AF1559

antibody from Novus Biologicals

Targeting: NOTCH3 CADASIL, CASIL

Western blot (Data presented on provider website)

Blocking/Neutralizing (Data presented on provider website)

Antibody Data

Product number

AF1559

Provider

Novus Biologicals

Product name

Sheep Polyclonal Notch-3 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects human Notch-3 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Notch-3 is observed and less than 5% cross-reactivity with recombinant human (rh) Notch-1 and rhNotch-2 is observed.

Reactivity

Human

Host

Sheep

Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.

Franciosa G, Diluvio G, Gaudio FD, Giuli MV, Palermo R, Grazioli P, Campese AF, Talora C, Bellavia D, D'Amati G, Besharat ZM, Nicoletti C, Siebel CW, Choy L, Rustighi A, Sal GD, Screpanti I, Checquolo S
Oncogene 2016 Sep 8;35(36):4741-51

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Notch3 activation modulates cell growth behaviour and cross-talk to Wnt/TCF signalling pathway.

Wang T, Holt CM, Xu C, Ridley C, P O Jones R, Baron M, Trump D
Cellular signalling 2007 Dec;19(12):2458-67