orb67166

antibody from Biorbyt

Targeting: CBL c-Cbl, CBL2, RNF55

Western blot (Data presented on provider website)

Antibody Data

Product number

orb67166

Provider

Biorbyt

Product name

CBL antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal to CBL.E3 ubiquitin-protein ligase CBL is an adapter protein that functions as a negative regulator of manysignaling pathways that are triggered by activation of cell surface receptors. It acts as an E3 ubiquitinproteinligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and thentransfers it to substrates promoting their degradation by the proteasome. CBL plays an important rolein the regulation of osteoblast differentiation and apoptosis and is essential for osteoclastic boneresorption. Defects in CBL are the cause of Noonan syndrome-like disorder with or without juvenilemyelomonocytic leukemia (NSLL).

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 ul

Storage

-20°C