Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B114 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-LRP6 monoclonal antibody, clone 2D20
- Antibody type
- Monoclonal
- Description
- Low density lipoprotein receptor-related protein 6 (LRP6) is a member of the low density lipoprotein receptor gene family (LDLR). LRP6 a cell surface protein, plays a critical role in embryonic development by functioning as a co-receptor specifically for the ÉÇ-catenin Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. When LRP6 binds to Wnt, it phosphorylates Wnt at multiple sites, which results in the recruitment of the scaffolding protein Axin to the cell membrane and ÉÇ catenin activation. LRP6 is the receptor for a novel Wnt antaganoist, DKK1. LRP6 is associated with autosomal dominant coronary artery disease type 2 and bone formation, as well as many human malignancies.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2D20
- Vial size
- 100_g
- Concentration
- 1 mg/mL
- Storage
- -20°C
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