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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [18]
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- Product number
- 67728-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- TXNRD1 antibody
- Antibody type
- Monoclonal
- Description
- TXNRD1 antibody (Cat. #67728-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1B10C4
- Vial size
- 20ul, 150ul
Submitted references Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.
Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells.
Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period.
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Protocol for assaying irreversible inhibitors of thioredoxin reductase 1.
Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells.
Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec(498) Residue of Cytosolic Selenoprotein Thioredoxin Reductase.
Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1).
Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function.
A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas.
Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer.
Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
A Robust Metabolic Enzyme-Based Prognostic Signature for Head and Neck Squamous Cell Carcinoma.
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.
Xu Z, Yang Z, Lv L, Yang J, Liu W
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.
Suganuma T, Hassan H, Swanson SK, Laxman S, Workman JL
NAR molecular medicine 2026 Jan;3(1):ugag010
NAR molecular medicine 2026 Jan;3(1):ugag010
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells.
Zhou H, Sun S, Liu H, Li T, Xu Y, Yang R, Liu H, He L, Xu W, Guan S, Xu J
Antioxidants (Basel, Switzerland) 2025 Oct 11;14(10)
Antioxidants (Basel, Switzerland) 2025 Oct 11;14(10)
Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period.
Xu M, Liu L, Fan Z, Niu L, Ning W, Cheng H, Li M, Huo W, Zhou P, Deng H, Chen W, Che L
Poultry science 2025 Jan;104(1):104615
Poultry science 2025 Jan;104(1):104615
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Yang R, Sun S, Zhang Q, Liu H, Wang L, Meng Y, Chen N, Wang Z, Liu H, Ji F, Dai Y, He G, Xu W, Ye Z, Zhang J, Ma Q, Xu J
Biological trace element research 2025 Apr;203(4):1949-1960
Biological trace element research 2025 Apr;203(4):1949-1960
Protocol for assaying irreversible inhibitors of thioredoxin reductase 1.
Sun S, Liu H, Shi W, Zhou H, Wu H, Xu W, Xu J
STAR protocols 2024 Sep 20;5(3):103235
STAR protocols 2024 Sep 20;5(3):103235
Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
Wang R, Mi Y, Ni J, Wang Y, Ding L, Ran X, Sun Q, Tan SY, Koeffler HP, Feng N, Chen YQ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(9):e2304939
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(9):e2304939
Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells.
Wang L, Sun S, Liu H, Zhang Q, Meng Y, Sun F, Zhang J, Liu H, Xu W, Ye Z, Zhang J, Sun B, Xu J
The FEBS journal 2024 Dec;291(23):5276-5289
The FEBS journal 2024 Dec;291(23):5276-5289
Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
Shi W, Sun S, Liu H, Meng Y, Ren K, Wang G, Liu M, Wu J, Zhang Y, Huang H, Shi M, Xu W, Ma Q, Sun B, Xu J
Redox biology 2024 Apr;70:103050
Redox biology 2024 Apr;70:103050
Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec(498) Residue of Cytosolic Selenoprotein Thioredoxin Reductase.
Liu M, Sun S, Meng Y, Wang L, Liu H, Shi W, Zhang Q, Xu W, Sun B, Xu J
Molecules (Basel, Switzerland) 2023 Sep 28;28(19)
Molecules (Basel, Switzerland) 2023 Sep 28;28(19)
Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1).
Zhao L, Zhong B, Zhu Y, Zheng H, Wang X, Hou Y, Lu JJ, Ai N, Guo X, Ge W, Ma YY, Chen X
Biochemical pharmacology 2023 Apr;210:115487
Biochemical pharmacology 2023 Apr;210:115487
Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function.
Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA
Function (Oxford, England) 2022;3(4):zqac034
Function (Oxford, England) 2022;3(4):zqac034
A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas.
Li W, Zou Z, An N, Wang M, Liu X, Mei Z
Frontiers in oncology 2022;12:996222
Frontiers in oncology 2022;12:996222
Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer.
Wang L, Hensley CR, Howell ME, Ning S
Frontiers in oncology 2022;12:923009
Frontiers in oncology 2022;12:923009
Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis.
Guo W, Wu Z, Chen J, Guo S, You W, Wang S, Ma J, Wang H, Wang X, Wang H, Ma J, Yang Y, Tian Y, Shi Q, Gao T, Yi X, Li C
Journal for immunotherapy of cancer 2022 Jun;10(6)
Journal for immunotherapy of cancer 2022 Jun;10(6)
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
A Robust Metabolic Enzyme-Based Prognostic Signature for Head and Neck Squamous Cell Carcinoma.
Mai Z, Chen H, Huang M, Zhao X, Cui L
Frontiers in oncology 2021;11:770241
Frontiers in oncology 2021;11:770241
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.
Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z, Chen C, Ju Z
Cell reports 2021 Mar 30;34(13):108922
Cell reports 2021 Mar 30;34(13):108922
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