19970-1-AP

antibody from Proteintech Group

Targeting: MAP3K1 MAPKKK1, MEKK, MEKK1

Provider product page for 19970-1-AP

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
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Product number: 19970-1-AP - Provider product page
Provider: Proteintech Group
Product name: MAP3K1 antibody
Antibody type: Polyclonal
Description: KD/KO validated MAP3K1 antibody (Cat. #19970-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAP3K1 protein structure - 19970-1-AP shown in red.

Submitted references Schaftoside inhibits neuroinflammation and exerts antidepressant effects through METTL3-mediated m6A modification of circ_0001470 sponging miR-183-5p to regulate MAP3K1 expression.

Wang H, Wu J, Ma K, Su T, Lin Q, Zhang H, Ma T, Wang P, Liu D
Psychopharmacology 2026 Mar 23;

Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy.

Xie X, Liu C, Liu X, Hou L, Zhang Y, Huang L, Peng W, Liu Y
Scientific reports 2026 Jan 13;16(1):5155

Salvianolic acid B and Senkyunolide I synergistically alleviate cardiac hypertrophy and regulate MAP3K1 signaling.

Liu C, Guo R, Zhou Y, Zhu M, Shao L, Wang Y, Zhao L
Chinese medicine 2025 Sep 28;20(1):148

Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA-Target Gene Interactions in Mice.

Li Y, Ao Y, Xie X, Ulan T, Liu D, Guo X
Biology 2025 May 9;14(5)

Downregulation of Circular RNA Gla Reduced Astrocyte Inflammatory Status by Regulating miR-488/MEKK1 Levels and Promoted Functional Recovery After Spinal Cord Injury.

Shao Q, Zhang Y, Zhang Z, Jiang W, Yin Y, Fang Y, Zhang C, Chen Q, Ning B
Journal of inflammation research 2024;17:7123-7139

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.

Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM
Cell 2024 Oct 31;187(22):6379-6392.e17

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.

Ganga AK, Sweeney LK, Rubio Ramos A, Wrinn CM, Bishop CS, Hamel V, Guichard P, Breslow DK
Current biology : CB 2024 Oct 21;34(20):4824-4834.e6

Circulating miR-320b Contributes to CD4+ T-Cell Proliferation in Systemic Lupus Erythematosus via MAP3K1.

Li Z, Wang R, Wang D, Zhang S, Song H, Ding S, Zhu Y, Wen X, Li H, Chen H, Liu S, Sun L
Journal of immunology research 2023;2023:6696967

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J, Shi Y, Jiang L
Cellular and molecular gastroenterology and hepatology 2023;15(2):307-325

Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas.

Bao JH, Lu WC, Duan H, Ye YQ, Li JB, Liao WT, Li YC, Sun YP
Frontiers in immunology 2022;13:933973

The MAP3K1/c-JUN signaling axis regulates glioblastoma stem cell invasion and tumor progression.

Zhou S, Niu R, Sun H, Kim SH, Jin X, Yin J
Biochemical and biophysical research communications 2022 Jul 5;612:188-195

Extracellular vesicles secreted from mesenchymal stem cells exert anti-apoptotic and anti-inflammatory effects via transmitting microRNA-18b in rats with diabetic retinopathy.

Xu Z, Tian N, Li S, Li K, Guo H, Zhang H, Jin H, An M, Yu X
International immunopharmacology 2021 Dec;101(Pt B):108234

LncRNA KCNQ1OT1 activated by c-Myc promotes cell proliferation via interacting with FUS to stabilize MAP3K1 in acute promyelocytic leukemia.

Tang D, Luo Y, Jiang Y, Hu P, Peng H, Wu S, Zhang G, Wang Y
Cell death & disease 2021 Aug 17;12(9):795

Next-Generation Sequencing Panel Analysis of Clinically Relevant Mutations in Circulating Cell-Free DNA from Patients with Gestational Trophoblastic Neoplasia: A Pilot Study.

Luo L, Lin L, Zhang X, Cai Q, Zhao H, Xu C, Cong Q
BioMed research international 2020;2020:1314967

LncRNA SLCO4A1-AS1 predicts poor prognosis and promotes proliferation and metastasis via the EGFR/MAPK pathway in colorectal cancer.

Tang R, Chen J, Tang M, Liao Z, Zhou L, Jiang J, Hu Y, Liao Q, Xiong W, Tang Y, Nie S
International journal of biological sciences 2019;15(13):2885-2896

USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling.

Zhou J, Qiu T, Wang T, Chen Z, Ma X, Zhang L, Zou J
Clinical science (London, England : 1979) 2019 Jan 31;133(2):335-349

MicroRNAs profiling in fibroblasts derived from patients with Gorlin syndrome.

Shiohama T, Fujii K, Miyashita T, Takatani T, Ikehara H, Uchikawa H, Motojima T, Uchida T, Shimojo N
Journal of human genetics 2019 Aug;64(8):757-765

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway.

Su L, Jiang Y, Xu Y, Li X, Gao W, Xu C, Zeng C, Song J, Weng W, Liang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:1111-1119

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