RA0354

antibody from Oursmab

Targeting: IL1A IL-1A, IL1, IL1-ALPHA, IL1F1

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0354

Provider

Oursmab

Product name

Bermekimab (Biosimilar Reference Antibody) (IL1A)

Antibody type

Monoclonal

Description

Bermekimab is a true human (non-immunogenic) monoclonal antibody of the IgG1¦Ë isotype that specifically targets and neutralizes interleukin-1 alpha (IL-1¦Á). It functions as a cytokine-blocking therapy by binding to IL-1¦Á, preventing it from engaging its receptor (IL-1R1) and initiating pro-inflammatory signaling. It has been investigated for the treatment of conditions driven by IL-1¦Á-mediated inflammation, including hidradenitis suppurativa (HS), cancer cachexia, and acne vulgaris. Clinical trials have shown promising results in reducing disease activity in HS and improving symptoms in cachexia associated with advanced cancers.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Bermekimab (Biosimilar Reference Antibody) (IL1A)-RA0354-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Bermekimab (Biosimilar Reference Antibody) (IL1A)-RA0354 in a linear range of 3.91-125 ng/mL.