Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [36]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 16765-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16765-1-AP, RRID:AB_10641044
- Product name
- IL-1 Alpha antibody
- Antibody type
- Polyclonal
- Description
- IL-1 Alpha antibody (Cat. #16765-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts.
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca(2+)/CaMK2b Pathway.
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
Potent anti-inflammatory responses: Role of hydrogen in IL-1α dominated early phase systemic inflammation.
Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer.
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17.
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Neuro death through autophagy via the acetylation of FoxO1 by SIRT2 in the hippocampus of mice in a autism spectrum disorder mice model.
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology.
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model.
EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion.
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Oridonin Delays Aging Through the AKT Signaling Pathway.
Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis.
Celecoxib, Beyond Anti-inflammation, Alleviates Tendon-Derived Stem Cell Senescence in Degenerative Rotator Cuff Tendinopathy.
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer.
Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models.
Gancaonin N from Glycyrrhiza uralensis Attenuates the Inflammatory Response by Downregulating the NF-κB/MAPK Pathway on an Acute Pneumonia In Vitro Model.
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models.
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Telbivudine antagonizes TLR4 to inhibit the epithelial-to-mesenchymal transition in human proximal tubular epithelial cells in vitro.
TLR4 gene in the regulation of periodontitis and its molecular mechanism.
Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA 4-Dependent CCN 1 Secretion.
Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration.
Tian J, Song D, Peng Y, Zhang J, Ma L, Chen Z, Liang L, Zhang Z, Yun X, Zhang L
Ecotoxicology and environmental safety 2024 Mar 15;273:116106
Ecotoxicology and environmental safety 2024 Mar 15;273:116106
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Yang F, Wang P, Dong X, Dai W, Chen W, Yuan G, Bai D, Xu H
Oral diseases 2024 Jul;30(5):3308-3320
Oral diseases 2024 Jul;30(5):3308-3320
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Sun DY, Wu WB, Wu JJ, Shi Y, Xu JJ, Ouyang SX, Chi C, Shi Y, Ji QX, Miao JH, Fu JT, Tong J, Zhang PP, Zhang JB, Li ZY, Qu LF, Shen FM, Li DJ, Wang P
Nature communications 2024 Feb 16;15(1):1429
Nature communications 2024 Feb 16;15(1):1429
Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca(2+)/CaMK2b Pathway.
Xia Y, Ding L, Zhang C, Xu Q, Shi M, Gao T, Zhou FQ, Deng DYB
Neuroscience bulletin 2024 Apr;40(4):421-438
Neuroscience bulletin 2024 Apr;40(4):421-438
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
He YF, Hu XM, Khan MA, Yu BY, Sheng YC, Xiao XZ, Wan XX, Tan SP, Xiong K
Mediators of inflammation 2023;2023:2252255
Mediators of inflammation 2023;2023:2252255
Potent anti-inflammatory responses: Role of hydrogen in IL-1α dominated early phase systemic inflammation.
Wei Y, Wang K, Zhang Y, Duan Y, Tian Y, Yin H, Fu X, Ma Z, Zhou J, Yu M, Ni Q, Tang W
Frontiers in pharmacology 2023;14:1138762
Frontiers in pharmacology 2023;14:1138762
Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer.
Venkata PP, Jayamohan S, He Y, Alejo S, Johnson JD, Palacios BE, Pratap UP, Chen Y, Liu Z, Zou Y, Lai Z, Suzuki T, Viswanadhapalli S, Weintraub ST, Palakurthi S, Valente PT, Tekmal RR, Kost ER, Vadlamudi RK, Sareddy GR
Cancer letters 2023 Oct 28;575:216383
Cancer letters 2023 Oct 28;575:216383
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17.
