Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
NOTCH3
Notch receptor 3CADASIL, CASIL
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
| Proteintech Group |  55114-1-AP |
25 references | Polyclonal |
WB
EL
IP
IHC
|
|
| Novus Biologicals | H00004854-M01 |
9 references | Monoclonal |
WB
EL
ICC
IHC
|
|
| R&D Systems | AF1308 |
3 references | Polyclonal |
WB
IHC
FC
BN
|
|
| Invitrogen Antibodies | PA5-13203 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| antibodies-online | ABIN250809 |
1 references | Polyclonal |
EL
ICC
IP
IHC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider