F8

gene product
DXS1253E, F8C, FVIII, HEMA
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
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966 antibodies from 37 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
85 antibodies
antibodies-online
296 antibodies
Green Mountain Antibodies
14 antibodies
Affinity Biosciences
2 antibodies
GeneTex
20 antibodies
Biorbyt
51 antibodies
NovoPro Bioscience Inc.
1 antibody
LifeSpan BioSciences, Inc.
184 antibodies
Abnova Corporation
15 antibodies
Santa Cruz Biotechnology
1 antibody
Bioworld Technology, Inc
2 antibodies
Invitrogen Antibodies
7 antibodies
Acris Antibodies GmbH
13 antibodies
Aviva Systems Biology
13 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Proteintech Group
1 antibody
OriGene
14 antibodies
Creative Biolabs
87 antibodies
MyBioSource
15 antibodies
Boster Biological Technology
2 antibodies
NSJ Bioreagents
1 antibody
St John's Laboratory
4 antibodies
FabGennix
3 antibodies
Abbiotec
3 antibodies
Abgent
4 antibodies
Creative Diagnostics
13 antibodies
EMD Millipore
3 antibodies
ProSci
2 antibodies
RayBiotech, Inc.
2 antibodies
United States Biological
40 antibodies