Antibody data
- Antibody Data
- Antigen structure
- References [59]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 16765-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16765-1-AP, RRID:AB_10641044
- Product name
- IL-1 Alpha antibody
- Antibody type
- Polyclonal
- Description
- IL-1 Alpha antibody (Cat. #16765-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.
The prognostic value of miR-323b-5p in non-small cell lung cancer and its mechanism of targeting IL1A in regulating the proliferation and cell cycle of non-small cell lung cancer cells.
Febuxostat alleviates gout-associated hyperuricemia and inflammation by downregulating IL1A to modulate TLR2/TLR4/NF-κB signaling pathway.
The Pomegranate Peel Polyphenols Protects Acne Vulgaris by Regulating Inflammation Through Notch/NF-κB Signal Pathway.
Synergistic overcoming of cisplatin resistance in ovarian cancer by combined Astragalus Membranaceus and cisplatin treatment: network pharmacology and experimental validation.
Efferocytosis-related signatures identified via Single-cell analysis and machine learning predict TNBC outcomes and immunotherapy response.
Modulating Skin Aging Molecular Targets and Longevity Drivers Through a Novel Natural Product: Rose-Derived Polydeoxyribonucleotide (Rose PDRN).
A senescence-responsive nanodrug amplifies radiotherapy efficacy.
Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease.
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
Rv2741 Promotes Mycobacterium Survival by Modulating Macrophage Function via the IL-1α-MAPK Axis.
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer.
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology.
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
Protocatechuic aldehyde ameliorates psoriasis-like skin inflammation and represses keratinocyte-derived IL-1α and CXCL9 via inhibiting STAT3 activation.
Combining RNA-seq, molecular docking and experimental verification to explore the mechanism of BAM15 as a potential drug for atherosclerosis.
Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis.
IRF1 and IL1A associated with PANoptosis serve as potential immune signatures for lung ischemia reperfusion injury following lung transplantation.
Gabapentin alleviates peripheral nerve sensitization induced by inflammatory arthritis via ionotropic glutamate receptor NR2B subunit.
Targeting microglial GLP1R in epilepsy: A novel approach to modulate neuroinflammation and neuronal apoptosis.
Methacrylated hyaluronic acid/laponite photosensitive, sustained-release hydrogel loaded with bilobalide for enhancing random flap survival through mitigation of endoplasmic reticulum stress.
Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts.
Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis.
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca(2+)/CaMK2b Pathway.
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
Potent anti-inflammatory responses: Role of hydrogen in IL-1α dominated early phase systemic inflammation.
Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer.
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17.
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Neuro death through autophagy via the acetylation of FoxO1 by SIRT2 in the hippocampus of mice in a autism spectrum disorder mice model.
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology.
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model.
EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion.
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Oridonin Delays Aging Through the AKT Signaling Pathway.
Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis.
Celecoxib, Beyond Anti-inflammation, Alleviates Tendon-Derived Stem Cell Senescence in Degenerative Rotator Cuff Tendinopathy.
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer.
Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models.
Gancaonin N from Glycyrrhiza uralensis Attenuates the Inflammatory Response by Downregulating the NF-κB/MAPK Pathway on an Acute Pneumonia In Vitro Model.
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models.
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Telbivudine antagonizes TLR4 to inhibit the epithelial-to-mesenchymal transition in human proximal tubular epithelial cells in vitro.
TLR4 gene in the regulation of periodontitis and its molecular mechanism.
Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA 4-Dependent CCN 1 Secretion.
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Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
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FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
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Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models.
Kimura N, Nakagami G, Minematsu T, Sanada H
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Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Zhao Z, Li J, Zheng B, Liang Y, Shi J, Zhang J, Han X, Chu L, Chu X, Gao Y
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Telbivudine antagonizes TLR4 to inhibit the epithelial-to-mesenchymal transition in human proximal tubular epithelial cells in vitro.
Chen J, Li D, Luo E
International immunopharmacology 2019 Sep;74:105683
International immunopharmacology 2019 Sep;74:105683
TLR4 gene in the regulation of periodontitis and its molecular mechanism.
Qi W, Yang X, Ye N, Li S, Han Q, Huang J, Wu B
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Experimental and therapeutic medicine 2019 Sep;18(3):1961-1966
Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA 4-Dependent CCN 1 Secretion.
Cui S, Xue L, Yang F, Dai S, Han Z, Liu K, Liu B, Yuan Q, Cui Z, Zhang Y, Xu F, Chen Y
Journal of the American Heart Association 2018 Sep 18;7(18):e009111
Journal of the American Heart Association 2018 Sep 18;7(18):e009111
Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration.
Li Y, Shen R, Wen G, Ding R, Du A, Zhou J, Dong Z, Ren X, Yao H, Zhao R, Zhang G, Lu Y, Wu X
Frontiers in pharmacology 2017;8:139
Frontiers in pharmacology 2017;8:139
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The IL 1 alpha antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IL 1 alpha. This antibody recognizes human, mouse antigen. The IL 1 alpha antibody has been validated for the following applications: ELISA, WB analysis.