YG
Antioxidants (Basel, Switzerland) 2023 Sep 11;12(9)
Antioxidants (Basel, Switzerland) 2023 Sep 11;12(9)
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Zou TF, Liu ZG, Cao PC, Zheng SH, Guo WT, Wang TX, Chen YL, Duan YJ, Li QS, Liao CZ, Xie ZL, Han JH, Yang XX
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.
Xihui Q, Jianli P, Guan X, Jie F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1200-1208
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1200-1208
Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway.
Wang N, Yao T, Luo C, Sun L, Wang Y, Hou SX
Life metabolism 2023 Oct;2(5):load036
Life metabolism 2023 Oct;2(5):load036
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Yang Q, Zou Y, Wei X, Ye P, Wu Y, Ai H, Zhang Z, Tan J, Zhou J, Yang Y, Dai Q, Dou C, Luo F
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Song Y, Sun W, Li W, Li W
International immunopharmacology 2023 Oct;123:110751
International immunopharmacology 2023 Oct;123:110751
Protective effects and mechanisms of Yi Qi Huo Xue Fang in cerebral ischemic stroke based on network pharmacology and experimental verification.
Li J, Zhang T, Liu K, Hu G
Journal of ethnopharmacology 2023 Oct 5;314:116611
Journal of ethnopharmacology 2023 Oct 5;314:116611
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.
Nakamura A, Sakai S, Taketomi Y, Tsuyama J, Miki Y, Hara Y, Arai N, Sugiura Y, Kawaji H, Murakami M, Shichita T
Neuron 2023 Oct 4;111(19):2995-3010.e9
Neuron 2023 Oct 4;111(19):2995-3010.e9
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Korean red ginseng formula attenuates non-alcoholic fatty liver disease in oleic acid-induced HepG2 cells and high-fat diet-induced rats.
Zheng M, Li Y, Dong Z, Zhang Y, Xi Z, Yuan M, Xu H
Heliyon 2023 Nov;9(11):e21846
Heliyon 2023 Nov;9(11):e21846
PPARγ regulates lipid metabolism and viability of sheep trophoblast cells.
Hao K, Liu X, Chen Y, Zeng W, Chen L, Wang J, Hu G
Reproduction in domestic animals = Zuchthygiene 2023 Nov;58(11):1559-1568
Reproduction in domestic animals = Zuchthygiene 2023 Nov;58(11):1559-1568
Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling.
Schuermans N, El Chehadeh S, Hemelsoet D, Gautheron J, Vantyghem MC, Nouioua S, Tazir M, Vigouroux C, Auclair M, Bogaert E, Dufour S, Okawa F, Hilbert P, Van Doninck N, Taquet MC, Rosseel T, De Clercq G, Debackere E, Van Haverbeke C, Cherif FR, Urtizberea JA, Chanson JB, Funalot B, Authier FJ, Kaya S, Terryn W, Callens S, Depypere B, Van Dorpe J, Program for Undiagnosed Diseases (UD-PrOZA), Poppe B, Impens F, Mizushima N, Depienne C, Jéru I, Dermaut B
Nature genetics 2023 Nov;55(11):1929-1940
Nature genetics 2023 Nov;55(11):1929-1940
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.
Ni S, Yi N, Yuan H, Li D, Chen X, Zhuang C
Phytotherapy research : PTR 2023 Nov;37(11):5394-5406
Phytotherapy research : PTR 2023 Nov;37(11):5394-5406
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Tang T, Xu Y, Wang L, Zhang P
Biotechnology journal 2023 Nov;18(11):e2300108
Biotechnology journal 2023 Nov;18(11):e2300108
Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
Hua B, Qiu J, Ye X, Kuang Y, Liu X
International immunopharmacology 2023 Nov;124(Pt B):111014
International immunopharmacology 2023 Nov;124(Pt B):111014
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Yan S, Ding J, Wang Z, Zhang F, Li J, Zhang Y, Wu S, Yang L, Pang X, Zhang Y, Yang J
International immunopharmacology 2023 Nov;124(Pt A):110840
International immunopharmacology 2023 Nov;124(Pt A):110840
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene.
Jiayao C, Jiaoling W, Chengyu H, Guixiang W, Linquan Z
Obesity research & clinical practice 2023 Nov-Dec;17(6):499-510
Obesity research & clinical practice 2023 Nov-Dec;17(6):499-510
Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
Tee JH, Vijayakumar U, Shanmugasundaram M, Lam TYW, Liao W, Yang Y, Wong WSF, Ge R
Respiratory research 2023 Nov 6;24(1):269
Respiratory research 2023 Nov 6;24(1):269
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization.
Hou C, Yan L, Sun K, Zhou T, Zou Y, Xiong W, Duan SZ
Cell death discovery 2023 Nov 29;9(1):429
Cell death discovery 2023 Nov 29;9(1):429
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation.
Liu Y, He T, Li Z, Sun Z, Wang S, Shen H, Hou L, Li S, Wei Y, Zhuo B, Li S, Zhou C, Guo H, Zhang R, Li B
iScience 2023 Nov 17;26(11):108312
iScience 2023 Nov 17;26(11):108312
Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Xiao-Yao-San in the Treatment of Inflammatory Response in CUMS Mice.
Zhang Y, Li XJ, Wang XR, Wang X, Li GH, Xue QY, Zhang MJ, Ao HQ
Pharmaceuticals (Basel, Switzerland) 2023 Nov 14;16(11)
Pharmaceuticals (Basel, Switzerland) 2023 Nov 14;16(11)
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Guo F, Xiong H, Tsao R, Shahidi F, Wen X, Liu J, Jiang L, Sun Y
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Chen B, Wu J, Hu S, Liu Q, Yang H, You Y
Neurochemical research 2023 May;48(5):1504-1515
Neurochemical research 2023 May;48(5):1504-1515
Impaired PPARγ activation by cadmium exacerbates infection-induced lung injury.
Larson-Casey JL, Liu S, Pyles JM, Lapi SE, Saleem K, Antony VB, Gonzalez ML, Crossman DK, Carter AB
JCI insight 2023 May 8;8(9)
JCI insight 2023 May 8;8(9)
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J
Life sciences 2023 May 15;321:121571
Life sciences 2023 May 15;321:121571
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Wang YN, Yu L, Wang T, Liu S
International journal of biological macromolecules 2023 May 1;236:123998
International journal of biological macromolecules 2023 May 1;236:123998
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Fructooligosaccharides attenuate non-alcoholic fatty liver disease by remodeling gut microbiota and association with lipid metabolism.
Huang X, Chen Q, Fan Y, Yang R, Gong G, Yan C, Song Y, Zhang B, Xi S, Huang Y, Xu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114300
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114300
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X, Liu D
Journal of neuroinflammation 2023 Mar 29;20(1):86
Journal of neuroinflammation 2023 Mar 29;20(1):86
A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.
Li Y, Li Z, Chen R, Lian M, Wang H, Wei Y, You Z, Zhang J, Li B, Li Y, Huang B, Chen Y, Liu Q, Lyu Z, Liang X, Miao Q, Xiao X, Wang Q, Fang J, Shi Y, Liu X, Seldin MF, Gershwin ME, Tang R, Ma X
Nature communications 2023 Mar 28;14(1):1732
Nature communications 2023 Mar 28;14(1):1732
An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.
Ruan GY, Ye LX, Lin JS, Lin HY, Yu LR, Wang CY, Mao XD, Zhang SH, Sun PM
Journal of translational medicine 2023 Mar 17;21(1):204
Journal of translational medicine 2023 Mar 17;21(1):204
Shared Genes of PPARG and NOS2 in Alzheimer's Disease and Ulcerative Colitis Drive Macrophages and Microglia Polarization: Evidence from Bioinformatics Analysis and Following Validation.
Dong L, Shen Y, Li H, Zhang R, Yu S, Wu Q
International journal of molecular sciences 2023 Mar 15;24(6)
International journal of molecular sciences 2023 Mar 15;24(6)
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Wang Z, Jian G, Chen T, Chen Y, Li J, Wang N
European journal of histochemistry : EJH 2023 Mar 1;67(1)
European journal of histochemistry : EJH 2023 Mar 1;67(1)
Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
Gao W, Zhang L, Wu J, Xu Y, Qi S, Liu W, Liu P, Shi S, Wang H, Zhang Q, Wang Y, Wang S
International journal of biological macromolecules 2023 Mar 1;230:123252
International journal of biological macromolecules 2023 Mar 1;230:123252
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Zhang P, Sun Y, Shi L, Sun D, Wang L, Feng D, Ding C
Tissue & cell 2023 Jun;82:102048
Tissue & cell 2023 Jun;82:102048
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
The role of PPARγ in intermittent hypoxia-related human umbilical vein endothelial cell injury.
Ning-Fang L, Yong-Xu J, Jia C, Cai-Yun W, Jie-Feng H, Qi-Chang L
Sleep & breathing = Schlaf & Atmung 2023 Jun;27(3):1155-1164
Sleep & breathing = Schlaf & Atmung 2023 Jun;27(3):1155-1164
5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.
Zong Y, Wang M, Liu Y, Suo X, Fan G, Yang X
Life sciences 2023 Jun 15;323:121703
Life sciences 2023 Jun 15;323:121703
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Cheng X, Han X, Zhou L, Sun Y, Zhou Q, Lin X, Gao Z, Wang J, Zhao W
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ.
Feng Z, Gao Z, Kong R, Zhuang T, Liu J, Liu T, Zheng X, Bai Y, Yao R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114815
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114815
PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.
Gou Q, Che S, Chen M, Chen H, Shi J, Hou Y
Cancer science 2023 Jul;114(7):2871-2881
Cancer science 2023 Jul;114(7):2871-2881
PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.
Jia X, Qian J, Chen H, Liu Q, Hussain S, Jin J, Shi J, Hou Y
European journal of pharmacology 2023 Jul 5;950:175749
European journal of pharmacology 2023 Jul 5;950:175749
Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway.
Guo F, Xiong H, Tsao R, Wen X, Liu J, Chen D, Jiang L, Sun Y
Food & function 2023 Jul 31;14(15):7195-7208
Food & function 2023 Jul 31;14(15):7195-7208
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
Shi M, Yang S, Huang X, Wang S, Li W, Yun J, Lu C, Yang Y, Cai C, Gao P, Guo X, Li B, Cao G
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.
