Tissue expression
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Protein structure

TXNRD1

Thioredoxin reductase 1
GRIM-12, Trxr1, TXNR 
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
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501 antibodies from 43 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
4 antibodies
Invitrogen Antibodies
32 antibodies
Biorbyt
41 antibodies
GeneTex
5 antibodies
NovoPro Bioscience Inc.
4 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Novus Biologicals
18 antibodies
Boster Biological Technology
2 antibodies
HUABIO Research
1 antibody
Santa Cruz Biotechnology
1 antibody
antibodies-online
134 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Abnova Corporation
9 antibodies
R&D Systems
8 antibodies
OriGene
11 antibodies
Acris Antibodies GmbH
11 antibodies
St John's Laboratory
4 antibodies
Antibodies.com
1 antibody
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
Atlas Antibodies
2 antibodies
RabMAbs
6 antibodies
Cell Signaling Technology, Inc
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
Bethyl Laboratories
1 antibody
United States Biological
30 antibodies
MyBioSource
11 antibodies
Creative Diagnostics
10 antibodies
Arigo
1 antibody
Aviva Systems Biology
1 antibody
GenWay
3 antibodies
RayBiotech, Inc.
2 antibodies
ProSci
3 antibodies
Leading Biology
6 antibodies
Abbexa
7 antibodies
Abgent
2 antibodies
Sino Biological Inc.
2 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
EMD Millipore
1 antibody
Creative Biolabs
16 antibodies