25818-1-AP

antibody from Proteintech Group

Targeting: CBL c-Cbl, CBL2, RNF55

Provider product page for 25818-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [23]
Comments [0]
Validations
Western blot [2]

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Product number: 25818-1-AP - Provider product page
Provider: Proteintech Group
Product name: c-Cbl antibody
Antibody type: Polyclonal
Description: KD/KO validated c-Cbl antibody (Cat. #25818-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CBL protein structure - 25818-1-AP shown in red.

Submitted references Kupffer cell calibration of T cell responses via VSIG4-CD5 interaction promotes tumor evasion.

Zhou X, Liu W, Hu J, Yao Q, Zhang F, Wu Q, Li L, Li J, Zhu L, Chen C, Zhang Q, Zhang R, Liu J, Shi C, Zhou H, Guo A, Wang J, Wang J, Hu Q, Li L, Jin T, Zeng Z
Nature immunology 2026 Apr 29;

SPRY1 Interaction with CBL Promotes Vimentin Stabilization to Enhance Malignant Progression and Metastasis in Wilms Tumor.

Huang F, Gao H, Lu Z, Wang Y, Li D, Li X, Sun F
Annals of surgical oncology 2025 Dec;32(13):10193-10212

TCDD inhibits the proliferation of C17.2 cells through the activation of the c-Cbl/β-catenin signaling pathway.

Cong Y, Wu Y, Liu Y, Ai Y, Wang X, Wei C, Ding H, Xu G, Sun W
Toxicology in vitro : an international journal published in association with BIBRA 2025 Apr;104:106014

Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.

Wei W, Li H, Tian S, Zhang C, Liu J, Tao W, Cai T, Dong Y, Wang C, Lu D, Ai Y, Zhang W, Wang H, Liu K, Fan Y, Gao Y, Huang Q, Ma X, Wang B, Zhang X, Huang Y
The Journal of clinical investigation 2025 Apr 15;135(8)

LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia.

Yan JH, Liao KQ, Yao L, Chen JL, Xiong LF, Tao XZ
American journal of translational research 2024;16(1):342-355

c-CBL/LCK/c-JUN/ETS1/CD28 axis restrains childhood asthma by suppressing Th2 differentiation.

Yang N, Wang T
Molecular medicine (Cambridge, Mass.) 2024 Sep 28;30(1):164

NSDHL promotes the degradation of sting in cholangiocarcinoma.

Yu W, Chen J, Tong Y, Zhu L, Deng Y, He J, Zhong C, Cai X
Heliyon 2024 Sep 15;10(17):e37592

c-Cbl induced podocin ubiquitination contributes to the podocytes injury in diabetic nephropathy.

Liang L, He M, Zhou P, Pan S, Chen J, Lv L, Hu M, Zhou S, Liu D, Liu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23662

ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.

He J, Yi J, Ji L, Dai L, Chen Y, Xue W
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69

Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ.

Xu F, Chen H, Zhou C, Zang T, Wang R, Shen S, Li C, Yu Y, Pei Z, Shen L, Qian J, Ge J
Frontiers of medicine 2024 Jun;18(3):465-483

AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression.

Wan S, Liu C, Li C, Wang Z, Zhao G, Li J, Ran W, Zhong X, Li Y, Zhang L, Cui H
Oncogene 2023 Sep;42(39):2905-2918

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells.

Xu L, Shi F, Wu Y, Yao S, Wang Y, Jiang X, Su L, Liu X
Cell communication and signaling : CCS 2023 Apr 21;21(1):83

SERPINA5 promotes tumour cell proliferation by modulating the PI3K/AKT/mTOR signalling pathway in gastric cancer.

Fan M, Xiong X, Han L, Zhang L, Gao S, Liu L, Wang X, Huang C, Tong D, Yang J, Zhao L, Shao Y
Journal of cellular and molecular medicine 2022 Sep;26(18):4837-4846

ZC3H15 promotes glioblastoma progression through regulating EGFR stability.

Hou J, Xu M, Gu H, Pei D, Liu Y, Huang P, Chang H, Cui H
Cell death & disease 2022 Jan 13;13(1):55

The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).

Yang Y, Xiao H, Lin Z, Chen R, Li S, Li C, Sun X, Hei Z, Gong W, Huang H
Biochemical pharmacology 2022 Dec;206:115339

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

Li H, Zhang J, Ke JR, Yu Z, Shi R, Gao SS, Li JF, Gao ZX, Ke CS, Han HX, Xu J, Leng Q, Wu GR, Li Y, Tao L, Zhang X, Sy MS, Li C
Cell reports 2022 Dec 20;41(12):111834

ORP5 promotes tumor metastasis via stabilizing c-Met in renal cell carcinoma.

Song L, Zhang L, Zhou Y, Shao X, Xu Y, Pei D, Wang Q
Cell death discovery 2022 Apr 21;8(1):219

Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.

Chen HK, Li YZ, Ge AN, Zhu YB, Wu SJ, Bai X, Bai HH, Liu YN
European journal of pharmacology 2022 Apr 15;921:174876

Imatinib co-loaded targeted realgar nanocrystal for synergistic therapy of chronic myeloid leukemia.

Wang S, Liu X, Wang S, Ouyang L, Li H, Ding J, Deng G, Zhou W
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:190-200

Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling.

Schwarz JJ, Grundmann L, Kokot T, Kläsener K, Fotteler S, Medgyesi D, Köhn M, Reth M, Warscheid B
Life science alliance 2021 Nov;4(11)

JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.

Ren Y, Chen D, Zhai Z, Chen J, Li A, Liang Y, Zhou J
Cell death discovery 2021 Apr 19;7(1):85

Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells.

Bai X, Jia X, Lu Y, Zhu L, Zhao Y, Cheng W, Shu M, Jin S
Oxidative medicine and cellular longevity 2020;2020:9595036

CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.

Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sy MS, Zhang B, Li C
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CBL antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CBL. This antibody recognizes human, mouse antigen. The CBL antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 25818-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse spleen tissue were subjected to SDS PAGE followed by western blot with 25818-1-AP( CBL Antibody) at dilution of 1:1000
Other comments: WB
Appendix: 25818-1-AP.pdf

: Show more