abx015712

antibody from Abbexa

Targeting: FGFR4 CD334, JTK2

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

abx015712

Provider

Abbexa

Product name

Fibroblast Growth Factor Receptor 4 (FGFR4) Antibody

Antibody type

Monoclonal

Description

FGFR4: fibroblast growth factor receptor 4.Entrez Protein NP_002002.It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution.FGFR family members differ from one another in their ligand affinities and tissue distribution.A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20.Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3.This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.