orb151957

antibody from Biorbyt
Targeting: HSPA5 BiP, GRP78
Provider product page for orb151957
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
orb151957 - Provider product page
Provider
Biorbyt
Product name
GRP78 (Bip) antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to GRP78 (ATTO-594). GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimers patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs ..
Reactivity
Human, Mouse, Rat, Canine, Drosophila, Hamster
Host
Rabbit
Conjugate
Red dye
Vial size
100 ug
Concentration
1 mg/ml
Storage
Conjugated antibodies should be stored at 4°C
HSPA5 protein structure - orb151957 shown in red.