AGTO-L079D

antibody from Creative Biolabs

Targeting: IL4R CD124

No application information provided.

Antibody Data

Product number

AGTO-L079D

Provider

Creative Biolabs

Product name

IL4-DT immunotoxin

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the IL-4 to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to acute lymphoblastic leukemia (ALL) cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of acute lymphoblastic leukemia (ALL).

Reactivity

Human

Host

Human