DPABH-14245

antibody from Creative Diagnostics
Targeting: MECP2 MRX16, MRX79, RTT
Provider product page for DPABH-14245
Western blot
ELISA
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry
Flow cytometry

Antibody data

Product number
DPABH-14245 - Provider product page
Provider
Creative Diagnostics
Proper citation
Creative Diagnostics Cat#DPABH-14245, RRID:AB_2517069
Product name
Rabbit Anti-Human MECP2 Polyclonal antibody
Antibody type
Polyclonal
Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 uL
MECP2 protein structure - DPABH-14245 shown in red.