Tissue expression
Cell line expression
Protein structure

MECP2

Methyl-CpG binding protein 2
MRX16, MRX79, RTT 
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
More gene data

All Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antigen sequence

Epitope

Antibody

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
882 antibodies from 47 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
3 antibodies
Invitrogen Antibodies
60 antibodies
antibodies-online
267 antibodies
Novus Biologicals
13 antibodies
GeneTex
8 antibodies
Cell Signaling Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
10 antibodies
Boster Biological Technology
5 antibodies
Atlas Antibodies
2 antibodies
OriGene
20 antibodies
Abnova Corporation
12 antibodies
Acris Antibodies GmbH
13 antibodies
NSJ Bioreagents
8 antibodies
St John's Laboratory
25 antibodies
Bioworld Technology, Inc
1 antibody
Cusabio Biotech Co., Ltd
5 antibodies
PhosphoSolutions
3 antibodies
Antibodies.com
2 antibodies
Aviva Systems Biology
11 antibodies
FineTest Biotech
1 antibody
Affinity Biosciences
3 antibodies
Creative Diagnostics
7 antibodies
FabGennix
6 antibodies
Arigo
2 antibodies
Abbexa
13 antibodies
Creative Biolabs
12 antibodies
Abgent
10 antibodies
MilliporeSigma / Merck KGaA
11 antibodies
ProSci
5 antibodies
Rockland Immunochemicals, Inc.
5 antibodies
Antibodies Incorporated / NeuroMab
2 antibodies
MyBioSource
13 antibodies
Leading Biology
16 antibodies
Active Motif
3 antibodies
United States Biological
107 antibodies
BioLegend
6 antibodies
EMD Millipore
5 antibodies
RabMAbs
2 antibodies
RayBiotech, Inc.
2 antibodies
Abbiotec
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Abiocode, Inc.
1 antibody
UC Davis/NIH NeuroMab Facility
2 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
GenWay
1 antibody