Pan Z, Chen X, Wu D, Li X, Gao W, Li G, Du G, Zhang C, Jin S, Geng Z
International journal of molecular sciences 2023 Jan 7;24(2)
International journal of molecular sciences 2023 Jan 7;24(2)
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
Lin W, Shen P, Huang Y, Han L, Ba X, Huang Y, Yan J, Li T, Xu L, Qin K, Chen Z, Tu S
Journal of ethnopharmacology 2023 Jan 30;301:115802
Journal of ethnopharmacology 2023 Jan 30;301:115802
Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition.
Deng Y, Dong G, Meng Y, Noinaj N, Huang R
Journal of medicinal chemistry 2023 Jan 26;66(2):1601-1615
Journal of medicinal chemistry 2023 Jan 26;66(2):1601-1615
Millet Bran Protein Hydrolysate Displays the Anti-non-alcoholic Fatty Liver Disease Effect via Activating Peroxisome Proliferator-Activated Receptor γ to Restrain Fatty Acid Uptake.
Shan S, Zhou J, Yin R, Zhang L, Shi J, Qiao Q, Li Z
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1628-1642
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1628-1642
Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-γ.
Li R, Qin X, Yue L, Liu W, Gao Y, Zhu F, Wang D, Zhou Q
Heliyon 2023 Feb;9(2):e13630
Heliyon 2023 Feb;9(2):e13630
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.
Zhang Z, Zhu Z, Fu J, Liu X, Mi Z, Tao H, Fan H
International immunopharmacology 2023 Feb;115:109684
International immunopharmacology 2023 Feb;115:109684
circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep.
Zhao B, Zhang H, Zhao D, Liang Y, Qiao L, Liu J, Pan Y, Yang K, Liu W
International journal of molecular sciences 2023 Feb 9;24(4)
International journal of molecular sciences 2023 Feb 9;24(4)
Effects of the CDC10 (Septin 7) Gene on the Proliferation and Differentiation of Bovine Intramuscular Preadipocyte and 3T3-L1 Cells.
Cheng Z, Li X, Bao S, Yamada T, Cao G, Liu J, Chen A, Tong B
Animals : an open access journal from MDPI 2023 Feb 9;13(4)
Animals : an open access journal from MDPI 2023 Feb 9;13(4)
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
[A convenient and time-saving method for primary culture of mature white adipocytes from mice].
Shentu Z, Gong X, Yang H
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Feb 20;43(2):213-218
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Feb 20;43(2):213-218
Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia.
Xie X, Zhang W, Zhou X, Xu B, Wang H, Qiu Y, Hu Y, Guo B, Ye Z, Hu L, Zhang H, Li Y, Bai X
Oncogene 2023 Dec;42(50):3657-3669
Oncogene 2023 Dec;42(50):3657-3669
Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling.
Zhang M, Hou L, Tang W, Lei W, Lin H, Wang Y, Long H, Lin S, Chen Z, Wang G, Zhao G
Journal of cellular and molecular medicine 2023 Dec;27(24):4155-4170
Journal of cellular and molecular medicine 2023 Dec;27(24):4155-4170
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Chen Y, Li Q, Zhao S, Sun L, Yin Z, Wang X, Li X, Iwakiri Y, Han J, Duan Y
Biochemical pharmacology 2023 Dec;218:115928
Biochemical pharmacology 2023 Dec;218:115928
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.
Ren X, Guo Q, Jiang H, Han X, He X, Liu H, Xiu Z, Dong Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155106
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155106
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients.
Yan L, Jiang MY, Fan XS
Journal of ethnopharmacology 2023 Dec 5;317:116773
Journal of ethnopharmacology 2023 Dec 5;317:116773
Diethylaminoethyl-dextran and monocyte cell membrane coated 1,8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis.
Jiang F, Wu G, Yang H, Zhang Y, Shen X, Tao L
International journal of biological macromolecules 2023 Dec 31;253(Pt 7):127365
International journal of biological macromolecules 2023 Dec 31;253(Pt 7):127365
Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithelial Homeostasis and Ameliorates Colitis.
Jean Wilson E, Sirpu Natesh N, Ghadermazi P, Pothuraju R, Prajapati DR, Pandey S, Kaifi JT, Dodam JR, Bryan JN, Lorson CL, Watrelot AA, Foster JM, Mansell TJ, Joshua Chan SH, Batra SK, Subbiah J, Rachagani S
International journal of molecular sciences 2023 Dec 30;25(1)
International journal of molecular sciences 2023 Dec 30;25(1)
Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D.
Liao Y, Zhu Z, Liu Y, Wu J, Li D, Li Z, Xu J, Yang R, Wang L
Cell communication and signaling : CCS 2023 Dec 21;21(1):366
Cell communication and signaling : CCS 2023 Dec 21;21(1):366
An optimized protocol for chromatin immunoprecipitation from murine inguinal white adipose tissue.
Katsouda A, Valakos D, Vatsellas G, Thanos D, Papapetropoulos A
STAR protocols 2023 Dec 15;4(4):102594
STAR protocols 2023 Dec 15;4(4):102594
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
Deng X, Zhang N, Wang Q, Huang Y, Huang Y, Lin Y, Huang M, Zheng F, Xiao M, Ye J
European journal of nutrition 2023 Aug;62(5):2177-2194
European journal of nutrition 2023 Aug;62(5):2177-2194
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
Tang T, Wei Y, Jia H, Wang L, Xu Y, Zhang P
Biotechnology journal 2023 Aug;18(8):e2200634
Biotechnology journal 2023 Aug;18(8):e2200634
1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-γ/TXNIP pathways.
Liu Z, Gan S, Fu L, Xu Y, Wang S, Zhang G, Pan D, Tao L, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114978
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114978
MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets.
Han Z, Li L, Zhao H, Wang R, Yan F, Tao Z, Fan J, Zheng Y, Zhao F, Huang Y, Tian Y, Li G, Luo Y
Translational stroke research 2023 Aug;14(4):589-607
Translational stroke research 2023 Aug;14(4):589-607
PPARγ agonist inhibits c-Myc-mediated colorectal cancer tumor immune escape.
Xu L, Che S, Chen H, Liu Q, Shi J, Jin J, Hou Y
Journal of cellular biochemistry 2023 Aug;124(8):1145-1154
Journal of cellular biochemistry 2023 Aug;124(8):1145-1154
C1q(+) tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion.
Zhang S, Peng W, Wang H, Xiang X, Ye L, Wei X, Wang Z, Xue Q, Chen L, Su Y, Zhou Q
Journal for immunotherapy of cancer 2023 Aug;11(8)
Journal for immunotherapy of cancer 2023 Aug;11(8)
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Tian J, Zhang L, La X, Fan X, Li A, Wu C, An Y, Yan S, Dong X, Wu H, Li Z
Cellular signalling 2023 Aug;108:110719
Cellular signalling 2023 Aug;108:110719
Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway.
Li Y, Zhang ZH, Huang SL, Yue ZB, Yin XS, Feng ZQ, Zhang XG, Song GL
Journal of dairy science 2023 Aug;106(8):5253-5265
Journal of dairy science 2023 Aug;106(8):5253-5265
RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect.
Wu J, Wang X, Zhang M, Mathews P, Kang Y
Cells 2023 Aug 3;12(15)
Cells 2023 Aug 3;12(15)
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Jiang W, Chen Y, Sun M, Huang X, Zhang H, Fu Z, Wang J, Zhang S, Lian C, Tang B, Xiang D, Wang Y, Zhang Y, Jian C, Yang C, Zhang J, Zhang D, Chen T, Zhang J
Cell reports 2023 Aug 29;42(8):112969
Cell reports 2023 Aug 29;42(8):112969
Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.
Wu ZY, Luo L, Kan YQ, Qin ML, Li HT, He QZ, Zeng HC
Toxics 2023 Aug 26;11(9)
Toxics 2023 Aug 26;11(9)
PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis.
Xue X, Dai T, Chen J, Xu Y, Yang Z, Huang J, Xu W, Li S, Meng Q
Journal of orthopaedic surgery and research 2023 Aug 24;18(1):620
Journal of orthopaedic surgery and research 2023 Aug 24;18(1):620
Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis.
Jean Wilson E, Sirpu Natesh N, Ghadermazi P, Pothuraju R, Shanmugam M, Prajapati DR, Pandey S, Kaifi JT, Dodam JR, Bryan J, Lorson CL, Watrelot AA, Foster JM, Mansel TJ, Joshua Chan SH, Batra SK, Subbiah J, Rachagani S
bioRxiv : the preprint server for biology 2023 Aug 24;
bioRxiv : the preprint server for biology 2023 Aug 24;
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Lu P, Li X, Li B, Li X, Wang C, Liu Z, Ji Y, Wang X, Wen Z, Fan J, Yi C, Song M, Wang X
European journal of pharmacology 2023 Aug 15;953:175835
European journal of pharmacology 2023 Aug 15;953:175835
Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway.
Su Q, Huang J, Chen X, Wang Y, Shao M, Yan H, Chen C, Ren H, Zhang F, Ni Y, Jose PA, Zhong J, Yang J
Molecular nutrition & food research 2023 Apr;67(7):e2200589
Molecular nutrition & food research 2023 Apr;67(7):e2200589
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.
Liu F, Cao L, Hu S, Ye H, Wu Q, Wu L
Cellular immunology 2023 Apr;386:104704
Cellular immunology 2023 Apr;386:104704
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249
Physiological research 2023 Apr 30;72(2):235-249
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
He T, Wang S, Li S, Shen H, Hou L, Liu Y, Wei Y, Xie F, Zhang Z, Zhao Z, Mo C, Guo H, Huang Q, Zhang R, Shen D, Li B
iScience 2023 Apr 21;26(4):106289
iScience 2023 Apr 21;26(4):106289
Upregulated estrogen receptors impairs myogenesis and elevates adipogenesis related factor levels in the paravertebral muscles of patients with idiopathic scoliosis.
Shu Q, Yang G, Tang M, Guo C, Zhang H, Li J
Biochemical and biophysical research communications 2023 Apr 16;652:22-30
Biochemical and biophysical research communications 2023 Apr 16;652:22-30
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Shang K, Ma N, Che J, Li H, Hu J, Sun H, Cao B
BMC cancer 2023 Apr 11;23(1):335
BMC cancer 2023 Apr 11;23(1):335
Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet.
