Ab112438

antibody from Aladdin Scientific

Targeting: XRCC5 KARP-1, KU80, Ku86, KUB2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab112438

Provider

Aladdin Scientific

Product name

Ku80 Mouse mAb

Antibody type

Monoclonal

Description

Application:WB: 1/500 - 1/2000. Detects a band of approximately 86 kDa (predicted molecular weight: 83 kDa). IHC: 1/200 - 1/1000 IF/ICC: 1/200 - 1/1000 Flow: 1/200 - 1/400ELISA: 1/10000The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

corresponding to amino acids 61-340
of Human Ku80


Antibody clone number

5C5

Vial size

100_l,10_l,1ml,50_l

Concentration

1 mg/ml

Storage

Shipped at 4¡C. Store at +4¡C short term (1-2 weeks). Store at -20¡C long term. Avoid repeated freeze / thaw cycles.