16-1249-82

antibody from Invitrogen Antibodies

Targeting: IL4R CD124

Flow cytometry (Supportive data in Antibodypedia)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

16-1249-82

Provider

Invitrogen Antibodies

Product name

CD124 Monoclonal Antibody (X2/45-12), Functional Grade, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: The X2/45-12 monoclonal antibody reacts with the human IL-4 receptor alpha chain. IL-4 receptor alpha chain (CD124) is crucial for the binding and signal transduction of IL-4. Both IL-4 and IL-13 use the IL-4 receptor alpha chain as their receptor component and activate many common signal pathways.

Antibody clone number

X2/45-12

Concentration

1 mg/mL

References

Submitted references

Interleukin-13 overexpression by tax transactivation: a potential autocrine stimulus in human T-cell leukemia virus-infected lymphocytes.

Wäldele K, Schneider G, Ruckes T, Grassmann R
Journal of virology 2004 Jun;78(12):6081-90

---

Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency.

Tony HP, Shen BJ, Reusch P, Sebald W
European journal of biochemistry 1994 Oct 15;225(2):659-65

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Surface staining of normal human peripheral blood cells with Anti-Human CD124 Purified followed by Anti-Mouse IgG Biotin and Streptavidin PE (Product # 12-4317-87). Appropriate isotype controls were used (open histogram). Cells in the lymphocyte population were used for analysis.

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

NULL