Zhang Y, Jia XB, Liu YC, Yu WQ, Si YH, Guo SD
Frontiers in nutrition 2022;9:971581
Frontiers in nutrition 2022;9:971581
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Cui L, Li Z, Xu F, Tian Y, Chen T, Li J, Guo Y, Lyu Q
Nutrition and cancer 2022;74(4):1399-1410
Nutrition and cancer 2022;74(4):1399-1410
Smilax china Polyphenols Stimulate Browning via [Formula: see text]3-Adrenergic Receptor/AMP-Activated Protein Kinase [Formula: see text] Signaling Pathway in 3T3-L1 Adipocytes.
Kong L, Xu M, Yang L, Liu S, Zheng G
The American journal of Chinese medicine 2022;50(5):1315-1329
The American journal of Chinese medicine 2022;50(5):1315-1329
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Yan R, Zhang Y, Yang Y, Liu L, Liu L, Guo Z, Yu H, Wang Y, Guo B
BioMed research international 2022;2022:9018379
BioMed research international 2022;2022:9018379
Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21.
Huang R, Zou C, Zhang C, Wang X, Zou X, Xiang Z, Wang Z, Gui B, Lin T, Hu H
Oxidative medicine and cellular longevity 2022;2022:7142314
Oxidative medicine and cellular longevity 2022;2022:7142314
Protective Effect of Shengmaiyin in Myocardial Hypertrophy-Induced Rats: A Genomic Analysis by 16S rDNA.
Ming S, Kan M, Liu L, Zhang Z, Liu X, Liu Y, Li Z, Zhang Y, Pang Q, Lin J, Li H, Yang Q, Sui X, Qu X, Li N
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3188292
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3188292
Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.
Wang M, Xiang Q, Sun W, Zhang H, Shi R, Guo J, Tong H, Fan M, Ding Y, Shi H, Yu P, Shen L, Wang Q, Chen X
Oxidative medicine and cellular longevity 2022;2022:2226168
Oxidative medicine and cellular longevity 2022;2022:2226168
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Fang Y, Dou R, Huang S, Han L, Fu H, Yang C, Song J, Zheng J, Zhang X, Liu K, Xiang Z, Zhang X, Wang S, Xiong B
International journal of biological sciences 2022;18(7):3082-3101
International journal of biological sciences 2022;18(7):3082-3101
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
Liu L, Fu Q, Li T, Shao K, Zhu X, Cong Y, Zhao X
PloS one 2022;17(2):e0262855
PloS one 2022;17(2):e0262855
Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's mouse model.
Weng H, Song W, Fu K, Guan Y, Cai G, Huang E, Chen X, Zou H, Ye Q
Frontiers in neuroscience 2022;16:1035444
Frontiers in neuroscience 2022;16:1035444
Effects of PPARD gene variants on the therapeutic responses to exenatide in chinese patients with type 2 diabetes mellitus.
Song J, Li N, Hu R, Yu Y, Xu K, Ling H, Lu Q, Yang T, Wang T, Yin X
Frontiers in endocrinology 2022;13:949990
Frontiers in endocrinology 2022;13:949990
Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.
Yang S, Cao S, Li C, Zhang J, Liu C, Qiu F, Kang N
Frontiers in pharmacology 2022;13:913378
Frontiers in pharmacology 2022;13:913378
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats.
Ge Y, Zhen F, Liu Z, Feng Z, Wang G, Zhang C, Wang X, Sun Y, Zheng X, Bai Y, Yao R
Frontiers in pharmacology 2022;13:766744
Frontiers in pharmacology 2022;13:766744
Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation.
Zhao B, Fu J, Ni H, Xu L, Xu C, He Q, Ni C, Wang Y, Kuang J, Tang M, Shou Q, Yao M
Frontiers in pharmacology 2022;13:1010483
Frontiers in pharmacology 2022;13:1010483
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex.
Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H, Li B
Theranostics 2022;12(18):7699-7716
Theranostics 2022;12(18):7699-7716
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Role and mechanism of the zinc finger protein ZNF580 in foam-cell formation.
Zhang Z, Qin X, Liu J, Li Y, Chen H, Xie H, Chen J, Li C, Tong Y, Yang M, Zhang M
Experimental and therapeutic medicine 2022 Sep;24(3):579
Experimental and therapeutic medicine 2022 Sep;24(3):579
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.
Gao Y, Ma K, Kang Y, Liu W, Liu X, Long X, Hayashi T, Hattori S, Mizuno K, Fujisaki H, Ikejima T
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Sep;1867(9):159181
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Sep;1867(9):159181
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Cheng J, Xu D, Chen L, Guo W, Hu G, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway.
Fang H, Wang H, Zeng C, Fu H, Zhao B, Liu A, Yan J
Toxicology in vitro : an international journal published in association with BIBRA 2022 Oct;84:105430
Toxicology in vitro : an international journal published in association with BIBRA 2022 Oct;84:105430
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo.
Zhou J, Wang J, Qu M, Huang X, Yin L, Liao Y, Huang F, Ning P, Zhong P, Zeng Y
Bioelectromagnetics 2022 Oct;43(7):438-447
Bioelectromagnetics 2022 Oct;43(7):438-447
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
He H, Liu M, He R, Zhao W
Food & function 2022 Oct 3;13(19):10265-10274
Food & function 2022 Oct 3;13(19):10265-10274
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
Zheng J, Duan Y, Zheng C, Yu J, Li F, Guo Q, Yin Y
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.
Magusto J, Beaupère C, Afonso MB, Auclair M, Delaunay JL, Soret PA, Courtois G, Aït-Slimane T, Housset C, Jéru I, Fève B, Ratziu V, Rodrigues CMP, Gautheron J
iScience 2022 Oct 21;25(10):105166
iScience 2022 Oct 21;25(10):105166
PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo.
Sha Y, Wu J, Paul B, Zhao Y, Mathews P, Li Z, Norris J, Wang E, McDonnell DP, Kang Y
Cancer letters 2022 Oct 1;545:215832
Cancer letters 2022 Oct 1;545:215832
The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Wang F, Guo L, Wu Z, Zhang T, Dong D, Wu B
The Journal of pharmacy and pharmacology 2022 Nov 4;74(11):1640-1650
The Journal of pharmacy and pharmacology 2022 Nov 4;74(11):1640-1650
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Hu J, Deng Y, Ding T, Dong J, Liang Y, Lou B
Acta biochimica et biophysica Sinica 2022 Nov 25;55(1):117-130
Acta biochimica et biophysica Sinica 2022 Nov 25;55(1):117-130
Rectal administration of butyrate ameliorates pulmonary fibrosis in mice through induction of hepatocyte growth factor in the colon via the HDAC-PPARγ pathway.
Zhang W, Zhang Q, Zhu Y, Zhang Y, Xia Y, Wei Z, Dai Y
Life sciences 2022 Nov 15;309:120972
Life sciences 2022 Nov 15;309:120972
Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats.
Otsuji J, Hayashi Y, Hitomi S, Soma C, Soma K, Shibuta I, Iwata K, Shirakawa T, Shinoda M
Scientific reports 2022 Nov 11;12(1):19314
Scientific reports 2022 Nov 11;12(1):19314
Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis.
Zou T, Ma L, Gu L, Xi S, Zhang K, Guo X
Chemico-biological interactions 2022 Nov 1;367:110145
Chemico-biological interactions 2022 Nov 1;367:110145
Serpina3c regulates adipose differentiation via the Wnt/β-catenin-PPARγ pathway.
Guo J, Qian L, Ji J, Ji Z, Jiang Y, Wu Y, Yang Z, Ma G, Yao Y
Cellular signalling 2022 May;93:110299
Cellular signalling 2022 May;93:110299
Acid-treated high-amylose corn starch suppresses high-fat diet-induced steatosis.
Yoshida R, Yano Y, Hoshi N, Okamoto N, Sui Y, Yamamoto A, Asaji N, Shiomi Y, Yasutomi E, Hatazawa Y, Hayashi H, Ueda Y, Kodama Y
Journal of food science 2022 May;87(5):2173-2184
Journal of food science 2022 May;87(5):2173-2184
PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.
Ye X, Wu Y, Xu J, Liu H, Wang H, Li Q, Li Q, Xuan A
Pharmacological research 2022 May;179:106235
Pharmacological research 2022 May;179:106235
Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Shi JH, Yang DJ, Jin Q, Cheng N, Shi YB, Bai Y, Yu DS, Guo WZ, Ge GB, Zhang SJ
Scientific reports 2022 May 6;12(1):7446
Scientific reports 2022 May 6;12(1):7446
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.
Qi W, Li X, Ren Y, Liu X, Fu H, Wang X, Li X, Xiong J, Zheng Q, Cai D, Liang F
Chinese medicine 2022 May 17;17(1):57
Chinese medicine 2022 May 17;17(1):57
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.
Xiong L, Huang J, Wang S, Yuan Q, Yang D, Zheng Z, Wu Y, Wu C, Gao Y, Zou L, Hu G
Archives of toxicology 2022 Mar;96(3):767-781
Archives of toxicology 2022 Mar;96(3):767-781
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.
Zhang M, Yang P, Yu T, Harmsen MC, Gao M, Liu D, Shi Y, Liu Y, Zhang X
Heliyon 2022 Mar;8(3):e09128
Heliyon 2022 Mar;8(3):e09128
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Huang H, Chen J, Hu X, Chen Y, Xie J, Ao T, Wang H, Xie J, Yu Q
Food & function 2022 Mar 7;13(5):2710-2728
Food & function 2022 Mar 7;13(5):2710-2728
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I
BMC medicine 2022 Mar 28;20(1):95
BMC medicine 2022 Mar 28;20(1):95
CRISPR/Cas9-Mediated Knockout of miR-130b Affects Mono- and Polyunsaturated Fatty Acid Content via PPARG-PGC1α Axis in Goat Mammary Epithelial Cells.
Huang L, Luo J, Song N, Gao W, Zhu L, Yao W
International journal of molecular sciences 2022 Mar 26;23(7)
International journal of molecular sciences 2022 Mar 26;23(7)
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
Chen L, You Q, Liu M, Li S, Wu Z, Hu J, Ma Y, Xia L, Zhou Y, Xu N, Zhang S
eLife 2022 Mar 24;11
eLife 2022 Mar 24;11
MicroRNA 573 Rescues Endothelial Dysfunction during Dengue Virus Infection under PPARγ Regulation.
Banerjee S, Xin CW, Chu JJH
Journal of virology 2022 Mar 23;96(6):e0199621
Journal of virology 2022 Mar 23;96(6):e0199621
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Wang Q, Wang L, Abdullah, Tian W, Song M, Cao Y, Xiao J
Food & function 2022 Mar 21;13(6):3419-3430
Food & function 2022 Mar 21;13(6):3419-3430
Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.
