TOP3B

gene product
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
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Antibodypedia Validation Initiative

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186 antibodies from 24 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
64 antibodies
Novus Biologicals
6 antibodies
Abnova Corporation
9 antibodies
Biorbyt
10 antibodies
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
33 antibodies
Bioworld Technology, Inc
1 antibody
Abgent
2 antibodies
GeneTex
3 antibodies
Affinity Biosciences
1 antibody
Acris Antibodies GmbH
2 antibodies
Aviva Systems Biology
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
OriGene
3 antibodies
Invitrogen Antibodies
2 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
2 antibodies
MyBioSource
3 antibodies
Boster Biological Technology
1 antibody
RayBiotech, Inc.
1 antibody
United States Biological
34 antibodies
Creative Diagnostics
2 antibodies
ProSci
1 antibody
Sigma-Aldrich
1 antibody