FGFR4

gene product
CD334, JTK2
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
More gene data

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
653 antibodies from 41 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Abnova Corporation
10 antibodies
antibodies-online
227 antibodies
Biorbyt
36 antibodies
Invitrogen Antibodies
14 antibodies
GeneTex
10 antibodies
OriGene
10 antibodies
NSJ Bioreagents
7 antibodies
Abgent
8 antibodies
Santa Cruz Biotechnology
1 antibody
Novus Biologicals
26 antibodies
NovoPro Bioscience Inc.
14 antibodies
R&D Systems
14 antibodies
ProSci
6 antibodies
Proteintech Group
1 antibody
Acris Antibodies GmbH
13 antibodies
Aviva Systems Biology
7 antibodies
LifeSpan BioSciences, Inc.
87 antibodies
Affinity Biosciences
5 antibodies
BioLegend
4 antibodies
Cell Signaling Technology, Inc
2 antibodies
Atlas Antibodies
3 antibodies
St John's Laboratory
5 antibodies
RabMAbs
4 antibodies
Bioworld Technology, Inc
2 antibodies
Boster Biological Technology
2 antibodies
United States Biological
31 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
MyBioSource
18 antibodies
Sino Biological Inc.
5 antibodies
Signalway Antibody LLC
1 antibody
Miltenyi Biotec
14 antibodies
FabGennix
6 antibodies
Creative Biolabs
26 antibodies
Abbiotec
4 antibodies
RayBiotech, Inc.
3 antibodies
Abiocode, Inc.
1 antibody
Sigma-Aldrich
5 antibodies
Creative Diagnostics
4 antibodies
EMD Millipore
1 antibody
Arigo
1 antibody