CABT-BL8131

antibody from Creative Diagnostics

Targeting: NOTCH3 CADASIL, CASIL

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8131

Provider

Creative Diagnostics

Product name

Anti-Notch3 Monoclonal antibody, clone NIO4-32 [APC]

Antibody type

Monoclonal

Description

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Reactivity

Human

Host

Mouse

Isotype

IgG