Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 345402 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#345402, RRID:AB_1953253
- Product name
- Purified anti-human Notch 3
- Antibody type
- Monoclonal
- Antigen
- Human Notch 3-human IgG1 Fc fusion protein
- Description
- The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C.
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