Wang Z, Chen X, Liu J, Wang Y, Zhang S
Autoimmunity 2022 Jun;55(4):223-232
Autoimmunity 2022 Jun;55(4):223-232
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression.
Chen M, Zhu H, Zhu Q, Wu X, Zhou Y, Gao R, Shi M, Zhang T, Yin T, Zhang H, Shang H, Li X
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):661-673
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):661-673
Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco.
Zhuo MQ, Chen J, Wu ML, Wang WB
Fish physiology and biochemistry 2022 Jun;48(3):571-583
Fish physiology and biochemistry 2022 Jun;48(3):571-583
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
Wang Y, Zhang J, Chu X, Wang M, Xin Y, Liu S
Lipids in health and disease 2022 Jun 15;21(1):54
Lipids in health and disease 2022 Jun 15;21(1):54
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation.
Ouyang Z, Kang D, Li K, Liang G, Liu Z, Mai Q, Chen Q, Yao C, Wei R, Tan X, Bai X, Huang B, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113164
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113164
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway.
Duan P, Wang H, Yi X, Zhang H, Chen H, Pan Z
Stem cell research & therapy 2022 Jul 26;13(1):342
Stem cell research & therapy 2022 Jul 26;13(1):342
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
Zhang J, Yan E, Zhang L, Wang T, Wang C
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth.
Liu J, Zhao H, Yang L, Wang X, Yang L, Xing Y, Lv X, Ma H, Song G
BMC endocrine disorders 2022 Jan 4;22(1):10
BMC endocrine disorders 2022 Jan 4;22(1):10
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Zhang X, Jiang L, Chen H, Wei S, Yao K, Sun X, Yang G, Jiang L, Zhang C, Wang N, Wang Y, Liu X
Toxicology 2022 Jan 15;465:153048
Toxicology 2022 Jan 15;465:153048
Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
Wu J, Lin T, Gao Y, Li X, Yang C, Zhang K, Wang C, Zhou X
Molecular and cellular endocrinology 2022 Jan 1;539:111490
Molecular and cellular endocrinology 2022 Jan 1;539:111490
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
Qi Y, Zhang H, Fan H, Wang X, Zhao A, Tian Y, Yang G, Li C, Wei J, Yao W, Hao C
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells.
Kobari L, Auclair M, Piau O, Ferrand N, Zaoui M, Delhommeau F, Fève B, Sabbah M, Garderet L
Leukemia 2022 Feb;36(2):540-548
Leukemia 2022 Feb;36(2):540-548
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Gao Z, Zhang C, Feng Z, Liu Z, Yang Y, Yang K, Chen L, Yao R
Experimental neurology 2022 Feb;348:113947
Experimental neurology 2022 Feb;348:113947
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease.
Li J, Chen L, Qin Q, Wang D, Zhao J, Gao H, Yuan X, Zhang J, Zou Y, Mao Z, Xiong Y, Min Z, Yan M, Wang CY, Xue Z
Neurobiology of disease 2022 Feb;163:105605
Neurobiology of disease 2022 Feb;163:105605
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Tan Z, Ren H, Liu Y, Yang H, Luo Q, Deng X
Experimental and therapeutic medicine 2022 Dec;24(6):737
Experimental and therapeutic medicine 2022 Dec;24(6):737
Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice.
Wang Y, Liu T, Xie Y, Li N, Liu Y, Wen J, Zhang M, Feng W, Huang J, Guo Y, Kabbas Junior T, Wang D, Granato D
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112008
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112008
Myoblast-derived exosomes promote the repair and regeneration of injured skeletal muscle in mice.
Ji S, Ma P, Cao X, Wang J, Yu X, Luo X, Lu J, Hou W, Zhang Z, Yan Y, Dong Y, Wang H
FEBS open bio 2022 Dec;12(12):2213-2226
FEBS open bio 2022 Dec;12(12):2213-2226
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.
Zhang L, Zhang H, Gu J, Xu W, Yuan N, Sun J, Li H
International immunopharmacology 2022 Dec;113(Pt B):109433
International immunopharmacology 2022 Dec;113(Pt B):109433
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Tan X, Zhu T, Zhang L, Fu L, Hu Y, Li H, Li C, Zhang J, Liang B, Liu J
Adipocyte 2022 Dec;11(1):120-132
Adipocyte 2022 Dec;11(1):120-132
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Li H, Huang Z, Zeng F
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Angiogenesis-Browning Interplay Mediated by Asprosin-Knockout Contributes to Weight Loss in Mice with Obesity.
Yin T, Chen S, Zeng G, Yuan W, Lu Y, Zhang Y, Huang Q, Xiong X, Xu B, Huang Q
International journal of molecular sciences 2022 Dec 18;23(24)
International journal of molecular sciences 2022 Dec 18;23(24)
Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation.
He H, Chen C, Zhao W
International journal of biological macromolecules 2022 Dec 1;222(Pt B):3057-3065
International journal of biological macromolecules 2022 Dec 1;222(Pt B):3057-3065
PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT.
Zhang Q, Feng W, Wang Q, Wang J, Chai L, Chen Y, Wang Y, Liu J, Li M, Xie X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113233
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113233
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.
Chen PW, Tseng SY, Chang HY, Lee CH, Chao TH
International journal of molecular sciences 2022 Aug 29;23(17)
International journal of molecular sciences 2022 Aug 29;23(17)
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice.
Pei Z, Ma L, Li Y, Yang J, Yang Q, Yao W, Li S
Frontiers in bioscience (Landmark edition) 2022 Aug 15;27(8):244
Frontiers in bioscience (Landmark edition) 2022 Aug 15;27(8):244
Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.
Xie P, Guo M, Xie JB, Xiao MY, Qi YS, Duan Y, Li FF, Piao XL
Journal of ethnopharmacology 2022 Aug 10;294:115335
Journal of ethnopharmacology 2022 Aug 10;294:115335
Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice.
Xiao Z, Shen D, Lan T, Wei C, Wu W, Sun Q, Luo Z, Chen W, Zhang Y, Hu L, Zhang C, Wang Y, Lu Y, Wang P, Yang F, Li Q
Redox biology 2022 Apr;50:102256
Redox biology 2022 Apr;50:102256
Inhibition of DNA methylation de-represses peroxisome proliferator-activated receptor-γ and attenuates pulmonary fibrosis.
Wei A, Gao Q, Chen F, Zhu X, Chen X, Zhang L, Su X, Dai J, Shi Y, Cao W
British journal of pharmacology 2022 Apr;179(7):1304-1318
British journal of pharmacology 2022 Apr;179(7):1304-1318
The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα.
Miao Y, Zhang C, Yang L, Zeng X, Hu Y, Xue X, Dai Y, Wei Z
Cell communication and signaling : CCS 2022 Apr 7;20(1):48
Cell communication and signaling : CCS 2022 Apr 7;20(1):48
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y
Food & function 2022 Apr 20;13(8):4399-4420
Food & function 2022 Apr 20;13(8):4399-4420
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome.
Bryant C, Rask G, Waller AP, Webb A, Galdino-Pitta MR, Amato AA, Cianciolo R, Govindarajan R, Becknell B, Kerlin BA, Neves FAR, Fornoni A, Agrawal S
iScience 2022 Apr 15;25(4):104001
iScience 2022 Apr 15;25(4):104001
Gold nanoclusters eliminate obesity induced by antipsychotics.
He M, Yao J, Zhang Z, Zhang Y, Chen R, Gu Z, Huang X, Deng C, Zhou R, Fan J, Zhang B, Xie Y, Gao G, Sun T
Scientific reports 2022 Apr 1;12(1):5502
Scientific reports 2022 Apr 1;12(1):5502
PPARγ/SOD2 Protects Against Mitochondrial ROS-Dependent Apoptosis via Inhibiting ATG4D-Mediated Mitophagy to Promote Pancreatic Cancer Proliferation.
Nie S, Shi Z, Shi M, Li H, Qian X, Peng C, Ding X, Zhang S, Lv Y, Wang L, Kong B, Zou X, Shen S
Frontiers in cell and developmental biology 2021;9:745554
Frontiers in cell and developmental biology 2021;9:745554
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
Li W, Wang S, Zhang H, Li B, Xu L, Li Y, Kong C, Jiao H, Wang Y, Pang Y, Qin W, Jia L, Jia J
Journal of Alzheimer's disease : JAD 2021;82(4):1475-1485
Journal of Alzheimer's disease : JAD 2021;82(4):1475-1485
The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.
Huang L, Zhang J, Zhu X, Mi X, Li Q, Gao J, Zhou J, Zhou J, Liu XM
Frontiers in nutrition 2021;8:756803
Frontiers in nutrition 2021;8:756803
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
Wu J, Lai G, Chen F, Zhang B, Zhao Y
Kidney & blood pressure research 2021;46(5):601-612
Kidney & blood pressure research 2021;46(5):601-612
Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α.
Zhou Y, Yin T, Shi M, Chen M, Wu X, Wang K, Cheang I, Li Y, Shang H, Zhang H, Li X
PPAR research 2021;2021:9947656
PPAR research 2021;2021:9947656
Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons.
Fu J, Zhao B, Ni C, Ni H, Xu L, He Q, Xu M, Xu C, Luo G, Zhu J, Tao J, Yao M
PPAR research 2021;2021:6086265
PPAR research 2021;2021:6086265
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Ma J, Zeng P, Liu L, Zhu M, Zheng J, Wang C, Zhao X, Hu W, Yang X, Duan Y, Han J, Miao QR, Chen Y
Frontiers in pharmacology 2021;12:817784
Frontiers in pharmacology 2021;12:817784
Identification of miRNA in Sheep Intramuscular Fat and the Role of miR-193a-5p in Proliferation and Differentiation of 3T3-L1.
Han F, Zhou L, Zhao L, Wang L, Liu L, Li H, Qiu J, He J, Liu N
Frontiers in genetics 2021;12:633295
Frontiers in genetics 2021;12:633295
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Lin L, Chen S, Wang H, Gao B, Kallakury B, Bhuvaneshwar K, Cahn K, Gusev Y, Wang X, Wu Y, Marshall JL, Zhi X, He AR
Theranostics 2021;11(9):4232-4250
Theranostics 2021;11(9):4232-4250
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.
