Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B9344 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Human Topo IIÉÇ monoclonal antibody, clone 50/Upqp JJÉÇ
- Antibody type
- Monoclonal
- Description
- Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression. Topoisomerases transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA. Two isoforms of DNA topoisomerase II have been identified: topo IIÏ« and topo IIÉÇ. These exhibit a high degree of homology, except for some divergence in the C-terminal region. Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization. Topo IIÏ« levels rise during late S phase and peak in G2-M, whereas topo IIÉÇ levels remain constant throughout the cell cycle. In addition, topo IIÏ« is expressed in proliferating cells, while topo IIÉÇ is expressed in a wide range of tissues. Although the exact role of these two isoforms during cell proliferation is not known, the differences in cellular expression implicate different physiological roles. Both isoforms may also be important targets for anticancer agents that exert cytotoxicity in proliferating cells via stabilization of a topo II-DNA complex.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 50/Upqp JJÉÇ
- Vial size
- 50ug, 150ug
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
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