Wang Y, Lou R, Zhang Z, Xiao C, Yu S, Wei S, Liu Y, Fu W, Li B, Chen YG
Science advances 2023 Oct 27;9(43):eadi1827
Science advances 2023 Oct 27;9(43):eadi1827
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Chen L, Xia S, Wang F, Zhou Y, Wang S, Yang T, Li Y, Xu M, Zhou Y, Kong D, Zhang Z, Shao J, Xu X, Zhang F, Zheng S
Pharmacological research 2023 Mar;189:106704
Pharmacological research 2023 Mar;189:106704
Neuro death through autophagy via the acetylation of FoxO1 by SIRT2 in the hippocampus of mice in a autism spectrum disorder mice model.
Guo L, Jiang ZM, Zhan YJ, Pan W, Wu QW, Song FX, Zhou X, Zhou XY, Liu LJ, Wang JT
Journal of cellular physiology 2023 Jun;238(6):1275-1287
Journal of cellular physiology 2023 Jun;238(6):1275-1287
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, Deng S, Wu D, Cao Y, Dong L, Bai F, Zhao S, Deng X, Peng C, Li H, Chen J, Shen B, Jiang L, Chen H
Nature communications 2023 Jul 31;14(1):4600
Nature communications 2023 Jul 31;14(1):4600
Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology.
Guo X, Xu JK, Qi X, Wei Y, Wang CW, Li H, Ma L, You C, Tian M
Neural regeneration research 2023 Jan;18(1):170-175
Neural regeneration research 2023 Jan;18(1):170-175
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Zhang JW, Zhang D, Yin HS, Zhang H, Hong KQ, Yuan JP, Yu BP
Gut microbes 2023 Jan-Dec;15(1):2197836
Gut microbes 2023 Jan-Dec;15(1):2197836
Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model.
Xu Y, Li W, Shi M, Xu X, Guo D, Liu Z, Chen L, Zhong X, Cao W
Neuropharmacology 2023 Aug 1;233:109560
Neuropharmacology 2023 Aug 1;233:109560
EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion.
Zhang ZJ, Sun ZX, Liu HJ
Heliyon 2023 Apr;9(4):e15305
Heliyon 2023 Apr;9(4):e15305
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J
Nature communications 2023 Apr 3;14(1):1840
Nature communications 2023 Apr 3;14(1):1840
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Qian Z, Chen H, Xia M, Chang J, Li X, Ye S, Wu S, Jiang S, Bao J, Wang B, Kong R, Zhang S, Zheng S, Cao X, Hong X
International journal of biological sciences 2022;18(4):1328-1346
International journal of biological sciences 2022;18(4):1328-1346
Oridonin Delays Aging Through the AKT Signaling Pathway.
An Y, Zhu J, Wang X, Sun X, Luo C, Zhang Y, Ye Y, Li X, Abulizi A, Huang Z, Zhang H, Yang B, Xie Z
Frontiers in pharmacology 2022;13:888247
Frontiers in pharmacology 2022;13:888247
Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.
Guo H, Liu R, He J, Yao W, Zheng W
Frontiers in physiology 2022;13:841149
Frontiers in physiology 2022;13:841149
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Sun J, Wei J, Zhang Y, Li J, Li J, Yan J, Guo M, Han J, Qiao H
Frontiers in immunology 2022;13:819680
Frontiers in immunology 2022;13:819680
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Luo L, Gong J, Wang Z, Liu Y, Cao J, Qin J, Zuo R, Zhang H, Wang S, Zhao P, Yang D, Zhang M, Wang Y, Zhang J, Zhou Y, Li C, Ni B, Tian Z, Liu M
Bioactive materials 2022 Sep;15:29-43
Bioactive materials 2022 Sep;15:29-43
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Hao H, Xie F, Xu F, Wang Q, Wu Y, Zhang D
International immunopharmacology 2022 Oct;111:109170
International immunopharmacology 2022 Oct;111:109170
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
Zhao W, Xu D, Hong W, Zhang L, Wu Q, Gao M, Wang J
International immunopharmacology 2022 Nov;112:109190
International immunopharmacology 2022 Nov;112:109190
L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis.
Yang X, Wang M, Kang X, Mo F, Si P, Ma J, Zhang P, Zheng S, Li J, Wang Y, Li Q, Zhang J
International journal of pharmaceutics 2022 Jun 25;622:121851
International journal of pharmaceutics 2022 Jun 25;622:121851
Celecoxib, Beyond Anti-inflammation, Alleviates Tendon-Derived Stem Cell Senescence in Degenerative Rotator Cuff Tendinopathy.
Cai Z, Zhang Y, Liu S, Liu X
The American journal of sports medicine 2022 Jul;50(9):2488-2496
The American journal of sports medicine 2022 Jul;50(9):2488-2496
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer.
Zhou L, Niu Z, Wang Y, Zheng Y, Zhu Y, Wang C, Gao X, Gao L, Zhang W, Zhang K, Melino G, Huang H, Wang X, Sun Q
Cell death discovery 2022 Jan 10;8(1):13
Cell death discovery 2022 Jan 10;8(1):13
Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models.
Zou HJ, Guo SW, Zhu L, Xu X, Liu JB
Frontiers in neuroscience 2021;15:628917
Frontiers in neuroscience 2021;15:628917
Gancaonin N from Glycyrrhiza uralensis Attenuates the Inflammatory Response by Downregulating the NF-κB/MAPK Pathway on an Acute Pneumonia In Vitro Model.
Ko HM, Lee SH, Jee W, Jung JH, Kim KI, Jung HJ, Jang HJ
Pharmaceutics 2021 Jul 6;13(7)
Pharmaceutics 2021 Jul 6;13(7)
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Jin W, Zhang Y, Xue Y, Han X, Zhang X, Ma Z, Sun S, Chu X, Cheng J, Guan S, Li Z, Chu L
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
Zhang C, Xie Y, Chen H, Lv L, Yao J, Zhang M, Xia K, Feng X, Li Y, Liang X, Sun X, Deng C, Liu G
Aging 2020 Jan 20;12(2):1272-1284
Aging 2020 Jan 20;12(2):1272-1284
Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models.
Kimura N, Nakagami G, Minematsu T, Sanada H
Journal of tissue viability 2020 Feb;29(1):51-57
Journal of tissue viability 2020 Feb;29(1):51-57
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Zhao Z, Li J, Zheng B, Liang Y, Shi J, Zhang J, Han X, Chu L, Chu X, Gao Y
Molecular medicine reports 2020 Dec;22(6):5271-5281
Molecular medicine reports 2020 Dec;22(6):5271-5281
Telbivudine antagonizes TLR4 to inhibit the epithelial-to-mesenchymal transition in human proximal tubular epithelial cells in vitro.
Chen J, Li D, Luo E
International immunopharmacology 2019 Sep;74:105683
International immunopharmacology 2019 Sep;74:105683
TLR4 gene in the regulation of periodontitis and its molecular mechanism.
Qi W, Yang X, Ye N, Li S, Han Q, Huang J, Wu B
Experimental and therapeutic medicine 2019 Sep;18(3):1961-1966
Experimental and therapeutic medicine 2019 Sep;18(3):1961-1966
Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA 4-Dependent CCN 1 Secretion.
Cui S, Xue L, Yang F, Dai S, Han Z, Liu K, Liu B, Yuan Q, Cui Z, Zhang Y, Xu F, Chen Y
Journal of the American Heart Association 2018 Sep 18;7(18):e009111
Journal of the American Heart Association 2018 Sep 18;7(18):e009111
Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration.
Li Y, Shen R, Wen G, Ding R, Du A, Zhou J, Dong Z, Ren X, Yao H, Zhao R, Zhang G, Lu Y, Wu X
Frontiers in pharmacology 2017;8:139
Frontiers in pharmacology 2017;8:139
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IL 1 alpha antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IL 1 alpha. This antibody recognizes human, mouse antigen. The IL 1 alpha antibody has been validated for the following applications: ELISA, WB analysis.