Jiang MJ, Li L, Huang WF, Su J, Li YH, Qu XS, Fan LL
Journal of natural medicines 2021 Sep;75(4):884-892
Journal of natural medicines 2021 Sep;75(4):884-892
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Okubo K, Miyai K, Kato K, Asano T, Sato A
Translational oncology 2021 Sep;14(9):101154
Translational oncology 2021 Sep;14(9):101154
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP
Cell death discovery 2021 Sep 27;7(1):265
Cell death discovery 2021 Sep 27;7(1):265
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Chen L, Yin Y, Liu G
Annals of translational medicine 2021 Oct;9(20):1547
Annals of translational medicine 2021 Oct;9(20):1547
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML
Redox biology 2021 Oct;46:102038
Redox biology 2021 Oct;46:102038
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
Su H, Liu N, Zhang Y, Kong J
Journal of advanced research 2021 Nov;33:69-80
Journal of advanced research 2021 Nov;33:69-80
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z
Nature communications 2021 Nov 2;12(1):6314
Nature communications 2021 Nov 2;12(1):6314
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
mTOR regulates PRMT1 expression and mitochondrial mass through STAT1 phosphorylation in hepatic cell.
Zhang X, Li L, Li Y, Li Z, Zhai W, Sun Q, Yang X, Roth M, Lu S
Biochimica et biophysica acta. Molecular cell research 2021 May;1868(6):119017
Biochimica et biophysica acta. Molecular cell research 2021 May;1868(6):119017
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.
Chen Y, Wu R, Chen W, Liu Y, Liao X, Zeng B, Guo G, Lou F, Xiang Y, Wang Y, Wang X
EMBO reports 2021 May 5;22(5):e52146
EMBO reports 2021 May 5;22(5):e52146
A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.
Guo Y, Zhu X, Zeng M, Qi L, Tang X, Wang D, Zhang M, Xie Y, Li H, Yang X, Chen D
Translational psychiatry 2021 May 27;11(1):328
Translational psychiatry 2021 May 27;11(1):328
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Asila A, Yang X, Kaisaer Y, Ma L
The journal of gene medicine 2021 Mar;23(3):e3296
The journal of gene medicine 2021 Mar;23(3):e3296
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Xiong L, Huang J, Gao Y, Gao Y, Wu C, He S, Zou L, Yang D, Han Y, Yuan Q, Zheng Z, Hu G
Toxicology research 2021 Mar;10(2):277-283
Toxicology research 2021 Mar;10(2):277-283
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Li YL, Li YQ, Zeng FQ, Lin XY, Li XT, Ren XQ, Yang DL
The Journal of pharmacy and pharmacology 2021 Mar 4;73(2):145-151
The Journal of pharmacy and pharmacology 2021 Mar 4;73(2):145-151
Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models.
Wang Y, Guo S, Jia Y, Yu X, Mou R, Li X
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):786-797
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):786-797
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model.
Zhao D, Pan Y, Yu N, Bai Y, Ma R, Mo F, Zuo J, Chen B, Jia Q, Zhang D, Liu J, Jiang G, Gao S
Royal Society open science 2021 Mar 17;8(3):200974
Royal Society open science 2021 Mar 17;8(3):200974
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Chen Y, Dai Y, Song K, Huang Y, Zhang L, Zhang C, Yan Q, Gao H
Cell death & disease 2021 Jun 3;12(6):572
Cell death & disease 2021 Jun 3;12(6):572
Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-κB and in a PPARγ-dependent manner.
Zhou JP, Yang XN, Song Y, Zhou F, Liu JJ, Hu YQ, Chen LG
Experimental and therapeutic medicine 2021 Jul;22(1):743
Experimental and therapeutic medicine 2021 Jul;22(1):743
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Zheng S, Huang H, Li Y, Wang Y, Zheng Y, Liang J, Zhang S, Liu M, Fang Z
Pharmacological research 2021 Jul;169:105639
Pharmacological research 2021 Jul;169:105639
Effects of energy supplements on the differentiation of skeletal muscle satellite cells.
Su R, Wang B, Zhang M, Luo Y, Wang D, Zhao L, Su L, Duan Y, Faucitano L, Jin Y
Food science & nutrition 2021 Jan;9(1):357-366
Food science & nutrition 2021 Jan;9(1):357-366
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.
Zhou L, Wang S, Cao L, Ren X, Li Y, Shao J, Xu L
International journal of environmental health research 2021 Jan;31(1):34-44
International journal of environmental health research 2021 Jan;31(1):34-44
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.
Chen R, Wang K, Feng Z, Zhang MY, Wu J, Geng JJ, Chen ZN
Cellular & molecular immunology 2021 Jan;18(1):171-181
Cellular & molecular immunology 2021 Jan;18(1):171-181
Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.
Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD
Cells 2021 Jan 20;10(2)
Cells 2021 Jan 20;10(2)
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring.
Lin XH, Gao L, Tian S, Klausen C, Guo MX, Gao Q, Liu ME, Wang H, Wu DD, Zhou CL, Yang J, Meng Y, Liu Y, Xu GF, Tan YJ, Ullah K, Zhu YM, Fraser WD, Sheng JZ, Leung PCK, Muglia LJ, Wu YT, Huang HF
Scientific reports 2021 Jan 11;11(1):316
Scientific reports 2021 Jan 11;11(1):316
Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.
Wang X, Song T, Sun Y, Men L, Gu Y, Zhang S, Chen X
Journal of proteome research 2021 Jan 1;20(1):960-971
Journal of proteome research 2021 Jan 1;20(1):960-971
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway.
Wang XQ, Tang YH, Zeng GR, Wu LF, Zhou YJ, Cheng ZN, Jiang DJ
Psychopharmacology 2021 Feb;238(2):501-516
Psychopharmacology 2021 Feb;238(2):501-516
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Wang W, Xu RL, He P, Chen R
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis.
Huang Y, Yang Q, Mi X, Qiu L, Tao X, Zhang Z, Xia J, Wu Q, Wei H
Journal of agricultural and food chemistry 2021 Feb 24;69(7):2190-2203
Journal of agricultural and food chemistry 2021 Feb 24;69(7):2190-2203
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.
Zhou Y, Wang C, Kou J, Wang M, Rong X, Pu X, Xie X, Han G, Pang X
Pharmaceutical biology 2021 Dec;59(1):1378-1387
Pharmaceutical biology 2021 Dec;59(1):1378-1387
Bergenin alleviates H(2) O(2) -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway.
Zhang G, Wang H, Zhang Q, Zhao Z, Zhu W, Zuo X
Environmental toxicology 2021 Dec;36(12):2541-2550
Environmental toxicology 2021 Dec;36(12):2541-2550
Decreased expression of PPARγ is associated with aortic endothelial cell apoptosis in intermittently hypoxic rats.
Lian N, Chen M, Zhang S, Chen L, Huang J, Lin Q
Sleep & breathing = Schlaf & Atmung 2021 Dec;25(4):2241-2250
Sleep & breathing = Schlaf & Atmung 2021 Dec;25(4):2241-2250
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
Zhao L, Luo R, Yu H, Li S, Yu Q, Wang W, Cai K, Xu T, Chen R, Tian W
Iranian journal of basic medical sciences 2021 Dec;24(12):1734-1742
Iranian journal of basic medical sciences 2021 Dec;24(12):1734-1742
IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
Hsu YH, Wu CH, Chiu CJ, Chen WT, Chang YC, Wabitsch M, Chang MS
Immunology 2021 Dec;164(4):817-833
Immunology 2021 Dec;164(4):817-833
Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet.
Kai Y, Gao J, Liu H, Wang Y, Tian C, Guo S, He L, Li M, Tian Z, Song X
International immunopharmacology 2021 Dec;101(Pt A):108209
International immunopharmacology 2021 Dec;101(Pt A):108209
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
Ding RR, Huang GY, Zhang YJ, Sun HL, Liu YM, Xu Z, Li WJ, Li X
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Liu H, Wang M, Jin Z, Sun D, Zhu T, Liu X, Tan X, Shi G
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.
Mou Q, Ji B, Zhao G, Liu Y, Sakurai R, Xie Y, Zhang Q, Dai J, Lu Y, Ge Y, Shi T, Xu S, Rehan VK
Pediatric pulmonology 2021 Aug;56(8):2537-2545
Pediatric pulmonology 2021 Aug;56(8):2537-2545
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway.
Liu J, Zhang Y, Yu C, Zhang P, Gu S, Wang G, Xiao H, Li S
Drug development research 2021 Apr;82(2):278-286
Drug development research 2021 Apr;82(2):278-286
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.
Li Z, Zheng M, Mo J, Li K, Yang X, Guo L, Zhang X, Abdalla BA, Nie Q
Journal of pineal research 2021 Apr;70(3):e12725
Journal of pineal research 2021 Apr;70(3):e12725
A small nucleolar RNA, SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway.
He Y, Wu Y, Mei B, Fang X, Cai G, Cai N, Wu Q, Huang Z, Ge C, Liang H, Zhang B, Chen X, Chu L
Journal of cellular physiology 2021 Apr;236(4):3001-3014
Journal of cellular physiology 2021 Apr;236(4):3001-3014
Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.
Chen R, Huang S, Lin T, Ma H, Shan W, Duan F, Lv J, Zhang J, Ren L, Nie L
Nature nanotechnology 2021 Apr;16(4):455-465
Nature nanotechnology 2021 Apr;16(4):455-465
Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.
Lou HX, Fu WC, Chen JX, Li TT, Jiang YY, Liu CH, Zhang W
BMC complementary medicine and therapies 2021 Apr 22;21(1):128
BMC complementary medicine and therapies 2021 Apr 22;21(1):128
Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia.
Nguyen TD, Miyatake Y, Yoshida T, Kawahara H, Hanayama R
International journal of cancer 2021 Apr 15;148(8):1982-1992
International journal of cancer 2021 Apr 15;148(8):1982-1992
ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression.
Cheng WL, Zhang Q, Cao JL, Chen XL, Li W, Zhang L, Chao SP, Zhao F
Journal of atherosclerosis and thrombosis 2021 Apr 1;28(4):375-384
Journal of atherosclerosis and thrombosis 2021 Apr 1;28(4):375-384
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.
Lu R, Zheng Z, Yin Y, Jiang Z
Food & nutrition research 2020;64
Food & nutrition research 2020;64
Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPARγ and LPL Gene in a High-Fat Diet C57BL/6 Mice Model.
Zhang M, Shao Y, Gao B, Chen J, Zhang P, Hu Y, Ding S
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9102475
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9102475
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway.
Yang H, Gan S, Jiang Z, Song X, Chen T, Xu Y, Fu L, Zhang Y, Tao L, Shen X
Chinese medicine 2020;15:4
Chinese medicine 2020;15:4
Alveolar Epithelial Cells Promote IGF-1 Production by Alveolar Macrophages Through TGF-β to Suppress Endogenous Inflammatory Signals.
Mu M, Gao P, Yang Q, He J, Wu F, Han X, Guo S, Qian Z, Song C
Frontiers in immunology 2020;11:1585
Frontiers in immunology 2020;11:1585
Sevoflurane Protects against Intestinal Ischemia-Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-κB Pathway in Rats.
Liu C, Ding R, Huang W, Miao L, Li J, Li Y
Pharmacology 2020;105(3-4):231-242
Pharmacology 2020;105(3-4):231-242
Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma.
Ni G, Wang K, Zhou Y, Wu X, Wang J, Shang H, Wang L, Li X
Annals of translational medicine 2020 Sep;8(17):1064
Annals of translational medicine 2020 Sep;8(17):1064
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Li DY, Tian YK, Ye DW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.
Gelfand CA, Sakurai R, Wang Y, Liu Y, Segal R, Rehan VK
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Kim TW, Hong DW, Kang CM, Hong SH
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Tissue Inhibitor of Metalloprotease-1 (TIMP-1) Regulates Adipogenesis of Adipose-derived Stem Cells (ASCs) via the Wnt Signaling Pathway in an MMP-independent Manner.
Wang L, Zhang CG, Jia YL, Hu L
Current medical science 2020 Oct;40(5):989-996
Current medical science 2020 Oct;40(5):989-996
The total flavonoids from Selaginella tamariscina (beauv.) Spring improve glucose and lipid metabolism in db/db mice.
Wang X, Feng A, Yuan P, Fu Y, Bai Z, Zhou N, Zheng X
Iranian journal of basic medical sciences 2020 Oct;23(10):1286-1292
Iranian journal of basic medical sciences 2020 Oct;23(10):1286-1292
3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells.
Lu J, Lu J, Chen Y, Feng Z, Liu S, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111575
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111575
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Yang T, Chen J, Gao L, Huang Y, Liao G, Cao Y
Toxicology letters 2020 Oct 10;332:65-73
Toxicology letters 2020 Oct 10;332:65-73
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866
Drug development research 2020 Nov;81(7):859-866
Citri Reticulatae Pericarpium protects against isoproterenol-induced chronic heart failure via activation of PPARγ.
Cheng H, Wu X, Ni G, Wang S, Peng W, Zhang H, Gao J, Li X
Annals of translational medicine 2020 Nov;8(21):1396
Annals of translational medicine 2020 Nov;8(21):1396
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Ye L, Chen T, Cao J, Sun L, Li W, Zhang C
International journal of oncology 2020 Nov;57(5):1116-1128
International journal of oncology 2020 Nov;57(5):1116-1128
Unconservative_15_2570409 suppresses progesterone receptor expression in the granulosa cells of Hu sheep.
Yao X, Wang Z, Gao X, Li X, Yang H, Ei-Samahy MA, Bao Y, Xiao S, Meng F, Wang F
Theriogenology 2020 Nov;157:303-313
Theriogenology 2020 Nov;157:303-313
TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.
Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, Wang X, Chen Y, Li L, Zhang Z, Duan Y, Han J, Yang X
The Journal of biological chemistry 2020 Nov 27;295(48):16314-16327
The Journal of biological chemistry 2020 Nov 27;295(48):16314-16327
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Chen Y, Yan Q, Lv M, Song K, Dai Y, Huang Y, Zhang L, Zhang C, Gao H
Cell death & disease 2020 Nov 20;11(11):994
Cell death & disease 2020 Nov 20;11(11):994
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.
Lei XX, Liu Y, Wang JX, Cai Q, Yan M, He HP, Liu Q, Long ZJ, Guan Z
Cell death & disease 2020 May 7;11(5):331
Cell death & disease 2020 May 7;11(5):331
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Wei L, Zhao C, Dong S, Yao S, Ji B, Zhao B, Liu Z, Liu X, Wang Y
Food & function 2020 May 1;11(5):3952-3963
Food & function 2020 May 1;11(5):3952-3963
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ(12,14) -PGJ(2) and Nogo.
Zhang S, Yu M, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao QR, Hu W, Hajjar DP, Zhu Y, Han J, Duan Y
British journal of pharmacology 2020 Mar;177(5):1041-1060
British journal of pharmacology 2020 Mar;177(5):1041-1060
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Xu L, Xia H, Ni D, Hu Y, Liu J, Qin Y, Zhou Q, Yi Q, Xie Y
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function.
Shen Y, Su Y, Silva FJ, Weller AH, Sostre-Colón J, Titchenell PM, Steger DJ, Seale P, Soccio RE
Cell reports 2020 Mar 3;30(9):3079-3091.e5
Cell reports 2020 Mar 3;30(9):3079-3091.e5
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in health and disease 2020 Mar 13;19(1):39
Lipids in health and disease 2020 Mar 13;19(1):39
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Zhou RJ, Zhao Y, Fan K, Xie ML
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 23;117(25):14280-14291
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 23;117(25):14280-14291
The opposite functions of miR-24 in the osteogenesis and adipogenesis of adipose-derived mesenchymal stem cells are mediated by the HOXB7/β-catenin complex.
Liu Z, Deng Y, Li T, Zhu F, Zhou X, He Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9034-9050
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9034-9050
m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Shi H, Wang F, Wang Y
Autophagy 2020 Jul;16(7):1221-1235
Autophagy 2020 Jul;16(7):1221-1235
Tributyltin reduces bone mineral density by reprograming bone marrow mesenchymal stem cells in rat.
Yao W, Wei X, Guo H, Cheng D, Li H, Sun L, Wang S, Guo D, Yang Y, Si J
Environmental toxicology and pharmacology 2020 Jan;73:103271
Environmental toxicology and pharmacology 2020 Jan;73:103271
Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma.
Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y, Chen Y
Cellular signalling 2020 Jan;65:109429
Cellular signalling 2020 Jan;65:109429
PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis.
Jiang YP, Tang YL, Wang SS, Wu JS, Zhang M, Pang X, Wu JB, Chen Y, Tang YJ, Liang XH
Cell proliferation 2020 Jan;53(1):e12705
Cell proliferation 2020 Jan;53(1):e12705
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, Yao W, Tao J, Tu M, Xiong B, Zhao L, Liu Z
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway.
Wu H, Zhu H, Zhuang Y, Zhang J, Ding X, Zhan L, Luo S, Zhang Q, Sun F, Zhang M, Pan Z, Lu Y
Journal of cellular and molecular medicine 2020 Jan;24(1):737-746
Journal of cellular and molecular medicine 2020 Jan;24(1):737-746
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Ma M, Wang C, Ao Y, He N, Hao F, Liang H, Liu D
Molecular and cellular probes 2020 Feb;49:101491
Molecular and cellular probes 2020 Feb;49:101491
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hang H, Wang LK, Ren SY, Song AJ, Wu GF
Current medical science 2020 Feb;40(1):55-62
Current medical science 2020 Feb;40(1):55-62
Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.
Ling Y, Shi Z, Yang X, Cai Z, Wang L, Wu X, Ye A, Jiang J
Experimental gerontology 2020 Feb;130:110786
Experimental gerontology 2020 Feb;130:110786
Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.
Ling SC, Zhuo MQ, Zhang DG, Cui HY, Luo Z
International journal of molecular sciences 2020 Feb 27;21(5)
International journal of molecular sciences 2020 Feb 27;21(5)
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Guo J, Ren R, Yao X, Ye Y, Sun K, Lin J, Wang G, Guo F, Xiao J, Xu T
Aging 2020 Feb 25;12(4):3976-3992
Aging 2020 Feb 25;12(4):3976-3992
Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway.
Duan L, Ma Y, Wang Y, Liu J, Tan Z, Wu Q, Wu Y, Yu X
International journal of molecular medicine 2020 Dec;46(6):2260-2270
International journal of molecular medicine 2020 Dec;46(6):2260-2270
CB11, a novel purine-based PPARɣ ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells.
Kim TW, Hong DW, Park JW, Hong SH
British journal of cancer 2020 Dec;123(12):1737-1748
British journal of cancer 2020 Dec;123(12):1737-1748
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.
Su ZL, Hang PZ, Hu J, Zheng YY, Sun HQ, Guo J, Liu KY, Du ZM
Acta pharmacologica Sinica 2020 Aug;41(8):1085-1092
Acta pharmacologica Sinica 2020 Aug;41(8):1085-1092
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Luo Y, Peng J, Huang C, Cao Y
Ecotoxicology and environmental safety 2020 Aug;199:110714
Ecotoxicology and environmental safety 2020 Aug;199:110714
Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ(1).
Cui L, Xu F, Wu K, Li L, Qiao T, Li Z, Chen T, Sun C
European journal of pharmacology 2020 Aug 15;881:173230
European journal of pharmacology 2020 Aug 15;881:173230
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Zhang H, Zhao F, Peng A, Guo S, Wang M, Elsabagh M, Loor JJ, Wang H
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Huang Y, Wang C, Tian X, Mao Y, Hou B, Sun Y, Gu X, Ma Z
Inflammation 2020 Apr;43(2):568-578
Inflammation 2020 Apr;43(2):568-578
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
Ji X, Liu T, Zhao S, Li J, Li L, Wang E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
IL-29 promoted obesity-induced inflammation and insulin resistance.
Lin TY, Chiu CJ, Kuan CH, Chen FH, Shen YC, Wu CH, Hsu YH
Cellular & molecular immunology 2020 Apr;17(4):369-379
Cellular & molecular immunology 2020 Apr;17(4):369-379
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Zhu Y, Yu F, Tan Y, Hong Y, Meng T, Liu Y, Dai S, Qiu G, Yuan H, Hu F
Theranostics 2019;9(23):6764-6779
Theranostics 2019;9(23):6764-6779
Effect of MicroRNA-20a on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells.
Luo T, Yang X, Sun Y, Huang X, Zou L, Liu J
Cells, tissues, organs 2019;208(3-4):148-157
Cells, tissues, organs 2019;208(3-4):148-157
UHRF1 Promotes Proliferation of Human Adipose-Derived Stem Cells and Suppresses Adipogenesis via Inhibiting Peroxisome Proliferator-Activated Receptor γ.
