10808-1-AP

antibody from Proteintech Group

Targeting: IFNGR1 CD119, IFNGR

Provider product page for 10808-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [26]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 10808-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10808-1-AP, RRID:AB_2121604
Product name: IFNGR1 antibody
Antibody type: Polyclonal
Description: IFNGR1 antibody (Cat. #10808-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IFNGR1 protein structure - 10808-1-AP shown in red.

Submitted references Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State.

Korcari A, Tauc H, Duggan J, Yun J, Wehbe F, Darmanis S, Modrusan Z, Pappu R, Garfield D, Jasper H, Castillo-Azofeifa D
Aging cell 2026 May;25(5):e70495

ST6Gal1 influences the esophageal squamous cell carcinoma resistance to IFN-γ by regulating the expression of IFN-γ receptor 1.

Zhang K, Zhang N, Zhang Y, Zhao W, Chen S, Song W, Li W
Biochimica et biophysica acta. General subjects 2026 Jun;1870(6):130941

Genome-wide mapping of RNA-protein associations through sequencing.

Qi Z, Xue S, Chen J, Zhao W, Johnson K, Wen X, Charles Richard JL, Lin P, Zhong S
Nature biotechnology 2025 Sep 9;

Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.

Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050

ACSM3 Suppresses Ovarian Cancer Progression by Inactivating the IFN-γ/JAK/STAT3 Signaling Pathway.

Wang J, Sun Y, Wu R
Advanced biology 2025 Mar;9(3):e2400093

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.

Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R
Science (New York, N.Y.) 2025 Mar 28;387(6741):eadq8331

An approach for psoriasis of microneedle patch simultaneously targeting multiple inflammatory cytokines and relapse related T cells.

Huang L, Luo Y, Kuai L, Zhang X, Zhang Y, Yang Z, Fei X, Sun J, Luo Y, Zhao Y, Xue T, Yin W, Chang J, Song J, Li Y, Li B, Li Y
Biomaterials 2025 Jul;318:123120

Impact of absent in melanoma 2 on head and neck squamous cell carcinoma development.

Reinartz DM, Escamilla-Rivera V, Shao M, Tribble SL, Caulin C, Wilson JE
Journal of immunology (Baltimore, Md. : 1950) 2025 Dec 1;214(12):3565-3578

Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis.

Gao Y, You L, Zhou J, Tao X, Jin Z, Wu C, Zhang F, Guo S, Wang H, Guan Y, Luo H, Wu J
Chinese medicine 2025 Aug 25;20(1):134

Systems Network Integration of Transcriptomic, Proteomic, and Bioinformatic Analyses Reveals the Mechanism of XuanYunNing Tablets in Meniere's Disease via JAK-STAT Pathway Modulation.

Jin Z, Wang C, Gao Y, Tao X, Wu C, Guo S, Huang J, Zhou J, Qiao C, Chai K, Chang H, Li C, Zou X, Wu J
Pharmaceuticals (Basel, Switzerland) 2025 Aug 25;18(9)

Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.

Soula M, Unlu G, Welch R, Chudnovskiy A, Uygur B, Shah V, Alwaseem H, Bunk P, Subramanyam V, Yeh HW, Khan A, Heissel S, Goodarzi H, Victora GD, Beyaz S, Birsoy K
Nature 2024 Sep;633(8029):451-458

Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts.

Tian J, Song D, Peng Y, Zhang J, Ma L, Chen Z, Liang L, Zhang Z, Yun X, Zhang L
Ecotoxicology and environmental safety 2024 Mar 15;273:116106

Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.

Jing ZL, Liu GL, Zhou N, Xu DY, Feng N, Lei Y, Ma LL, Tang MS, Tong GH, Tang N, Deng YJ
Scientific reports 2024 Mar 13;14(1):6053

Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis.

Luo R, Liu J, Cheng Q, Shionoya M, Gao C, Wang R
Science advances 2024 Jun 28;10(26):eado6798

Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.

Jain A, Heremans I, Rademaker G, Detomasi TC, Hernandez GA, Zhang J, Gupta S, von Linde T, Lange M, Spacci M, Rohweder P, Anderson D, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R
bioRxiv : the preprint server for biology 2024 Dec 14;

Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia.

Xie X, Zhang W, Zhou X, Xu B, Wang H, Qiu Y, Hu Y, Guo B, Ye Z, Hu L, Zhang H, Li Y, Bai X
Oncogene 2023 Dec;42(50):3657-3669

E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.

Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477

MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer.

Alburquerque-Bejar JJ, Navajas-Chocarro P, Saigi M, Ferrero-Andres A, Morillas JM, Vilarrubi A, Gomez A, Mate JL, Munoz-Marmol AM, Romero OA, Blecua P, Davalos V, Esteller M, Pros E, Llabata P, Torres-Diz M, Esteve-Codina A, Sanchez-Cespedes M
Cell reports. Medicine 2023 Apr 18;4(4):101006

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis.

Qu S, Jiao Z, Lu G, Xu J, Yao B, Wang T, Wang J, Yao Y, Yan X, Wang T, Liang H, Zen K
Molecular therapy oncolytics 2022 Jun 16;25:276-287

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.

Sha X, Dai Y, Chong L, Wei M, Xing M, Zhang C, Li J
Journal of nanobiotechnology 2022 Dec 1;20(1):506

Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells.

Parmigiani E, Ivanek R, Rolando C, Hafen K, Turchinovich G, Lehmann FM, Gerber A, Brkic S, Frank S, Meyer SC, Wakimoto H, Günel M, Louvi A, Mariani L, Finke D, Holländer G, Hutter G, Tussiwand R, Taylor V, Giachino C
Developmental cell 2022 Aug 8;57(15):1847-1865.e9

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.

Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB
Nature communications 2022 Apr 19;13(1):2059

Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.

Du W, Hua F, Li X, Zhang J, Li S, Wang W, Zhou J, Wang W, Liao P, Yan Y, Li G, Wei S, Grove S, Vatan L, Zgodziński W, Majewski M, Wallner G, Chen H, Kryczek I, Fang JY, Zou W
Cancer discovery 2021 Jul;11(7):1826-1843

Impact of adipose tissue or umbilical cord derived mesenchymal stem cells on the immunogenicity of human cord blood derived endothelial progenitor cells.

Tan K, Zheng K, Li D, Lu H, Wang S, Sun X
PloS one 2017;12(5):e0178624

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

Kroczynska B, Blyth GT, Rafidi RL, Majchrzak-Kita B, Xu L, Saleiro D, Kosciuczuk EM, Jemielity J, Su B, Altman JK, Eklund EA, Fish EN, Platanias LC
The Journal of biological chemistry 2017 Mar 17;292(11):4743-4752

Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.

Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart CG, Sarkaria JN, Gutmann DH
Journal of neuropathology and experimental neurology 2008 Dec;67(12):1194-204

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 10808-1-AP(IFNGR1 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IFNGR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFNGR1. This antibody recognizes human antigen. The IFNGR1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10808-1-AP.pdf

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