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- Product number
- 16643-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16643-1-AP, RRID:AB_10596794
- Product name
- PPAR Gamma antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PPAR Gamma antibody (Cat. #16643-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cited2 inhibited hypoxia-induced proliferation and migration of PASMCs via the TGF-β1/Cited2/PPARγ pathway.
Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway.
SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.
The autophagic regulation of rosiglitazone-promoted adipocyte browning.
Comprehensive analysis of peroxisome proliferator-activated receptors to predict the drug resistance, immune microenvironment, and prognosis in stomach adenocarcinomas.
Inhibiting Soluble Epoxide Hydrolase Suppresses NF-κB p65 Signaling and Reduces CXCL10 Expression as a Potential Therapeutic Target in Hashimoto's Thyroiditis.
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease.
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.
Total ginsenosides decrease Aβ production through activating PPARγ.
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells.
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ.
The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages.
B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling.
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway.
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.
Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through CCDC18.
Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action.
Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
KLF2/PPARγ axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction.
ATR induces hepatic lipid metabolism disorder in rats by activating IRE1α/XBP1 signaling pathway.
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Yi-shen-hua-shi granules modulate immune and inflammatory damage via the ALG3/PPARγ/NF-κB pathway in the treatment of immunoglobulin a nephropathy.
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF-κB signaling pathway.
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Elucidating the Role of circTIAM1 in Guangling Large-Tailed Sheep Adipocyte Proliferation and Differentiation via the miR-485-3p/PLCB1 Pathway.
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake.
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
The role of miR-369-3p in proliferation and differentiation of preadipocytes in Aohan fine-wool sheep.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Abdominal Massage Ameliorates Inguinal Fat Accumulation via Augmentation of PPARγ Signaling in High-Fat Diet-Induced Obese Mice.
Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway.
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress.
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway.
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Protective effects and mechanisms of Yi Qi Huo Xue Fang in cerebral ischemic stroke based on network pharmacology and experimental verification.
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Korean red ginseng formula attenuates non-alcoholic fatty liver disease in oleic acid-induced HepG2 cells and high-fat diet-induced rats.
PPARγ regulates lipid metabolism and viability of sheep trophoblast cells.
Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling.
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene.
Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization.
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation.
Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Xiao-Yao-San in the Treatment of Inflammatory Response in CUMS Mice.
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Impaired PPARγ activation by cadmium exacerbates infection-induced lung injury.
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Fructooligosaccharides attenuate non-alcoholic fatty liver disease by remodeling gut microbiota and association with lipid metabolism.
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.
An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.
Shared Genes of PPARG and NOS2 in Alzheimer's Disease and Ulcerative Colitis Drive Macrophages and Microglia Polarization: Evidence from Bioinformatics Analysis and Following Validation.
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
The role of PPARγ in intermittent hypoxia-related human umbilical vein endothelial cell injury.
5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ.
PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.
PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.
Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway.
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition.
Millet Bran Protein Hydrolysate Displays the Anti-non-alcoholic Fatty Liver Disease Effect via Activating Peroxisome Proliferator-Activated Receptor γ to Restrain Fatty Acid Uptake.
Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-γ.
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.
circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep.
Effects of the CDC10 (Septin 7) Gene on the Proliferation and Differentiation of Bovine Intramuscular Preadipocyte and 3T3-L1 Cells.
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
[A convenient and time-saving method for primary culture of mature white adipocytes from mice].
Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia.
Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling.
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients.
Diethylaminoethyl-dextran and monocyte cell membrane coated 1,8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis.
Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithelial Homeostasis and Ameliorates Colitis.
Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D.
An optimized protocol for chromatin immunoprecipitation from murine inguinal white adipose tissue.
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-γ/TXNIP pathways.
MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets.
PPARγ agonist inhibits c-Myc-mediated colorectal cancer tumor immune escape.
C1q(+) tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion.
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway.
RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect.
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.
PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis.
Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis.
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway.
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
Upregulated estrogen receptors impairs myogenesis and elevates adipogenesis related factor levels in the paravertebral muscles of patients with idiopathic scoliosis.
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet.
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Smilax china Polyphenols Stimulate Browning via [Formula: see text]3-Adrenergic Receptor/AMP-Activated Protein Kinase [Formula: see text] Signaling Pathway in 3T3-L1 Adipocytes.
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21.
Protective Effect of Shengmaiyin in Myocardial Hypertrophy-Induced Rats: A Genomic Analysis by 16S rDNA.
Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's mouse model.
Effects of PPARD gene variants on the therapeutic responses to exenatide in chinese patients with type 2 diabetes mellitus.
Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats.
Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation.
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Role and mechanism of the zinc finger protein ZNF580 in foam-cell formation.
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo.
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.
PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo.
The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Rectal administration of butyrate ameliorates pulmonary fibrosis in mice through induction of hepatocyte growth factor in the colon via the HDAC-PPARγ pathway.
Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats.
Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis.
Serpina3c regulates adipose differentiation via the Wnt/β-catenin-PPARγ pathway.
Acid-treated high-amylose corn starch suppresses high-fat diet-induced steatosis.
PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.
Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
CRISPR/Cas9-Mediated Knockout of miR-130b Affects Mono- and Polyunsaturated Fatty Acid Content via PPARG-PGC1α Axis in Goat Mammary Epithelial Cells.
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
MicroRNA 573 Rescues Endothelial Dysfunction during Dengue Virus Infection under PPARγ Regulation.
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression.
Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco.
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation.
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway.
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth.
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells.
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease.
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice.
Myoblast-derived exosomes promote the repair and regeneration of injured skeletal muscle in mice.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Angiogenesis-Browning Interplay Mediated by Asprosin-Knockout Contributes to Weight Loss in Mice with Obesity.
Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation.
PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT.
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice.
Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.
Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice.
Inhibition of DNA methylation de-represses peroxisome proliferator-activated receptor-γ and attenuates pulmonary fibrosis.
The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα.
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome.
Gold nanoclusters eliminate obesity induced by antipsychotics.
PPARγ/SOD2 Protects Against Mitochondrial ROS-Dependent Apoptosis via Inhibiting ATG4D-Mediated Mitophagy to Promote Pancreatic Cancer Proliferation.
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α.
Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons.
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Identification of miRNA in Sheep Intramuscular Fat and the Role of miR-193a-5p in Proliferation and Differentiation of 3T3-L1.
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
mTOR regulates PRMT1 expression and mitochondrial mass through STAT1 phosphorylation in hepatic cell.
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.
A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models.
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model.
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-κB and in a PPARγ-dependent manner.
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Effects of energy supplements on the differentiation of skeletal muscle satellite cells.
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.
Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring.
Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway.
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis.
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.
Bergenin alleviates H(2) O(2) -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway.
Decreased expression of PPARγ is associated with aortic endothelial cell apoptosis in intermittently hypoxic rats.
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet.
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway.
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.
A small nucleolar RNA, SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway.
Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.
Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.
Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia.
ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression.
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.
Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPARγ and LPL Gene in a High-Fat Diet C57BL/6 Mice Model.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway.
Alveolar Epithelial Cells Promote IGF-1 Production by Alveolar Macrophages Through TGF-β to Suppress Endogenous Inflammatory Signals.
Sevoflurane Protects against Intestinal Ischemia-Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-κB Pathway in Rats.
Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma.
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Tissue Inhibitor of Metalloprotease-1 (TIMP-1) Regulates Adipogenesis of Adipose-derived Stem Cells (ASCs) via the Wnt Signaling Pathway in an MMP-independent Manner.
The total flavonoids from Selaginella tamariscina (beauv.) Spring improve glucose and lipid metabolism in db/db mice.
3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells.
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Citri Reticulatae Pericarpium protects against isoproterenol-induced chronic heart failure via activation of PPARγ.
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Unconservative_15_2570409 suppresses progesterone receptor expression in the granulosa cells of Hu sheep.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ(12,14) -PGJ(2) and Nogo.
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
The opposite functions of miR-24 in the osteogenesis and adipogenesis of adipose-derived mesenchymal stem cells are mediated by the HOXB7/β-catenin complex.
m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Tributyltin reduces bone mineral density by reprograming bone marrow mesenchymal stem cells in rat.
Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma.
PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis.
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway.
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.
Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway.
CB11, a novel purine-based PPARɣ ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells.
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ(1).
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
IL-29 promoted obesity-induced inflammation and insulin resistance.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Effect of MicroRNA-20a on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells.
UHRF1 Promotes Proliferation of Human Adipose-Derived Stem Cells and Suppresses Adipogenesis via Inhibiting Peroxisome Proliferator-Activated Receptor γ.
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
A Network Pharmacology Approach for Uncovering the Osteogenic Mechanisms of Psoralea corylifolia Linn.
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Cathelicidin-WA Facilitated Intestinal Fatty Acid Absorption Through Enhancing PPAR-γ Dependent Barrier Function.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Hydroxytyrosol prevents PM(2.5)-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model.
PPAR Gamma-Regulated MicroRNA 199a-5p Underlies Bone Marrow Adiposity in Aplastic Anemia.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression.
MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice.
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Rosiglitazone attenuates paraquat-induced lung fibrosis in rats in a PPAR gamma-dependent manner.
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.
Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells.
EETs/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy.
Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.
Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice.
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Phenethyl isothiocyanate induces IPEC-J2 cells cytotoxicity and apoptosis via S-G(2)/M phase arrest and mitochondria-mediated Bax/Bcl-2 pathway.
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Evaluation of MEDAG gene expression in papillary thyroid microcarcinoma: associations with histological features, regional lymph node metastasis and prognosis.
Dan-Lou Prescription Inhibits Foam Cell Formation Induced by ox-LDL via the TLR4/NF-κB and PPARγ Signaling Pathways.
Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice.
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway.
PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection.
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ.
Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
Corilagin Counteracts IL-13Rα1 Signaling Pathway in Macrophages to Mitigate Schistosome Egg-Induced Hepatic Fibrosis.
Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway.
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression.
Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
miR-148a-3p regulates adipocyte and osteoblast differentiation by targeting lysine-specific demethylase 6b.
5-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway.
The novel ZIP4 regulation and its role in ovarian cancer.
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1.
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.
Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.
Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.
Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction.
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM.
Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.
Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells.
Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop.
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.
miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling.
miR-20a regulates adipocyte differentiation by targeting lysine-specific demethylase 6b and transforming growth factor-β signaling.
Systemic adaptation of lipid metabolism in response to low- and high-fat diet in Nile tilapia (Oreochromis niloticus).
Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients.
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Potent effects of dioscin against liver fibrosis.
Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways.
miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6.
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Wang HJ, Ma L, Yu Q
Iranian journal of basic medical sciences 2024;27(4):509-517
Iranian journal of basic medical sciences 2024;27(4):509-517
Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway.
Zhang X, Zheng Y, Wang G, Liu Y, Wang Y, Jiang X, Liang Y, Zhao X, Li P, Zhang Y
Stem cells international 2024;2024:6693292
Stem cells international 2024;2024:6693292
SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.
Liu LX, Zheng XH, Hai JH, Zhang CM, Ti Y, Chen TS, Bu PL
PloS one 2024;19(4):e0301990
PloS one 2024;19(4):e0301990
The autophagic regulation of rosiglitazone-promoted adipocyte browning.
Li Y, Zheng W, Li X, Lue Z, Liu Y, Wu J, Zhang X
Frontiers in pharmacology 2024;15:1412520
Frontiers in pharmacology 2024;15:1412520
Comprehensive analysis of peroxisome proliferator-activated receptors to predict the drug resistance, immune microenvironment, and prognosis in stomach adenocarcinomas.
Jia Q, Li B, Wang X, Ma Y, Li G
PeerJ 2024;12:e17082
PeerJ 2024;12:e17082
Inhibiting Soluble Epoxide Hydrolase Suppresses NF-κB p65 Signaling and Reduces CXCL10 Expression as a Potential Therapeutic Target in Hashimoto's Thyroiditis.
Feng J, Xu X, Cai W, Yang X, Niu R, Han Z, Tian L
The Journal of clinical endocrinology and metabolism 2024 Sep 16;109(10):2579-2588
The Journal of clinical endocrinology and metabolism 2024 Sep 16;109(10):2579-2588
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease.
Chen N, Luo J, Zhou T, Shou Y, Du C, Song G, Xu L, Zhao K, Jin Y, Li C, Yu D
Biochemical pharmacology 2024 Oct;228:115936
Biochemical pharmacology 2024 Oct;228:115936
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.
Yang S, Cao SJ, Li CY, Zhang Q, Zhang BL, Qiu F, Kang N
Journal of ethnopharmacology 2024 Oct 5;332:118354
Journal of ethnopharmacology 2024 Oct 5;332:118354
Total ginsenosides decrease Aβ production through activating PPARγ.
He S, Shi J, Ma L, Pei H, Zhang P, Shi D, Li H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116577
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116577
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells.
Zhang J, Jiang J, Liu H, Wang S, Ke K, Liu S, Jiang Y, Liu L, Gao X, He B, Su Y
Genes & diseases 2024 May;11(3):101075
Genes & diseases 2024 May;11(3):101075
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ.
Yi T, Zhang W, Hua Y, Xin X, Wu Z, Li Y, Wen C, Fan Y, Ji J, Xu L
Chemico-biological interactions 2024 May 1;394:110972
Chemico-biological interactions 2024 May 1;394:110972
The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.
Yu W, Yao Y, Ye N, Zhao Y, Ye Z, Wei W, Zhang L, Chen J
American journal of physiology. Cell physiology 2024 May 1;326(5):C1320-C1333
American journal of physiology. Cell physiology 2024 May 1;326(5):C1320-C1333
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages.
Fu Q, Shen N, Fang T, Zhang H, Di Y, Liu X, Du C, Guo J
Genes & genomics 2024 Mar;46(3):323-332
Genes & genomics 2024 Mar;46(3):323-332
B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling.
Zeng C, Chen H, Cao T, Wang L, Jiao S, Lin C, Zhang B, Cai H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114490
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114490
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Yu S, Lee HM, Lee J, Hwang JT, Choi HK, Lee YG
International journal of molecular sciences 2024 Mar 4;25(5)
International journal of molecular sciences 2024 Mar 4;25(5)
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway.
Wang H, Tian Q, Zhang R, Du Q, Hu J, Gao T, Gao S, Fan K, Cheng X, Yan S, Zheng G, Dong H
Lipids in health and disease 2024 Mar 11;23(1):76
Lipids in health and disease 2024 Mar 11;23(1):76
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.
Wan X, Wang L, Khan MA, Peng L, Zhang K, Sun X, Yi X, Wang Z, Chen K
Cell death discovery 2024 Mar 11;10(1):129
Cell death discovery 2024 Mar 11;10(1):129
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.
Liu T, Yang L, Li Z, Sun M, Lv N
Chemico-biological interactions 2024 Mar 1;391:110891
Chemico-biological interactions 2024 Mar 1;391:110891
Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through CCDC18.
Liu L, Wang W, Liu W, Li X, Yi G, Adetula AA, Huang H, Tang Z
International journal of molecular sciences 2024 Mar 1;25(5)
International journal of molecular sciences 2024 Mar 1;25(5)
Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action.
Tan B, Lan X, Zhang Y, Liu P, Jin Q, Wang Z, Liang Z, Song W, Xuan Y, Sun Y, Li Y
Experimental and therapeutic medicine 2024 Jun;27(6):239
Experimental and therapeutic medicine 2024 Jun;27(6):239
Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.
Jing R, Fu M, Huang Y, Zhang K, Ye J, Gong F, Jihea Ali Naji Nasser AB, Xu X, Xiao J, Yu G, Lin S, Zhao W, Xu N, Li X, Li Z, Gao S
British journal of pharmacology 2024 Jun;181(11):1596-1613
British journal of pharmacology 2024 Jun;181(11):1596-1613
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
Bian H, Liang X, Lu D, Lin J, Lu X, Jin J, Zhang L, Wu Y, Chen H, Zhang W, Luan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2308435
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2308435
KLF2/PPARγ axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Liu W, Tu B, Ruan H, Li J, Fan C
Cell proliferation 2024 Jan;57(1):e13521
Cell proliferation 2024 Jan;57(1):e13521
ATR induces hepatic lipid metabolism disorder in rats by activating IRE1α/XBP1 signaling pathway.
Qian H, Zhao Y, Wang Y, Zhao H, Cui J, Wang Z, Ye H, Fang X, Ge Z, Zhang Y, Ye L
Toxicology 2024 Jan;501:153696
Toxicology 2024 Jan;501:153696
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Peng L, Yang R, Wang Z, Jian H, Tan X, Li J, He Z, Huang R, Zeng P, Gao W
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
Yi-shen-hua-shi granules modulate immune and inflammatory damage via the ALG3/PPARγ/NF-κB pathway in the treatment of immunoglobulin a nephropathy.
Xu R, Zhang J, Hu X, Xu P, Huang S, Cui S, Guo Y, Yang H, Chen X, Jiang C
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117204
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117204
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Liu H, Chang Z, Liu S, Zhu R, Ma J, Lu X, Li L, Zhang Z
Heliyon 2024 Jan 15;10(1):e24241
Heliyon 2024 Jan 15;10(1):e24241
Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
Zhao MF, Zhang XG, Tang YP, Zhu YX, Nie HY, Bu DD, Fang L, Li CJ
The Journal of biological chemistry 2024 Feb;300(2):105617
The Journal of biological chemistry 2024 Feb;300(2):105617
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF-κB signaling pathway.
Zhao T, Jia J
CNS neuroscience & therapeutics 2024 Feb;30(2):e14581
CNS neuroscience & therapeutics 2024 Feb;30(2):e14581
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Meng M, Wang J, Wang C, Zhao J, Wang H, Zhang Y, Sun H, Liu M
Calcified tissue international 2024 Feb;114(2):182-199
Calcified tissue international 2024 Feb;114(2):182-199
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Wu D, Shen Z, Gou Y, Yu T, Hong J, Wang Y, Ni F, Qiqige N, Lu H, Xue E
Chemico-biological interactions 2024 Feb 25;390:110877
Chemico-biological interactions 2024 Feb 25;390:110877
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D
Cell death discovery 2024 Feb 22;10(1):95
Cell death discovery 2024 Feb 22;10(1):95
Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish.
Zhang L, Zhao J, Peng Z, Zhang Z, Huang S, Dong X, Gao J, Guo X
Acta diabetologica 2024 Aug;61(8):975-985
Acta diabetologica 2024 Aug;61(8):975-985
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117
EMBO reports 2024 Apr;25(4):2097-2117
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Elucidating the Role of circTIAM1 in Guangling Large-Tailed Sheep Adipocyte Proliferation and Differentiation via the miR-485-3p/PLCB1 Pathway.
Liang Y, Zhao B, Shen Y, Peng M, Qiao L, Liu J, Pan Y, Yang K, Liu W
International journal of molecular sciences 2024 Apr 23;25(9)
International journal of molecular sciences 2024 Apr 23;25(9)
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake.
Cheng Y, Zhu Y, Liu Y, Liu X, Ding Y, Li D, Zhang X, Liu Y
International journal of oral science 2024 Apr 16;16(1):31
International journal of oral science 2024 Apr 16;16(1):31
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.
Chu Y, Gui S, Zheng Y, Zhao J, Zhao Y, Li Y, Chen X
European journal of pharmacology 2024 Apr 15;969:176438
European journal of pharmacology 2024 Apr 15;969:176438
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Ang B, Yang T, Wang Z, Cheng Y, Chen Q, Wang Z, Zeng M, Chen J, He Z
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
The role of miR-369-3p in proliferation and differentiation of preadipocytes in Aohan fine-wool sheep.
Xue S, Liu K, Zhao L, Zhou L, Gao X, Liu L, Liu N, He J
Archives animal breeding 2023;66(1):93-102
Archives animal breeding 2023;66(1):93-102
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Wu YJ, Zhang SS, Yin Q, Lei M, Wang QH, Chen WG, Luo TT, Zhou P, Ji CL
Drug design, development and therapy 2023;17:563-577
Drug design, development and therapy 2023;17:563-577
Abdominal Massage Ameliorates Inguinal Fat Accumulation via Augmentation of PPARγ Signaling in High-Fat Diet-Induced Obese Mice.
Zhang J, Wang T, Shi Y, Liu Y, Lu T
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:2409-2418
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:2409-2418
Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway.
Chen NN, Ma XD, Miao Z, Zhang XM, Han BY, Almaamari AA, Huang JM, Chen XY, Liu YJ, Su SW
Frontiers in pharmacology 2023;14:1150861
Frontiers in pharmacology 2023;14:1150861
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Tan Y, Kang J, Li H, Zhong A, Liu Y, Zhang Z, Huang R, Cheng X, Peng W
Frontiers in immunology 2023;14:1149810
Frontiers in immunology 2023;14:1149810
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Wang L, Yang K, Jing R, Zhao W, Guo K, Hu Z, Liu G, Xu N, Zhao J, Lin L, Gao S
Frontiers in pharmacology 2023;14:1089537
Frontiers in pharmacology 2023;14:1089537
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Zhang C, Wu X, Shi P, Ma H, Fang F, Feng Q, Zhao S, Zhang R, Huang J, Xu X, Xiao W, Cao G, Ji X
Frontiers in pharmacology 2023;14:1066758
Frontiers in pharmacology 2023;14:1066758
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.
Xu H, Gao K, Liu C, Li T, Ding Y, Ma J
PeerJ 2023;11:e15280
PeerJ 2023;11:e15280
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
Chen X, Shi W, Zhu L, Zhou X, Wang Y
Cellular signalling 2023 Sep;109:110752
Cellular signalling 2023 Sep;109:110752
Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Zeng Q, Zhou TT, Huang WJ, Huang XT, Huang L, Zhang XH, Sang XX, Luo YY, Tian YM, Wu B, Liu L, Luo ZQ, He B, Liu W, Tang SY
Scientific reports 2023 Sep 7;13(1):14706
Scientific reports 2023 Sep 7;13(1):14706
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693
Chemico-biological interactions 2023 Sep 25;383:110693
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress.
Mao Z, Ma X, Jing Y, Shen M, Ma X, Zhu J, Liu H, Zhang G, Chen F
Cell death & disease 2023 Sep 2;14(9):584
Cell death & disease 2023 Sep 2;14(9):584
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway.
Yan SW, Zhang R, Guo X, Wang BN, Long SR, Liu RD, Wang ZQ, Cui J
Veterinary research 2023 Sep 13;54(1):77
Veterinary research 2023 Sep 13;54(1):77
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.
Hong S, Park SK, Lee J, Park SH, Kim YS, Park JH, Yu S, Lee YG
Antioxidants (Basel, Switzerland) 2023 Sep 11;12(9)
Antioxidants (Basel, Switzerland) 2023 Sep 11;12(9)
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Zou TF, Liu ZG, Cao PC, Zheng SH, Guo WT, Wang TX, Chen YL, Duan YJ, Li QS, Liao CZ, Xie ZL, Han JH, Yang XX
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.
Xihui Q, Jianli P, Guan X, Jie F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1200-1208
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1200-1208
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Yang Q, Zou Y, Wei X, Ye P, Wu Y, Ai H, Zhang Z, Tan J, Zhou J, Yang Y, Dai Q, Dou C, Luo F
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Song Y, Sun W, Li W, Li W
International immunopharmacology 2023 Oct;123:110751
International immunopharmacology 2023 Oct;123:110751
Protective effects and mechanisms of Yi Qi Huo Xue Fang in cerebral ischemic stroke based on network pharmacology and experimental verification.
Li J, Zhang T, Liu K, Hu G
Journal of ethnopharmacology 2023 Oct 5;314:116611
Journal of ethnopharmacology 2023 Oct 5;314:116611
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.
Nakamura A, Sakai S, Taketomi Y, Tsuyama J, Miki Y, Hara Y, Arai N, Sugiura Y, Kawaji H, Murakami M, Shichita T
Neuron 2023 Oct 4;111(19):2995-3010.e9
Neuron 2023 Oct 4;111(19):2995-3010.e9
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Korean red ginseng formula attenuates non-alcoholic fatty liver disease in oleic acid-induced HepG2 cells and high-fat diet-induced rats.
Zheng M, Li Y, Dong Z, Zhang Y, Xi Z, Yuan M, Xu H
Heliyon 2023 Nov;9(11):e21846
Heliyon 2023 Nov;9(11):e21846
PPARγ regulates lipid metabolism and viability of sheep trophoblast cells.
Hao K, Liu X, Chen Y, Zeng W, Chen L, Wang J, Hu G
Reproduction in domestic animals = Zuchthygiene 2023 Nov;58(11):1559-1568
Reproduction in domestic animals = Zuchthygiene 2023 Nov;58(11):1559-1568
Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling.
Schuermans N, El Chehadeh S, Hemelsoet D, Gautheron J, Vantyghem MC, Nouioua S, Tazir M, Vigouroux C, Auclair M, Bogaert E, Dufour S, Okawa F, Hilbert P, Van Doninck N, Taquet MC, Rosseel T, De Clercq G, Debackere E, Van Haverbeke C, Cherif FR, Urtizberea JA, Chanson JB, Funalot B, Authier FJ, Kaya S, Terryn W, Callens S, Depypere B, Van Dorpe J, Program for Undiagnosed Diseases (UD-PrOZA), Poppe B, Impens F, Mizushima N, Depienne C, Jéru I, Dermaut B
Nature genetics 2023 Nov;55(11):1929-1940
Nature genetics 2023 Nov;55(11):1929-1940
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.
Ni S, Yi N, Yuan H, Li D, Chen X, Zhuang C
Phytotherapy research : PTR 2023 Nov;37(11):5394-5406
Phytotherapy research : PTR 2023 Nov;37(11):5394-5406
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Tang T, Xu Y, Wang L, Zhang P
Biotechnology journal 2023 Nov;18(11):e2300108
Biotechnology journal 2023 Nov;18(11):e2300108
Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
Hua B, Qiu J, Ye X, Kuang Y, Liu X
International immunopharmacology 2023 Nov;124(Pt B):111014
International immunopharmacology 2023 Nov;124(Pt B):111014
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Yan S, Ding J, Wang Z, Zhang F, Li J, Zhang Y, Wu S, Yang L, Pang X, Zhang Y, Yang J
International immunopharmacology 2023 Nov;124(Pt A):110840
International immunopharmacology 2023 Nov;124(Pt A):110840
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene.
Jiayao C, Jiaoling W, Chengyu H, Guixiang W, Linquan Z
Obesity research & clinical practice 2023 Nov-Dec;17(6):499-510
Obesity research & clinical practice 2023 Nov-Dec;17(6):499-510
Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
Tee JH, Vijayakumar U, Shanmugasundaram M, Lam TYW, Liao W, Yang Y, Wong WSF, Ge R
Respiratory research 2023 Nov 6;24(1):269
Respiratory research 2023 Nov 6;24(1):269
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization.
Hou C, Yan L, Sun K, Zhou T, Zou Y, Xiong W, Duan SZ
Cell death discovery 2023 Nov 29;9(1):429
Cell death discovery 2023 Nov 29;9(1):429
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation.
Liu Y, He T, Li Z, Sun Z, Wang S, Shen H, Hou L, Li S, Wei Y, Zhuo B, Li S, Zhou C, Guo H, Zhang R, Li B
iScience 2023 Nov 17;26(11):108312
iScience 2023 Nov 17;26(11):108312
Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Xiao-Yao-San in the Treatment of Inflammatory Response in CUMS Mice.
Zhang Y, Li XJ, Wang XR, Wang X, Li GH, Xue QY, Zhang MJ, Ao HQ
Pharmaceuticals (Basel, Switzerland) 2023 Nov 14;16(11)
Pharmaceuticals (Basel, Switzerland) 2023 Nov 14;16(11)
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Guo F, Xiong H, Tsao R, Shahidi F, Wen X, Liu J, Jiang L, Sun Y
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Chen B, Wu J, Hu S, Liu Q, Yang H, You Y
Neurochemical research 2023 May;48(5):1504-1515
Neurochemical research 2023 May;48(5):1504-1515
Impaired PPARγ activation by cadmium exacerbates infection-induced lung injury.
Larson-Casey JL, Liu S, Pyles JM, Lapi SE, Saleem K, Antony VB, Gonzalez ML, Crossman DK, Carter AB
JCI insight 2023 May 8;8(9)
JCI insight 2023 May 8;8(9)
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J
Life sciences 2023 May 15;321:121571
Life sciences 2023 May 15;321:121571
Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.
Wang YN, Yu L, Wang T, Liu S
International journal of biological macromolecules 2023 May 1;236:123998
International journal of biological macromolecules 2023 May 1;236:123998
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Fructooligosaccharides attenuate non-alcoholic fatty liver disease by remodeling gut microbiota and association with lipid metabolism.
Huang X, Chen Q, Fan Y, Yang R, Gong G, Yan C, Song Y, Zhang B, Xi S, Huang Y, Xu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114300
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114300
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X, Liu D
Journal of neuroinflammation 2023 Mar 29;20(1):86
Journal of neuroinflammation 2023 Mar 29;20(1):86
A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.
Li Y, Li Z, Chen R, Lian M, Wang H, Wei Y, You Z, Zhang J, Li B, Li Y, Huang B, Chen Y, Liu Q, Lyu Z, Liang X, Miao Q, Xiao X, Wang Q, Fang J, Shi Y, Liu X, Seldin MF, Gershwin ME, Tang R, Ma X
Nature communications 2023 Mar 28;14(1):1732
Nature communications 2023 Mar 28;14(1):1732
An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.
Ruan GY, Ye LX, Lin JS, Lin HY, Yu LR, Wang CY, Mao XD, Zhang SH, Sun PM
Journal of translational medicine 2023 Mar 17;21(1):204
Journal of translational medicine 2023 Mar 17;21(1):204
Shared Genes of PPARG and NOS2 in Alzheimer's Disease and Ulcerative Colitis Drive Macrophages and Microglia Polarization: Evidence from Bioinformatics Analysis and Following Validation.
Dong L, Shen Y, Li H, Zhang R, Yu S, Wu Q
International journal of molecular sciences 2023 Mar 15;24(6)
International journal of molecular sciences 2023 Mar 15;24(6)
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Wang Z, Jian G, Chen T, Chen Y, Li J, Wang N
European journal of histochemistry : EJH 2023 Mar 1;67(1)
European journal of histochemistry : EJH 2023 Mar 1;67(1)
Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
Gao W, Zhang L, Wu J, Xu Y, Qi S, Liu W, Liu P, Shi S, Wang H, Zhang Q, Wang Y, Wang S
International journal of biological macromolecules 2023 Mar 1;230:123252
International journal of biological macromolecules 2023 Mar 1;230:123252
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Zhang P, Sun Y, Shi L, Sun D, Wang L, Feng D, Ding C
Tissue & cell 2023 Jun;82:102048
Tissue & cell 2023 Jun;82:102048
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
The role of PPARγ in intermittent hypoxia-related human umbilical vein endothelial cell injury.
Ning-Fang L, Yong-Xu J, Jia C, Cai-Yun W, Jie-Feng H, Qi-Chang L
Sleep & breathing = Schlaf & Atmung 2023 Jun;27(3):1155-1164
Sleep & breathing = Schlaf & Atmung 2023 Jun;27(3):1155-1164
5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.
Zong Y, Wang M, Liu Y, Suo X, Fan G, Yang X
Life sciences 2023 Jun 15;323:121703
Life sciences 2023 Jun 15;323:121703
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Cheng X, Han X, Zhou L, Sun Y, Zhou Q, Lin X, Gao Z, Wang J, Zhao W
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ.
Feng Z, Gao Z, Kong R, Zhuang T, Liu J, Liu T, Zheng X, Bai Y, Yao R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114815
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114815
PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.
Gou Q, Che S, Chen M, Chen H, Shi J, Hou Y
Cancer science 2023 Jul;114(7):2871-2881
Cancer science 2023 Jul;114(7):2871-2881
PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.
Jia X, Qian J, Chen H, Liu Q, Hussain S, Jin J, Shi J, Hou Y
European journal of pharmacology 2023 Jul 5;950:175749
European journal of pharmacology 2023 Jul 5;950:175749
Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway.
Guo F, Xiong H, Tsao R, Wen X, Liu J, Chen D, Jiang L, Sun Y
Food & function 2023 Jul 31;14(15):7195-7208
Food & function 2023 Jul 31;14(15):7195-7208
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
Shi M, Yang S, Huang X, Wang S, Li W, Yun J, Lu C, Yang Y, Cai C, Gao P, Guo X, Li B, Cao G
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.
Pan Z, Chen X, Wu D, Li X, Gao W, Li G, Du G, Zhang C, Jin S, Geng Z
International journal of molecular sciences 2023 Jan 7;24(2)
International journal of molecular sciences 2023 Jan 7;24(2)
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
Lin W, Shen P, Huang Y, Han L, Ba X, Huang Y, Yan J, Li T, Xu L, Qin K, Chen Z, Tu S
Journal of ethnopharmacology 2023 Jan 30;301:115802
Journal of ethnopharmacology 2023 Jan 30;301:115802
Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition.
Deng Y, Dong G, Meng Y, Noinaj N, Huang R
Journal of medicinal chemistry 2023 Jan 26;66(2):1601-1615
Journal of medicinal chemistry 2023 Jan 26;66(2):1601-1615
Millet Bran Protein Hydrolysate Displays the Anti-non-alcoholic Fatty Liver Disease Effect via Activating Peroxisome Proliferator-Activated Receptor γ to Restrain Fatty Acid Uptake.
Shan S, Zhou J, Yin R, Zhang L, Shi J, Qiao Q, Li Z
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1628-1642
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1628-1642
Nuciferine improves cardiac function in mice subjected to myocardial ischemia/reperfusion injury by upregulating PPAR-γ.
Li R, Qin X, Yue L, Liu W, Gao Y, Zhu F, Wang D, Zhou Q
Heliyon 2023 Feb;9(2):e13630
Heliyon 2023 Feb;9(2):e13630
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.
Zhang Z, Zhu Z, Fu J, Liu X, Mi Z, Tao H, Fan H
International immunopharmacology 2023 Feb;115:109684
International immunopharmacology 2023 Feb;115:109684
circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep.
Zhao B, Zhang H, Zhao D, Liang Y, Qiao L, Liu J, Pan Y, Yang K, Liu W
International journal of molecular sciences 2023 Feb 9;24(4)
International journal of molecular sciences 2023 Feb 9;24(4)
Effects of the CDC10 (Septin 7) Gene on the Proliferation and Differentiation of Bovine Intramuscular Preadipocyte and 3T3-L1 Cells.
Cheng Z, Li X, Bao S, Yamada T, Cao G, Liu J, Chen A, Tong B
Animals : an open access journal from MDPI 2023 Feb 9;13(4)
Animals : an open access journal from MDPI 2023 Feb 9;13(4)
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
[A convenient and time-saving method for primary culture of mature white adipocytes from mice].
Shentu Z, Gong X, Yang H
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Feb 20;43(2):213-218
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Feb 20;43(2):213-218
Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia.
Xie X, Zhang W, Zhou X, Xu B, Wang H, Qiu Y, Hu Y, Guo B, Ye Z, Hu L, Zhang H, Li Y, Bai X
Oncogene 2023 Dec;42(50):3657-3669
Oncogene 2023 Dec;42(50):3657-3669
Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling.
Zhang M, Hou L, Tang W, Lei W, Lin H, Wang Y, Long H, Lin S, Chen Z, Wang G, Zhao G
Journal of cellular and molecular medicine 2023 Dec;27(24):4155-4170
Journal of cellular and molecular medicine 2023 Dec;27(24):4155-4170
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Chen Y, Li Q, Zhao S, Sun L, Yin Z, Wang X, Li X, Iwakiri Y, Han J, Duan Y
Biochemical pharmacology 2023 Dec;218:115928
Biochemical pharmacology 2023 Dec;218:115928
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.
Ren X, Guo Q, Jiang H, Han X, He X, Liu H, Xiu Z, Dong Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155106
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155106
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients.
Yan L, Jiang MY, Fan XS
Journal of ethnopharmacology 2023 Dec 5;317:116773
Journal of ethnopharmacology 2023 Dec 5;317:116773
Diethylaminoethyl-dextran and monocyte cell membrane coated 1,8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis.
Jiang F, Wu G, Yang H, Zhang Y, Shen X, Tao L
International journal of biological macromolecules 2023 Dec 31;253(Pt 7):127365
International journal of biological macromolecules 2023 Dec 31;253(Pt 7):127365
Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithelial Homeostasis and Ameliorates Colitis.
Jean Wilson E, Sirpu Natesh N, Ghadermazi P, Pothuraju R, Prajapati DR, Pandey S, Kaifi JT, Dodam JR, Bryan JN, Lorson CL, Watrelot AA, Foster JM, Mansell TJ, Joshua Chan SH, Batra SK, Subbiah J, Rachagani S
International journal of molecular sciences 2023 Dec 30;25(1)
International journal of molecular sciences 2023 Dec 30;25(1)
Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D.
Liao Y, Zhu Z, Liu Y, Wu J, Li D, Li Z, Xu J, Yang R, Wang L
Cell communication and signaling : CCS 2023 Dec 21;21(1):366
Cell communication and signaling : CCS 2023 Dec 21;21(1):366
An optimized protocol for chromatin immunoprecipitation from murine inguinal white adipose tissue.
Katsouda A, Valakos D, Vatsellas G, Thanos D, Papapetropoulos A
STAR protocols 2023 Dec 15;4(4):102594
STAR protocols 2023 Dec 15;4(4):102594
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
Deng X, Zhang N, Wang Q, Huang Y, Huang Y, Lin Y, Huang M, Zheng F, Xiao M, Ye J
European journal of nutrition 2023 Aug;62(5):2177-2194
European journal of nutrition 2023 Aug;62(5):2177-2194
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
Tang T, Wei Y, Jia H, Wang L, Xu Y, Zhang P
Biotechnology journal 2023 Aug;18(8):e2200634
Biotechnology journal 2023 Aug;18(8):e2200634
1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-γ/TXNIP pathways.
Liu Z, Gan S, Fu L, Xu Y, Wang S, Zhang G, Pan D, Tao L, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114978
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114978
MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets.
Han Z, Li L, Zhao H, Wang R, Yan F, Tao Z, Fan J, Zheng Y, Zhao F, Huang Y, Tian Y, Li G, Luo Y
Translational stroke research 2023 Aug;14(4):589-607
Translational stroke research 2023 Aug;14(4):589-607
PPARγ agonist inhibits c-Myc-mediated colorectal cancer tumor immune escape.
Xu L, Che S, Chen H, Liu Q, Shi J, Jin J, Hou Y
Journal of cellular biochemistry 2023 Aug;124(8):1145-1154
Journal of cellular biochemistry 2023 Aug;124(8):1145-1154
C1q(+) tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion.
Zhang S, Peng W, Wang H, Xiang X, Ye L, Wei X, Wang Z, Xue Q, Chen L, Su Y, Zhou Q
Journal for immunotherapy of cancer 2023 Aug;11(8)
Journal for immunotherapy of cancer 2023 Aug;11(8)
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Tian J, Zhang L, La X, Fan X, Li A, Wu C, An Y, Yan S, Dong X, Wu H, Li Z
Cellular signalling 2023 Aug;108:110719
Cellular signalling 2023 Aug;108:110719
Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway.
Li Y, Zhang ZH, Huang SL, Yue ZB, Yin XS, Feng ZQ, Zhang XG, Song GL
Journal of dairy science 2023 Aug;106(8):5253-5265
Journal of dairy science 2023 Aug;106(8):5253-5265
RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect.
Wu J, Wang X, Zhang M, Mathews P, Kang Y
Cells 2023 Aug 3;12(15)
Cells 2023 Aug 3;12(15)
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Jiang W, Chen Y, Sun M, Huang X, Zhang H, Fu Z, Wang J, Zhang S, Lian C, Tang B, Xiang D, Wang Y, Zhang Y, Jian C, Yang C, Zhang J, Zhang D, Chen T, Zhang J
Cell reports 2023 Aug 29;42(8):112969
Cell reports 2023 Aug 29;42(8):112969
Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.
Wu ZY, Luo L, Kan YQ, Qin ML, Li HT, He QZ, Zeng HC
Toxics 2023 Aug 26;11(9)
Toxics 2023 Aug 26;11(9)
PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis.
Xue X, Dai T, Chen J, Xu Y, Yang Z, Huang J, Xu W, Li S, Meng Q
Journal of orthopaedic surgery and research 2023 Aug 24;18(1):620
Journal of orthopaedic surgery and research 2023 Aug 24;18(1):620
Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis.
Jean Wilson E, Sirpu Natesh N, Ghadermazi P, Pothuraju R, Shanmugam M, Prajapati DR, Pandey S, Kaifi JT, Dodam JR, Bryan J, Lorson CL, Watrelot AA, Foster JM, Mansel TJ, Joshua Chan SH, Batra SK, Subbiah J, Rachagani S
bioRxiv : the preprint server for biology 2023 Aug 24;
bioRxiv : the preprint server for biology 2023 Aug 24;
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Lu P, Li X, Li B, Li X, Wang C, Liu Z, Ji Y, Wang X, Wen Z, Fan J, Yi C, Song M, Wang X
European journal of pharmacology 2023 Aug 15;953:175835
European journal of pharmacology 2023 Aug 15;953:175835
Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway.
Su Q, Huang J, Chen X, Wang Y, Shao M, Yan H, Chen C, Ren H, Zhang F, Ni Y, Jose PA, Zhong J, Yang J
Molecular nutrition & food research 2023 Apr;67(7):e2200589
Molecular nutrition & food research 2023 Apr;67(7):e2200589
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.
Liu F, Cao L, Hu S, Ye H, Wu Q, Wu L
Cellular immunology 2023 Apr;386:104704
Cellular immunology 2023 Apr;386:104704
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249
Physiological research 2023 Apr 30;72(2):235-249
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
He T, Wang S, Li S, Shen H, Hou L, Liu Y, Wei Y, Xie F, Zhang Z, Zhao Z, Mo C, Guo H, Huang Q, Zhang R, Shen D, Li B
iScience 2023 Apr 21;26(4):106289
iScience 2023 Apr 21;26(4):106289
Upregulated estrogen receptors impairs myogenesis and elevates adipogenesis related factor levels in the paravertebral muscles of patients with idiopathic scoliosis.
Shu Q, Yang G, Tang M, Guo C, Zhang H, Li J
Biochemical and biophysical research communications 2023 Apr 16;652:22-30
Biochemical and biophysical research communications 2023 Apr 16;652:22-30
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Shang K, Ma N, Che J, Li H, Hu J, Sun H, Cao B
BMC cancer 2023 Apr 11;23(1):335
BMC cancer 2023 Apr 11;23(1):335
Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet.
Zhang Y, Jia XB, Liu YC, Yu WQ, Si YH, Guo SD
Frontiers in nutrition 2022;9:971581
Frontiers in nutrition 2022;9:971581
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Cui L, Li Z, Xu F, Tian Y, Chen T, Li J, Guo Y, Lyu Q
Nutrition and cancer 2022;74(4):1399-1410
Nutrition and cancer 2022;74(4):1399-1410
Smilax china Polyphenols Stimulate Browning via [Formula: see text]3-Adrenergic Receptor/AMP-Activated Protein Kinase [Formula: see text] Signaling Pathway in 3T3-L1 Adipocytes.
Kong L, Xu M, Yang L, Liu S, Zheng G
The American journal of Chinese medicine 2022;50(5):1315-1329
The American journal of Chinese medicine 2022;50(5):1315-1329
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Yan R, Zhang Y, Yang Y, Liu L, Liu L, Guo Z, Yu H, Wang Y, Guo B
BioMed research international 2022;2022:9018379
BioMed research international 2022;2022:9018379
Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21.
Huang R, Zou C, Zhang C, Wang X, Zou X, Xiang Z, Wang Z, Gui B, Lin T, Hu H
Oxidative medicine and cellular longevity 2022;2022:7142314
Oxidative medicine and cellular longevity 2022;2022:7142314
Protective Effect of Shengmaiyin in Myocardial Hypertrophy-Induced Rats: A Genomic Analysis by 16S rDNA.
Ming S, Kan M, Liu L, Zhang Z, Liu X, Liu Y, Li Z, Zhang Y, Pang Q, Lin J, Li H, Yang Q, Sui X, Qu X, Li N
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3188292
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3188292
Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.
Wang M, Xiang Q, Sun W, Zhang H, Shi R, Guo J, Tong H, Fan M, Ding Y, Shi H, Yu P, Shen L, Wang Q, Chen X
Oxidative medicine and cellular longevity 2022;2022:2226168
Oxidative medicine and cellular longevity 2022;2022:2226168
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Fang Y, Dou R, Huang S, Han L, Fu H, Yang C, Song J, Zheng J, Zhang X, Liu K, Xiang Z, Zhang X, Wang S, Xiong B
International journal of biological sciences 2022;18(7):3082-3101
International journal of biological sciences 2022;18(7):3082-3101
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
Liu L, Fu Q, Li T, Shao K, Zhu X, Cong Y, Zhao X
PloS one 2022;17(2):e0262855
PloS one 2022;17(2):e0262855
Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's mouse model.
Weng H, Song W, Fu K, Guan Y, Cai G, Huang E, Chen X, Zou H, Ye Q
Frontiers in neuroscience 2022;16:1035444
Frontiers in neuroscience 2022;16:1035444
Effects of PPARD gene variants on the therapeutic responses to exenatide in chinese patients with type 2 diabetes mellitus.
Song J, Li N, Hu R, Yu Y, Xu K, Ling H, Lu Q, Yang T, Wang T, Yin X
Frontiers in endocrinology 2022;13:949990
Frontiers in endocrinology 2022;13:949990
Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.
Yang S, Cao S, Li C, Zhang J, Liu C, Qiu F, Kang N
Frontiers in pharmacology 2022;13:913378
Frontiers in pharmacology 2022;13:913378
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats.
Ge Y, Zhen F, Liu Z, Feng Z, Wang G, Zhang C, Wang X, Sun Y, Zheng X, Bai Y, Yao R
Frontiers in pharmacology 2022;13:766744
Frontiers in pharmacology 2022;13:766744
Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation.
Zhao B, Fu J, Ni H, Xu L, Xu C, He Q, Ni C, Wang Y, Kuang J, Tang M, Shou Q, Yao M
Frontiers in pharmacology 2022;13:1010483
Frontiers in pharmacology 2022;13:1010483
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex.
Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H, Li B
Theranostics 2022;12(18):7699-7716
Theranostics 2022;12(18):7699-7716
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Role and mechanism of the zinc finger protein ZNF580 in foam-cell formation.
Zhang Z, Qin X, Liu J, Li Y, Chen H, Xie H, Chen J, Li C, Tong Y, Yang M, Zhang M
Experimental and therapeutic medicine 2022 Sep;24(3):579
Experimental and therapeutic medicine 2022 Sep;24(3):579
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.
Gao Y, Ma K, Kang Y, Liu W, Liu X, Long X, Hayashi T, Hattori S, Mizuno K, Fujisaki H, Ikejima T
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Sep;1867(9):159181
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Sep;1867(9):159181
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Cheng J, Xu D, Chen L, Guo W, Hu G, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway.
Fang H, Wang H, Zeng C, Fu H, Zhao B, Liu A, Yan J
Toxicology in vitro : an international journal published in association with BIBRA 2022 Oct;84:105430
Toxicology in vitro : an international journal published in association with BIBRA 2022 Oct;84:105430
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo.
Zhou J, Wang J, Qu M, Huang X, Yin L, Liao Y, Huang F, Ning P, Zhong P, Zeng Y
Bioelectromagnetics 2022 Oct;43(7):438-447
Bioelectromagnetics 2022 Oct;43(7):438-447
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
He H, Liu M, He R, Zhao W
Food & function 2022 Oct 3;13(19):10265-10274
Food & function 2022 Oct 3;13(19):10265-10274
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
Zheng J, Duan Y, Zheng C, Yu J, Li F, Guo Q, Yin Y
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.
Magusto J, Beaupère C, Afonso MB, Auclair M, Delaunay JL, Soret PA, Courtois G, Aït-Slimane T, Housset C, Jéru I, Fève B, Ratziu V, Rodrigues CMP, Gautheron J
iScience 2022 Oct 21;25(10):105166
iScience 2022 Oct 21;25(10):105166
PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo.
Sha Y, Wu J, Paul B, Zhao Y, Mathews P, Li Z, Norris J, Wang E, McDonnell DP, Kang Y
Cancer letters 2022 Oct 1;545:215832
Cancer letters 2022 Oct 1;545:215832
The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Wang F, Guo L, Wu Z, Zhang T, Dong D, Wu B
The Journal of pharmacy and pharmacology 2022 Nov 4;74(11):1640-1650
The Journal of pharmacy and pharmacology 2022 Nov 4;74(11):1640-1650
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Hu J, Deng Y, Ding T, Dong J, Liang Y, Lou B
Acta biochimica et biophysica Sinica 2022 Nov 25;55(1):117-130
Acta biochimica et biophysica Sinica 2022 Nov 25;55(1):117-130
Rectal administration of butyrate ameliorates pulmonary fibrosis in mice through induction of hepatocyte growth factor in the colon via the HDAC-PPARγ pathway.
Zhang W, Zhang Q, Zhu Y, Zhang Y, Xia Y, Wei Z, Dai Y
Life sciences 2022 Nov 15;309:120972
Life sciences 2022 Nov 15;309:120972
Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats.
Otsuji J, Hayashi Y, Hitomi S, Soma C, Soma K, Shibuta I, Iwata K, Shirakawa T, Shinoda M
Scientific reports 2022 Nov 11;12(1):19314
Scientific reports 2022 Nov 11;12(1):19314
Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis.
Zou T, Ma L, Gu L, Xi S, Zhang K, Guo X
Chemico-biological interactions 2022 Nov 1;367:110145
Chemico-biological interactions 2022 Nov 1;367:110145
Serpina3c regulates adipose differentiation via the Wnt/β-catenin-PPARγ pathway.
Guo J, Qian L, Ji J, Ji Z, Jiang Y, Wu Y, Yang Z, Ma G, Yao Y
Cellular signalling 2022 May;93:110299
Cellular signalling 2022 May;93:110299
Acid-treated high-amylose corn starch suppresses high-fat diet-induced steatosis.
Yoshida R, Yano Y, Hoshi N, Okamoto N, Sui Y, Yamamoto A, Asaji N, Shiomi Y, Yasutomi E, Hatazawa Y, Hayashi H, Ueda Y, Kodama Y
Journal of food science 2022 May;87(5):2173-2184
Journal of food science 2022 May;87(5):2173-2184
PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.
Ye X, Wu Y, Xu J, Liu H, Wang H, Li Q, Li Q, Xuan A
Pharmacological research 2022 May;179:106235
Pharmacological research 2022 May;179:106235
Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Shi JH, Yang DJ, Jin Q, Cheng N, Shi YB, Bai Y, Yu DS, Guo WZ, Ge GB, Zhang SJ
Scientific reports 2022 May 6;12(1):7446
Scientific reports 2022 May 6;12(1):7446
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.
Qi W, Li X, Ren Y, Liu X, Fu H, Wang X, Li X, Xiong J, Zheng Q, Cai D, Liang F
Chinese medicine 2022 May 17;17(1):57
Chinese medicine 2022 May 17;17(1):57
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.
Xiong L, Huang J, Wang S, Yuan Q, Yang D, Zheng Z, Wu Y, Wu C, Gao Y, Zou L, Hu G
Archives of toxicology 2022 Mar;96(3):767-781
Archives of toxicology 2022 Mar;96(3):767-781
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.
Zhang M, Yang P, Yu T, Harmsen MC, Gao M, Liu D, Shi Y, Liu Y, Zhang X
Heliyon 2022 Mar;8(3):e09128
Heliyon 2022 Mar;8(3):e09128
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Huang H, Chen J, Hu X, Chen Y, Xie J, Ao T, Wang H, Xie J, Yu Q
Food & function 2022 Mar 7;13(5):2710-2728
Food & function 2022 Mar 7;13(5):2710-2728
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I
BMC medicine 2022 Mar 28;20(1):95
BMC medicine 2022 Mar 28;20(1):95
CRISPR/Cas9-Mediated Knockout of miR-130b Affects Mono- and Polyunsaturated Fatty Acid Content via PPARG-PGC1α Axis in Goat Mammary Epithelial Cells.
Huang L, Luo J, Song N, Gao W, Zhu L, Yao W
International journal of molecular sciences 2022 Mar 26;23(7)
International journal of molecular sciences 2022 Mar 26;23(7)
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy.
Chen L, You Q, Liu M, Li S, Wu Z, Hu J, Ma Y, Xia L, Zhou Y, Xu N, Zhang S
eLife 2022 Mar 24;11
eLife 2022 Mar 24;11
MicroRNA 573 Rescues Endothelial Dysfunction during Dengue Virus Infection under PPARγ Regulation.
Banerjee S, Xin CW, Chu JJH
Journal of virology 2022 Mar 23;96(6):e0199621
Journal of virology 2022 Mar 23;96(6):e0199621
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Wang Q, Wang L, Abdullah, Tian W, Song M, Cao Y, Xiao J
Food & function 2022 Mar 21;13(6):3419-3430
Food & function 2022 Mar 21;13(6):3419-3430
Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.
Wang Z, Chen X, Liu J, Wang Y, Zhang S
Autoimmunity 2022 Jun;55(4):223-232
Autoimmunity 2022 Jun;55(4):223-232
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression.
Chen M, Zhu H, Zhu Q, Wu X, Zhou Y, Gao R, Shi M, Zhang T, Yin T, Zhang H, Shang H, Li X
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):661-673
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):661-673
Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco.
Zhuo MQ, Chen J, Wu ML, Wang WB
Fish physiology and biochemistry 2022 Jun;48(3):571-583
Fish physiology and biochemistry 2022 Jun;48(3):571-583
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
Wang Y, Zhang J, Chu X, Wang M, Xin Y, Liu S
Lipids in health and disease 2022 Jun 15;21(1):54
Lipids in health and disease 2022 Jun 15;21(1):54
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation.
Ouyang Z, Kang D, Li K, Liang G, Liu Z, Mai Q, Chen Q, Yao C, Wei R, Tan X, Bai X, Huang B, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113164
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113164
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway.
Duan P, Wang H, Yi X, Zhang H, Chen H, Pan Z
Stem cell research & therapy 2022 Jul 26;13(1):342
Stem cell research & therapy 2022 Jul 26;13(1):342
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
Zhang J, Yan E, Zhang L, Wang T, Wang C
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth.
Liu J, Zhao H, Yang L, Wang X, Yang L, Xing Y, Lv X, Ma H, Song G
BMC endocrine disorders 2022 Jan 4;22(1):10
BMC endocrine disorders 2022 Jan 4;22(1):10
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Zhang X, Jiang L, Chen H, Wei S, Yao K, Sun X, Yang G, Jiang L, Zhang C, Wang N, Wang Y, Liu X
Toxicology 2022 Jan 15;465:153048
Toxicology 2022 Jan 15;465:153048
Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis.
Wu J, Lin T, Gao Y, Li X, Yang C, Zhang K, Wang C, Zhou X
Molecular and cellular endocrinology 2022 Jan 1;539:111490
Molecular and cellular endocrinology 2022 Jan 1;539:111490
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
Qi Y, Zhang H, Fan H, Wang X, Zhao A, Tian Y, Yang G, Li C, Wei J, Yao W, Hao C
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells.
Kobari L, Auclair M, Piau O, Ferrand N, Zaoui M, Delhommeau F, Fève B, Sabbah M, Garderet L
Leukemia 2022 Feb;36(2):540-548
Leukemia 2022 Feb;36(2):540-548
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Gao Z, Zhang C, Feng Z, Liu Z, Yang Y, Yang K, Chen L, Yao R
Experimental neurology 2022 Feb;348:113947
Experimental neurology 2022 Feb;348:113947
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease.
Li J, Chen L, Qin Q, Wang D, Zhao J, Gao H, Yuan X, Zhang J, Zou Y, Mao Z, Xiong Y, Min Z, Yan M, Wang CY, Xue Z
Neurobiology of disease 2022 Feb;163:105605
Neurobiology of disease 2022 Feb;163:105605
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Tan Z, Ren H, Liu Y, Yang H, Luo Q, Deng X
Experimental and therapeutic medicine 2022 Dec;24(6):737
Experimental and therapeutic medicine 2022 Dec;24(6):737
Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice.
Wang Y, Liu T, Xie Y, Li N, Liu Y, Wen J, Zhang M, Feng W, Huang J, Guo Y, Kabbas Junior T, Wang D, Granato D
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112008
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112008
Myoblast-derived exosomes promote the repair and regeneration of injured skeletal muscle in mice.
Ji S, Ma P, Cao X, Wang J, Yu X, Luo X, Lu J, Hou W, Zhang Z, Yan Y, Dong Y, Wang H
FEBS open bio 2022 Dec;12(12):2213-2226
FEBS open bio 2022 Dec;12(12):2213-2226
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.
Zhang L, Zhang H, Gu J, Xu W, Yuan N, Sun J, Li H
International immunopharmacology 2022 Dec;113(Pt B):109433
International immunopharmacology 2022 Dec;113(Pt B):109433
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Tan X, Zhu T, Zhang L, Fu L, Hu Y, Li H, Li C, Zhang J, Liang B, Liu J
Adipocyte 2022 Dec;11(1):120-132
Adipocyte 2022 Dec;11(1):120-132
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Li H, Huang Z, Zeng F
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Angiogenesis-Browning Interplay Mediated by Asprosin-Knockout Contributes to Weight Loss in Mice with Obesity.
Yin T, Chen S, Zeng G, Yuan W, Lu Y, Zhang Y, Huang Q, Xiong X, Xu B, Huang Q
International journal of molecular sciences 2022 Dec 18;23(24)
International journal of molecular sciences 2022 Dec 18;23(24)
Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation.
He H, Chen C, Zhao W
International journal of biological macromolecules 2022 Dec 1;222(Pt B):3057-3065
International journal of biological macromolecules 2022 Dec 1;222(Pt B):3057-3065
PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT.
Zhang Q, Feng W, Wang Q, Wang J, Chai L, Chen Y, Wang Y, Liu J, Li M, Xie X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113233
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113233
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.
Chen PW, Tseng SY, Chang HY, Lee CH, Chao TH
International journal of molecular sciences 2022 Aug 29;23(17)
International journal of molecular sciences 2022 Aug 29;23(17)
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice.
Pei Z, Ma L, Li Y, Yang J, Yang Q, Yao W, Li S
Frontiers in bioscience (Landmark edition) 2022 Aug 15;27(8):244
Frontiers in bioscience (Landmark edition) 2022 Aug 15;27(8):244
Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.
Xie P, Guo M, Xie JB, Xiao MY, Qi YS, Duan Y, Li FF, Piao XL
Journal of ethnopharmacology 2022 Aug 10;294:115335
Journal of ethnopharmacology 2022 Aug 10;294:115335
Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice.
Xiao Z, Shen D, Lan T, Wei C, Wu W, Sun Q, Luo Z, Chen W, Zhang Y, Hu L, Zhang C, Wang Y, Lu Y, Wang P, Yang F, Li Q
Redox biology 2022 Apr;50:102256
Redox biology 2022 Apr;50:102256
Inhibition of DNA methylation de-represses peroxisome proliferator-activated receptor-γ and attenuates pulmonary fibrosis.
Wei A, Gao Q, Chen F, Zhu X, Chen X, Zhang L, Su X, Dai J, Shi Y, Cao W
British journal of pharmacology 2022 Apr;179(7):1304-1318
British journal of pharmacology 2022 Apr;179(7):1304-1318
The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα.
Miao Y, Zhang C, Yang L, Zeng X, Hu Y, Xue X, Dai Y, Wei Z
Cell communication and signaling : CCS 2022 Apr 7;20(1):48
Cell communication and signaling : CCS 2022 Apr 7;20(1):48
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y
Food & function 2022 Apr 20;13(8):4399-4420
Food & function 2022 Apr 20;13(8):4399-4420
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome.
Bryant C, Rask G, Waller AP, Webb A, Galdino-Pitta MR, Amato AA, Cianciolo R, Govindarajan R, Becknell B, Kerlin BA, Neves FAR, Fornoni A, Agrawal S
iScience 2022 Apr 15;25(4):104001
iScience 2022 Apr 15;25(4):104001
Gold nanoclusters eliminate obesity induced by antipsychotics.
He M, Yao J, Zhang Z, Zhang Y, Chen R, Gu Z, Huang X, Deng C, Zhou R, Fan J, Zhang B, Xie Y, Gao G, Sun T
Scientific reports 2022 Apr 1;12(1):5502
Scientific reports 2022 Apr 1;12(1):5502
PPARγ/SOD2 Protects Against Mitochondrial ROS-Dependent Apoptosis via Inhibiting ATG4D-Mediated Mitophagy to Promote Pancreatic Cancer Proliferation.
Nie S, Shi Z, Shi M, Li H, Qian X, Peng C, Ding X, Zhang S, Lv Y, Wang L, Kong B, Zou X, Shen S
Frontiers in cell and developmental biology 2021;9:745554
Frontiers in cell and developmental biology 2021;9:745554
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
Li W, Wang S, Zhang H, Li B, Xu L, Li Y, Kong C, Jiao H, Wang Y, Pang Y, Qin W, Jia L, Jia J
Journal of Alzheimer's disease : JAD 2021;82(4):1475-1485
Journal of Alzheimer's disease : JAD 2021;82(4):1475-1485
The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.
Huang L, Zhang J, Zhu X, Mi X, Li Q, Gao J, Zhou J, Zhou J, Liu XM
Frontiers in nutrition 2021;8:756803
Frontiers in nutrition 2021;8:756803
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
Wu J, Lai G, Chen F, Zhang B, Zhao Y
Kidney & blood pressure research 2021;46(5):601-612
Kidney & blood pressure research 2021;46(5):601-612
Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α.
Zhou Y, Yin T, Shi M, Chen M, Wu X, Wang K, Cheang I, Li Y, Shang H, Zhang H, Li X
PPAR research 2021;2021:9947656
PPAR research 2021;2021:9947656
Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons.
Fu J, Zhao B, Ni C, Ni H, Xu L, He Q, Xu M, Xu C, Luo G, Zhu J, Tao J, Yao M
PPAR research 2021;2021:6086265
PPAR research 2021;2021:6086265
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Ma J, Zeng P, Liu L, Zhu M, Zheng J, Wang C, Zhao X, Hu W, Yang X, Duan Y, Han J, Miao QR, Chen Y
Frontiers in pharmacology 2021;12:817784
Frontiers in pharmacology 2021;12:817784
Identification of miRNA in Sheep Intramuscular Fat and the Role of miR-193a-5p in Proliferation and Differentiation of 3T3-L1.
Han F, Zhou L, Zhao L, Wang L, Liu L, Li H, Qiu J, He J, Liu N
Frontiers in genetics 2021;12:633295
Frontiers in genetics 2021;12:633295
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Lin L, Chen S, Wang H, Gao B, Kallakury B, Bhuvaneshwar K, Cahn K, Gusev Y, Wang X, Wu Y, Marshall JL, Zhi X, He AR
Theranostics 2021;11(9):4232-4250
Theranostics 2021;11(9):4232-4250
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.
Jiang MJ, Li L, Huang WF, Su J, Li YH, Qu XS, Fan LL
Journal of natural medicines 2021 Sep;75(4):884-892
Journal of natural medicines 2021 Sep;75(4):884-892
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Okubo K, Miyai K, Kato K, Asano T, Sato A
Translational oncology 2021 Sep;14(9):101154
Translational oncology 2021 Sep;14(9):101154
Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.
Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534
ACS nano 2021 Sep 28;15(9):14522-14534
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.
Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP
Cell death discovery 2021 Sep 27;7(1):265
Cell death discovery 2021 Sep 27;7(1):265
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Chen L, Yin Y, Liu G
Annals of translational medicine 2021 Oct;9(20):1547
Annals of translational medicine 2021 Oct;9(20):1547
Mechanisms of impaired mitochondrial homeostasis and NAD(+) metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.
Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML
Redox biology 2021 Oct;46:102038
Redox biology 2021 Oct;46:102038
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
Su H, Liu N, Zhang Y, Kong J
Journal of advanced research 2021 Nov;33:69-80
Journal of advanced research 2021 Nov;33:69-80
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z
Nature communications 2021 Nov 2;12(1):6314
Nature communications 2021 Nov 2;12(1):6314
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
mTOR regulates PRMT1 expression and mitochondrial mass through STAT1 phosphorylation in hepatic cell.
Zhang X, Li L, Li Y, Li Z, Zhai W, Sun Q, Yang X, Roth M, Lu S
Biochimica et biophysica acta. Molecular cell research 2021 May;1868(6):119017
Biochimica et biophysica acta. Molecular cell research 2021 May;1868(6):119017
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.
Chen Y, Wu R, Chen W, Liu Y, Liao X, Zeng B, Guo G, Lou F, Xiang Y, Wang Y, Wang X
EMBO reports 2021 May 5;22(5):e52146
EMBO reports 2021 May 5;22(5):e52146
A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.
Guo Y, Zhu X, Zeng M, Qi L, Tang X, Wang D, Zhang M, Xie Y, Li H, Yang X, Chen D
Translational psychiatry 2021 May 27;11(1):328
Translational psychiatry 2021 May 27;11(1):328
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Asila A, Yang X, Kaisaer Y, Ma L
The journal of gene medicine 2021 Mar;23(3):e3296
The journal of gene medicine 2021 Mar;23(3):e3296
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Xiong L, Huang J, Gao Y, Gao Y, Wu C, He S, Zou L, Yang D, Han Y, Yuan Q, Zheng Z, Hu G
Toxicology research 2021 Mar;10(2):277-283
Toxicology research 2021 Mar;10(2):277-283
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Li YL, Li YQ, Zeng FQ, Lin XY, Li XT, Ren XQ, Yang DL
The Journal of pharmacy and pharmacology 2021 Mar 4;73(2):145-151
The Journal of pharmacy and pharmacology 2021 Mar 4;73(2):145-151
Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models.
Wang Y, Guo S, Jia Y, Yu X, Mou R, Li X
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):786-797
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):786-797
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model.
Zhao D, Pan Y, Yu N, Bai Y, Ma R, Mo F, Zuo J, Chen B, Jia Q, Zhang D, Liu J, Jiang G, Gao S
Royal Society open science 2021 Mar 17;8(3):200974
Royal Society open science 2021 Mar 17;8(3):200974
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Chen Y, Dai Y, Song K, Huang Y, Zhang L, Zhang C, Yan Q, Gao H
Cell death & disease 2021 Jun 3;12(6):572
Cell death & disease 2021 Jun 3;12(6):572
Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-κB and in a PPARγ-dependent manner.
Zhou JP, Yang XN, Song Y, Zhou F, Liu JJ, Hu YQ, Chen LG
Experimental and therapeutic medicine 2021 Jul;22(1):743
Experimental and therapeutic medicine 2021 Jul;22(1):743
Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.
Zheng S, Huang H, Li Y, Wang Y, Zheng Y, Liang J, Zhang S, Liu M, Fang Z
Pharmacological research 2021 Jul;169:105639
Pharmacological research 2021 Jul;169:105639
Effects of energy supplements on the differentiation of skeletal muscle satellite cells.
Su R, Wang B, Zhang M, Luo Y, Wang D, Zhao L, Su L, Duan Y, Faucitano L, Jin Y
Food science & nutrition 2021 Jan;9(1):357-366
Food science & nutrition 2021 Jan;9(1):357-366
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.
Zhou L, Wang S, Cao L, Ren X, Li Y, Shao J, Xu L
International journal of environmental health research 2021 Jan;31(1):34-44
International journal of environmental health research 2021 Jan;31(1):34-44
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ.
Chen R, Wang K, Feng Z, Zhang MY, Wu J, Geng JJ, Chen ZN
Cellular & molecular immunology 2021 Jan;18(1):171-181
Cellular & molecular immunology 2021 Jan;18(1):171-181
Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.
Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD
Cells 2021 Jan 20;10(2)
Cells 2021 Jan 20;10(2)
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring.
Lin XH, Gao L, Tian S, Klausen C, Guo MX, Gao Q, Liu ME, Wang H, Wu DD, Zhou CL, Yang J, Meng Y, Liu Y, Xu GF, Tan YJ, Ullah K, Zhu YM, Fraser WD, Sheng JZ, Leung PCK, Muglia LJ, Wu YT, Huang HF
Scientific reports 2021 Jan 11;11(1):316
Scientific reports 2021 Jan 11;11(1):316
Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.
Wang X, Song T, Sun Y, Men L, Gu Y, Zhang S, Chen X
Journal of proteome research 2021 Jan 1;20(1):960-971
Journal of proteome research 2021 Jan 1;20(1):960-971
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway.
Wang XQ, Tang YH, Zeng GR, Wu LF, Zhou YJ, Cheng ZN, Jiang DJ
Psychopharmacology 2021 Feb;238(2):501-516
Psychopharmacology 2021 Feb;238(2):501-516
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Wang W, Xu RL, He P, Chen R
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis.
Huang Y, Yang Q, Mi X, Qiu L, Tao X, Zhang Z, Xia J, Wu Q, Wei H
Journal of agricultural and food chemistry 2021 Feb 24;69(7):2190-2203
Journal of agricultural and food chemistry 2021 Feb 24;69(7):2190-2203
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.
Zhou Y, Wang C, Kou J, Wang M, Rong X, Pu X, Xie X, Han G, Pang X
Pharmaceutical biology 2021 Dec;59(1):1378-1387
Pharmaceutical biology 2021 Dec;59(1):1378-1387
Bergenin alleviates H(2) O(2) -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway.
Zhang G, Wang H, Zhang Q, Zhao Z, Zhu W, Zuo X
Environmental toxicology 2021 Dec;36(12):2541-2550
Environmental toxicology 2021 Dec;36(12):2541-2550
Decreased expression of PPARγ is associated with aortic endothelial cell apoptosis in intermittently hypoxic rats.
Lian N, Chen M, Zhang S, Chen L, Huang J, Lin Q
Sleep & breathing = Schlaf & Atmung 2021 Dec;25(4):2241-2250
Sleep & breathing = Schlaf & Atmung 2021 Dec;25(4):2241-2250
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
Zhao L, Luo R, Yu H, Li S, Yu Q, Wang W, Cai K, Xu T, Chen R, Tian W
Iranian journal of basic medical sciences 2021 Dec;24(12):1734-1742
Iranian journal of basic medical sciences 2021 Dec;24(12):1734-1742
IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
Hsu YH, Wu CH, Chiu CJ, Chen WT, Chang YC, Wabitsch M, Chang MS
Immunology 2021 Dec;164(4):817-833
Immunology 2021 Dec;164(4):817-833
Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet.
Kai Y, Gao J, Liu H, Wang Y, Tian C, Guo S, He L, Li M, Tian Z, Song X
International immunopharmacology 2021 Dec;101(Pt A):108209
International immunopharmacology 2021 Dec;101(Pt A):108209
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
Ding RR, Huang GY, Zhang YJ, Sun HL, Liu YM, Xu Z, Li WJ, Li X
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Liu H, Wang M, Jin Z, Sun D, Zhu T, Liu X, Tan X, Shi G
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.
Mou Q, Ji B, Zhao G, Liu Y, Sakurai R, Xie Y, Zhang Q, Dai J, Lu Y, Ge Y, Shi T, Xu S, Rehan VK
Pediatric pulmonology 2021 Aug;56(8):2537-2545
Pediatric pulmonology 2021 Aug;56(8):2537-2545
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway.
Liu J, Zhang Y, Yu C, Zhang P, Gu S, Wang G, Xiao H, Li S
Drug development research 2021 Apr;82(2):278-286
Drug development research 2021 Apr;82(2):278-286
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.
Li Z, Zheng M, Mo J, Li K, Yang X, Guo L, Zhang X, Abdalla BA, Nie Q
Journal of pineal research 2021 Apr;70(3):e12725
Journal of pineal research 2021 Apr;70(3):e12725
A small nucleolar RNA, SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway.
He Y, Wu Y, Mei B, Fang X, Cai G, Cai N, Wu Q, Huang Z, Ge C, Liang H, Zhang B, Chen X, Chu L
Journal of cellular physiology 2021 Apr;236(4):3001-3014
Journal of cellular physiology 2021 Apr;236(4):3001-3014
Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.
Chen R, Huang S, Lin T, Ma H, Shan W, Duan F, Lv J, Zhang J, Ren L, Nie L
Nature nanotechnology 2021 Apr;16(4):455-465
Nature nanotechnology 2021 Apr;16(4):455-465
Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.
Lou HX, Fu WC, Chen JX, Li TT, Jiang YY, Liu CH, Zhang W
BMC complementary medicine and therapies 2021 Apr 22;21(1):128
BMC complementary medicine and therapies 2021 Apr 22;21(1):128
Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia.
Nguyen TD, Miyatake Y, Yoshida T, Kawahara H, Hanayama R
International journal of cancer 2021 Apr 15;148(8):1982-1992
International journal of cancer 2021 Apr 15;148(8):1982-1992
ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression.
Cheng WL, Zhang Q, Cao JL, Chen XL, Li W, Zhang L, Chao SP, Zhao F
Journal of atherosclerosis and thrombosis 2021 Apr 1;28(4):375-384
Journal of atherosclerosis and thrombosis 2021 Apr 1;28(4):375-384
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.
Lu R, Zheng Z, Yin Y, Jiang Z
Food & nutrition research 2020;64
Food & nutrition research 2020;64
Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPARγ and LPL Gene in a High-Fat Diet C57BL/6 Mice Model.
Zhang M, Shao Y, Gao B, Chen J, Zhang P, Hu Y, Ding S
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9102475
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9102475
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway.
Yang H, Gan S, Jiang Z, Song X, Chen T, Xu Y, Fu L, Zhang Y, Tao L, Shen X
Chinese medicine 2020;15:4
Chinese medicine 2020;15:4
Alveolar Epithelial Cells Promote IGF-1 Production by Alveolar Macrophages Through TGF-β to Suppress Endogenous Inflammatory Signals.
Mu M, Gao P, Yang Q, He J, Wu F, Han X, Guo S, Qian Z, Song C
Frontiers in immunology 2020;11:1585
Frontiers in immunology 2020;11:1585
Sevoflurane Protects against Intestinal Ischemia-Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-κB Pathway in Rats.
Liu C, Ding R, Huang W, Miao L, Li J, Li Y
Pharmacology 2020;105(3-4):231-242
Pharmacology 2020;105(3-4):231-242
Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma.
Ni G, Wang K, Zhou Y, Wu X, Wang J, Shang H, Wang L, Li X
Annals of translational medicine 2020 Sep;8(17):1064
Annals of translational medicine 2020 Sep;8(17):1064
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Li DY, Tian YK, Ye DW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.
Gelfand CA, Sakurai R, Wang Y, Liu Y, Segal R, Rehan VK
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Kim TW, Hong DW, Kang CM, Hong SH
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Tissue Inhibitor of Metalloprotease-1 (TIMP-1) Regulates Adipogenesis of Adipose-derived Stem Cells (ASCs) via the Wnt Signaling Pathway in an MMP-independent Manner.
Wang L, Zhang CG, Jia YL, Hu L
Current medical science 2020 Oct;40(5):989-996
Current medical science 2020 Oct;40(5):989-996
The total flavonoids from Selaginella tamariscina (beauv.) Spring improve glucose and lipid metabolism in db/db mice.
Wang X, Feng A, Yuan P, Fu Y, Bai Z, Zhou N, Zheng X
Iranian journal of basic medical sciences 2020 Oct;23(10):1286-1292
Iranian journal of basic medical sciences 2020 Oct;23(10):1286-1292
3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells.
Lu J, Lu J, Chen Y, Feng Z, Liu S, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111575
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111575
Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.
Yang T, Chen J, Gao L, Huang Y, Liao G, Cao Y
Toxicology letters 2020 Oct 10;332:65-73
Toxicology letters 2020 Oct 10;332:65-73
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.
Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866
Drug development research 2020 Nov;81(7):859-866
Citri Reticulatae Pericarpium protects against isoproterenol-induced chronic heart failure via activation of PPARγ.
Cheng H, Wu X, Ni G, Wang S, Peng W, Zhang H, Gao J, Li X
Annals of translational medicine 2020 Nov;8(21):1396
Annals of translational medicine 2020 Nov;8(21):1396
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Ye L, Chen T, Cao J, Sun L, Li W, Zhang C
International journal of oncology 2020 Nov;57(5):1116-1128
International journal of oncology 2020 Nov;57(5):1116-1128
Unconservative_15_2570409 suppresses progesterone receptor expression in the granulosa cells of Hu sheep.
Yao X, Wang Z, Gao X, Li X, Yang H, Ei-Samahy MA, Bao Y, Xiao S, Meng F, Wang F
Theriogenology 2020 Nov;157:303-313
Theriogenology 2020 Nov;157:303-313
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Chen Y, Yan Q, Lv M, Song K, Dai Y, Huang Y, Zhang L, Zhang C, Gao H
Cell death & disease 2020 Nov 20;11(11):994
Cell death & disease 2020 Nov 20;11(11):994
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.
Lei XX, Liu Y, Wang JX, Cai Q, Yan M, He HP, Liu Q, Long ZJ, Guan Z
Cell death & disease 2020 May 7;11(5):331
Cell death & disease 2020 May 7;11(5):331
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Wei L, Zhao C, Dong S, Yao S, Ji B, Zhao B, Liu Z, Liu X, Wang Y
Food & function 2020 May 1;11(5):3952-3963
Food & function 2020 May 1;11(5):3952-3963
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ(12,14) -PGJ(2) and Nogo.
Zhang S, Yu M, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao QR, Hu W, Hajjar DP, Zhu Y, Han J, Duan Y
British journal of pharmacology 2020 Mar;177(5):1041-1060
British journal of pharmacology 2020 Mar;177(5):1041-1060
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Xu L, Xia H, Ni D, Hu Y, Liu J, Qin Y, Zhou Q, Yi Q, Xie Y
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function.
Shen Y, Su Y, Silva FJ, Weller AH, Sostre-Colón J, Titchenell PM, Steger DJ, Seale P, Soccio RE
Cell reports 2020 Mar 3;30(9):3079-3091.e5
Cell reports 2020 Mar 3;30(9):3079-3091.e5
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in health and disease 2020 Mar 13;19(1):39
Lipids in health and disease 2020 Mar 13;19(1):39
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Zhou RJ, Zhao Y, Fan K, Xie ML
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 23;117(25):14280-14291
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 23;117(25):14280-14291
The opposite functions of miR-24 in the osteogenesis and adipogenesis of adipose-derived mesenchymal stem cells are mediated by the HOXB7/β-catenin complex.
Liu Z, Deng Y, Li T, Zhu F, Zhou X, He Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9034-9050
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9034-9050
m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Shi H, Wang F, Wang Y
Autophagy 2020 Jul;16(7):1221-1235
Autophagy 2020 Jul;16(7):1221-1235
Tributyltin reduces bone mineral density by reprograming bone marrow mesenchymal stem cells in rat.
Yao W, Wei X, Guo H, Cheng D, Li H, Sun L, Wang S, Guo D, Yang Y, Si J
Environmental toxicology and pharmacology 2020 Jan;73:103271
Environmental toxicology and pharmacology 2020 Jan;73:103271
Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma.
Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y, Chen Y
Cellular signalling 2020 Jan;65:109429
Cellular signalling 2020 Jan;65:109429
PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis.
Jiang YP, Tang YL, Wang SS, Wu JS, Zhang M, Pang X, Wu JB, Chen Y, Tang YJ, Liang XH
Cell proliferation 2020 Jan;53(1):e12705
Cell proliferation 2020 Jan;53(1):e12705
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, Yao W, Tao J, Tu M, Xiong B, Zhao L, Liu Z
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway.
Wu H, Zhu H, Zhuang Y, Zhang J, Ding X, Zhan L, Luo S, Zhang Q, Sun F, Zhang M, Pan Z, Lu Y
Journal of cellular and molecular medicine 2020 Jan;24(1):737-746
Journal of cellular and molecular medicine 2020 Jan;24(1):737-746
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Ma M, Wang C, Ao Y, He N, Hao F, Liang H, Liu D
Molecular and cellular probes 2020 Feb;49:101491
Molecular and cellular probes 2020 Feb;49:101491
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hang H, Wang LK, Ren SY, Song AJ, Wu GF
Current medical science 2020 Feb;40(1):55-62
Current medical science 2020 Feb;40(1):55-62
Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.
Ling Y, Shi Z, Yang X, Cai Z, Wang L, Wu X, Ye A, Jiang J
Experimental gerontology 2020 Feb;130:110786
Experimental gerontology 2020 Feb;130:110786
Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.
Ling SC, Zhuo MQ, Zhang DG, Cui HY, Luo Z
International journal of molecular sciences 2020 Feb 27;21(5)
International journal of molecular sciences 2020 Feb 27;21(5)
PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.
Guo J, Ren R, Yao X, Ye Y, Sun K, Lin J, Wang G, Guo F, Xiao J, Xu T
Aging 2020 Feb 25;12(4):3976-3992
Aging 2020 Feb 25;12(4):3976-3992
Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway.
Duan L, Ma Y, Wang Y, Liu J, Tan Z, Wu Q, Wu Y, Yu X
International journal of molecular medicine 2020 Dec;46(6):2260-2270
International journal of molecular medicine 2020 Dec;46(6):2260-2270
CB11, a novel purine-based PPARɣ ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells.
Kim TW, Hong DW, Park JW, Hong SH
British journal of cancer 2020 Dec;123(12):1737-1748
British journal of cancer 2020 Dec;123(12):1737-1748
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.
Su ZL, Hang PZ, Hu J, Zheng YY, Sun HQ, Guo J, Liu KY, Du ZM
Acta pharmacologica Sinica 2020 Aug;41(8):1085-1092
Acta pharmacologica Sinica 2020 Aug;41(8):1085-1092
Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
Luo Y, Peng J, Huang C, Cao Y
Ecotoxicology and environmental safety 2020 Aug;199:110714
Ecotoxicology and environmental safety 2020 Aug;199:110714
Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ(1).
Cui L, Xu F, Wu K, Li L, Qiao T, Li Z, Chen T, Sun C
European journal of pharmacology 2020 Aug 15;881:173230
European journal of pharmacology 2020 Aug 15;881:173230
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Zhang H, Zhao F, Peng A, Guo S, Wang M, Elsabagh M, Loor JJ, Wang H
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Huang Y, Wang C, Tian X, Mao Y, Hou B, Sun Y, Gu X, Ma Z
Inflammation 2020 Apr;43(2):568-578
Inflammation 2020 Apr;43(2):568-578
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
Ji X, Liu T, Zhao S, Li J, Li L, Wang E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
IL-29 promoted obesity-induced inflammation and insulin resistance.
Lin TY, Chiu CJ, Kuan CH, Chen FH, Shen YC, Wu CH, Hsu YH
Cellular & molecular immunology 2020 Apr;17(4):369-379
Cellular & molecular immunology 2020 Apr;17(4):369-379
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Zhu Y, Yu F, Tan Y, Hong Y, Meng T, Liu Y, Dai S, Qiu G, Yuan H, Hu F
Theranostics 2019;9(23):6764-6779
Theranostics 2019;9(23):6764-6779
Effect of MicroRNA-20a on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells.
Luo T, Yang X, Sun Y, Huang X, Zou L, Liu J
Cells, tissues, organs 2019;208(3-4):148-157
Cells, tissues, organs 2019;208(3-4):148-157
UHRF1 Promotes Proliferation of Human Adipose-Derived Stem Cells and Suppresses Adipogenesis via Inhibiting Peroxisome Proliferator-Activated Receptor γ.
Chen K, Guo Z, Luo Y, Yuan J, Mo Z
BioMed research international 2019;2019:9456847
BioMed research international 2019;2019:9456847
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J, Zhou Y
Mediators of inflammation 2019;2019:6175091
Mediators of inflammation 2019;2019:6175091
A Network Pharmacology Approach for Uncovering the Osteogenic Mechanisms of Psoralea corylifolia Linn.
Ge L, Cheng K, Han J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2160175
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2160175
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation.
Huang YH, Kuo HC, Yang YL, Wang FS
International journal of medical sciences 2019;16(2):212-220
International journal of medical sciences 2019;16(2):212-220
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Cathelicidin-WA Facilitated Intestinal Fatty Acid Absorption Through Enhancing PPAR-γ Dependent Barrier Function.
Zong X, Cao X, Wang H, Xiao X, Wang Y, Lu Z
Frontiers in immunology 2019;10:1674
Frontiers in immunology 2019;10:1674
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Hydroxytyrosol prevents PM(2.5)-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model.
Wang N, Ma Y, Liu Z, Liu L, Yang K, Wei Y, Liu Y, Chen X, Sun X, Wen D
Free radical biology & medicine 2019 Sep;141:393-407
Free radical biology & medicine 2019 Sep;141:393-407
PPAR Gamma-Regulated MicroRNA 199a-5p Underlies Bone Marrow Adiposity in Aplastic Anemia.
Zhang X, Liu L, Dou C, Cheng P, Liu L, Liu H, Ren S, Wang C, Jia S, Chen L, Zhang H, Chen M
Molecular therapy. Nucleic acids 2019 Sep 6;17:678-687
Molecular therapy. Nucleic acids 2019 Sep 6;17:678-687
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Ding S, Huang J, Qiu H, Chen R, Zhang J, Huang B, Cheng O, Jiang Q
Experimental cell research 2019 Sep 1;382(1):111455
Experimental cell research 2019 Sep 1;382(1):111455
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression.
Huang X, Chen W, Yan C, Yang R, Chen Q, Xu H, Huang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109258
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109258
MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice.
Lin HY, Wang FS, Yang YL, Huang YH
Cells 2019 Oct 22;8(10)
Cells 2019 Oct 22;8(10)
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Wang Y, He G, Wang F, Zhang C, Ge Z, Zheng X, Deng H, Yuan C, Zhou B, Tao X, Zhang J, Tang K
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
Journal of cellular and molecular medicine 2019 Nov;23(11):7535-7544
Rosiglitazone attenuates paraquat-induced lung fibrosis in rats in a PPAR gamma-dependent manner.
Zhang H, You L, Zhao M
European journal of pharmacology 2019 May 15;851:133-143
European journal of pharmacology 2019 May 15;851:133-143
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, Huang L, Chen X, LeRoith D, Liang B, Li X, Wu Y
iScience 2019 Jun 28;16:106-121
iScience 2019 Jun 28;16:106-121
Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Hao Z, Zhang Z, Lu D, Ding B, Shu L, Zhang Q, Wang C
Chemical research in toxicology 2019 Jun 17;32(6):1250-1258
Chemical research in toxicology 2019 Jun 17;32(6):1250-1258
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.
Xu P, Guo H, Wang H, Lee SC, Liu M, Pan Y, Zheng J, Zheng K, Wang H, Xie Y, Bai X, Liu Y, Zhao M, Wang L
Toxicology 2019 Jul 1;423:112-122
Toxicology 2019 Jul 1;423:112-122
Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
Ding S, Qiu H, Huang J, Chen R, Zhang J, Huang B, Zou X, Cheng O, Jiang Q
Chemico-biological interactions 2019 Jul 1;307:116-124
Chemico-biological interactions 2019 Jul 1;307:116-124
Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells.
Zhang Q, Bai J, Yao X, Jiang L, Wu W, Yang L, Gao N, Qiu T, Yang G, Habtemariam Hidru T, Sun X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:815-822
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:815-822
EETs/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy.
Zhang J, Qiu H, Huang J, Ding S, Huang B, Zhou P, Jiang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1498-1505
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1498-1505
Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.
Zhu Y, Wang Y, Jia Y, Xu J, Chai Y
Stem cell research & therapy 2019 Jan 22;10(1):37
Stem cell research & therapy 2019 Jan 22;10(1):37
Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice.
Jiang F, Wu G, Li W, Yang J, Yan J, Wang Y, Yao W, Zhou X, He Z, Wu L, Xiao C, Xiao T, Zhang M, Shen X, Tao L
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Jan 15;127:14-23
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Jan 15;127:14-23
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Xu L, Liu JT, Li K, Wang SY, Xu S
Life sciences 2019 Jan 1;216:140-146
Life sciences 2019 Jan 1;216:140-146
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Wang XM, Wang XY, Huang YM, Chen X, Lü MH, Shi L, Li CP
International journal of molecular medicine 2019 Dec;44(6):2201-2212
International journal of molecular medicine 2019 Dec;44(6):2201-2212
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Cai Z, Liang Y, Xing C, Wang H, Hu P, Li J, Huang H, Wang W, Jiang C
Oncology reports 2019 Dec;42(6):2537-2549
Oncology reports 2019 Dec;42(6):2537-2549
Phenethyl isothiocyanate induces IPEC-J2 cells cytotoxicity and apoptosis via S-G(2)/M phase arrest and mitochondria-mediated Bax/Bcl-2 pathway.
Liu S, Zhu Y, Yan S, Xiao H, Yi J, Li R, Wu J, Wen L
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2019 Dec;226:108574
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2019 Dec;226:108574
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Kao YC, Wei WY, Tsai KJ, Wang LC
International journal of molecular sciences 2019 Dec 27;21(1)
International journal of molecular sciences 2019 Dec 27;21(1)
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Dong Y, Zhang S, Tao J, Zhang X, Zhang J, Yang J, Liang H, Liu D, Cang M
Research in veterinary science 2019 Aug;125:351-359
Research in veterinary science 2019 Aug;125:351-359
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Gao N, Yao X, Jiang L, Yang L, Qiu T, Wang Z, Pei P, Yang G, Liu X, Sun X
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Zheng M, Li YY, Wang GF, Jin JY, Wang YH, Wang TM, Yang L, Liu SY, Wu JS, Wang ZT, Ma YM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108701
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108701
Evaluation of MEDAG gene expression in papillary thyroid microcarcinoma: associations with histological features, regional lymph node metastasis and prognosis.
Song Y, Fu LJ, Li HT, Qiu XG
Scientific reports 2019 Apr 9;9(1):5800
Scientific reports 2019 Apr 9;9(1):5800
Dan-Lou Prescription Inhibits Foam Cell Formation Induced by ox-LDL via the TLR4/NF-κB and PPARγ Signaling Pathways.
Gao LN, Zhou X, Lu YR, Li K, Gao S, Yu CQ, Cui YL
Frontiers in physiology 2018;9:590
Frontiers in physiology 2018;9:590
Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice.
