Tissue expression
Cell line expression
Protein structure
IL4R
Interleukin 4 receptorCD124
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Top validated antibodies |
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R&D Systems | MAB230-100 | 17 references | Monoclonal |
WB
ICC
IHC
FC
BN
|
|
Invitrogen Antibodies | MA5-23814 | Monoclonal |
WB
ICC
IHC
FC
BN
OA |
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Novus Biologicals | MAB230-100 | Monoclonal |
WB
ICC
IHC
FC
BN
|
||
OriGene | BM990 | Monoclonal |
WB
EL
IHC
FC
FA
|
||
Biorbyt | orb429746 | Monoclonal |
WB
EL
IHC
FC
FA
|
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Supportive data in Antibodypedia
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