Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Western blot [1]
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Validation data
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- Product number
- 600-401-955 - Provider product page
- Provider
- Rockland Immunochemicals, Inc.
- Proper citation
- Rockland Cat#600-401-955, RRID:AB_2250922
- Product name
- Anti-MyD88 (RABBIT) Antibody - 600-401-955
- Antibody type
- Polyclonal
- Vial size
- 100 µl
Submitted references Biochemical Isolation of the Myddosome from Murine Macrophages.
Tan Y, Kagan JC
Methods in molecular biology (Clifton, N.J.) 2018;1714:79-95
Methods in molecular biology (Clifton, N.J.) 2018;1714:79-95
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Supportive validation
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- Rockland Immunochemicals, Inc. (provider)
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- Experimental details
- Western blot using Rockland's affinity purified anti-MyD88 antibody shows detection of MyD88 in Jurkat whole cell lysate. The membrane was probed with the primary antibody diluted to 1:500. Background Information: MyD88 (Myeloid differentiation primary response protein). The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and the dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), both members of the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to the bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. The MyD88 gene is expressed in many tissues.
- Validation comment
- Western Blot