Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
IL4R
Interleukin 4 receptorCD124
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Top validated antibodies |
|||||
| R&D Systems |  MAB230-100 |
17 references | Monoclonal |
WB
ICC
IHC
FC
BN
|
|
| Invitrogen Antibodies | MA5-23814 |
Monoclonal |
WB
ICC
IHC
FC
BN
OA
|
||
| Novus Biologicals | MAB230-100 |
Monoclonal |
WB
ICC
IHC
FC
BN
|
||
| Proteintech Group | 28331-1-AP |
1 references | Polyclonal |
WB
EL
IHC
FC
|
|
| LSBio | LS-C807240 |
Polyclonal |
WB
EL
ICC
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider