PTPN11

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Description

protein tyrosine phosphatase, non-receptor type 11

Protein family

Cancer-related genes, Disease related genes, Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014), RAS pathway related proteins

Chromosome

12:q24.13 (112418351 - 112509913)

Ensembl ID

ENSG00000179295  (ver. 84.38)

Orthologs

Mouse Ptpn11: ENSMUSG00000043733

UniProt

Q06124

neXtProt

NX_Q06124

Human splice variants
Mouse splice variants