Wang T, Cui X, Xie L, Xing R, You P, Zhao Y, Yang Y, Xu Y, Zeng L, Chen H, Liu M
Frontiers in physiology 2018;9:209
Frontiers in physiology 2018;9:209
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway.
Wang Q, Cai J, Fang C, Yang C, Zhou J, Tan Y, Wang Y, Li Y, Meng X, Zhao K, Yi K, Zhang S, Zhang J, Jiang C, Zhang J, Kang C
Theranostics 2018;8(17):4733-4749
Theranostics 2018;8(17):4733-4749
PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection.
Zhu Y, Ni Y, Liu R, Hou M, Yang B, Song J, Sun H, Xu Z, Ji M
Journal of immunology research 2018;2018:6398078
Journal of immunology research 2018;2018:6398078
Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway.
Yang X, Xiao X, Wang H, Li Y, Wang L, Li G, Deng S
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3450141
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3450141
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124
Neurobiology of disease 2018 Sep;117:114-124
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
Qin DD, Yang YF, Pu ZQ, Liu D, Yu C, Gao P, Chen JC, Zong C, Zhang YC, Li X, Wang XD, Liu YT
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Zhai X, Lin D, Zhao Y, Li W, Yang X
Food & function 2018 Oct 17;9(10):5260-5272
Food & function 2018 Oct 17;9(10):5260-5272
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ.
Zhang JR, Lu QB, Feng WB, Wang HP, Tang ZH, Cheng H, Du Q, Wang YB, Li KX, Sun HJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:711-717
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:711-717
Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.
Chen L, Cao Y, Zhang H, Lv D, Zhao Y, Liu Y, Ye G, Chai Y
Journal of ethnopharmacology 2018 Jun 12;219:359-368
Journal of ethnopharmacology 2018 Jun 12;219:359-368
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Zhang J, Qiu H, Huang J, Ding S, Huang B, Wu Q, Jiang Q
Biochemical and biophysical research communications 2018 Jul 7;502(1):55-61
Biochemical and biophysical research communications 2018 Jul 7;502(1):55-61
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
Liu L, Pan Y, Zhai C, Zhu Y, Ke R, Shi W, Wang J, Yan X, Su X, Song Y, Gao L, Li M
Journal of cellular physiology 2018 Jan;234(1):669-681
Journal of cellular physiology 2018 Jan;234(1):669-681
Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Xie X, Li S, Zhu Y, Liu L, Ke R, Wang J, Yan X, Yang L, Gao L, Zang W, Li M
Molecular biology of the cell 2018 Feb 1;29(3):356-362
Molecular biology of the cell 2018 Feb 1;29(3):356-362
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q
EBioMedicine 2018 Dec;38:178-190
EBioMedicine 2018 Dec;38:178-190
Corilagin Counteracts IL-13Rα1 Signaling Pathway in Macrophages to Mitigate Schistosome Egg-Induced Hepatic Fibrosis.
Li YQ, Chen YF, Dang YP, Wang Y, Shang ZZ, Ma Q, Wang YJ, Zhang J, Luo L, Li QQ, Zhao L
Frontiers in cellular and infection microbiology 2017;7:443
Frontiers in cellular and infection microbiology 2017;7:443
Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway.
Wei L, Mao J, Lu J, Gao J, Zhu D, Tian L, Chen Z, Jia L, Wang L, Fu R
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2228-2242
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2228-2242
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.
Sun H, Zhu X, Lin W, Zhou Y, Cai W, Qiu L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1227-1239
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1227-1239
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, Zong C, Qin D, Wang Y, Yingfeng Yang Y, Wang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression.
Xu J, Pan M, Wang X, Xu L, Li L, Xu C
PPAR research 2017;2017:8130968
PPAR research 2017;2017:8130968
Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
Sun HJ, Chen D, Wang PY, Wan MY, Zhang CX, Zhang ZX, Lin W, Zhang F
Oxidative medicine and cellular longevity 2017;2017:6905217
Oxidative medicine and cellular longevity 2017;2017:6905217
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Xie X, Li S, Zhu Y, Liu L, Pan Y, Wang J, Shi W, Song Y, Yang L, Gao L, Zang W, Li M
Cell and tissue research 2017 Sep;369(3):527-539
Cell and tissue research 2017 Sep;369(3):527-539
miR-148a-3p regulates adipocyte and osteoblast differentiation by targeting lysine-specific demethylase 6b.
Tian L, Zheng F, Li Z, Wang H, Yuan H, Zhang X, Ma Z, Li X, Gao X, Wang B
Gene 2017 Sep 5;627:32-39
Gene 2017 Sep 5;627:32-39
5-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway.
Ke R, Xie X, Li S, Pan Y, Wang J, Yan X, Zang W, Gao L, Li M
Oncotarget 2017 Sep 22;8(42):72910-72920
Oncotarget 2017 Sep 22;8(42):72910-72920
The novel ZIP4 regulation and its role in ovarian cancer.
Fan Q, Cai Q, Li P, Wang W, Wang J, Gerry E, Wang TL, Shih IM, Nephew KP, Xu Y
Oncotarget 2017 Oct 27;8(52):90090-90107
Oncotarget 2017 Oct 27;8(52):90090-90107
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Li F, Zhu Y, Wan Y, Xie X, Ke R, Zhai C, Pan Y, Yan X, Wang J, Shi W, Li M
European journal of pharmacology 2017 Nov 5;814:324-334
European journal of pharmacology 2017 Nov 5;814:324-334
Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.
Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J, Duan Y
Arteriosclerosis, thrombosis, and vascular biology 2017 Jul;37(7):1290-1300
Arteriosclerosis, thrombosis, and vascular biology 2017 Jul;37(7):1290-1300
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1.
Zong C, Qin D, Yu C, Gao P, Chen J, Lu S, Zhang Y, Liu Y, Yang Y, Pu Z, Li X, Fu Y, Guan Q, Wang X
Cellular signalling 2017 Jul;35:129-139
Cellular signalling 2017 Jul;35:129-139
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Ji J, Zeng XN, Cao LL, Zhang L, Zhao Z, Yang DD, Sun XL
Neuropharmacology 2017 Feb;113(Pt A):396-406
Neuropharmacology 2017 Feb;113(Pt A):396-406
Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.
Zhang W, Shen XY, Zhang WW, Chen H, Xu WP, Wei W
Toxicology and applied pharmacology 2017 Feb 1;316:17-26
Toxicology and applied pharmacology 2017 Feb 1;316:17-26
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.
Yang X, Wang Q, Pang ZR, Pan MR, Zhang W
Pharmaceutical biology 2017 Dec;55(1):1207-1214
Pharmaceutical biology 2017 Dec;55(1):1207-1214
Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.
Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin MW, Liu H
Scientific reports 2017 Apr 25;7(1):1123
Scientific reports 2017 Apr 25;7(1):1123
Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.
Sun H, Zhu X, Cai W, Qiu L
International journal of molecular sciences 2017 Apr 17;18(4)
International journal of molecular sciences 2017 Apr 17;18(4)
Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction.
Xiang H, Wang G, Qu J, Xia S, Tao X, Qi B, Zhang Q, Shang D
Frontiers in pharmacology 2016;7:378
Frontiers in pharmacology 2016;7:378
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
Hu Y, Tao X, Han X, Xu L, Yin L, Qi Y, Zhao Y, Xu Y, Wang C, Peng J
Chemico-biological interactions 2016 Oct 25;258:234-44
Chemico-biological interactions 2016 Oct 25;258:234-44
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Chen L, Lv D, Wang D, Chen X, Zhu Z, Cao Y, Chai Y
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.
Zhu WS, Tang CM, Xiao Z, Zhu JN, Lin QX, Fu YH, Hu ZQ, Zhang Z, Yang M, Zheng XL, Wu SL, Shan ZX
Oncotarget 2016 Nov 29;7(48):78331-78342
Oncotarget 2016 Nov 29;7(48):78331-78342
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
Jin M, Wu Y, Wang J, Chen J, Huang Y, Rao J, Feng C
Biochemical and biophysical research communications 2016 May 20;474(1):76-82
Biochemical and biophysical research communications 2016 May 20;474(1):76-82
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Bai J, Yao X, Jiang L, Zhang Q, Guan H, Liu S, Wu W, Qiu T, Gao N, Yang L, Yang G, Sun X
Scientific reports 2016 Jun 13;6:27733
Scientific reports 2016 Jun 13;6:27733
Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE.
Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J, Duan Y
The Journal of biological chemistry 2016 Jul 15;291(29):15108-18
The Journal of biological chemistry 2016 Jul 15;291(29):15108-18
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM.
Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J, Duan Y
The Journal of biological chemistry 2016 Aug 12;291(33):16977-89
The Journal of biological chemistry 2016 Aug 12;291(33):16977-89
Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
Liu X, Liu M, Mo Y, Peng H, Gong J, Li Z, Chen J, Xie J
Iranian journal of basic medical sciences 2016 Apr;19(4):417-22
Iranian journal of basic medical sciences 2016 Apr;19(4):417-22
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.
Lu L, Wang J, Lu H, Zhang G, Liu Y, Wang J, Zhang Y, Shang H, Ji H, Chen X, Duan Y, Li Y
Biochemical and biophysical research communications 2015 Sep 25;465(3):387-93
Biochemical and biophysical research communications 2015 Sep 25;465(3):387-93
Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells.
Zhang S, Liu F, Mao X, Huang J, Yang J, Yin X, Wu L, Zheng L, Wang Q
International journal of oncology 2015 Nov;47(5):1759-66
International journal of oncology 2015 Nov;47(5):1759-66
Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar LM, Pereira L
Journal of virology 2015 May;89(9):5134-47
Journal of virology 2015 May;89(9):5134-47
miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop.
Guan X, Gao Y, Zhou J, Wang J, Zheng F, Guo F, Chang A, Li X, Wang B
Stem cells (Dayton, Ohio) 2015 May;33(5):1589-600
Stem cells (Dayton, Ohio) 2015 May;33(5):1589-600
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J, Duan Y
Scientific reports 2015 Jun 10;5:11219
Scientific reports 2015 Jun 10;5:11219
Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.
Ma X, Li SF, Qin ZS, Ye J, Zhao ZL, Fang HH, Yao ZW, Gu MN, Hu YW
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2015 Jul-Aug;24(4):230-5
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2015 Jul-Aug;24(4):230-5
miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, Yang W, Mo Z
Scientific reports 2015 Jul 7;5:11909
Scientific reports 2015 Jul 7;5:11909
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
Jin Y, Liu K, Peng J, Wang C, Kang L, Chang N, Sun H
Toxicology letters 2015 Jan 5;232(1):149-58
Toxicology letters 2015 Jan 5;232(1):149-58
miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling.
Zhang X, Chang A, Li Y, Gao Y, Wang H, Ma Z, Li X, Wang B
Scientific reports 2015 Dec 11;5:18118
Scientific reports 2015 Dec 11;5:18118
miR-20a regulates adipocyte differentiation by targeting lysine-specific demethylase 6b and transforming growth factor-β signaling.
Zhou J, Guo F, Wang G, Wang J, Zheng F, Guan X, Chang A, Zhang X, Dai C, Li S, Li X, Wang B
International journal of obesity (2005) 2015 Aug;39(8):1282-91
International journal of obesity (2005) 2015 Aug;39(8):1282-91
Systemic adaptation of lipid metabolism in response to low- and high-fat diet in Nile tilapia (Oreochromis niloticus).
He AY, Ning LJ, Chen LQ, Chen YL, Xing Q, Li JM, Qiao F, Li DL, Zhang ML, Du ZY
Physiological reports 2015 Aug;3(8)
Physiological reports 2015 Aug;3(8)
Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients.
Pan X, Wang P, Luo J, Wang Z, Song Y, Ye J, Hou X
Endocrine 2015 Apr;48(3):834-47
Endocrine 2015 Apr;48(3):834-47
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Wang Q, Wang ST, Yang X, You PP, Zhang W
Nutrition research (New York, N.Y.) 2015 Apr;35(4):317-27
Nutrition research (New York, N.Y.) 2015 Apr;35(4):317-27
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways.
Wang G, Ji Y, Li Z, Han X, Guo N, Song Q, Quan L, Wang T, Han W, Pang D, Ouyang H, Tang X
Scientific reports 2014 May 9;4:4905
Scientific reports 2014 May 9;4:4905
miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6.
Wang J, Guan X, Guo F, Zhou J, Chang A, Sun B, Cai Y, Ma Z, Dai C, Li X, Wang B
Cell death & disease 2013 Oct 10;4(10):e845
Cell death & disease 2013 Oct 10;4(10):e845
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
Hong Y, Zhou Y, Wang Y, Xiao S, Liao DJ, Zhao Q
Molecular biology reports 2013 Nov;40(11):6287-93
Molecular biology reports 2013 Nov;40(11):6287-93
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Chang MJ, Xiao JH, Wang Y, Yan YL, Yang J, Wang JL
PloS one 2012;7(12):e50291
PloS one 2012;7(12):e50291
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- U-937 cells were subjected to SDS PAGE followed by western blot with 16643-1-AP(PPARG antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPAR gamma antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPAR gamma. This antibody recognizes human,mouse,rat antigen. The PPAR gamma antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
