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LearnABIN362412
antibody from antibodies-online
Targeting: PTPN11
BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN362412 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (pTyr580) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr580 (R-V-Y (p) -E-N) derived from Human SHP-2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr580
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation.
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.
Ferjoux G, Lopez F, Esteve JP, Ferrand A, Vivier E, Vely F, Saint-Laurent N, Pradayrol L, Buscail L, Susini C
Molecular biology of the cell 2003 Sep;14(9):3911-28
Molecular biology of the cell 2003 Sep;14(9):3911-28
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.
Shi ZQ, Yu DH, Park M, Marshall M, Feng GS
Molecular and cellular biology 2000 Mar;20(5):1526-36
Molecular and cellular biology 2000 Mar;20(5):1526-36
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.
Li C, Friedman JM
Proceedings of the National Academy of Sciences of the United States of America 1999 Aug 17;96(17):9677-82
Proceedings of the National Academy of Sciences of the United States of America 1999 Aug 17;96(17):9677-82
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
Oh ES, Gu H, Saxton TM, Timms JF, Hausdorff S, Frevert EU, Kahn BB, Pawson T, Neel BG, Thomas SM
Molecular and cellular biology 1999 Apr;19(4):3205-15
Molecular and cellular biology 1999 Apr;19(4):3205-15
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.
Mañes S, Mira E, Gómez-Mouton C, Zhao ZJ, Lacalle RA, Martínez-A C
Molecular and cellular biology 1999 Apr;19(4):3125-35
Molecular and cellular biology 1999 Apr;19(4):3125-35
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