Tissue expression
Cell line expression

HSPA5

gene product
BiP, GRP78 
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
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Antibodies

 

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1783 antibodies from 48 providers.

Antibody properties

Applications

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
2 antibodies
GeneTex
16 antibodies
Novus Biologicals
166 antibodies
Invitrogen Antibodies
27 antibodies
antibodies-online
658 antibodies
Wuhan Fine Biotech Co., Ltd.
3 antibodies
NovoPro Bioscience Inc.
2 antibodies
Biorbyt
147 antibodies
NSJ Bioreagents
9 antibodies
Abgent
8 antibodies
Arigo
6 antibodies
Santa Cruz Biotechnology
1 antibody
OriGene
26 antibodies
Cell Signaling Technology, Inc
5 antibodies
Aviva Systems Biology
5 antibodies
Abnova Corporation
12 antibodies
LifeSpan BioSciences, Inc.
277 antibodies
HUABIO Research
6 antibodies
Enzo Life Sciences
4 antibodies
Cusabio Biotech Co., Ltd
13 antibodies
Affinity Biosciences
4 antibodies
ProSci
6 antibodies
Boster Biological Technology
4 antibodies
Acris Antibodies GmbH
24 antibodies
R&D Systems
2 antibodies
Bioworld Technology, Inc
3 antibodies
St John's Laboratory
14 antibodies
Antibodies.com
2 antibodies
Atlas Antibodies
2 antibodies
Abbkine Scientific Co.Ltd.
4 antibodies
Signalway Antibody LLC
1 antibody
Creative Diagnostics
12 antibodies
Creative Biolabs
77 antibodies
MyBioSource
24 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
RabMAbs
6 antibodies
Abbexa
56 antibodies
ABEOMICS Inc.
2 antibodies
MilliporeSigma / Merck KGaA
6 antibodies
United States Biological
106 antibodies
Spring Bioscience
4 antibodies
RayBiotech, Inc.
3 antibodies
Abbiotec
2 antibodies
Abiocode, Inc.
1 antibody
EMD Millipore
4 antibodies
GenWay
2 antibodies
Leading Biology
1 antibody