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Cell line expression
Protein structure
LRP6
LDL receptor related protein 6ADCAD2
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. [provided by RefSeq, Dec 2009]
Top validated antibodies |
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| LSBio |  LS-C100405 |
Polyclonal |
WB
IHC
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| Novus Biologicals | NB100-1475 |
3 references | Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN2840612 |
4 references | Polyclonal |
WB
IHC
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| R&D Systems | AF1505 |
4 references | Polyclonal |
WB
FC
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| Abnova Corporation | PAB12632 |
3 references | Polyclonal |
WB
OA
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