Chen K, Guo Z, Luo Y, Yuan J, Mo Z
BioMed research international 2019;2019:9456847
BioMed research international 2019;2019:9456847
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J, Zhou Y
Mediators of inflammation 2019;2019:6175091
Mediators of inflammation 2019;2019:6175091
A Network Pharmacology Approach for Uncovering the Osteogenic Mechanisms of Psoralea corylifolia Linn.
Ge L, Cheng K, Han J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2160175
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2160175
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation.
Huang YH, Kuo HC, Yang YL, Wang FS
International journal of medical sciences 2019;16(2):212-220
International journal of medical sciences 2019;16(2):212-220
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis.
Liu B, Huang B, Hu G, He D, Li Y, Ran X, Du J, Fu S, Liu D
Frontiers in immunology 2019;10:2650
Frontiers in immunology 2019;10:2650
Cathelicidin-WA Facilitated Intestinal Fatty Acid Absorption Through Enhancing PPAR-γ Dependent Barrier Function.
Zong X, Cao X, Wang H, Xiao X, Wang Y, Lu Z
Frontiers in immunology 2019;10:1674
Frontiers in immunology 2019;10:1674
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Hydroxytyrosol prevents PM(2.5)-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model.
Wang N, Ma Y, Liu Z, Liu L, Yang K, Wei Y, Liu Y, Chen X, Sun X, Wen D
Free radical biology & medicine 2019 Sep;141:393-407
Free radical biology & medicine 2019 Sep;141:393-407
PPAR Gamma-Regulated MicroRNA 199a-5p Underlies Bone Marrow Adiposity in Aplastic Anemia.
Zhang X, Liu L, Dou C, Cheng P, Liu L, Liu H, Ren S, Wang C, Jia S, Chen L, Zhang H, Chen M
Molecular therapy. Nucleic acids 2019 Sep 6;17:678-687
Molecular therapy. Nucleic acids 2019 Sep 6;17:678-687
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Ding S, Huang J, Qiu H, Chen R, Zhang J, Huang B, Cheng O, Jiang Q
Experimental cell research 2019 Sep 1;382(1):111455
Experimental cell research 2019 Sep 1;382(1):111455
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression.
Huang X, Chen W, Yan C, Yang R, Chen Q, Xu H, Huang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109258
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109258
MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice.
Lin HY, Wang FS, Yang YL, Huang YH
Cells 2019 Oct 22;8(10)
Cells 2019 Oct 22;8(10)
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Wang Y, He G, Wang F, Zhang C, Ge Z, Zheng X, Deng H, Yuan C, Zhou B, Tao X, Zhang J, Tang K
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
Rosiglitazone attenuates paraquat-induced lung fibrosis in rats in a PPAR gamma-dependent manner.
Zhang H, You L, Zhao M
European journal of pharmacology 2019 May 15;851:133-143
European journal of pharmacology 2019 May 15;851:133-143
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, Huang L, Chen X, LeRoith D, Liang B, Li X, Wu Y
iScience 2019 Jun 28;16:106-121
iScience 2019 Jun 28;16:106-121
Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Hao Z, Zhang Z, Lu D, Ding B, Shu L, Zhang Q, Wang C
Chemical research in toxicology 2019 Jun 17;32(6):1250-1258
Chemical research in toxicology 2019 Jun 17;32(6):1250-1258
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.
Xu P, Guo H, Wang H, Lee SC, Liu M, Pan Y, Zheng J, Zheng K, Wang H, Xie Y, Bai X, Liu Y, Zhao M, Wang L
Toxicology 2019 Jul 1;423:112-122
Toxicology 2019 Jul 1;423:112-122
Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
Ding S, Qiu H, Huang J, Chen R, Zhang J, Huang B, Zou X, Cheng O, Jiang Q
Chemico-biological interactions 2019 Jul 1;307:116-124
Chemico-biological interactions 2019 Jul 1;307:116-124
Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells.
Zhang Q, Bai J, Yao X, Jiang L, Wu W, Yang L, Gao N, Qiu T, Yang G, Habtemariam Hidru T, Sun X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:815-822
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:815-822
EETs/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy.
Zhang J, Qiu H, Huang J, Ding S, Huang B, Zhou P, Jiang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1498-1505
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1498-1505
Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.
Zhu Y, Wang Y, Jia Y, Xu J, Chai Y
Stem cell research & therapy 2019 Jan 22;10(1):37
Stem cell research & therapy 2019 Jan 22;10(1):37
Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice.
Jiang F, Wu G, Li W, Yang J, Yan J, Wang Y, Yao W, Zhou X, He Z, Wu L, Xiao C, Xiao T, Zhang M, Shen X, Tao L
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Jan 15;127:14-23
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Jan 15;127:14-23
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Xu L, Liu JT, Li K, Wang SY, Xu S
Life sciences 2019 Jan 1;216:140-146
Life sciences 2019 Jan 1;216:140-146
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Wang XM, Wang XY, Huang YM, Chen X, Lü MH, Shi L, Li CP
International journal of molecular medicine 2019 Dec;44(6):2201-2212
International journal of molecular medicine 2019 Dec;44(6):2201-2212
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Cai Z, Liang Y, Xing C, Wang H, Hu P, Li J, Huang H, Wang W, Jiang C
Oncology reports 2019 Dec;42(6):2537-2549
Oncology reports 2019 Dec;42(6):2537-2549
Phenethyl isothiocyanate induces IPEC-J2 cells cytotoxicity and apoptosis via S-G(2)/M phase arrest and mitochondria-mediated Bax/Bcl-2 pathway.
Liu S, Zhu Y, Yan S, Xiao H, Yi J, Li R, Wu J, Wen L
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2019 Dec;226:108574
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2019 Dec;226:108574
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Kao YC, Wei WY, Tsai KJ, Wang LC
International journal of molecular sciences 2019 Dec 27;21(1)
International journal of molecular sciences 2019 Dec 27;21(1)
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Dong Y, Zhang S, Tao J, Zhang X, Zhang J, Yang J, Liang H, Liu D, Cang M
Research in veterinary science 2019 Aug;125:351-359
Research in veterinary science 2019 Aug;125:351-359
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Gao N, Yao X, Jiang L, Yang L, Qiu T, Wang Z, Pei P, Yang G, Liu X, Sun X
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Zheng M, Li YY, Wang GF, Jin JY, Wang YH, Wang TM, Yang L, Liu SY, Wu JS, Wang ZT, Ma YM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108701
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108701
Evaluation of MEDAG gene expression in papillary thyroid microcarcinoma: associations with histological features, regional lymph node metastasis and prognosis.
Song Y, Fu LJ, Li HT, Qiu XG
Scientific reports 2019 Apr 9;9(1):5800
Scientific reports 2019 Apr 9;9(1):5800
Dan-Lou Prescription Inhibits Foam Cell Formation Induced by ox-LDL via the TLR4/NF-κB and PPARγ Signaling Pathways.
Gao LN, Zhou X, Lu YR, Li K, Gao S, Yu CQ, Cui YL
Frontiers in physiology 2018;9:590
Frontiers in physiology 2018;9:590
Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice.
Wang T, Cui X, Xie L, Xing R, You P, Zhao Y, Yang Y, Xu Y, Zeng L, Chen H, Liu M
Frontiers in physiology 2018;9:209
Frontiers in physiology 2018;9:209
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway.
Wang Q, Cai J, Fang C, Yang C, Zhou J, Tan Y, Wang Y, Li Y, Meng X, Zhao K, Yi K, Zhang S, Zhang J, Jiang C, Zhang J, Kang C
Theranostics 2018;8(17):4733-4749
Theranostics 2018;8(17):4733-4749
PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection.
Zhu Y, Ni Y, Liu R, Hou M, Yang B, Song J, Sun H, Xu Z, Ji M
Journal of immunology research 2018;2018:6398078
Journal of immunology research 2018;2018:6398078
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Yang X, Xiao X, Wang H, Li Y, Wang L, Li G, Deng S
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3450141
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3450141
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124
Neurobiology of disease 2018 Sep;117:114-124
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
Qin DD, Yang YF, Pu ZQ, Liu D, Yu C, Gao P, Chen JC, Zong C, Zhang YC, Li X, Wang XD, Liu YT
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Zhai X, Lin D, Zhao Y, Li W, Yang X
Food & function 2018 Oct 17;9(10):5260-5272
Food & function 2018 Oct 17;9(10):5260-5272
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ.
Zhang JR, Lu QB, Feng WB, Wang HP, Tang ZH, Cheng H, Du Q, Wang YB, Li KX, Sun HJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:711-717
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:711-717
Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.
Chen L, Cao Y, Zhang H, Lv D, Zhao Y, Liu Y, Ye G, Chai Y
Journal of ethnopharmacology 2018 Jun 12;219:359-368
Journal of ethnopharmacology 2018 Jun 12;219:359-368
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Zhang J, Qiu H, Huang J, Ding S, Huang B, Wu Q, Jiang Q
Biochemical and biophysical research communications 2018 Jul 7;502(1):55-61
Biochemical and biophysical research communications 2018 Jul 7;502(1):55-61
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
Liu L, Pan Y, Zhai C, Zhu Y, Ke R, Shi W, Wang J, Yan X, Su X, Song Y, Gao L, Li M
Journal of cellular physiology 2018 Jan;234(1):669-681
Journal of cellular physiology 2018 Jan;234(1):669-681
Sini Decoction Intervention on Atherosclerosis via PPARγ-LXRα-ABCA1 Pathway in Rabbits.
Ju S, Chang X, Wang J, Zou X, Zhao Z, Huang Z, Wang Y, Yu B
Open life sciences 2018 Jan;13:446-455
Open life sciences 2018 Jan;13:446-455
Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Xie X, Li S, Zhu Y, Liu L, Ke R, Wang J, Yan X, Yang L, Gao L, Zang W, Li M
Molecular biology of the cell 2018 Feb 1;29(3):356-362
Molecular biology of the cell 2018 Feb 1;29(3):356-362
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q
EBioMedicine 2018 Dec;38:178-190
EBioMedicine 2018 Dec;38:178-190
Corilagin Counteracts IL-13Rα1 Signaling Pathway in Macrophages to Mitigate Schistosome Egg-Induced Hepatic Fibrosis.
Li YQ, Chen YF, Dang YP, Wang Y, Shang ZZ, Ma Q, Wang YJ, Zhang J, Luo L, Li QQ, Zhao L
Frontiers in cellular and infection microbiology 2017;7:443
Frontiers in cellular and infection microbiology 2017;7:443
Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway.
Wei L, Mao J, Lu J, Gao J, Zhu D, Tian L, Chen Z, Jia L, Wang L, Fu R
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2228-2242
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2228-2242
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.
Sun H, Zhu X, Lin W, Zhou Y, Cai W, Qiu L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1227-1239
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1227-1239
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, Zong C, Qin D, Wang Y, Yingfeng Yang Y, Wang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression.
Xu J, Pan M, Wang X, Xu L, Li L, Xu C
PPAR research 2017;2017:8130968
PPAR research 2017;2017:8130968
Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
Sun HJ, Chen D, Wang PY, Wan MY, Zhang CX, Zhang ZX, Lin W, Zhang F
Oxidative medicine and cellular longevity 2017;2017:6905217
Oxidative medicine and cellular longevity 2017;2017:6905217
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Xie X, Li S, Zhu Y, Liu L, Pan Y, Wang J, Shi W, Song Y, Yang L, Gao L, Zang W, Li M
Cell and tissue research 2017 Sep;369(3):527-539
Cell and tissue research 2017 Sep;369(3):527-539
miR-148a-3p regulates adipocyte and osteoblast differentiation by targeting lysine-specific demethylase 6b.
Tian L, Zheng F, Li Z, Wang H, Yuan H, Zhang X, Ma Z, Li X, Gao X, Wang B
Gene 2017 Sep 5;627:32-39
Gene 2017 Sep 5;627:32-39
5-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway.
Ke R, Xie X, Li S, Pan Y, Wang J, Yan X, Zang W, Gao L, Li M
Oncotarget 2017 Sep 22;8(42):72910-72920
Oncotarget 2017 Sep 22;8(42):72910-72920
The novel ZIP4 regulation and its role in ovarian cancer.
Fan Q, Cai Q, Li P, Wang W, Wang J, Gerry E, Wang TL, Shih IM, Nephew KP, Xu Y
Oncotarget 2017 Oct 27;8(52):90090-90107
Oncotarget 2017 Oct 27;8(52):90090-90107
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Li F, Zhu Y, Wan Y, Xie X, Ke R, Zhai C, Pan Y, Yan X, Wang J, Shi W, Li M
European journal of pharmacology 2017 Nov 5;814:324-334
European journal of pharmacology 2017 Nov 5;814:324-334
Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.
Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J, Duan Y
Arteriosclerosis, thrombosis, and vascular biology 2017 Jul;37(7):1290-1300
Arteriosclerosis, thrombosis, and vascular biology 2017 Jul;37(7):1290-1300
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1.
Zong C, Qin D, Yu C, Gao P, Chen J, Lu S, Zhang Y, Liu Y, Yang Y, Pu Z, Li X, Fu Y, Guan Q, Wang X
Cellular signalling 2017 Jul;35:129-139
Cellular signalling 2017 Jul;35:129-139
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Ji J, Zeng XN, Cao LL, Zhang L, Zhao Z, Yang DD, Sun XL
Neuropharmacology 2017 Feb;113(Pt A):396-406
Neuropharmacology 2017 Feb;113(Pt A):396-406
Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.
Zhang W, Shen XY, Zhang WW, Chen H, Xu WP, Wei W
Toxicology and applied pharmacology 2017 Feb 1;316:17-26
Toxicology and applied pharmacology 2017 Feb 1;316:17-26
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.
Yang X, Wang Q, Pang ZR, Pan MR, Zhang W
Pharmaceutical biology 2017 Dec;55(1):1207-1214
Pharmaceutical biology 2017 Dec;55(1):1207-1214
Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.
Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin MW, Liu H
Scientific reports 2017 Apr 25;7(1):1123
Scientific reports 2017 Apr 25;7(1):1123
Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.
Sun H, Zhu X, Cai W, Qiu L
International journal of molecular sciences 2017 Apr 17;18(4)
International journal of molecular sciences 2017 Apr 17;18(4)
Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction.
Xiang H, Wang G, Qu J, Xia S, Tao X, Qi B, Zhang Q, Shang D
Frontiers in pharmacology 2016;7:378
Frontiers in pharmacology 2016;7:378
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
Hu Y, Tao X, Han X, Xu L, Yin L, Qi Y, Zhao Y, Xu Y, Wang C, Peng J
Chemico-biological interactions 2016 Oct 25;258:234-44
Chemico-biological interactions 2016 Oct 25;258:234-44
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Chen L, Lv D, Wang D, Chen X, Zhu Z, Cao Y, Chai Y
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.
Zhu WS, Tang CM, Xiao Z, Zhu JN, Lin QX, Fu YH, Hu ZQ, Zhang Z, Yang M, Zheng XL, Wu SL, Shan ZX
Oncotarget 2016 Nov 29;7(48):78331-78342
Oncotarget 2016 Nov 29;7(48):78331-78342
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
Jin M, Wu Y, Wang J, Chen J, Huang Y, Rao J, Feng C
Biochemical and biophysical research communications 2016 May 20;474(1):76-82
Biochemical and biophysical research communications 2016 May 20;474(1):76-82
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Bai J, Yao X, Jiang L, Zhang Q, Guan H, Liu S, Wu W, Qiu T, Gao N, Yang L, Yang G, Sun X
Scientific reports 2016 Jun 13;6:27733
Scientific reports 2016 Jun 13;6:27733
Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE.
Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J, Duan Y
The Journal of biological chemistry 2016 Jul 15;291(29):15108-18
The Journal of biological chemistry 2016 Jul 15;291(29):15108-18
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM.
Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J, Duan Y
The Journal of biological chemistry 2016 Aug 12;291(33):16977-89
The Journal of biological chemistry 2016 Aug 12;291(33):16977-89
Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
Liu X, Liu M, Mo Y, Peng H, Gong J, Li Z, Chen J, Xie J
Iranian journal of basic medical sciences 2016 Apr;19(4):417-22
Iranian journal of basic medical sciences 2016 Apr;19(4):417-22
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.
Lu L, Wang J, Lu H, Zhang G, Liu Y, Wang J, Zhang Y, Shang H, Ji H, Chen X, Duan Y, Li Y
Biochemical and biophysical research communications 2015 Sep 25;465(3):387-93
Biochemical and biophysical research communications 2015 Sep 25;465(3):387-93
Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells.
Zhang S, Liu F, Mao X, Huang J, Yang J, Yin X, Wu L, Zheng L, Wang Q
International journal of oncology 2015 Nov;47(5):1759-66
International journal of oncology 2015 Nov;47(5):1759-66
Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar LM, Pereira L
Journal of virology 2015 May;89(9):5134-47
Journal of virology 2015 May;89(9):5134-47
miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop.
Guan X, Gao Y, Zhou J, Wang J, Zheng F, Guo F, Chang A, Li X, Wang B
Stem cells (Dayton, Ohio) 2015 May;33(5):1589-600
Stem cells (Dayton, Ohio) 2015 May;33(5):1589-600
miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling.
He H, Chen K, Wang F, Zhao L, Wan X, Wang L, Mo Z
International journal of molecular medicine 2015 Jun;35(6):1587-95
International journal of molecular medicine 2015 Jun;35(6):1587-95
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J, Duan Y
Scientific reports 2015 Jun 10;5:11219
Scientific reports 2015 Jun 10;5:11219
Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.
Ma X, Li SF, Qin ZS, Ye J, Zhao ZL, Fang HH, Yao ZW, Gu MN, Hu YW
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miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, Yang W, Mo Z
Scientific reports 2015 Jul 7;5:11909
Scientific reports 2015 Jul 7;5:11909
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
Jin Y, Liu K, Peng J, Wang C, Kang L, Chang N, Sun H
Toxicology letters 2015 Jan 5;232(1):149-58
Toxicology letters 2015 Jan 5;232(1):149-58
miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling.
Zhang X, Chang A, Li Y, Gao Y, Wang H, Ma Z, Li X, Wang B
Scientific reports 2015 Dec 11;5:18118
Scientific reports 2015 Dec 11;5:18118
miR-20a regulates adipocyte differentiation by targeting lysine-specific demethylase 6b and transforming growth factor-β signaling.
Zhou J, Guo F, Wang G, Wang J, Zheng F, Guan X, Chang A, Zhang X, Dai C, Li S, Li X, Wang B
International journal of obesity (2005) 2015 Aug;39(8):1282-91
International journal of obesity (2005) 2015 Aug;39(8):1282-91
Systemic adaptation of lipid metabolism in response to low- and high-fat diet in Nile tilapia (Oreochromis niloticus).
He AY, Ning LJ, Chen LQ, Chen YL, Xing Q, Li JM, Qiao F, Li DL, Zhang ML, Du ZY
Physiological reports 2015 Aug;3(8)
Physiological reports 2015 Aug;3(8)
Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients.
Pan X, Wang P, Luo J, Wang Z, Song Y, Ye J, Hou X
Endocrine 2015 Apr;48(3):834-47
Endocrine 2015 Apr;48(3):834-47
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Wang Q, Wang ST, Yang X, You PP, Zhang W
Nutrition research (New York, N.Y.) 2015 Apr;35(4):317-27
Nutrition research (New York, N.Y.) 2015 Apr;35(4):317-27
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
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Scientific reports 2015 Apr 8;5:9713
Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways.
Wang G, Ji Y, Li Z, Han X, Guo N, Song Q, Quan L, Wang T, Han W, Pang D, Ouyang H, Tang X
Scientific reports 2014 May 9;4:4905
Scientific reports 2014 May 9;4:4905
miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6.
Wang J, Guan X, Guo F, Zhou J, Chang A, Sun B, Cai Y, Ma Z, Dai C, Li X, Wang B
Cell death & disease 2013 Oct 10;4(10):e845
Cell death & disease 2013 Oct 10;4(10):e845
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
Hong Y, Zhou Y, Wang Y, Xiao S, Liao DJ, Zhao Q
Molecular biology reports 2013 Nov;40(11):6287-93
Molecular biology reports 2013 Nov;40(11):6287-93
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Chang MJ, Xiao JH, Wang Y, Yan YL, Yang J, Wang JL
PloS one 2012;7(12):e50291
PloS one 2012;7(12):e50291
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- U-937 cells were subjected to SDS PAGE followed by western blot with 16643-1-AP(PPARG antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPAR gamma antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPAR gamma. This antibody recognizes human,mouse,rat antigen. The PPAR gamma antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
