LRP6

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. [provided by RefSeq, Dec 2009]

Description

LDL receptor related protein 6

Protein family

Cancer-related genes, Disease related genes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

12:p13.2 (12116025 - 12267012)

Ensembl ID

ENSG00000070018  (ver. 84.38)

Orthologs

Mouse Lrp6: ENSMUSG00000030201

UniProt

O75581

neXtProt

NX_O75581

Human splice variants
Mouse splice variants