TOP2B

gene product
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]
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190 antibodies from 29 providers.

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AntibodyRefsTypeAVIWBELICCIPIHCFC
Atlas Antibodies
1 antibody
Bethyl Laboratories, Inc.
8 antibodies
Novus Biologicals
8 antibodies
NovoPro Bioscience Inc.
1 antibody
antibodies-online
54 antibodies
Proteintech Group
1 antibody
Biorbyt
10 antibodies
Acris Antibodies GmbH
6 antibodies
GeneTex
3 antibodies
Invitrogen Antibodies
2 antibodies
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
27 antibodies
Aviva Systems Biology
3 antibodies
Abnova Corporation
6 antibodies
OriGene
4 antibodies
R&D Systems
2 antibodies
Bioworld Technology, Inc
1 antibody
RabMAbs
2 antibodies
MyBioSource
5 antibodies
United States Biological
26 antibodies
Spring Bioscience
4 antibodies
Creative Biolabs
3 antibodies
St John's Laboratory
2 antibodies
Creative Diagnostics
3 antibodies
Abbiotec
1 antibody
Sigma-Aldrich
2 antibodies
EMD Millipore
1 antibody
GenWay
2 antibodies
RayBiotech, Inc.
1 antibody