Tissue expression
Cell line expression

CBL

gene product
c-Cbl, CBL2, RNF55 
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
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1181 antibodies from 48 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
391 antibodies
Abnova Corporation
20 antibodies
GeneTex
13 antibodies
OriGene
19 antibodies
Acris Antibodies GmbH
17 antibodies
Biorbyt
71 antibodies
Proteintech Group
2 antibodies
Novus Biologicals
9 antibodies
Boster Biological Technology
8 antibodies
Invitrogen Antibodies
61 antibodies
Atlas Antibodies
1 antibody
LifeSpan BioSciences, Inc.
139 antibodies
Cusabio Biotech Co., Ltd
14 antibodies
Affinity Biosciences
9 antibodies
Abgent
13 antibodies
Signalway Antibody LLC
2 antibodies
NovoPro Bioscience Inc.
7 antibodies
Arigo
2 antibodies
Santa Cruz Biotechnology
1 antibody
Bioworld Technology, Inc
6 antibodies
Cell Signaling Technology, Inc
6 antibodies
Aviva Systems Biology
8 antibodies
ProSci
5 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
R&D Systems
2 antibodies
RabMAbs
15 antibodies
Abbkine Scientific Co.Ltd.
6 antibodies
Bethyl Laboratories
2 antibodies
Antibodies.com
1 antibody
Abbexa
21 antibodies
NSJ Bioreagents
4 antibodies
Creative Diagnostics
18 antibodies
EMD Millipore
3 antibodies
Everest Biotech
1 antibody
Creative Biolabs
34 antibodies
Leading Biology
7 antibodies
BioLegend
1 antibody
United States Biological
109 antibodies
Miltenyi Biotec
12 antibodies
Abiocode, Inc.
4 antibodies
MyBioSource
12 antibodies
RayBiotech, Inc.
2 antibodies
Abbiotec
1 antibody
HUABIO Research
1 antibody
MilliporeSigma / Merck KGaA
8 antibodies
GenWay
4 antibodies
Rockland Immunochemicals, Inc.
1 antibody